{"id":"https://openalex.org/W4389007342","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.723.4","title":"Hypertensive mechanical stretch: A model for monocyte\u2010derived dendritic cell differentiation","display_name":"Hypertensive mechanical stretch: A model for monocyte\u2010derived dendritic cell differentiation","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W4389007342","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.723.4"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.723.4","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.723.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.723.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067137874","display_name":"Roxana Loperena","orcid":"https://orcid.org/0000-0002-4783-3291","observed_orcids":["https://orcid.org/0000-0002-4783-3291"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roxana Loperena","raw_affiliation_strings":["Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344377","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0002-0634-8150","observed_orcids":["https://orcid.org/0000-0002-0634-8150"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091099970","display_name":"Annet Kirabo","orcid":"https://orcid.org/0000-0001-8580-9359","observed_orcids":["https://orcid.org/0000-0001-8580-9359"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annet Kirabo","raw_affiliation_strings":["Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011627807","display_name":"David Glenn Harrison","orcid":"https://orcid.org/0000-0001-9363-6451","observed_orcids":["https://orcid.org/0000-0001-9363-6451"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Glenn Harrison","raw_affiliation_strings":["Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I901861585"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36373507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0478999987244606,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7129999995231628},{"id":"https://openalex.org/keywords/mechanical-stretching","display_name":"mechanical stretch","score":0.8600000143051147},{"id":"https://openalex.org/keywords/monocyte-derived-dendritic-cells","display_name":"monocyte-derived dendritic cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dendritic-cell-differentiation","display_name":"dendritic cell differentiation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7860000133514404},{"id":"https://openalex.org/keywords/th17-polarization","display_name":"Th17 polarization","score":0.7379999756813049},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8040000200271606},{"id":"https://openalex.org/keywords/il23a","display_name":"IL23A","score":0.7979999780654907},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8180000185966492},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.9430000185966492},{"id":"https://openalex.org/keywords/nadph-oxidase-p22phox","display_name":"NADPH oxidase p22phox","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dc-sign","display_name":"DC-SIGN","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cd83","display_name":"CD83","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.7343517541885376},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.7092489004135132},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.6123413443565369},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5864152908325195},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5377734899520874},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4909129738807678},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4809778928756714},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.44742351770401},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4249197244644165},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41933560371398926},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3229931592941284},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26204511523246765},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26044586300849915},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17796611785888672},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12538138031959534}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.723.4","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.723.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.723.