{"id":"https://openalex.org/W4388974232","doi":"https://doi.org/10.1093/jjco/hyad162","title":"Stepwise prolongation of overall survival from first to third generation EGFR-TKIs for EGFR mutation-positive non-small-cell lung cancer: the Tokushukai REAl-world Data project (TREAD 01)","display_name":"Stepwise prolongation of overall survival from first to third generation EGFR-TKIs for EGFR mutation-positive non-small-cell lung cancer: the Tokushukai REAl-world Data project (TREAD 01)","publication_year":2023,"publication_date":"2023-11-23","ids":{"openalex":"https://openalex.org/W4388974232","doi":"https://doi.org/10.1093/jjco/hyad162","pmid":"https://pubmed.ncbi.nlm.nih.gov/37997468"},"language":"en","primary_location":{"id":"doi:10.1093/jjco/hyad162","doi":"https://doi.org/10.1093/jjco/hyad162","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jjco/hyad162","pdf_url":null,"source":{"id":"https://openalex.org/S149902429","display_name":"Japanese Journal of Clinical Oncology","issn_l":"0368-2811","issn":["0368-2811","1465-3621"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024402580","display_name":"Kiyoaki Uryu","orcid":"https://orcid.org/0009-0008-6068-1385","observed_orcids":["https://orcid.org/0009-0008-6068-1385"]},"institutions":[{"id":"https://openalex.org/I4210119053","display_name":"Yao Tokushukai General Hospital","ror":"https://ror.org/01rg6cx71","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210119053"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoaki Uryu","raw_affiliation_strings":["Yao Tokushukai General Hospital Department of Medical Oncology, , Yao-shi, Osaka , Japan"],"raw_orcid":"https://orcid.org/0009-0008-6068-1385","affiliations":[{"raw_affiliation_string":"Yao Tokushukai General Hospital Department of Medical Oncology, , Yao-shi, Osaka , Japan","institution_ids":["https://openalex.org/I4210119053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023937165","display_name":"Yoshinori Imamura","orcid":"https://orcid.org/0000-0002-5202-531X","observed_orcids":["https://orcid.org/0000-0002-5202-531X"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Imamura","raw_affiliation_strings":["Kobe University Graduate School of Medicine Department of Medical Oncology and Hematology, , Kobe, Hyougo , Japan"],"raw_orcid":"https://orcid.org/0000-0002-5202-531X","affiliations":[{"raw_affiliation_string":"Kobe University Graduate School of Medicine Department of Medical Oncology and Hematology, , Kobe, Hyougo , Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019927738","display_name":"Rai Shimoyama","orcid":"https://orcid.org/0000-0001-8601-0442","observed_orcids":["https://orcid.org/0000-0001-8601-0442"]},"institutions":[{"id":"https://openalex.org/I4210151342","display_name":"Shonan Kamakura General Hospital","ror":"https://ror.org/03xz3hj66","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151342"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rai Shimoyama","raw_affiliation_strings":["Shonan Kamakura General Hospital Department of General Surgery, , Kamakura, Kanagawa , Japan"],"raw_orcid":"https://orcid.org/0000-0001-8601-0442","affiliations":[{"raw_affiliation_string":"Shonan Kamakura General Hospital Department of General Surgery, , Kamakura, Kanagawa , Japan","institution_ids":["https://openalex.org/I4210151342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091025405","display_name":"Takahiro Mase","orcid":"https://orcid.org/0009-0003-6071-550X","observed_orcids":["https://orcid.org/0009-0003-6071-550X"]},"institutions":[{"id":"https://openalex.org/I4405257620","display_name":"Ogaki Tokushukai Hospital","ror":"https://ror.org/05fkc6595","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4405257620"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Mase","raw_affiliation_strings":["Ogaki Tokushukai Hospital Department of Breast Surgery, , Ogaki-shi, Gifu , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ogaki Tokushukai Hospital Department of Breast Surgery, , Ogaki-shi, Gifu , Japan","institution_ids":["https://openalex.org/I4405257620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011820775","display_name":"Yoshiaki Fujimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshiaki Fujimura","raw_affiliation_strings":["Tokushukai Information System Inc , Kita-ku, Osaka , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushukai Information System Inc , Kita-ku, Osaka , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maki Hayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maki Hayashi","raw_affiliation_strings":["Mirai Iryo Research Center Inc , Chiyoda-ku, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirai Iryo Research Center Inc , Chiyoda-ku, Tokyo , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109468696","display_name":"Megu Ohtaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megu Ohtaki","raw_affiliation_strings":["deCult Co., Ltd. , Hatsukaichi-shi, Hiroshima , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"deCult Co., Ltd. , Hatsukaichi-shi, Hiroshima , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010706879","display_name":"Keiko Otani","orcid":"https://orcid.org/0000-0001-6153-2244","observed_orcids":["https://orcid.org/0000-0001-6153-2244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keiko Otani","raw_affiliation_strings":["deCult Co., Ltd. , Hatsukaichi-shi, Hiroshima , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"deCult Co., Ltd. , Hatsukaichi-shi, Hiroshima , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056748024","display_name":"Makoto Hibino","orcid":"https://orcid.org/0000-0002-1638-5027","observed_orcids":["https://orcid.org/0000-0002-1638-5027"]},"institutions":[{"id":"https://openalex.org/I4405254078","display_name":"Shonan Fujisawa Tokusyukai Hospital","ror":"https://ror.org/01crjdg76","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405254078"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Hibino","raw_affiliation_strings":["Shonan Fujisawa Tokushukai Hospital Department of Respiratory Medicine, , Fujisawa-shi, Kanagawa , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shonan Fujisawa Tokushukai Hospital Department of Respiratory Medicine, , Fujisawa-shi, Kanagawa , Japan","institution_ids":["https://openalex.org/I4405254078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113180650","display_name":"Shigeto Horiuchi","orcid":"https://orcid.org/0009-0006-5105-2056","observed_orcids":["https://orcid.org/0009-0006-5105-2056"]},"institutions":[{"id":"https://openalex.org/I4405254078","display_name":"Shonan Fujisawa Tokusyukai Hospital","ror":"https://ror.org/01crjdg76","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405254078"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeto Horiuchi","raw_affiliation_strings":["Shonan Fujisawa Tokushukai Hospital Department of Respiratory Medicine, , Fujisawa-shi, Kanagawa , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shonan Fujisawa Tokushukai Hospital Department of Respiratory Medicine, , Fujisawa-shi, Kanagawa , Japan","institution_ids":["https://openalex.org/I4405254078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016906128","display_name":"Tomoya Fukui","orcid":"https://orcid.org/0000-0003-4814-4401","observed_orcids":["https://orcid.org/0000-0003-4814-4401"]},"institutions":[{"id":"https://openalex.org/I4210151342","display_name":"Shonan Kamakura General Hospital","ror":"https://ror.org/03xz3hj66","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151342"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoya Fukui","raw_affiliation_strings":["Shonan Kamakura General Hospital Department of Respiratory Medicine, , Kamakura, Kanagawa , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shonan Kamakura General Hospital Department of Respiratory Medicine, , Kamakura, Kanagawa , Japan","institution_ids":["https://openalex.org/I4210151342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087724421","display_name":"Ryuta Fukai","orcid":"https://orcid.org/0000-0001-8483-7788","observed_orcids":["https://orcid.org/0000-0001-8483-7788"]},"institutions":[{"id":"https://openalex.org/I4210151342","display_name":"Shonan Kamakura General Hospital","ror":"https://ror.org/03xz3hj66","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151342"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuta Fukai","raw_affiliation_strings":["Shonan Kamakura General Hospital Department of General Thoracic Surgery, , Kamakura, Kanagawa , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shonan Kamakura General Hospital Department of General Thoracic Surgery, , Kamakura, Kanagawa , Japan","institution_ids":["https://openalex.org/I4210151342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032787341","display_name":"Yusuke Chihara","orcid":"https://orcid.org/0000-0002-7533-844X","observed_orcids":["https://orcid.org/0000-0002-7533-844X"]},"institutions":[{"id":"https://openalex.org/I4405253600","display_name":"Uji-Tokushukai Medical Center","ror":"https://ror.org/00w16jn86","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405253600"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Chihara","raw_affiliation_strings":["Uji Tokushukai Medical Center Department of Respiratory Medicine, , Uji-shi, Kyoto , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uji Tokushukai Medical Center Department of Respiratory Medicine, , Uji-shi, Kyoto , Japan","institution_ids":["https://openalex.org/I4405253600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025255485","display_name":"Akihiko Iwase","orcid":"https://orcid.org/0000-0002-8201-9922","observed_orcids":["https://orcid.org/0000-0002-8201-9922"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akihiko Iwase","raw_affiliation_strings":["Chibanishi General Hospital Department of Respiratory Medicine, , Matsudo-shi, Chiba , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chibanishi General Hospital Department of Respiratory Medicine, , Matsudo-shi, Chiba , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109967440","display_name":"Noriko Yamada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noriko Yamada","raw_affiliation_strings":["Chibanishi General Hospital Department of General Thoracic Surgery, , Matsudo-shi, Chiba , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chibanishi General Hospital Department of General Thoracic Surgery, , Matsudo-shi, Chiba , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073891222","display_name":"Yukihiro Tamura","orcid":"https://orcid.org/0009-0004-4910-1846","observed_orcids":["https://orcid.org/0009-0004-4910-1846"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukihiro Tamura","raw_affiliation_strings":["Oosumi Kanoya Hospital Department of General Internal Medicine, , Kanoya-shi, Kagoshima , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oosumi Kanoya Hospital Department of General Internal Medicine, , Kanoya-shi, Kagoshima , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006216575","display_name":"Hiromasa Harada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119053","display_name":"Yao Tokushukai General Hospital","ror":"https://ror.org/01rg6cx71","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210119053"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromasa Harada","raw_affiliation_strings":["Yao Tokushukai General Hospital Department of Respiratory Medicine, , Yao-shi, Osaka , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yao Tokushukai General Hospital Department of Respiratory Medicine, , Yao-shi, Osaka , Japan","institution_ids":["https://openalex.org/I4210119053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108437268","display_name":"Nobuaki Shinozaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151342","display_name":"Shonan Kamakura General Hospital","ror":"https://ror.org/03xz3hj66","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151342"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuaki Shinozaki","raw_affiliation_strings":["General Incorporated Association Tokushukai , Chiyoda-ku, Tokyo , Japan","Shonan Kamakura General Hospital Department of General Surgery, , Kamakura, Kanagawa , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Incorporated Association Tokushukai , Chiyoda-ku, Tokyo , Japan","institution_ids":[]},{"raw_affiliation_string":"Shonan Kamakura General Hospital Department of General Surgery, , Kamakura, Kanagawa , Japan","institution_ids":["https://openalex.org/I4210151342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111896428","display_name":"Asuka Tsuya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132249","display_name":"Izumi City General Hospital","ror":"https://ror.org/03yj19r32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132249"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Asuka Tsuya","raw_affiliation_strings":["Izumi City General Hospital Department of Medical Oncology, , Izumi, Osaka , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Izumi City General Hospital Department of Medical Oncology, , Izumi, Osaka , Japan","institution_ids":["https://openalex.org/I4210132249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108393803","display_name":"Masahiro Fukuoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132249","display_name":"Izumi City General Hospital","ror":"https://ror.org/03yj19r32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132249"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Fukuoka","raw_affiliation_strings":["Izumi City General Hospital Department of Medical Oncology, , Izumi, Osaka , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Izumi City General Hospital Department of Medical Oncology, , Izumi, Osaka , Japan","institution_ids":["https://openalex.org/I4210132249"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089137663","display_name":"Hironobu Minami","orcid":"https://orcid.org/0000-0001-8630-9145","observed_orcids":["https://orcid.org/0000-0001-8630-9145"]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironobu Minami","raw_affiliation_strings":["Kobe University Graduate