{"id":"https://openalex.org/W4389018809","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.802.26","title":"Choline and betaine alter fetal brain expression of genes related to docosahexaenoic acid availability in a mouse model of gestational diabetes","display_name":"Choline and betaine alter fetal brain expression of genes related to docosahexaenoic acid availability in a mouse model of gestational diabetes","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389018809","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.802.26"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.802.26","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.802.26","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.802.26","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021482127","display_name":"Yaelle Joselit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83041322","display_name":"Brooklyn College","ror":"https://ror.org/019k4jq75","country_code":"US","type":"education","lineage":["https://openalex.org/I83041322"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaelle Joselit","raw_affiliation_strings":["Health and Nutrition Sciences, Brooklyn College, Brooklyn, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health and Nutrition Sciences, Brooklyn College, Brooklyn, NY","institution_ids":["https://openalex.org/I83041322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050992746","display_name":"Chauntelle Jack\u2010Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83041322","display_name":"Brooklyn College","ror":"https://ror.org/019k4jq75","country_code":"US","type":"education","lineage":["https://openalex.org/I83041322"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chauntelle Jack\u2010Roberts","raw_affiliation_strings":["Health and Nutrition Sciences, Brooklyn College, Brooklyn, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health and Nutrition Sciences, Brooklyn College, Brooklyn, NY","institution_ids":["https://openalex.org/I83041322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109658615","display_name":"Kathleen V. Axen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83041322","display_name":"Brooklyn College","ror":"https://ror.org/019k4jq75","country_code":"US","type":"education","lineage":["https://openalex.org/I83041322"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Axen","raw_affiliation_strings":["Health and Nutrition Sciences, Brooklyn College, Brooklyn, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health and Nutrition Sciences, Brooklyn College, Brooklyn, NY","institution_ids":["https://openalex.org/I83041322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063512499","display_name":"Xinyin Jiang","orcid":"https://orcid.org/0000-0001-6090-371X","observed_orcids":["https://orcid.org/0000-0001-6090-371X"]},"institutions":[{"id":"https://openalex.org/I83041322","display_name":"Brooklyn College","ror":"https://ror.org/019k4jq75","country_code":"US","type":"education","lineage":["https://openalex.org/I83041322"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinyin Jiang","raw_affiliation_strings":["Health and Nutrition Sciences, Brooklyn College, Brooklyn, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health and Nutrition Sciences, Brooklyn College, Brooklyn, NY","institution_ids":["https://openalex.org/I83041322"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I83041322"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.46131782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":0.9670000076293945},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9010000228881836},{"id":"https://openalex.org/keywords/choline-supplementation","display_name":"choline supplementation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/betaine","display_name":"betaine","score":0.8389999866485596},{"id":"https://openalex.org/keywords/fetal-brain-development","display_name":"fetal brain development","score":0.765999972820282},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.906000018119812},{"id":"https://openalex.org/keywords/fabp7","display_name":"FABP7","score":0.828000009059906},{"id":"https://openalex.org/keywords/fabp5","display_name":"FABP5","score":0.9070000052452087},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pla2g6","display_name":"PLA2G6","score":0.9049999713897705},{"id":"https://openalex.org/keywords/maternal-nutrition","display_name":"maternal