{"id":"https://openalex.org/W4388969698","doi":"https://doi.org/10.1186/s12951-023-02222-5","title":"Plasma exosomes improve peripheral neuropathy via miR-20b-3p/Stat3 in type I diabetic rats","display_name":"Plasma exosomes improve peripheral neuropathy via miR-20b-3p/Stat3 in type I diabetic rats","publication_year":2023,"publication_date":"2023-11-24","ids":{"openalex":"https://openalex.org/W4388969698","doi":"https://doi.org/10.1186/s12951-023-02222-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/38001489","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10675980"},"language":"en","primary_location":{"id":"doi:10.1186/s12951-023-02222-5","doi":"https://doi.org/10.1186/s12951-023-02222-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-023-02222-5","pdf_url":"https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-023-02222-5","source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-023-02222-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jiayang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayang Li","raw_affiliation_strings":["Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110128253","display_name":"Guangzhi Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangzhi Wu","raw_affiliation_strings":["Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078908779","display_name":"Weiye Li","orcid":"https://orcid.org/0000-0002-4977-5021","observed_orcids":["https://orcid.org/0000-0002-4977-5021"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiye Li","raw_affiliation_strings":["Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102583111","display_name":"Xiongyao Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiongyao Zhou","raw_affiliation_strings":["Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110371438","display_name":"Weizhen Li","orcid":"https://orcid.org/0000-0002-1909-7397","observed_orcids":["https://orcid.org/0000-0002-1909-7397"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weizhen Li","raw_affiliation_strings":["Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiong Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiong Xu","raw_affiliation_strings":["Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ke Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Xu","raw_affiliation_strings":["Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065405331","display_name":"Rangjuan Cao","orcid":"https://orcid.org/0000-0002-8279-614X","observed_orcids":["https://orcid.org/0000-0002-8279-614X"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rangjuan Cao","raw_affiliation_strings":["Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China. caorj@jlu.edu.cn","Department of Hand and Foot Surgery, The Third Bethune Hospital of Jilin University, Changchun, China. caorj@jlu.edu.cn","Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China. caorj@jlu.edu.cn","Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China. caorj@jlu.edu.cn","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Department of Hand and Foot Surgery, The Third Bethune Hospital of Jilin University, Changchun, China. caorj@jlu.edu.cn","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China. caorj@jlu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039860525","display_name":"Shusen Cui","orcid":"https://orcid.org/0000-0003-2840-8166","observed_orcids":["https://orcid.org/0000-0003-2840-8166"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shusen Cui","raw_affiliation_strings":["Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China. cuiss@jlu.edu.cn","Department of Hand and Foot Surgery, The Third Bethune Hospital of Jilin University, Changchun, China. cuiss@jlu.edu.cn","Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China. cuiss@jlu.edu.cn","Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China. cuiss@jlu.edu.cn","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Department of Hand and Foot Surgery, The Third Bethune Hospital of Jilin University, Changchun, China. cuiss@jlu.edu.cn","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China. cuiss@jlu.edu.cn","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Peripheral Nerve Injury and Regeneration of Jilin Province, Changchun, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039860525","https://openalex.org/A5065405331"],"corresponding_institution_ids":["https://openalex.org/I194450716"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":2.8578,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.93191303,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"21","issue":"1","first_page":"447","last_page":"447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-peripheral-neuropathy","display_name":"diabetic