{"id":"https://openalex.org/W4389006947","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.687.18","title":"Evidence of an Exaggerated Muscle Metaboreflex Response in Heart Failure with Preserved Ejection Fraction","display_name":"Evidence of an Exaggerated Muscle Metaboreflex Response in Heart Failure with Preserved Ejection Fraction","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389006947","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.687.18"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.687.18","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.687.18","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.687.18","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057165826","display_name":"Heather Lynn Clifton","orcid":"https://orcid.org/0000-0003-4546-4346","observed_orcids":["https://orcid.org/0000-0003-4546-4346"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210089864","display_name":"VA Salt Lake City Healthcare System","ror":"https://ror.org/007fyq698","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540"]},{"id":"https://openalex.org/I4210095710","display_name":"Lake City VA Medical Center","ror":"https://ror.org/00nvney28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210095710","https://openalex.org/I4210118777","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Lynn Clifton","raw_affiliation_strings":["Department of Internal Medicine, University of Utah, Salt Lake City, UT","Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT","institution_ids":["https://openalex.org/I4210089864","https://openalex.org/I4210095710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041638395","display_name":"Stephen M. Ratchford","orcid":"https://orcid.org/0000-0002-6300-7600","observed_orcids":["https://orcid.org/0000-0002-6300-7600"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210089864","display_name":"VA Salt Lake City Healthcare System","ror":"https://ror.org/007fyq698","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540"]},{"id":"https://openalex.org/I4210095710","display_name":"Lake City VA Medical Center","ror":"https://ror.org/00nvney28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210095710","https://openalex.org/I4210118777","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen M Ratchford","raw_affiliation_strings":["Department of Internal Medicine, University of Utah, Salt Lake City, UT","Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT","institution_ids":["https://openalex.org/I4210089864","https://openalex.org/I4210095710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026417766","display_name":"Jennifer R. Vranish","orcid":"https://orcid.org/0000-0002-4252-6639","observed_orcids":["https://orcid.org/0000-0002-4252-6639"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer R Vranish","raw_affiliation_strings":["Department of Kinesiology, University of Texas at Arlington, Arlington, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology, University of Texas at Arlington, Arlington, TX","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035467273","display_name":"Joel Douglas Trinity","orcid":"https://orcid.org/0000-0001-8271-6536","observed_orcids":["https://orcid.org/0000-0001-8271-6536"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210089864","display_name":"VA Salt Lake City Healthcare System","ror":"https://ror.org/007fyq698","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540"]},{"id":"https://openalex.org/I4210095710","display_name":"Lake City VA Medical Center","ror":"https://ror.org/00nvney28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210095710","https://openalex.org/I4210118777","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel D Trinity","raw_affiliation_strings":["Center on Aging, University of Utah, Salt Lake City, UT","Department of Internal Medicine, University of Utah, Salt Lake City, UT","Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center on Aging, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT","institution_ids":["https://openalex.org/I4210089864","https://openalex.org/I4210095710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082176880","display_name":"John Jake Ryan","orcid":"https://orcid.org/0000-0002-9203-5512","observed_orcids":["https://orcid.org/0000-0002-9203-5512"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J Ryan","raw_affiliation_strings":["Center on Aging, University of Utah, Salt Lake City, UT","Department of Internal Medicine, University of Utah, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center on Aging, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016791114","display_name":"Russell S. Richardson","orcid":"https://orcid.org/0000-0003-0233-5923","observed_orcids":["https://orcid.org/0000-0003-0233-5923"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210089864","display_name":"VA Salt Lake City Healthcare System","ror":"https://ror.org/007fyq698","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540"]},{"id":"https://openalex.org/I4210095710","display_name":"Lake City VA Medical Center","ror":"https://ror.org/00nvney28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210095710","https://openalex.org/I4210118777","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell S Richardson","raw_affiliation_strings":["Center on Aging, University of Utah, Salt Lake City, UT","Department of Internal Medicine, University of Utah, Salt Lake City, UT","Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT","Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center on