{"id":"https://openalex.org/W4388977381","doi":"https://doi.org/10.3390/v15122304","title":"The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation","display_name":"The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation","publication_year":2023,"publication_date":"2023-11-24","ids":{"openalex":"https://openalex.org/W4388977381","doi":"https://doi.org/10.3390/v15122304","pmid":"https://pubmed.ncbi.nlm.nih.gov/38140545","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10747396"},"language":"en","primary_location":{"id":"doi:10.3390/v15122304","doi":"https://doi.org/10.3390/v15122304","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v15122304","pdf_url":"https://www.mdpi.com/1999-4915/15/12/2304/pdf?version=1700808464","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4915/15/12/2304/pdf?version=1700808464","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081477532","display_name":"Congcong Huang","orcid":"https://orcid.org/0000-0002-1928-4440","observed_orcids":["https://orcid.org/0000-0002-1928-4440"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huang Congcong","raw_affiliation_strings":["Jinan University , Guangzhou , China;","Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","Institute of Virology, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jinan University , Guangzhou , China;","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Institute of Virology, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101203271","display_name":"Yiping Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2800232565","display_name":"Beijing Chao-Yang Hospital, Capital Medical University","ror":"https://ror.org/01eff5662","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800232565","https://openalex.org/I4210110145","https://openalex.org/I4210135108"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiping Yin","raw_affiliation_strings":["Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","Department of Respiratory and Critical Care Medicine , Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital , Capital Medical University , Beijing , China","Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100054, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","institution_ids":["https://openalex.org/I4210140357"]},{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine , Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital , Capital Medical University , Beijing , China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]},{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100054, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100667160","display_name":"Pan Pan","orcid":"https://orcid.org/0000-0002-7214-1393","observed_orcids":["https://orcid.org/0000-0002-7214-1393"]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pan Pan","raw_affiliation_strings":["The First Affiliated Hospital of","The First Affiliated Hospital of Jinan University, Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of","institution_ids":[]},{"raw_affiliation_string":"The First Affiliated Hospital of Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101992150","display_name":"Yanping Huang","orcid":"https://orcid.org/0000-0002-2234-3499","observed_orcids":["https://orcid.org/0000-0002-2234-3499"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanping Huang","raw_affiliation_strings":["Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","institution_ids":["https://openalex.org/I4210140357"]},{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100622562","display_name":"Siwei Chen","orcid":"https://orcid.org/0000-0003-1244-834X","observed_orcids":["https://orcid.org/0000-0003-1244-834X"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siwei Chen","raw_affiliation_strings":["Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","institution_ids":["https://openalex.org/I4210140357"]},{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104122069","display_name":"Junkai Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junkai Chen","raw_affiliation_strings":["Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","institution_ids":["https://openalex.org/I4210140357"]},{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101270887","display_name":"Ju Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ju Wang","raw_affiliation_strings":["Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","institution_ids":["https://openalex.org/I4210140357"]},{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102182840","display_name":"Guoqing Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoqing Xu","raw_affiliation_strings":["Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","institution_ids":["https://openalex.org/I4210140357"]},{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xuan Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Tao","raw_affiliation_strings":["Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","institution_ids":["https://openalex.org/I4210140357"]},{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100451733","display_name":"Xiao Xiao","orcid":"https://orcid.org/0000-0002-8687-5689","observed_orcids":["https://orcid.org/0000-0002-8687-5689"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Xiao","raw_affiliation_strings":["Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","Institute of Virology, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Institute of Virology, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402448","display_name":"Jian Li","orcid":"https://orcid.org/0000-0001-9434-7803","observed_orcids":["https://orcid.org/0000-0001-9434-7803"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Li","raw_affiliation_strings":["Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","Institute of Virology, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":"https://orcid.org/0000-0001-9434-7803","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Institute of Virology, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Yang","raw_affiliation_strings":["Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","Institute of