{"id":"https://openalex.org/W4389008098","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.1211.4","title":"Matricryptin p1158/59 Modulates Vascular Remodeling During Carotid Artery Bypass","display_name":"Matricryptin p1158/59 Modulates Vascular Remodeling During Carotid Artery Bypass","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W4389008098","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.1211.4"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.1211.4","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.1211.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.1211.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042057533","display_name":"Patti R. Shaver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patti R Shaver","raw_affiliation_strings":["Physiology, East Carolina University, Greenville, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, East Carolina University, Greenville, NC","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000439047","display_name":"Gabriel Araujo Grilo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel A Grilo","raw_affiliation_strings":["Physiology, East Carolina University, Greenville, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, East Carolina University, Greenville, NC","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073853718","display_name":"Katherine C Barefoot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine C Barefoot","raw_affiliation_strings":["Physiology, East Carolina University, Greenville, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, East Carolina University, Greenville, NC","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010831803","display_name":"Andrew W. Holt","orcid":"https://orcid.org/0000-0003-2794-1858","observed_orcids":["https://orcid.org/0000-0003-2794-1858"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew W Holt","raw_affiliation_strings":["Physiology, East Carolina University, Greenville, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, East Carolina University, Greenville, NC","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005382945","display_name":"David A. Tulis","orcid":"https://orcid.org/0000-0003-3490-2283","observed_orcids":["https://orcid.org/0000-0003-3490-2283"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A Tulis","raw_affiliation_strings":["Physiology, East Carolina University, Greenville, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, East Carolina University, Greenville, NC","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007744549","display_name":"Robert M. Lust","orcid":"https://orcid.org/0000-0001-5816-0005","observed_orcids":["https://orcid.org/0000-0001-5816-0005"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M Lust","raw_affiliation_strings":["Physiology, East Carolina University, Greenville, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, East Carolina University, Greenville, NC","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090245008","display_name":"Lisandra E. de Castro Br\u00e1s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisandra E. de Castro Br\u00e1s","raw_affiliation_strings":["Physiology, East Carolina University, Greenville, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, East Carolina University, Greenville, NC","institution_ids":["https://openalex.org/I186335123"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I186335123"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43141468,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.09640000015497208,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saphenous-vein-graft","display_name":"saphenous vein graft","score":0.8629999756813049},{"id":"https://openalex.org/keywords/coronary-artery-bypass-grafting","display_name":"coronary artery bypass grafting","score":0.8980000019073486},{"id":"https://openalex.org/keywords/graft-patency","display_name":"graft patency","score":0.7020000219345093},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.8579999804496765},{"id":"https://openalex.org/keywords/neointimal-hyperplasia","display_name":"intimal hyperplasia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.48500001430511475},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.41200000047683716},{"id":"https://openalex.org/keywords/carotid-artery-bypass","display_name":"carotid artery bypass","score":0.7260000109672546},{"id":"https://openalex.org/keywords/vein-graft-failure","display_name":"vein graft failure","score":0.5960000157356262},{"id":"https://openalex.org/keywords/graft-thrombosis","display_name":"graft thrombosis","score":0.6240000128746033},{"id":"https://openalex.org/keywords/canine-model","display_name":"canine model","score":0.5680000185966492},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.4909999966621399},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.4580000042915344},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8679558038711548},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.6069856286048889},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5987242460250854},{"id":"https://openalex.org/C2777339539","wikidata":"https://www.wikidata.org/wiki/Q6993039","display_name":"Neointima","level":4,"score":0.5007462501525879},{"id":"https://openalex.org/C2779751240","wikidata":"https://www.wikidata.org/wiki/Q16909635","display_name":"Intimal hyperplasia","level":3,"score":0.5003476142883301},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4908364415168762},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4320381283760071},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.42209747433662415},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36717480421066284},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.1173543930053711},{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.09681335091590881},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.1211.4","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.1211.