{"id":"https://openalex.org/W4389018347","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.819.10","title":"Cadmium Ion Upregulates the Activity of Human Organic Cation Transporter 2","display_name":"Cadmium Ion Upregulates the Activity of Human Organic Cation Transporter 2","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389018347","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.819.10"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.819.10","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.819.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.819.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"HONG YANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HONG YANG","raw_affiliation_strings":["School of Pharmacy, University of Maryland, Baltimore, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Maryland, Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017542783","display_name":"Dong Guo","orcid":"https://orcid.org/0000-0002-1055-482X","observed_orcids":["https://orcid.org/0000-0002-1055-482X"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Guo","raw_affiliation_strings":["School of Pharmacy, University of Maryland, Baltimore, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Maryland, Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065113416","display_name":"Yan Shu","orcid":"https://orcid.org/0000-0001-8492-1437","observed_orcids":["https://orcid.org/0000-0001-8492-1437"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Shu","raw_affiliation_strings":["School of Pharmacy, University of Maryland, Baltimore, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Maryland, Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.1425,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.51216081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.31049999594688416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cadmium-ions","display_name":"cadmium ions","score":0.7450000047683716},{"id":"https://openalex.org/keywords/organic-cation-transporter-2","display_name":"organic cation transporter 2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hoct2","display_name":"hOCT2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/renal-cadmium-accumulation","display_name":"renal cadmium accumulation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.33899998664855957},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.5860000252723694},{"id":"https://openalex.org/keywords/transport-kinetics","display_name":"transport kinetics","score":0.6100000143051147},{"id":"https://openalex.org/keywords/membrane-protein-expression","display_name":"membrane protein expression","score":0.7300000190734863},{"id":"https://openalex.org/keywords/acute-cadmium-exposure","display_name":"acute cadmium exposure","score":0.6800000071525574},{"id":"https://openalex.org/keywords/renal-tubular-epithelial-cells","display_name":"renal tubular epithelial cells","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8909355401992798},{"id":"https://openalex.org/C544657597","wikidata":"https://www.wikidata.org/wiki/Q1091","display_name":"Cadmium","level":2,"score":0.605986475944519},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5291866660118103},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5195301175117493},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.4838780164718628},{"id":"https://openalex.org/C2780473477","wikidata":"https://www.wikidata.org/wiki/Q3072135","display_name":"Toxicant","level":3,"score":0.4420570731163025},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.426771342754364},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41036880016326904},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3454495668411255},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24131107330322266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18403643369674683},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.17956513166427612},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11390411853790283},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.819.10","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.819.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.819.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1377666068","display_name":null,"funder_award_id":"U01 FD004320","funder_id":"https://openalex.org/F4320332163","funder_display_name":"U.S. Food and Drug Administration"},{"id":"https://openalex.org/G3338188491","display_name":"Xenobiotic Transporter Regulation and IRIP Function","funder_award_id":"R01GM099742","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2262951971","https://openalex.org/W1966642037","https://openalex.org/W3173742008","https://openalex.org/W1975559238","https://openalex.org/W3155770618","https://openalex.org/W1919547142","https://openalex.org/W2167355204","https://openalex.org/W2100282012","https://openalex.org/W2009323095","https://openalex.org/W4392375031"],"abstract_inverted_index":{"Cadmium":[0],"(Cd)":[1],"is":[2,195],"an":[3,141],"environmentally":[4],"prevalent":[5],"toxicant":[6],"posing":[7],"increasing":[8,183],"risk":[9],"to":[10,203],"human":[11,26,93],"health":[12],"worldwide.":[13],"Recent":[14],"publications":[15],"had":[16],"identified":[17],"cadmium":[18,41,66],"ion":[19],"(Cd2+)":[20],"as":[21,35],"the":[22,25,38,55,63,69,90,103,117,128,134,146,166,178,184,191,205,211,251],"substrate":[23,136],"of":[24,37,57,65,71,85,92,116,133,154,180,186,207,217,228,234,248],"organic":[27],"cation":[28],"transporter":[29],"2":[30],"(hOCT2),":[31],"which":[32],"might":[33,200],"serve":[34],"one":[36],"mechanism":[39,144],"for":[40,149],"accumulation":[42],"in":[43,95,127],"kidney.":[44],"In":[45],"contrast,":[46],"little":[47,100],"was":[48,110,157],"known":[49],"about":[50],"how":[51],"Cd2+":[52,86,160,175,199,209,231,241,244],"could":[53,87,176],"affect":[54],"function":[56],"hOCT2.":[58,72,150,218],"Herein,":[59],"we":[60],"further":[61],"investigated":[62],"effect":[64,101,164],"exposure":[67,82],"on":[68,102,165,188,250],"activity":[70,179],"Interestingly,":[73],"preliminary":[74],"data":[75],"from":[76],"our":[77],"lab":[78],"showed":[79],"that":[80,174,198],"acute":[81],"(20":[83],"minutes)":[84],"significantly":[88],"upregulate":[89,177],"activities":[91],"hOCT2":[94,156,181,187,229,235,249],"a":[96,113,124],"dose-dependent":[97],"manner,":[98],"with":[99,112,123,162],"control":[104,239],"cells":[105,214],"(Figure":[106,138,169],"1).":[107],"The":[108],"upregulation":[109,216,227],"accompanied":[111],"significant":[114,152],"increase":[115,153],"maximal":[118],"transport":[119],"rate":[120],"(Vmax),":[121],"while":[122],"negligible":[125],"change":[126],"kinetic":[129],"affinity":[130],"constant":[131],"(Km)":[132],"probe":[135],"metformin":[137],"2),":[139],"suggesting":[140],"instantly":[142],"regulatory":[143],"at":[145],"protein":[147,168],"level":[148],"Moreover,":[151],"membrane":[155,252],"observed":[158],"after":[159],"treatment,":[161],"no":[163],"total":[167],"3).":[170],"Our":[171],"finding":[172],"suggested":[173],"by":[182,230],"expression":[185,247],"membrane.":[189],"On":[190],"other":[192],"hand,":[193],"it":[194],"thus":[196],"likely":[197],"be":[201],"able":[202],"facilitate":[204],"entry":[206],"more":[208],"into":[210],"renal":[212],"tubular":[213],"through":[215],"Support":[219],"or":[220],"Funding":[221],"Information":[222],"NIH:":[223],"R01GM099742FDA:":[224],"U01FD004320":[225],"Dose-dependent":[226],"pre-incubation":[232,242,245],"Comparison":[233],"kinetics":[236],"profile":[237],"between":[238],"and":[240],"group":[243],"increases":[246]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}