Virology, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Institute of Virology, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101153582","display_name":"Zhixiong Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhixiong Jin","raw_affiliation_strings":["Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","Institute of Virology, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Institute of Virology, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100356451","display_name":"Bei Li","orcid":"https://orcid.org/0000-0002-4766-5005","observed_orcids":["https://orcid.org/0000-0002-4766-5005"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bei Li","raw_affiliation_strings":["Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","Institute of Virology, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Institute of Virology, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101484161","display_name":"Zhaohui Tong","orcid":"https://orcid.org/0000-0002-5341-6857","observed_orcids":["https://orcid.org/0000-0002-5341-6857","https://orcid.org/0000-0003-0525-5646"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2800232565","display_name":"Beijing Chao-Yang Hospital, Capital Medical University","ror":"https://ror.org/01eff5662","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800232565","https://openalex.org/I4210110145","https://openalex.org/I4210135108"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"ZhaoHui Tong","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine , Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital , Capital Medical University , Beijing , China","Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100054, China"],"raw_orcid":"https://orcid.org/0000-0002-5341-6857","affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine , Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital , Capital Medical University , Beijing , China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]},{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100054, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056135195","display_name":"Weixing Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weixing Du","raw_affiliation_strings":["Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases , Renmin Hospital , School of Basic Medical Sciences ,","institution_ids":["https://openalex.org/I4210140357"]},{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058491122","display_name":"Long Liu","orcid":"https://orcid.org/0000-0002-1265-7603","observed_orcids":["https://orcid.org/0000-0002-1265-7603"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Long Liu","raw_affiliation_strings":["Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","Institute of Virology, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Institute of Virology, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100700533","display_name":"Zhixin Liu","orcid":"https://orcid.org/0000-0001-7253-7438","observed_orcids":["https://orcid.org/0000-0001-7253-7438"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhixin Liu","raw_affiliation_strings":["Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","Institute of Virology, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":"https://orcid.org/0000-0001-7253-7438","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Institute of Virology, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5056135195","https://openalex.org/A5058491122","https://openalex.org/A5100700533","https://openalex.org/A5101484161"],"corresponding_institution_ids":["https://openalex.org/I1285929390","https://openalex.org/I183519381","https://openalex.org/I2800232565","https://openalex.org/I4210140357"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":1.407,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.79131912,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"15","issue":"12","first_page":"2304","last_page":"2304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9200000166893005},{"id":"https://openalex.org/keywords/nucleocapsid-protein","display_name":"nucleocapsid protein","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ube2i","display_name":"Ubc9","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mavs","display_name":"MAVS","score":0.921999990940094},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9929999709129333},{"id":"https://openalex.org/keywords/type-i-interferon-response","display_name":"type I interferon response","score":0.7710000276565552},{"id":"https://openalex.org/keywords/innate-immune-evasion","display_name":"innate immune evasion","score":0.7950000166893005},{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.8479999899864197},{"id":"https://openalex.org/keywords/irf3","display_name":"IRF3","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ikkalpha","display_name":"IKK\u03b1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/covid-19-pathogenesis","display_name":"COVID-19 pathogenesis","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C171350616","wikidata":"https://www.wikidata.org/wiki/Q61506","display_name":"SUMO protein","level":4,"score":0.9356704950332642},{"id":"https://openalex.org/C2780209191","wikidata":"https://www.wikidata.org/wiki/Q14914339","display_name":"IRF3","level":4,"score":0.7716071009635925},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7425249218940735},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6667125225067139},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.660571277141571},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5423714518547058},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5246165990829468},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4754642844200134},{"id":"https://openalex.org/C182561583","wikidata":"https://www.wikidata.org/wiki/Q7876535","display_name":"Ubiquitin-conjugating enzyme","level":5,"score":0.41334834694862366},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.27184176445007324},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26575595140457153},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23291584849357605},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14117243885993958},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07820585370063782}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D000098843","descriptor_name":"Ubiquitin-Conjugating Enzyme UBC9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058207","descriptor_name":"Sumoylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/v15122304","doi":"https://doi.org/10.3390/v15122304","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v15122304","pdf_url":"https://www.mdpi.com/1999-4915/15/12/2304/pdf?version=1700808464","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202310.1507.v1","doi":"https://doi.org/10.20944/preprints202310.1507.