{"id":"https://openalex.org/W4389019148","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.760.20","title":"Cellular protein p32/gC1qR recruits PKC to Viral Protein ICP34.5 and Facilitates HSV Nuclear Egress","display_name":"Cellular protein p32/gC1qR recruits PKC to Viral Protein ICP34.5 and Facilitates HSV Nuclear Egress","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389019148","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.760.20"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.760.20","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.760.20","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.760.20","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048723811","display_name":"Cuizhu Zhang","orcid":"https://orcid.org/0009-0007-6722-8180","observed_orcids":["https://orcid.org/0009-0007-6722-8180"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cuizhu Zhang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030651742","display_name":"Songfang Wu","orcid":"https://orcid.org/0000-0001-7464-6398","observed_orcids":["https://orcid.org/0000-0001-7464-6398"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Songfang Wu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090302033","display_name":"Yu Wang","orcid":"https://orcid.org/0000-0001-5665-3164","observed_orcids":["https://orcid.org/0000-0001-5665-3164"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Wang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100461478","display_name":"Liming Zhang","orcid":"https://orcid.org/0000-0002-3500-9043","observed_orcids":["https://orcid.org/0000-0002-3500-9043","https://orcid.org/0000-0001-9049-9930"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liming Zhang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036309714","display_name":"Shuang Pan","orcid":"https://orcid.org/0000-0002-5087-3737","observed_orcids":["https://orcid.org/0000-0002-5087-3737"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Pan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100732104","display_name":"Yaohui Liu","orcid":"https://orcid.org/0000-0002-0973-097X","observed_orcids":["https://orcid.org/0000-0002-0973-097X"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaohui Liu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101061718","display_name":"Mengmeng Yang","orcid":"https://orcid.org/0009-0009-8229-0323","observed_orcids":["https://orcid.org/0009-0009-8229-0323"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengmeng Yang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100392736","display_name":"Da Chen","orcid":"https://orcid.org/0009-0006-8678-8274","observed_orcids":["https://orcid.org/0009-0006-8678-8274"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Da Chen","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058583649","display_name":"Jiyan Wang","orcid":"https://orcid.org/0000-0002-0518-8626","observed_orcids":["https://orcid.org/0000-0002-0518-8626","https://orcid.org/0000-0001-5078-6732"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiyan Wang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101494989","display_name":"Bin He","orcid":"https://orcid.org/0000-0001-7385-5542","observed_orcids":["https://orcid.org/0000-0001-7385-5542"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin He","raw_affiliation_strings":["Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001017107","display_name":"Youjia Cao","orcid":"https://orcid.org/0000-0003-2077-1999","observed_orcids":["https://orcid.org/0000-0003-2077-1999"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youjia Cao","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China","institution_ids":["https://openalex.org/I205237279"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/icp34-5","display_name":"ICP34.5","score":0.9020000100135803},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/nuclear-egress","display_name":"nuclear egress","score":0.8709999918937683},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8169999718666077},{"id":"https://openalex.org/keywords/nuclear-lamina","display_name":"nuclear lamina","score":0.8420000076293945},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.8209999799728394},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.7350000143051147},{"id":"https://openalex.org/keywords/nuclear-envelope-integrity","display_name":"nuclear envelope