Aging, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT","institution_ids":["https://openalex.org/I4210089864","https://openalex.org/I4210095710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062302009","display_name":"Paul J. Fadel","orcid":"https://orcid.org/0000-0002-0115-0743","observed_orcids":["https://orcid.org/0000-0002-0115-0743"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J Fadel","raw_affiliation_strings":["Department of Kinesiology, University of Texas at Arlington, Arlington, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology, University of Texas at Arlington, Arlington, TX","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029108683","display_name":"Satyam Sarma","orcid":"https://orcid.org/0000-0002-0628-4919","observed_orcids":["https://orcid.org/0000-0002-0628-4919"]},"institutions":[{"id":"https://openalex.org/I2800861319","display_name":"Texas Health Dallas","ror":"https://ror.org/05k07p323","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800861319","https://openalex.org/I4210163017","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I4210145855","display_name":"Institute for Exercise and Environmental Medicine","ror":"https://ror.org/03gqc7y13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800861319","https://openalex.org/I4210145855","https://openalex.org/I4210163017","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satyam Sarma","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX","Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX","institution_ids":["https://openalex.org/I2800861319","https://openalex.org/I4210145855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061669365","display_name":"Mark J. Haykowsky","orcid":"https://orcid.org/0000-0002-7217-2747","observed_orcids":["https://orcid.org/0000-0002-7217-2747"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Haykowsky","raw_affiliation_strings":["College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058940412","display_name":"Walter Wray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210089864","display_name":"VA Salt Lake City Healthcare System","ror":"https://ror.org/007fyq698","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540"]},{"id":"https://openalex.org/I4210095710","display_name":"Lake City VA Medical Center","ror":"https://ror.org/00nvney28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210095710","https://openalex.org/I4210118777","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter Wray","raw_affiliation_strings":["Center on Aging, University of Utah, Salt Lake City, UT","Department of Internal Medicine, University of Utah, Salt Lake City, UT","Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT","Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center on Aging, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT","institution_ids":["https://openalex.org/I4210089864","https://openalex.org/I4210095710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.4056,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.73184671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/muscle-metaboreflex","display_name":"muscle metaboreflex","score":0.9800000190734863},{"id":"https://openalex.org/keywords/exercise-intolerance","display_name":"exercise intolerance","score":0.8460000157356262},{"id":"https://openalex.org/keywords/post-exercise-circulatory-occlusion","display_name":"post-exercise circulatory occlusion","score":0.8619999885559082},{"id":"https://openalex.org/keywords/heart-rate-response","display_name":"heart rate response","score":0.7429999709129333},{"id":"https://openalex.org/keywords/handgrip-exercise","display_name":"handgrip exercise","score":0.8500000238418579},{"id":"https://openalex.org/keywords/muscle-afferents","display_name":"muscle afferents","score":0.7250000238418579},{"id":"https://openalex.org/keywords/autonomic-nervous-system","display_name":"autonomic nervous system","score":0.640999972820282},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.3840000033378601},{"id":"https://openalex.org/keywords/baroreflex","display_name":"baroreflex","score":0.5249999761581421},{"id":"https://openalex.org/keywords/heart-failure-with-reduced-ejection-fraction","display_name":"heart failure with reduced ejection fraction","score":0.5849999785423279},{"id":"https://openalex.org/keywords/isometric-exercise","display_name":"isometric exercise","score":0.4269999861717224},{"id":"https://openalex.org/keywords/autonomic-dysfunction","display_name":"autonomic dysfunction","score":0.38100001215934753},{"id":"https://openalex.org/keywords/orthostatic-intolerance","display_name":"orthostatic intolerance","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8571820855140686},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.8023171424865723},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.7519394755363464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7303527593612671},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.709041953086853},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.6775438189506531},{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.6700531244277954},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.6047511696815491},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5749544501304626},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5261088013648987},{"id":"https://openalex.org/C2777321227","wikidata":"https://www.wikidata.org/wiki/Q5420062","display_name":"Exercise intolerance","level":3,"score":0.42763620615005493}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.687.18","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.687.18","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.687.18","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G164795462","display_name":"Peripheral