nutrition","score":0.6299999952316284},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5210000276565552},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.7927783727645874},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.7514907121658325},{"id":"https://openalex.org/C2777248517","wikidata":"https://www.wikidata.org/wiki/Q72052841","display_name":"Betaine","level":2,"score":0.7324565649032593},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.6601805090904236},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6478852033615112},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6296834349632263},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5583584904670715},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.5084354281425476},{"id":"https://openalex.org/C2779434492","wikidata":"https://www.wikidata.org/wiki/Q126691","display_name":"Gestational diabetes","level":4,"score":0.437389075756073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42904970049858093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38495978713035583},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3514530062675476},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.3277639150619507},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.3202245831489563},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2664529085159302},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.2654534876346588},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.25424596667289734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20161482691764832},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.802.26","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.802.26","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.802.26","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1141325463","https://openalex.org/W1482383627","https://openalex.org/W2883859393","https://openalex.org/W2897508831","https://openalex.org/W4390324442","https://openalex.org/W3030638561","https://openalex.org/W2978140809","https://openalex.org/W4280542666","https://openalex.org/W4405668791","https://openalex.org/W2949204577"],"abstract_inverted_index":{"Gestational":[0],"diabetes":[1],"mellitus":[2],"(GDM)":[3],"is":[4,30],"associated":[5],"with":[6,32,53],"lower":[7],"cord":[8],"blood":[9],"docosahexaenoic":[10],"acid":[11,132],"(DHA)":[12],"concentrations,":[13],"which":[14,139,144,172],"can":[15],"potentially":[16],"delay":[17],"brain":[18,112,230],"development":[19],"of":[20,39,45,51,63,130,159,166,179,183,190,197,238,249],"affected":[21],"infants.":[22],"Phosphatidylcholine":[23],"synthesized":[24],"via":[25],"the":[26,61,123,128,157,176,180,194,236],"de":[27],"novo":[28],"pathway":[29],"enriched":[31],"DHA,":[33,141],"thereby":[34],"providing":[35],"an":[36],"available":[37],"source":[38],"DHA.":[40],"Using":[41],"a":[42,77,216],"mouse":[43],"model":[44],"GDM,":[46],"we":[47],"assessed":[48],"whether":[49],"supplementation":[50,121,153,223],"dams":[52,126],"choline":[54,99,163,209,220],"or":[55,103,210,221,242],"its":[56],"oxidative":[57],"derivative,":[58],"betaine,":[59,102],"modified":[60],"expression":[62,118,129,158,165,234],"genes":[64],"related":[65],"to":[66,90],"DHA":[67,174,192,226],"availability":[68,189,227],"in":[69,122,149,193,224,228,235],"fetal":[70,150,229],"brains.":[71,151],"C57BL/6J":[72],"female":[73],"mice":[74],"were":[75,114,205],"fed":[76,125],"high\u2010fat":[78,124],"diet":[79],"(60%":[80],"kcal":[81],"from":[82,175],"fat)":[83],"six":[84],"weeks":[85],"before":[86],"and":[87,142,201],"throughout":[88],"gestation":[89],"induce":[91],"GDM\u2010like":[92],"symptoms.":[93],"The":[94],"animals":[95],"received":[96],"25":[97],"mM":[98],"chloride,":[100],"1%":[101],"control":[104],"drinking":[105],"water":[106],"until":[107],"embryonic":[108],"day":[109],"17.5.":[110],"Fetal":[111],"samples":[113],"collected":[115],"for":[116,218],"gene":[117,233],"analysis.":[119],"Betaine":[120],"increased":[127],"fatty":[131,147],"binding":[133],"protein":[134],"7":[135],"(":[136,169],"Fabp7":[137],"),":[138,171],"transports":[140,145],"Fabp5,":[143],"saturated":[146],"acids":[148],"Choline":[152],"did":[154],"not":[155,206],"alter":[156],"Fabp":[160],"genes.":[161],"However,":[162],"upregulated":[164],"phospholipase":[167],"A2":[168],"Pla2g6":[170],"releases":[173],"middle":[177],"position":[178],"glycerol":[181],"backbone":[182],"phospholipids":[184],"such":[185],"as":[186],"phosphatidylcholine,":[187],"enhancing":[188],"free":[191],"brain.":[195],"Expression":[196],"arachidonate":[198],"15\u2010lipoxygenase,":[199],"cyclooxygenase\u20102,":[200],"brain\u2010derived":[202],"neurotrophic":[203],"factor":[204],"altered":[207],"by":[208,231],"betaine":[211,222],"supplementation.":[212],"Our":[213],"results":[214],"support":[215],"role":[217],"maternal":[219],"modifying":[225],"altering":[232],"offspring":[237],"GDM":[239],"dams.":[240],"Support":[241],"Funding":[243],"Information":[244],"NIH,":[245],"New":[246],"York":[247],"Academy":[248],"Sciences,":[250],"PSC\u2010CUNY":[251]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}