integrity","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.6745175123214722},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6307803988456726},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.5374330878257751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5364642143249512},{"id":"https://openalex.org/C94912109","wikidata":"https://www.wikidata.org/wiki/Q687194","display_name":"Nuclear lamina","level":5,"score":0.5253236293792725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5028071403503418},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5001890659332275},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.471581369638443},{"id":"https://openalex.org/C198410946","wikidata":"https://www.wikidata.org/wiki/Q845312","display_name":"Budding","level":2,"score":0.45653825998306274},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.44808685779571533},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.4372679591178894},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3466203510761261},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.2558678686618805},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.151292622089386},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.05836048722267151}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.760.20","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.760.20","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.760.20","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G606964391","display_name":null,"funder_award_id":"81672010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7192542328","display_name":"\u9e1f\u82f7\u9178\u4ea4\u6362\u56e0\u5b50Vav1\u5bf9\u9499\u4fe1\u53f7\u7684\u8c03\u63a7\u53ca\u5176\u5728T\u7ec6\u80de\u4e0e\u764c\u7ec6\u80de\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u63a2\u8ba8","funder_award_id":"31370862","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1985932355","https://openalex.org/W2519023924","https://openalex.org/W1821479442","https://openalex.org/W7143630089","https://openalex.org/W2110098549","https://openalex.org/W2000915748","https://openalex.org/W2081021921","https://openalex.org/W807431125","https://openalex.org/W2119827521","https://openalex.org/W130368268"],"abstract_inverted_index":{"The":[0],"nuclear":[1,25,57,115,122,152,163,190],"envelop":[2],"is":[3,38,119,137,145,159],"considered":[4],"anatural":[5],"barrier":[6],"of":[7,15,21,24,32,59,67,80,96,108,132,188,196,219],"virus":[8,47,151],"budding":[9,31],"and":[10,94,110,121,142,165,198],"efficient":[11,56],"replication.":[12,86],"Several":[13],"lines":[14],"evidence":[16],"suggest":[17,185],"that":[18,54,90,186],"the":[19,22,29,55,65,91,102,106,114,162,189,194,214],"disruption":[20],"integrity":[23,123],"lamina":[26,191],"correlate":[27],"with":[28,175],"nucleocapsid":[30,99],"herpesviruses.":[33],"Mammalian":[34],"cellular":[35,68],"protein":[36],"p32":[37,69,82,158,197],"identified":[39],"as":[40],"a":[41,148],"new":[42],"target":[43],"for":[44,139],"Herpes":[45],"simplex":[46],"1":[48],"(HSV\u20101)virulent":[49],"protein,":[50],"ICP34.5.":[51],"We":[52],"found":[53],"egress":[58],"HSV\u20101":[60,76,97],"particles":[61],"was":[62,211],"impaired":[63],"in":[64,75,150,170],"absence":[66],"protein.":[70],"Lacking":[71],"ICP34.5":[72,95,109,133,176,199],"encoding":[73],"gene":[74],"or":[77,134,206],"reduced":[78],"expression":[79],"host":[81],"severely":[83],"affects":[84],"viral":[85,140],"Here":[87],"we":[88],"report":[89],"interaction":[92],"betweenp32":[93],"facilitates":[98],"release":[100],"to":[101,105,113,147,161,179,223],"cytoplasm.":[103],"P32binds":[104],"NH2\u2010terminus":[107],"recruits":[111],"PKC":[112,167],"lamina,":[116],"where":[117],"LaminA/C":[118],"phosphorylated":[120],"disturbed.":[124],"Unlike":[125],"wildtype":[126],"virus,":[127],"an":[128],"HSV":[129,155,174,201],"mutant":[130],"devoid":[131],"its":[135],"amino\u2010terminus":[136],"crippled":[138],"growth":[141],"release.":[143],"This":[144,209],"attributable":[146],"defect":[149],"egress.":[153],"In":[154],"infected":[156,172],"cells,":[157],"recruited":[160],"membrane":[164],"triggers":[166],"activation":[168],"whereas":[169],"cells":[171],"by":[173,193,213],"mutants":[177],"fail":[178],"exert":[180],"any":[181],"effect.":[182],"These":[183],"results":[184],"disintegration":[187],"mediated":[192],"association":[195],"promotes":[200],"replication":[202],"via":[203],"PKC.":[204],"Support":[205],"Funding":[207],"Information":[208],"work":[210],"supported":[212],"National":[215],"Natural":[216],"Science":[217],"Foundation":[218],"China":[220],"(31370862;":[221],"81672010":[222],"YC)":[224]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}