{"id":"https://openalex.org/W4388992284","doi":"https://doi.org/10.3920/9789086867653_027","title":"Vitamin D and insulin sensitivity","display_name":"Vitamin D and insulin sensitivity","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W4388992284","doi":"https://doi.org/10.3920/9789086867653_027"},"language":"en","primary_location":{"id":"doi:10.3920/9789086867653_027","doi":"https://doi.org/10.3920/9789086867653_027","is_oa":false,"landing_page_url":"https://doi.org/10.3920/9789086867653_027","pdf_url":null,"source":{"id":"https://openalex.org/S4306464271","display_name":"Wageningen Academic Publishers eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of vitamin D in human health","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2505327384","display_name":"Handbook of vitamin D in human health"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052983138","display_name":"Brienna Larrick","orcid":"https://orcid.org/0000-0002-5154-8098","observed_orcids":["https://orcid.org/0000-0002-5154-8098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Larrick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037126715","display_name":"Shawn Scott Donkin","orcid":"https://orcid.org/0000-0003-3571-4946","observed_orcids":["https://orcid.org/0000-0003-3571-4946"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Donkin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5026812062","display_name":"Dorothy Teegarden","orcid":"https://orcid.org/0000-0002-7045-3748","observed_orcids":["https://orcid.org/0000-0002-7045-3748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Teegarden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.750998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"501","last_page":"524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":1.0},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9380000233650208},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9919999837875366},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9350000023841858},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.9679999947547913},{"id":"https://openalex.org/keywords/1alpha-25-dihydroxyvitamin-d","display_name":"1\u03b1,25-dihydroxyvitamin D","score":0.9679999947547913},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.8539999723434448},{"id":"https://openalex.org/keywords/insulin-synthesis","display_name":"insulin biosynthesis","score":0.5540000200271606},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.796999990940094},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6600000262260437},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8821392059326172},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.733069658279419},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7275785207748413},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6834704279899597},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6348738670349121},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.629370927810669},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.5910878777503967},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5723904371261597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.541847825050354},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.502007007598877},{"id":"https://openalex.org/C2780106736","wikidata":"https://www.wikidata.org/wiki/Q139347","display_name":"Cholecalciferol","level":3,"score":0.45609888434410095},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.43659132719039917}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3920/9789086867653_027","doi":"https://doi.org/10.3920/9789086867653_027","is_oa":false,"landing_page_url":"https://doi.org/10.3920/9789086867653_027","pdf_url":null,"source":{"id":"https://openalex.org/S4306464271","display_name":"Wageningen Academic Publishers eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of vitamin D in human health","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2142699855","https://openalex.org/W7099872741","https://openalex.org/W1985978903","https://openalex.org/W2407101158","https://openalex.org/W4386008936","https://openalex.org/W1968912276","https://openalex.org/W1979785484","https://openalex.org/W4381889656","https://openalex.org/W4366690714","https://openalex.org/W3006763344"],"abstract_inverted_index":{"Insulin":[0],"resistance":[1,31,37],"is":[2,15,167],"characterized":[3],"by":[4,125,156],"an":[5,85],"insufficient":[6],"response":[7],"of":[8,20,54,71,77,82,87,114,122,181],"the":[9,29,52,75,110,123,154,179],"body":[10],"to":[11,27,169,187],"insulin":[12,30,36,78,119,130,141,162,182],"secretion,":[13,144],"and":[14,44,48,63,65,98,143,164,184],"associated":[16,34,93],"with":[17,35,94,107],"a":[18,69],"cluster":[19],"metabolic":[21],"disorders":[22],"that":[23,105,133],"are":[24],"collectively":[25],"referred":[26],"as":[28,145,147],"syndrome.":[32],"Features":[33],"include":[38],"glucose":[39,96,165],"intolerance,":[40],"hyperinsulinema,":[41],"hyperglycemia,":[42],"hypertriglyceridemia,":[43],"hypertension,":[45],"among":[46],"others,":[47],"together":[49],"these":[50],"increase":[51],"likelihood":[53],"developing":[55],"type":[56,188],"2":[57,189],"diabetes.":[58,190],"Evidence":[59],"from":[60,100],"epidemiological,":[61],"clinical,":[62],"tissue-":[64],"cell-based":[66],"studies":[67,103],"suggest":[68,132],"role":[70],"vitamin":[72,88,115,127,134,158,172],"D":[73,89,128,135,159,173],"in":[74,177],"prevention":[76],"resistance.":[79],"Serum":[80],"levels":[81],"25-hydroxyvitamin":[83],"D,":[84,109,116],"indicator":[86],"status,":[90],"have":[91,137],"been":[92],"improved":[95],"homeostasis,":[97],"data":[99],"clinical":[101],"intervention":[102],"support":[104],"treatment":[106],"1\u03b1,25-dihydroxyvitamin":[108],"hormonally":[111],"active":[112],"form":[113],"may":[117,136,160,174],"improve":[118,161],"sensitivity.":[120],"Investigations":[121],"mechanisms":[124,155],"which":[126,157],"improves":[129],"sensitivity":[131,163],"direct":[138],"effects":[139,149],"on":[140,150],"synthesis":[142],"well":[146],"insulin-sensitizing":[148],"target":[151],"tissues.":[152],"Defining":[153],"homeostasis":[166],"critical":[168],"understanding":[170],"how":[171],"be":[175],"effective":[176],"preventing":[178],"development":[180],"resistance,":[183],"its":[185],"progression":[186]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2023-11-25T00:00:00"}