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202310.1507.v1","pdf_url":"https://www.preprints.org/manuscript/202310.1507/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10747396","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10747396","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10747396/pdf/viruses-15-02304.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"Text"},{"id":"pmid:38140545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38140545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:dc700d05e8604d03bf94fe66e14da4bb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dc700d05e8604d03bf94fe66e14da4bb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Viruses, Vol 15, Iss 12, p 2304 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/v15122304","doi":"https://doi.org/10.3390/v15122304","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v15122304","pdf_url":"https://www.mdpi.com/1999-4915/15/12/2304/pdf?version=1700808464","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1596733301","display_name":null,"funder_award_id":"2023AFB855","funder_id":"https://openalex.org/F4320322186","funder_display_name":"Natural Science Foundation of Hubei Province"},{"id":"https://openalex.org/G2496836609","display_name":null,"funder_award_id":"HBMUPI202102","funder_id":"https://openalex.org/F4320328434","funder_display_name":"Hubei University of Medicine"},{"id":"https://openalex.org/G8307440388","display_name":null,"funder_award_id":"2022CFB324","funder_id":"https://openalex.org/F4320322186","funder_display_name":"Natural Science Foundation of Hubei Province"}],"funders":[{"id":"https://openalex.org/F4320322186","display_name":"Natural Science Foundation of Hubei Province","ror":null},{"id":"https://openalex.org/F4320328434","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756"},{"id":"https://openalex.org/F4320329781","display_name":"Hubei University","ror":"https://ror.org/03a60m280"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388977381.pdf","grobid_xml":"https://content.openalex.org/works/W4388977381.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W343513958","https://openalex.org/W2009127910","https://openalex.org/W2028575270","https://openalex.org/W2045543293","https://openalex.org/W2053476949","https://openalex.org/W2058434102","https://openalex.org/W2562210432","https://openalex.org/W2887534894","https://openalex.org/W2992428563","https://openalex.org/W3011498764","https://openalex.org/W3041960835","https://openalex.org/W3045552416","https://openalex.org/W3116021319","https://openalex.org/W3123980263","https://openalex.org/W3165403061","https://openalex.org/W3180384198","https://openalex.org/W3183492501","https://openalex.org/W3196190359","https://openalex.org/W3200727625","https://openalex.org/W3205293336","https://openalex.org/W3213008578","https://openalex.org/W4200075065","https://openalex.org/W4206373442","https://openalex.org/W4213200965","https://openalex.org/W4214578575","https://openalex.org/W4283650181","https://openalex.org/W4289238792","https://openalex.org/W4296757638","https://openalex.org/W4376617879"],"related_works":["https://openalex.org/W3128756947","https://openalex.org/W3181250621","https://openalex.org/W3166037847","https://openalex.org/W3196427335","https://openalex.org/W3116021319","https://openalex.org/W3131178825","https://openalex.org/W4240310412","https://openalex.org/W3213008578","https://openalex.org/W4403378697","https://openalex.org/W4405423591"],"abstract_inverted_index":{"Severe":[0],"COVID-19":[1],"patients":[2],"exhibit":[3],"impaired":[4],"IFN-I":[5],"response":[6,111],"due":[7],"to":[8,71,121,139],"decreased":[9],"IFN-\u03b2":[10,35,93,125],"production,":[11],"allowing":[12],"persistent":[13],"viral":[14],"load":[15],"and":[16,65,89,117,145],"exacerbated":[17],"inflammation.":[18],"While":[19],"the":[20,37,53,60,81,98,101,108,114,124,133,141],"SARS-CoV-2":[21,54,105,138],"nucleocapsid":[22],"(N)":[23],"protein":[24,56,103],"has":[25],"been":[26],"implicated":[27],"in":[28,80,106],"inhibiting":[29,76],"innate":[30,109],"immunity":[31],"by":[32,112,137],"interfering":[33],"with":[34],"signaling,":[36],"specific":[38],"underlying":[39],"mechanism":[40],"still":[41],"needs":[42],"further":[43],"investigation":[44],"for":[45,149],"a":[46],"comprehensive":[47],"understanding.":[48],"This":[49,95],"study":[50,96],"reveals":[51],"that":[52],"N":[55,102],"enhances":[57],"interaction":[58,69],"between":[59],"human":[61],"SUMO-conjugating":[62],"enzyme":[63],"UBC9":[64],"MAVS.":[66],"Increased":[67],"MAVS-UBC9":[68],"leads":[70],"enhanced":[72],"SUMOylation":[73,116],"of":[74,83,100,104,123],"MAVS,":[75],"its":[77],"ubiquitination,":[78],"resulting":[79],"inhibition":[82,122],"phosphorylation":[84],"events":[85],"involving":[86],"IKK\u03b1,":[87],"TBK1,":[88],"IRF3,":[90],"thus":[91],"disrupting":[92],"signaling.":[94],"highlights":[97],"role":[99],"modulating":[107],"immune":[110],"affecting":[113],"MAVS":[115],"ubiquitination":[118],"processes,":[119],"leading":[120],"signaling":[126],"pathway.":[127],"These":[128],"findings":[129],"shed":[130],"light":[131],"on":[132],"complex":[134],"mechanisms":[135],"utilized":[136],"manipulate":[140],"host's":[142],"antiviral":[143],"defenses":[144],"provide":[146],"potential":[147],"insights":[148],"developing":[150],"targeted":[151],"therapeutic":[152],"strategies":[153],"against":[154],"severe":[155],"COVID-19.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-11-25T00:00:00"}