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3175345589","https://openalex.org/W2994287502","https://openalex.org/W3173783872","https://openalex.org/W1802950967","https://openalex.org/W2485214800","https://openalex.org/W2807801230","https://openalex.org/W3084238885","https://openalex.org/W2803875087","https://openalex.org/W2904323685","https://openalex.org/W2808872380"],"abstract_inverted_index":{"Hypertension":[0],"is":[1,71,91],"a":[2,374,384,436],"leading":[3],"cause":[4],"of":[5,25,62,127,151,157,188,214,227,233,243,268,296,327],"mortality":[6],"in":[7,11,69,93,293,335,377,387,445],"Western":[8],"society,":[9],"attributed":[10],"part":[12,336],"to":[13,23,31,97,103,120,146,171,180,205,254,260,277,284,304,340,350,370,398,401,412,419],"the":[14,63,81,89,160,181,190,215,234,239,244,265,272,294],"oxidative":[15],"injury":[16],"and":[17,34,50,102,107,194,221,238,271,322,357,366,383,428],"inflammation.":[18],"Fatty":[19],"acid":[20],"oxidation":[21],"leads":[22],"formation":[24,68],"highly":[26],"reactive":[27,99],"isoketals,":[28],"which":[29,440],"adduct":[30],"protein":[32],"lysines":[33],"modify":[35],"proteins.":[36],"We":[37,113,138,198,247],"have":[38,75],"shown":[39,76],"that":[40,54,77,109,115,133,200,250,291,408,421],"dendritic":[41],"cells":[42,118,144,229,252,282,348,391,410],"(DCs)":[43],"from":[44,174,346,456],"hypertensive":[45,121,154,206,225,255,297,351,371,413],"mice":[46],"accumulate":[47,425],"isoketal\u2010adducted":[48,301,426],"proteins":[49,302,427],"act":[51],"as":[52,262,317,343,393],"neoantigens":[53],"promote":[55,125,416,429],"T":[56,136,380,390,430],"cell":[57,183,329,339,341,381,431],"activation.":[58],"The":[59,287,325],"cellular":[60],"source":[61],"oxidant":[64],"responsible":[65],"for":[66,165],"isoketal":[67],"DCs":[70,132,290,420,441],"not":[72,354],"known.":[73],"Others":[74],"human":[78,116,128,141,176],"monocytes":[79,129,173,191,278,399],"traversing":[80],"endothelium":[82,90],"differentiate":[83],"into":[84,130],"monocyte\u2010derived":[85],"DCs.":[86],"In":[87,223],"addition,":[88,224],"activated":[92,444],"angiotensin\u2010II":[94],"induced":[95],"hypertension":[96],"produce":[98],"oxygen":[100],"species":[101],"express":[104,422],"adhesion":[105],"molecules":[106],"chemokines":[108],"attract":[110],"inflammatory":[111,423],"cells.":[112,137],"hypothesized":[114],"endothelial":[117,143,182,228,251,281,328,347,409],"exposed":[119,139,204,253,283,349,369,400,411],"mechanical":[122,207,414],"stretch":[123,150,156,208,226,256,298,330,352,372,415],"will":[124],"conversion":[126],"functional":[131],"can":[134,442],"activate":[135],"confluent":[140],"aortic":[142],"(HAECs)":[145],"either":[147],"normotensive":[148,175,402],"cyclical":[149,155],"5%":[152,285,403],"or":[153,448],"10%":[158],"using":[159],"Flexcell":[161],"\u00ae":[162],"Tension":[163],"System":[164],"48":[166,186],"hours.":[167],"During":[168],"these":[169],"exposures":[170],"stretch,":[172,189],"volunteers":[177],"were":[178,192],"added":[179],"culture.":[184],"Following":[185],"hours":[187],"isolated":[193],"mRNA":[195,212,231],"was":[196,334],"analyzed.":[197],"found":[199,249],"co\u2010culture":[201],"with":[202,280],"HAECs":[203],"markedly":[209],"increased":[210],"monocyte":[211,235,258,288,332,417],"expression":[213,232,267],"Th17":[216],"polarizing":[217],"cytokines":[218],"IL\u20106,":[219],"I\u201023A":[220],"IL\u20101b.":[222],"stimulated":[230],"chemokine":[236],"CCL4":[237],"p22":[240,362],"phox":[241,363],"subunit":[242],"NADPH":[245],"oxidase.":[246],"also":[248,299],"promoted":[257,373],"differentiation":[259,418],"DCs,":[261],"evidenced":[263,318],"by":[264,319,338,395,439],"surface":[266],"DC\u2010SIGN,":[269],"CD83":[270],"co\u2010stimulatory":[273],"marker":[274],"CD86":[275],"compared":[276,303,397],"co\u2010cultured":[279],"stretch.":[286,404],"derived":[289],"formed":[292],"presence":[295],"contained":[300],"controls":[305],"(69.73":[306],"\u00b1":[307,311],"5.802":[308],"vs":[309],"10.79":[310],"1.854":[312],"respectively,":[313],"p":[314],"=":[315],"0.0001)":[316],"intracellular":[320],"staining":[321],"flow":[323],"cytometry.":[324],"effect":[326],"on":[331],"activation":[333],"mediated":[337],"contact,":[342],"conditioned":[344],"media":[345],"did":[353,360],"increase":[355,361,376,386],"IL\u20106":[356],"IL\u20101b,":[358],"but":[359],",":[364],"IL\u201023A":[365],"TGFb\u20101.":[367],"Monocytes":[368],"1,500\u2010fold":[375],"CD4":[378],"+":[379,389],"proliferation":[382,392],"1,300\u2010fold":[385],"CD8":[388],"monitored":[394],"CFSE,":[396],"These":[405,433],"data":[406],"show":[407],"cytokines,":[424],"proliferation.":[432],"findings":[434],"suggest":[435],"new":[437],"mechanism":[438],"become":[443],"hypertension.":[446],"Support":[447],"Funding":[449],"Information":[450],"William":[451],"Townsend":[452],"Porter":[453],"Pre\u2010doctoral":[454],"Fellowship":[455],"American":[457],"Physiological":[458],"Society":[459]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-27T00:00:00"}