Vasoconstriction in Heart Failure: Mechanisms & Modulatory Influences","funder_award_id":"R01HL118313","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1940281350","display_name":null,"funder_award_id":"RX001697","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G229625944","display_name":null,"funder_award_id":"RX001418","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G3958766278","display_name":null,"funder_award_id":"E6910-R","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4376130817","https://openalex.org/W3215048216","https://openalex.org/W4407925531","https://openalex.org/W3017152878","https://openalex.org/W2794786816","https://openalex.org/W4378648710","https://openalex.org/W3100528928","https://openalex.org/W34601894","https://openalex.org/W2564207197","https://openalex.org/W2737462686"],"abstract_inverted_index":{"Background":[0],"Exercise":[1],"intolerance":[2,474],"is":[3,432,460],"the":[4,38,68,76,184,203,366,393,407,428,441,457,472,488,495],"primary":[5],"chronic":[6],"symptom":[7],"in":[8,37,52,95,140,217,392,420,427,462,471,476,485],"heart":[9,53,87],"failure":[10,54],"patients":[11,101,305,395,442,463],"with":[12,21,55,440,464],"preserved":[13],"ejection":[14,57,116],"fraction":[15,58,117],"(HFpEF),":[16],"and":[17,72,90,121,166,191,202,209,219,224,231,272,334,466,494],"often":[18,448],"persists":[19],"even":[20],"optimized":[22],"treatment.":[23],"Though":[24],"there":[25,382],"are":[26],"many":[27],"mechanisms":[28],"that":[29,51,436,456],"may":[30,41,468],"contribute":[31],"to":[32,67,82,182,213,434],"this":[33,79,141,467,477],"deficit,":[34],"disease\u2010related":[35],"changes":[36,216],"muscle":[39,64,185,458],"metaboreflex":[40,84,186,459],"play":[42],"a":[43,307,384,387,417],"role.":[44],"Indeed,":[45],"it":[46],"has":[47],"been":[48],"previously":[49],"shown":[50],"reduced":[56],"(HFrEF),":[59],"input":[60],"from":[61],"group":[62],"III/IV":[63],"afferents":[65],"contributes":[66],"development":[69],"of":[70,78,86,153,160,168,177,207,491,498],"fatigue":[71],"exercise":[73,163,208,473],"intolerance.":[74],"Therefore,":[75],"purpose":[77],"study":[80],"was":[81,211,287,328,363,383,413,423],"examine":[83],"modulation":[85],"rate":[88],"(HR)":[89],"mean":[91],"arterial":[92,192],"pressure":[93,194,422],"(MAP)":[94],"HFpEF":[96,100,230,269,282,301,304,320,333,378,394,429],"patients.":[97,430],"Methods":[98],"Eight":[99],"(6M,":[102],"2F;":[103],"age":[104,127],"67":[105],"\u00b1":[106,111,119,129,134,234,238,242,246,262,266,275,279,294,298,313,317,339,343,350,354,371,375,397,401],"4":[107,243,265],"yrs;":[108,131],"BMI":[109,132],"35":[110],"3":[112,130,299,318,340,402],"kg/m":[113,136],"2":[114,137,158,175,267,278,295,314,344,355,376],";":[115],"63":[118],"3%)":[120],"seven":[122],"healthy":[123],"controls":[124,232,335],"(4M,":[125],"3F;":[126],"59":[128],"30":[133,151,205],"1":[135,263,276,280,351,353],")":[138],"participated":[139],"study.":[142],"Patients":[143],"were":[144,199,226,255],"studied":[145],"under":[146],"their":[147,444],"normal":[148,445],"pharmacotherapy.":[149],"After":[150],"min":[152,159,176],"supine":[154],"rest,":[155],"participants":[156],"performed":[157],"isometric":[161],"handgrip":[162,260,292,337,369,412],"at":[164,360],"30%":[165,251],"40%":[167,325,361],"maximal":[169],"voluntary":[170],"contraction":[171],"(MVC),":[172],"followed":[173],"by":[174,487],"post\u2010exercise":[178],"circulatory":[179],"occlusion":[180],"(PECO)":[181],"isolate":[183],"response.":[187],"HR":[188,218,223],"(3\u2010lead":[189],"ECG)":[190],"blood":[193,421],"(Finapres":[195],"Medical":[196],"Systems":[197],"BV)":[198],"measured":[200],"continuously,":[201],"last":[204],"sec":[206],"PECO":[210,273,311,348,391,426],"averaged":[212],"determine":[214],"peak":[215],"MAP.":[220],"Results":[221],"Baseline":[222],"MAP":[225],"not":[227,329],"different":[228,331],"between":[229,257,289,332,365,415],"(70":[233],"7":[235],"vs.":[236,244,264,270,277,283,296,302,315,321,341,352,373,379,399],"68":[237],"5":[239,247,372,398],"bpm;":[240],"97":[241],"103":[245],"mmHg,":[248,300,319,377,403],"respectively).":[249,357],"At":[250,324],"MVC,":[252,326],"comparable":[253,364,414],"\u0394HR":[254,327],"observed":[256,424,475],"groups":[258,290,367],"during":[259,291,310,336,368,390,411,425],"(6":[261],"bpm,":[268,281,345,356],"control)":[271],"(2":[274],"control).":[284],"While":[285,406],"\u0394MAP":[286,309,359,389],"similar":[288],"(15":[293],"14":[297],"control),":[303,380],"exhibited":[306],"greater":[308,388],"(16":[312],"8":[316],"control,":[322],"p<0.05).":[323],"significantly":[330],"(7":[338],"12":[342],"respectively)":[346],"or":[347,481],"(1":[349],"Similarly,":[358],"MVC":[362],"(24":[370,396],"24":[374],"whereas":[381],"trend":[385],"towards":[386],"16":[400],"p=0.16).":[404],"Conclusions":[405],"overall":[408],"pressor":[409],"response":[410],"groups,":[416],"notable":[418],"elevation":[419],"It":[431],"important":[433],"note":[435],"these":[437],"differences":[438],"occurred":[439],"maintaining":[443],"pharmacotherapy,":[446],"which":[447],"includes":[449],"antihypertensive":[450],"agents.":[451],"These":[452],"preliminary":[453],"findings":[454],"suggest":[455],"exaggerated":[461],"HFpEF,":[465],"be":[469],"involved":[470],"patient":[478],"population.":[479],"Support":[480],"Funding":[482],"Information":[483],"Funded":[484],"part":[486],"National":[489],"Institutes":[490],"Health":[492],"(HL118313)":[493],"U.S.":[496],"Department":[497],"Veterans":[499],"Affairs":[500],"(RX001697,":[501],"RX001418,":[502],"E6910R)":[503]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-26T00:00:00"}