School of Medicine Department of Medical Oncology and Hematology, , Kobe, Hyougo , Japan","Kobe University Hospital Cancer Center, , Kobe, Hyougo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kobe University Graduate School of Medicine Department of Medical Oncology and Hematology, , Kobe, Hyougo , Japan","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Kobe University Hospital Cancer Center, , Kobe, Hyougo , Japan","institution_ids":["https://openalex.org/I4210089895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.9817,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.73652394,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"54","issue":"3","first_page":"319","last_page":"328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-mutant-non-small-cell-lung-cancer","display_name":"EGFR-mutant non-small cell lung cancer","score":0.8659999966621399},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/osimertinib","display_name":"osimertinib","score":0.8650000095367432},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.984000027179718},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9800000190734863},{"id":"https://openalex.org/keywords/afatinib","display_name":"afatinib","score":1.0},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8119999766349792},{"id":"https://openalex.org/keywords/real-world-outcomes","display_name":"real-world outcomes","score":0.6499999761581421},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.5659999847412109},{"id":"https://openalex.org/keywords/treatment-adoption","display_name":"treatment adoption","score":0.49399998784065247},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9139999747276306},{"id":"https://openalex.org/keywords/time-to-treatment-failure","display_name":"time to treatment failure","score":0.8040000200271606},{"id":"https://openalex.org/keywords/japan","display_name":"Japan","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9315357804298401},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.8543152809143066},{"id":"https://openalex.org/C2780586478","wikidata":"https://www.wikidata.org/wiki/Q4688818","display_name":"Afatinib","level":5,"score":0.8020050525665283},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.7635082006454468},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7121076583862305},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5924215912818909},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5726518034934998},{"id":"https://openalex.org/C2909325608","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib Hydrochloride","level":5,"score":0.5311001539230347},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5061907172203064},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4996325969696045},{"id":"https://openalex.org/C2777626846","wikidata":"https://www.wikidata.org/wiki/Q21506464","display_name":"Osimertinib","level":5,"score":0.49645310640335083},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.44775623083114624},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4404067397117615},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.4223196506500244},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3672437071800232}],"mesh":[{"descriptor_ui":"D000069347","descriptor_name":"Erlotinib Hydrochloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077716","descriptor_name":"Afatinib","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jjco/hyad162","doi":"https://doi.org/10.1093/jjco/hyad162","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jjco/hyad162","pdf_url":null,"source":{"id":"https://openalex.org/S149902429","display_name":"Japanese Journal of Clinical Oncology","issn_l":"0368-2811","issn":["0368-2811","1465-3621"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:37997468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37997468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of clinical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1942770305","https://openalex.org/W2055402151","https://openalex.org/W2058815839","https://openalex.org/W2065799563","https://openalex.org/W2096198395","https://openalex.org/W2098395191","https://openalex.org/W2105559970","https://openalex.org/W2111662961","https://openalex.org/W2129360604","https://openalex.org/W2132157071","https://openalex.org/W2132870547","https://openalex.org/W2133149289","https://openalex.org/W2139804581","https://openalex.org/W2146404049","https://openalex.org/W2160982674","https://openalex.org/W2166084034","https://openalex.org/W2168691181","https://openalex.org/W2171139285","https://openalex.org/W2339311613","https://openalex.org/W2414167252","https://openalex.org/W2543818161","https://openalex.org