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.1211.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4336994553","display_name":null,"funder_award_id":"14SDG18860050","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2524883967","https://openalex.org/W2417159165","https://openalex.org/W2022960456","https://openalex.org/W2060336882","https://openalex.org/W4385323218","https://openalex.org/W2938509383","https://openalex.org/W2380611282","https://openalex.org/W2312648903","https://openalex.org/W2275789924","https://openalex.org/W2117228124"],"abstract_inverted_index":{"When":[0],"atherosclerosis":[1],"develops":[2],"in":[3,179,322,357,381,390,415,419],"the":[4,15,24,188,195,214,227,258,272,279,295,305,314,350,358,370,391,416,420,424,460],"coronary":[5,30],"arteries,":[6],"blood":[7],"flow":[8],"is":[9,23,78,96],"compromised":[10],"and":[11,38,64,111,133,158,164,174,194,207,216,236,246,251,254,266,327,355,376,438,447],"disease":[12],"progression":[13],"increases":[14],"risk":[16],"of":[17,51,145,182,187,271,307,349,373,405,413,423,444],"myocardial":[18],"infarction.":[19],"Saphenous":[20],"vein":[21],"(SV)":[22],"most":[25],"common":[26,218],"conduit":[27],"used":[28],"for":[29,249],"artery":[31,147,229],"bypass":[32,148],"grafting;":[33],"however,":[34,304],"its":[35],"long\u2010term":[36],"patency":[37,224],"survival":[39],"rates":[40],"are":[41],"not":[42],"ideal.":[43],"One":[44,185],"year":[45],"after":[46,441],"surgery,":[47],"10%":[48,62],"to":[49,61,71,81,101,121,289,313,368,377,397,428],"20%":[50,70],"SV":[52,75,118,183,189,242,260,299,393,445],"grafts":[53,243,274,283,394],"fail,":[54,63],"from":[55,65,92,459],"1\u20135":[56],"years":[57],"an":[58,68],"additional":[59],"5%":[60],"6\u201310":[66],"years,":[67],"added":[69],"25%":[72],"fail.":[73],"Early":[74],"graft":[76,140,223,425,436],"failure":[77,90],"mainly":[79],"due":[80],"thrombosis":[82],"(graft":[83],"spasm)":[84],"or":[85,453],"technical":[86],"error,":[87],"whereas":[88],"longer\u2010term":[89],"results":[91],"neointimal":[93],"hyperplasia.":[94],"p1158/59":[95,117,201,328,359,434],"a":[97,291],"collagen\u2010derived":[98],"matricryptin":[99],"shown":[100],"facilitate":[102],"tissue":[103,247],"regeneration":[104],"through":[105],"targeted":[106],"basement":[107],"membrane":[108],"protein":[109,252],"deposition":[110],"vascularization.":[112],"Accordingly,":[113],"we":[114],"hypothesized":[115],"that":[116],"treatment,":[119],"prior":[120],"grafting,":[122],"would":[123],"modulate":[124],"early":[125],"vascular":[126,406,449],"remodeling":[127],"by":[128],"modifying":[129],"basal":[130],"lamina":[131],"composition":[132],"modulating":[134],"intima":[135],"growth,":[136],"consistent":[137],"with":[138,160,200,286,383],"better":[139],"patency.":[141],"A":[142,167],"canine":[143],"model":[144],"carotid":[146,219],"was":[149,172,198,225,230,309,319,387],"used.":[150],"Animals":[151],"(n=12;":[152],"25\u201335":[153],"kg)":[154],"were":[155,210,244,264,268,275,284,302],"anesthetized,":[156],"intubated,":[157],"ventilated":[159],"1\u20133%":[161],"isoflurane,":[162],"oxygen,":[163],"room":[165],"air.":[166],"lateral":[168],"hind":[169],"limb":[170],"incision":[171],"made":[173],"approximately":[175],"12\u201315":[176],"cm":[177],"(":[178],"situ":[180],")":[181],"harvested.":[184],"half":[186,197],"served":[190],"as":[191,311],"control":[192],"(vehicle\u2010treated)":[193],"other":[196,296],"treated":[199,298],"(1":[202],"\u03bcM;":[203],"1.5":[204],"h).":[205],"Vehicle\u2010":[206],"p1158/59\u2010treated":[208,280,392,417],"veins":[209],"anastomosed":[211],"end\u2010to\u2010side":[212],"into":[213],"right":[215],"left":[217],"arteries":[220],"respectively.":[221],"Once":[222],"established,":[226],"native":[228],"divided,":[231],"all":[232],"surgical":[233],"wounds":[234],"repaired,":[235],"animals":[237],"recovered.":[238],"Ten":[239],"days":[240,443],"later,":[241],"removed":[245],"stored":[248],"gene":[250],"expression":[253,348,404],"histological":[255],"assessments.":[256],"Of":[257,294],"12":[259],"vehicle":[261,316,326,398,429],"grafts,":[262,300],"2":[263,282,335,342],"thrombosed":[265,285],"10":[267,297,442],"patent;":[269],"6":[270,331,333,338,340],"patent":[273],"heavily":[276],"encapsulated.":[277],"In":[278],"group,":[281],"one":[287],"continuing":[288],"show":[290],"weak":[292],"pulse.":[293],"4":[301],"encapsulated;":[303],"level":[306],"adhesions":[308],"fewer":[310],"compared":[312,396,427],"respective":[315],"graft.":[317],"There":[318],"no":[320],"difference":[321],"lumen":[323],"area":[324,422],"between":[325,408],"groups":[329,360,409],"(1.20\u00d710":[330],"\u00b10.11\u00d710":[332],"\u03bcm":[334,341],"versus":[336,363],"1.33\u00d710":[337],"\u00b10.12\u00d710":[339],").":[343],"Gene":[344],"array":[345],"revealed":[346,402],"increased":[347,411],"pro\u2010angiogenic":[351],"factors":[352],"EGF,":[353],"HGF,":[354],"TGF\u2010\u03b23":[356],"(all":[361],"p<0.05":[362],"vehicle).":[364],"Aminopeptidase":[365],"N,":[366],"known":[367],"regulate":[369],"biological":[371],"activity":[372],"various":[374],"peptides":[375],"be":[378],"highly":[379],"expressed":[380],"macrophages":[382],"elevated":[384],"phagocytic":[385],"function,":[386],"also":[388],"overexpressed":[389],"when":[395,426],"(p<0.05).":[399,430],"Histological":[400],"analysis":[401],"similar":[403],"elastin":[407],"but":[410],"levels":[412],"collagen":[414,450],"group":[418],"distal":[421],"Our":[431],"data":[432],"suggest":[433],"reduced":[435],"encapsulation":[437],"adhesion":[439],"formation":[440],"engraftment":[446],"modulated":[448],"remodeling.":[451],"Support":[452],"Funding":[454],"Information":[455],"We":[456],"acknowledge":[457],"support":[458],"American":[461],"Heart":[462],"Association":[463],"14SDG18860050":[464]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}
