{"id":"https://openalex.org/W4389018554","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.807.10","title":"Inhibition of CHOP Chemotherapy\u2010stimulated Hematological Tumor Growth with Resolvins","display_name":"Inhibition of CHOP Chemotherapy\u2010stimulated Hematological Tumor Growth with Resolvins","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389018554","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.807.10"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.807.10","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.807.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.807.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Djanira Fernandes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Djanira Fernandes","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074925782","display_name":"Molly M. Gilligan","orcid":"https://orcid.org/0000-0002-7342-9858","observed_orcids":["https://orcid.org/0000-0002-7342-9858"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molly Gilligan","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060208068","display_name":"Mark W. Kieran","orcid":"https://orcid.org/0000-0003-2184-7692","observed_orcids":["https://orcid.org/0000-0003-2184-7692"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Kieran","raw_affiliation_strings":["Divison of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divison of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019206785","display_name":"Sui Huang","orcid":"https://orcid.org/0000-0002-3545-4665","observed_orcids":["https://orcid.org/0000-0002-3545-4665"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sui Huang","raw_affiliation_strings":["Institute of Systems Biology, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Systems Biology, Seattle, WA","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029525374","display_name":"Charles Nicholas Serhan","orcid":"https://orcid.org/0000-0003-4627-8545","observed_orcids":["https://orcid.org/0000-0003-4627-8545"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Serhan","raw_affiliation_strings":["Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108417438","display_name":"Dipak Panigrahy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dipak Panigrahy","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.46074414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.4982999861240387,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.4982999861240387,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.3978999853134155,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.03970000147819519,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resolvins","display_name":"resolvins","score":0.953000009059906},{"id":"https://openalex.org/keywords/chop-chemotherapy","display_name":"CHOP chemotherapy","score":0.9190000295639038},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.8690000176429749},{"id":"https://openalex.org/keywords/omega-3-polyunsaturated-fatty-acids","display_name":"omega-3 polyunsaturated fatty acids","score":0.8939999938011169},{"id":"https://openalex.org/keywords/macrophage-phagocytosis","display_name":"macrophage phagocytosis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tumor-microenvironment-inflammation","display_name":"tumor microenvironment inflammation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.6079999804496765},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8920000195503235},{"id":"https://openalex.org/keywords/el4-lymphoma","display_name":"EL4 lymphoma","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tumor-growth-promotion","display_name":"tumor growth promotion","score":0.5630000233650208},{"id":"https://openalex.org/keywords/phosphatidylserine-liposomes","display_name":"phosphatidylserine liposomes","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6008559465408325},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.5725880861282349},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5520393252372742},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.49525848031044006},{"id":"https://openalex.org/C2779725641","wikidata":"https://www.wikidata.org/wiki/Q1076228","display_name":"CHOP","level":3,"score":0.48205503821372986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41281285881996155},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.37185031175613403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35125046968460083},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3131491541862488},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.2982485890388489},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2896469235420227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18418529629707336},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.807.10","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.807.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.807.