/W2560717039","https://openalex.org/W2565077351","https://openalex.org/W2587420003","https://openalex.org/W2724823385","https://openalex.org/W2760639821","https://openalex.org/W2770828094","https://openalex.org/W2783363324","https://openalex.org/W2791274828","https://openalex.org/W2806325305","https://openalex.org/W2809161550","https://openalex.org/W2810609012","https://openalex.org/W2886144609","https://openalex.org/W2903043657","https://openalex.org/W2924237217","https://openalex.org/W2984947153","https://openalex.org/W2985252086","https://openalex.org/W2995864319","https://openalex.org/W3041287670","https://openalex.org/W3048896255","https://openalex.org/W3086933470","https://openalex.org/W3087229737","https://openalex.org/W3128646645","https://openalex.org/W3205918530","https://openalex.org/W3213427500","https://openalex.org/W4220824310","https://openalex.org/W4307240997","https://openalex.org/W4307945768"],"related_works":["https://openalex.org/W4402694376","https://openalex.org/W2568946109","https://openalex.org/W4286265319","https://openalex.org/W6958519083","https://openalex.org/W4415726690","https://openalex.org/W2783363324","https://openalex.org/W2312086742","https://openalex.org/W4281747485","https://openalex.org/W3095448852","https://openalex.org/W2750615175"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,196,231],"introduction":[2],"of":[3,34,53,65,101,123,139,237,264,285],"new-generation":[4],"epidermal":[5,170],"growth":[6,171],"factor":[7,172],"receptor":[8,173],"tyrosine":[9,174],"kinase":[10,175],"inhibitors":[11],"(EGFR-TKIs)":[12],"has":[13],"afforded":[14],"promising":[15],"overall":[16,42,90,144,199,282],"survival":[17,43,91,145,200,283],"outcomes":[18],"in":[19,59,116,127,267],"clinical":[20,63,304],"trials":[21],"for":[22,185,202,299],"non-small-cell":[23,69,272],"lung":[24,70,273],"cancer.":[25],"We":[26],"aim":[27],"to":[28,234],"investigate":[29],"the":[30,38,87,132,142,259],"current":[31],"adoption":[32],"rate":[33],"these":[35,277,300],"agents":[36],"and":[37,77,81,92,95,168,193,206,224,241,247,261,275],"real-world":[39,255],"impact":[40],"on":[41],"among":[44],"institutions.":[45],"METHODS:":[46],"In":[47,153],"a":[48,136,154,294],"nationwide":[49],"retrospective":[50],"cohort":[51],"study":[52,189],"46":[54],"Tokushukai":[55],"Medical":[56],"Group":[57],"hospitals":[58],"Japan,":[60],"we":[61],"analyzed":[62],"data":[64,256],"consecutive":[66],"patients":[67,103,114,125,268,301],"with":[68,269],"cancer":[71],"receiving":[72],"EGFR-TKIs":[73,266,279],"between":[74,89],"April":[75],"2010":[76],"March":[78],"2020.":[79],"Univariate":[80],"multivariate":[82,155],"Cox":[83,156],"regression":[84,157],"analyses":[85],"examined":[86],"associations":[88],"patient/tumor-related":[93],"factors":[94,182,187],"first-line":[96,133,169],"EGFR-TKIs.":[97],"RESULTS:":[98],"A":[99],"total":[100],"758":[102],"(58.5%":[104],"females;":[105],"median":[106,137,143,232],"age,":[107,159],"73":[108],"years)":[109],"were":[110,177,208,243],"included.":[111],"Of":[112],"40":[113],"diagnosed":[115,126],"2010,":[117],"72.5%":[118],"received":[119,129],"gefitinib,":[120,203,238],"whereas":[121],"81.3%":[122],"107":[124],"2019":[128],"osimertinib":[130,207,242,291],"as":[131,179],"EGFR-TKI.":[134],"With":[135],"follow-up":[138],"15.8":[140],"months,":[141],"was":[146],"28.4":[147],"months":[148,249],"(95%":[149,210,215,220,226],"confidence":[150,211,216,221,227],"interval,":[151],"15.3-31.0).":[152],"analysis,":[158],"body":[160],"mass":[161],"index,":[162],"disease":[163],"status,":[164],"EGFR":[165,270],"mutational":[166],"status":[167],"inhibitor":[176],"identified":[178],"significant":[180],"prognostic":[181],"after":[183],"adjusting":[184],"background":[186],"including":[188],"period,":[190],"hospital":[191,194,286],"volume":[192,287],"type.":[195,289],"estimated":[197],"2-year":[198],"rates":[201],"erlotinib,":[204,239],"afatinib":[205,240],"70.1%":[209],"interval":[212,217,222,228],"59.7-82.4),":[213],"67.8%":[214],"55.3-83.2),":[218],"75.5%":[219],"64.7-88.0)":[223],"90.8%":[225],"84.8-97.3),":[229],"respectively.":[230,252],"time":[233],"treatment":[235,298],"failure":[236],"12.8,":[244],"8.8,":[245],"12.0":[246],"16.9":[248],"or":[250,288],"more,":[251],"CONCLUSIONS:":[253],"Our":[254],"revealed":[257],"that":[258,276],"swift":[260],"widespread":[262],"utilization":[263],"newer-generation":[265,278],"mutation-positive":[271],"cancer,":[274],"can":[280],"prolong":[281],"regardless":[284],"Therefore,":[290],"could":[292],"be":[293],"reasonable":[295],"first":[296],"choice":[297],"across":[302],"various":[303],"practice":[305],"settings.":[306]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-11-25T00:00:00"}