peripheral neuropathy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/plasma-exosomes","display_name":"plasma exosomes","score":0.9049999713897705},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9490000009536743},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9079999923706055},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":1.0},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.746999979019165},{"id":"https://openalex.org/keywords/microrna-delivery","display_name":"microRNA delivery","score":0.4959999918937683},{"id":"https://openalex.org/keywords/nerve-regeneration","display_name":"nerve regeneration","score":0.5759999752044678},{"id":"https://openalex.org/keywords/remyelination","display_name":"remyelination","score":0.621999979019165},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.6309999823570251},{"id":"https://openalex.org/keywords/blood-therapy","display_name":"blood therapy","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.7579277157783508},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.6859369277954102},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5206388831138611},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4899956285953522},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.44283580780029297},{"id":"https://openalex.org/C2779178840","wikidata":"https://www.wikidata.org/wiki/Q2046550","display_name":"Diabetic neuropathy","level":3,"score":0.4145694375038147},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32265937328338623},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.24612295627593994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2346692681312561},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18887493014335632},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11129558086395264},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12951-023-02222-5","doi":"https://doi.org/10.1186/s12951-023-02222-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-023-02222-5","pdf_url":"https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-023-02222-5","source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10675980","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10675980","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Nanobiotechnology","raw_type":"Text"},{"id":"pmid:38001489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38001489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nanobiotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8fc510f57e1f49ec85cf968d7927bc17","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8fc510f57e1f49ec85cf968d7927bc17","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-21 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12951-023-02222-5","doi":"https://doi.org/10.1186/s12951-023-02222-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-023-02222-5","pdf_url":"https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-023-02222-5","source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2882410625","display_name":null,"funder_award_id":"82271414","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6530013871","display_name":null,"funder_award_id":"YDZJ202301ZYTS017","funder_id":"https://openalex.org/F4320335953","funder_display_name":"Jilin Scientific and Technological Development Program"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320322300","display_name":"Jilin University","ror":"https://ror.org/00js3aw79"},{"id":"https://openalex.org/F4320335953","display_name":"Jilin Scientific and Technological Development Program","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388969698.pdf","grobid_xml":"https://content.openalex.org/works/W4388969698.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W266819147","https://openalex.org/W1877686344","https://openalex.org/W1979638441","https://openalex.org/W1994601869","https://openalex.org/W2005631387","https://openalex.org/W2007066925","https://openalex.org/W2007193535","https://openalex.org/W2011137716","https://openalex.org/W2014007136","https://openalex.org/W2017588551","https://openalex.org/W2032735323","https://openalex.org/W2049245068","https://openalex.org/W2101456000","https://openalex.org/W2103351070","https://openalex.org/W2107277218","https://openalex.org/W2109748103","https://openalex.org/W2113880168","https://openalex.org/W2114360920","https://openalex.org/W2143044967","https://openalex.org/W2152073445","https://openalex.org/W2200183975","https://openalex.org/W2763447646","https://openalex.org/W2768241957","https://openalex.org/W2770068166","https://openalex.org/W2784187817","https://openalex.org/W2808993958","https://openalex.org/W2889573274","https://openalex.org/W2923975695","https://openalex.org/W2942910851","https://openalex.org/W2943410960","https://openalex.org/W2966266646","https://openalex.org/W2971784302","https://openalex.org/W2972869264","https://openalex.org/W2987239393","https://openalex.org/W2998634777","https://openalex.org/W2999784269","https://openalex.org/W3001673009","https://openalex.org/W3007168360","https://openalex.org/W3010833967","https://openalex.org/W3091854175","https://openalex.org/W3128258347","https://openalex.org/W3136183120","https://openalex.org/W3159664745","https://openalex.org/W3163876756","https://openalex.org/W3165218090","https://openalex.org/W3201150214","https://openalex.org/W3210399345","https://openalex.org/W3215968833","https://openalex.org/W4200189653","https://openalex.org/W4200622772","https://openalex.org/W4212865003","https://openalex.org/W4214649653","https://openalex.org/W4220711949","https://openalex.org/W4223969062","https://openalex.org/W4247544731","https://openalex.org/W4281397667","https://openalex.org/W4285724918","https://openalex.org/W4288077923","https://openalex.org/W4288427183","https://openalex.org/W4295958045","https://openalex.org/W4322763006","https://openalex.org/W4385872154","https://openalex.org/W4385872156","https://openalex.org/W4385879071"],"related_works":["https://openalex.org/W6939662211","https://openalex.org/W2999784269","https://openalex.org/W2987239393","https://openalex.org/W2808800485","https://openalex.org/W4411137719","https://openalex.org/W4390956432","https://openalex.org/W3136183120","https://openalex.org/W3127919036","https://openalex.org/W4312054038","https://openalex.org/W4402141151"],"abstract_inverted_index":{"BACKGROUND:":[0],"Diabetic":[1],"peripheral":[2],"neuropathy":[3],"(DPN)":[4],"is":[5,39],"one":[6],"of":[7,12,18,35,69,78,84,92,117,152,165,184,209,228,246,255,269],"the":[8,15,33,89,97,106,118,162,207,267],"most":[9],"common":[10],"complications":[11],"diabetes":[13],"and":[14,100,105,129,133,155,204,217,235,244,264],"main":[16],"cause":[17],"non-traumatic":[19],"amputation,":[20],"with":[21,141],"no":[22],"ideal":[23],"treatment.":[24,170],"Multiple":[25],"cell-derived":[26],"exosomes":[27,68,143,151,230],"have":[28,42],"been":[29],"reported":[30],"to":[31,41,158,177,181,219],"improve":[32,52],"progression":[34,268],"DPN.":[36,270],"Blood":[37],"therapy":[38],"thought":[40],"a":[43,178],"powerful":[44],"repairing":[45],"effect.":[46],"However,":[47],"whether":[48],"it":[49],"could":[50,248],"also":[51,186],"DPN":[53,80,87,93,166,175,220,234,250],"remains":[54],"unclear.":[55],"RESULTS:":[56],"In":[57],"this":[58],"study,":[59],"we":[60],"found":[61,157,199],"that":[62,77,200,226],"microRNA":[63],"(miRNA)":[64],"expression":[65],"in":[66,144,150,161,194,242,258],"plasma-derived":[67],"healthy":[70,153,237],"rats":[71,94,167],"(hplasma-exos)":[72],"was":[73,95,110,147,156,231,240],"significantly":[74],"different":[75,232],"from":[76],"age-matched":[79,236],"rats.":[81,238],"By":[82],"injection":[83],"hplasma-exos":[85,138,169],"into":[86],"rats,":[88],"mechanical":[90],"sensitivity":[91,99],"decreased,":[96],"thermal":[98],"motor":[101],"ability":[102],"were":[103],"increased,":[104],"nerve":[107,123,164],"conduction":[108],"speed":[109],"accelerated.":[111],"Histological":[112],"analysis":[113],"showed":[114],"myelin":[115],"regeneration":[116],"sciatic":[119,163],"nerve,":[120],"increased":[121],"intraepidermal":[122],"fibers,":[124],"distal":[125],"local":[126],"blood":[127],"perfusion,":[128],"enhanced":[130],"neuromuscular":[131],"junction":[132],"muscle":[134],"spindle":[135],"innervation":[136],"after":[137,168],"administration.":[139],"Compared":[140],"plasma":[142,154,229],"DPN,":[145],"miR-20b-3p":[146,172,201],"specifically":[148],"enriched":[149,241],"be":[159],"re-upregulated":[160],"Moreover,":[171],"agomir":[173],"improved":[174],"symptoms":[176],"level":[179],"similar":[180],"hplasma-exos,":[182,243],"both":[183,245],"which":[185,211],"alleviated":[187,249],"autophagy":[188,215,254],"impairment":[189],"induced":[190],"by":[191,261],"high":[192],"glucose":[193],"Schwann":[195,256],"cells.":[196],"Mechanistic":[197],"studies":[198],"targeted":[202],"Stat3":[203,263],"consequently":[205],"reduced":[206],"amount":[208],"p-Stat3,":[210],"then":[212],"negatively":[213],"regulated":[214,253],"processes":[216],"contributed":[218],"improvement.":[221],"CONCLUSIONS:":[222],"This":[223],"study":[224],"demonstrated":[225],"miRNA":[227],"between":[233],"MiR-20b-3p":[239,252],"them":[247],"symptoms.":[251],"cells":[257],"pathological":[259],"states":[260],"targeting":[262],"thereby":[265],"inhibited":[266]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-11-25T00:00:00"}