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2771932310","https://openalex.org/W2752986003","https://openalex.org/W1810690762","https://openalex.org/W4253033012","https://openalex.org/W1026909922","https://openalex.org/W2477785170","https://openalex.org/W4385294452","https://openalex.org/W3182175212","https://openalex.org/W2781217878","https://openalex.org/W1523652136"],"abstract_inverted_index":{"Background":[0],"Current":[1],"therapeutic":[2],"approaches":[3],"for":[4],"non\u2010Hodgkin":[5],"lymphoma,":[6],"such":[7],"as":[8,307],"CHOP":[9,370],"chemotherapy":[10],"(cyclophosphamide,":[11],"doxorubicin,":[12],"vincristine,":[13],"prednisone),":[14],"reduce":[15],"tumor":[16,20,25,35,39,100,122,187,194,214,219,232,253,294,323,333,343,355,363,372,391],"burden":[17],"by":[18,117,124,153,248,350],"inducing":[19],"cell":[21,26,101,135,197,314,344,364,373],"death":[22,136],"thereby":[23],"creating":[24],"debris.":[27,365],"This":[28],"debris":[29,102,123,147,162,198,211,229,236,315,345,374],"can":[30,103],"stimulate":[31],"inflammation":[32,52,83],"in":[33,51,114,138,190,216,285,296,300,312,325],"the":[34,57,94,157,261,273,313,386],"microenvironment":[36],"contributing":[37],"to":[38,302,381,395],"growth,":[40],"making":[41],"cytotoxic":[42],"therapies":[43],"a":[44,60,111,139,179,276,297,308,326,378],"double\u2010edged":[45],"sword":[46],".":[47],"A":[48],"new":[49],"direction":[50],"research":[53],"has":[54],"emerged":[55],"with":[56,178,329],"discovery":[58],"of":[59,63,96,99,121,150,159,182,193,239,258,263,275,279,288,332,361,369],"novel":[61,82,112,379],"genus":[62],"endogenous":[64,97,119],"anti\u2010inflammatory":[65],"and":[66,133,141,341],"pro\u2010resolving":[67],"lipid\u2010autacoid":[68],"mediators":[69],"derived":[70],"from":[71,237],"omega\u20103":[72],"polyunsaturated":[73],"fatty":[74],"acids,":[75],"including":[76,388],"resolvins":[77,109,376],",":[78,165,168,171],"which":[79],"have":[80],"potent":[81],"clearing":[84],"(\u2018pro\u2010resolution\u2019)":[85],"activity":[86],"without":[87],"being":[88],"immunosuppressive.":[89],"We":[90],"hypothesize":[91],"that":[92],"(1)":[93],"failure":[95],"clearance":[98,120,368],"promote":[104],"hematological":[105,382,397],"cancer":[106,115,383,398],"progression":[107],"(2)":[108],"represent":[110],"modality":[113],"treatment":[116],"enhancing":[118],"macrophage":[125,359],"phagocytosis.":[126],"Results":[127],"Flow":[128],"cytometry":[129],"confirmed":[130],"chemotherapy\u2010generated":[131],"apoptotic":[132],"necrotic":[134],"(debris)":[137],"dose\u2010":[140],"time\u2010dependent":[142],"manner.":[143],"Vincristine\u2010generated":[144,209],"EL4":[145,151,161,186,210,252,268,282,293],"lymphoma":[146,227],"stimulated":[148,213,230,250,272,292,346],"growth":[149,215,262,274,295,324,334,356,392],"tumors":[152],"over":[154],"100\u2010fold.":[155],"Increasing":[156],"amount":[158],"vincristine\u2010generated":[160,342],"(1\u00d710":[163],"5":[164,167,170],"3\u00d710":[166],"9\u00d710":[169],"or":[172,223,244,401],"1.8\u00d710":[173],"6":[174,267],"dead":[175],"cells)":[176],"co\u2010injected":[177],"subthreshold":[180,277],"inoculum":[181,278],"1\u00d710":[183,280],"4":[184,281],"living":[185,269,283],"cells":[188,241,284],"resulted":[189],"progressive":[191],"acceleration":[192],"growth.":[195,233,254],"Tumor":[196],"alone":[199],"did":[200],"not":[201],"produce":[202],"tumors,":[203],"even":[204],"at":[205],"250":[206],"days":[207],"post\u2010injection.":[208,338],"also":[212],"3":[217],"other":[218],"types":[220],"(LLC,":[221],"B16F10,":[222],"PancOH7).":[224],"Similarly,":[225],"doxorubicin\u2010generated":[226],"(EL4)":[228],"primary":[231,251],"In":[234],"addition,":[235],"cultures":[238],"non\u2010tumorigenic":[240],"(NIH\u20103T3":[242],"fibroblasts":[243],"MelaC":[245],"melanocytes)":[246],"generated":[247],"vincristine":[249,259,271],"While":[255],"systemic":[256],"administration":[257],"inhibited":[260,353],"1":[264],"\u00d7":[265],"10":[266],"cells,":[270],"mice.":[286],"Co\u2010injection":[287],"phosphatidylserine":[289],"(PS)":[290],"liposomes":[291,305],"dose\u2010dependent":[298,327],"manner":[299],"comparison":[301],"phosphatidylcholine":[303],"(PC)":[304],"utilized":[306],"control.":[309],"Blocking":[310],"PS":[311],"using":[316],"recombinant":[317],"annexin":[318],"V":[319],"protein":[320],"suppressed":[321],"debris\u2010stimulated":[322,354,390],"manner,":[328],"complete":[330],"suppression":[331],"until":[335],"day":[336],"12":[337],"Both":[339],"doxorubicin":[340],"pro\u2010inflammatory":[347],"cytokine":[348],"production":[349],"macrophages.":[351],"Resolvins":[352],"via":[357,375],"stimulating":[358],"phagocytosis":[360],"chemotherapy\u2010induced":[362],"Conclusions":[366],"The":[367],"therapy\u2010induced":[371],"provides":[377],"approach":[380],"therapy.":[384],"Understanding":[385],"mechanisms":[387],"PS\u2010dependent":[389],"is":[393],"critical":[394],"improving":[396],"treatment.":[399],"Support":[400],"Funding":[402],"Information":[403],"R01\u2010170549":[404]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}