{"id":"https://openalex.org/W4389007736","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.967.8","title":"Distinct regulation of the basolateral conductance in the collecting duct by Na + and K + intake","display_name":"Distinct regulation of the basolateral conductance in the collecting duct by Na + and K + intake","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W4389007736","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.967.8"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.967.8","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.967.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.967.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108221132","display_name":"Oleg Zaika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oleg Zaika","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, USA, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, USA, Houston, TX","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064579974","display_name":"Viktor N. Tomilin","orcid":"https://orcid.org/0000-0001-8486-2481","observed_orcids":["https://orcid.org/0000-0001-8486-2481"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viktor Tomilin","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, USA, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, USA, Houston, TX","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025348068","display_name":"Mykola Mamenko","orcid":"https://orcid.org/0000-0001-8683-0715","observed_orcids":["https://orcid.org/0000-0001-8683-0715"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mykola Mamenko","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, USA, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, USA, Houston, TX","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014657118","display_name":"Oleh M. Pochynyuk","orcid":"https://orcid.org/0000-0002-5397-6897","observed_orcids":["https://orcid.org/0000-0002-5397-6897"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oleh Pochynyuk","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, USA, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, USA, Houston, TX","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I919571938"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27193395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.09399999678134918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12876","display_name":"Potassium and Related Disorders","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collecting-duct","display_name":"collecting duct","score":0.9769999980926514},{"id":"https://openalex.org/keywords/principal-cells","display_name":"principal cells","score":0.7829999923706055},{"id":"https://openalex.org/keywords/intercalated-cells","display_name":"intercalated cells","score":1.0},{"id":"https://openalex.org/keywords/low-sodium-diet","display_name":"sodium restriction","score":0.9729999899864197},{"id":"https://openalex.org/keywords/enac","display_name":"epithelial sodium channel","score":0.7680000066757202},{"id":"https://openalex.org/keywords/na-k-exchange","display_name":"Na+/K+ exchange","score":0.8379999995231628},{"id":"https://openalex.org/keywords/basolateral-membrane-potential","display_name":"basolateral membrane potential","score":0.8009999990463257},{"id":"https://openalex.org/keywords/potassium-reabsorption","display_name":"potassium reabsorption","score":0.6660000085830688},{"id":"https://openalex.org/keywords/chloride-reabsorption","display_name":"chloride reabsorption","score":0.9139999747276306},{"id":"https://openalex.org/keywords/renal-electrolyte-transport","display_name":"renal electrolyte transport","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7069107294082642},{"id":"https://openalex.org/C39587587","wikidata":"https://www.wikidata.org/wiki/Q5383698","display_name":"Epithelial polarity","level":3,"score":0.6139549016952515},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.6023356914520264},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5769139528274536},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5368301272392273},{"id":"https://openalex.org/C131453863","wikidata":"https://www.wikidata.org/wiki/Q1641079","display_name":"Hyperpolarization (physics)","level":3,"score":0.5327285528182983},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5321188569068909},{"id":"https://openalex.org/C121932024","wikidata":"https://www.wikidata.org/wiki/Q5159376","display_name":"Conductance","level":2,"score":0.5046335458755493},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4978342056274414},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.49162036180496216},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.44951486587524414},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.4449882209300995},{"id":"https://openalex.org/C2910744950","wikidata":"https://www.wikidata.org/wiki/Q452419","display_name":"Intercalated Cell","level":3,"score":0.4399574100971222},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3078276216983795},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.23731020092964172},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21304908394813538},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.18212628364562988},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.13024532794952393},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09448063373565674},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.0736396312713623},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.967.8","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.967.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.967.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389019855","https://openalex.org/W2767984476","https://openalex.org/W2196732892","https://openalex.org/W2162327997","https://openalex.org/W3173686340","https://openalex.org/W2132758671","https://openalex.org/W4308652078","https://openalex.org/W205344011","https://openalex.org/W2904282091","https://openalex.org/W2088123639"],"abstract_inverted_index":{"Distal":[0],"renal":[1],"tubule":[2],"segments,":[3],"such":[4],"as":[5],"the":[6,69,77,96,126,132,160,170,188,201,224,234,257],"collecting":[7,20,88],"duct,":[8],"underlie":[9,233],"final":[10],"regulation":[11],"of":[12,23,95,104,111,137,162,223],"electrolyte":[13],"transport":[14],"to":[15,49,114,125,255],"maintain":[16],"systemic":[17],"homeostasis.":[18],"The":[19],"duct":[21],"comprises":[22],"principal":[24,109,202],"and":[25,34,44,80,102,159,193,210,227,247,251],"intercalated":[26,167,215],"cells":[27,110,203],"having":[28],"primarily":[29],"K":[30,98,118,138,190,196,244],"ir":[31,139,197],"4.1/5.1\u2010mediated":[32],"potassium":[33,42,150],"ClC\u2010K2\u2010dependent":[35],"chloride":[36],"basolateral":[37,70,97,105,154,189,225],"conductance,":[38],"respectively.":[39],"Both":[40],"dietary":[41,149,172,243],"load":[43,246],"sodium":[45,262],"restriction":[46,175],"are":[47],"known":[48,61],"stimulate":[50],"apical":[51],"electrogenic":[52],"Na":[53,173,177,236,249],"+":[54,99,119,174,178,191,237,239,245,250],"reabsorption":[55,254],"via":[56],"ENaC.":[57],"However,":[58],"little":[59],"is":[60],"whether":[62],"this":[63,220],"also":[64],"affects":[65],"ion":[66],"fluxes":[67],"across":[68],"membrane.":[71],"Using":[72],"patch":[73],"clamp":[74],"electrophysiology":[75],"at":[76],"single":[78,194],"channel":[79,144,195],"whole":[81],"cell":[82],"levels":[83,136,213],"in":[84,108,166,200,214,231],"freshly":[85],"isolated":[86],"mouse":[87],"ducts,":[89],"we":[90],"found":[91],"a":[92,115,184],"marked":[93],"upregulation":[94],"\u2010selective":[100,157],"current":[101,158,192,209],"hyperpolarization":[103],"membrane":[106],"potential":[107],"mice":[112],"subjected":[113],"high":[116],"(5%)":[117],"diet":[120],"for":[121,180],"one":[122,181],"week":[123,182],"compared":[124],"control.":[127],"This":[128],"stimulation":[129],"stemmed":[130],"from":[131,143],"significantly":[133,205],"increased":[134,211],"functional":[135],"4.1/5.1":[140,198],"but":[141,204],"not":[142],"open":[145],"probability.":[146],"Moreover,":[147],"elevated":[148],"intake":[151],"drastically":[152],"decreased":[153],"Cl":[155,207,252],"\u2212":[156,208,253],"number":[161],"active":[163],"ClC\u2010K2":[164,212],"channels":[165],"cells.":[168,216],"On":[169],"contrary,":[171],"(<0.01%":[176],")":[179],"had":[183],"minor":[185],"effect":[186],"on":[187],"activity":[199],"stimulated":[206],"We":[217],"conclude":[218],"that":[219],"different":[221],"response":[222],"K+":[226],"Cl\u2212":[228],"conductance":[229],"may":[230],"part":[232],"preferential":[235],"/K":[238],"exchange":[240],"observed":[241],"during":[242],"net":[248],"protect":[256],"circulating":[258],"volume":[259],"upon":[260],"reduced":[261],"intake.":[263]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}