{"id":"https://openalex.org/W4388948022","doi":"https://doi.org/10.1016/j.jtocrr.2023.100611","title":"The Timing, Trajectory, and Incidence of Immune-Related Adverse Events in NSCLC Treated With Atezolizumab","display_name":"The Timing, Trajectory, and Incidence of Immune-Related Adverse Events in NSCLC Treated With Atezolizumab","publication_year":2023,"publication_date":"2023-11-23","ids":{"openalex":"https://openalex.org/W4388948022","doi":"https://doi.org/10.1016/j.jtocrr.2023.100611","pmid":"https://pubmed.ncbi.nlm.nih.gov/38162172","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10755354"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtocrr.2023.100611","doi":"https://doi.org/10.1016/j.jtocrr.2023.100611","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtocrr.2023.100611","pdf_url":"https://www.jtocrr.org/article/S2666-3643(23)00154-6/pdf","source":{"id":"https://openalex.org/S4210220242","display_name":"JTO Clinical and Research Reports","issn_l":"2666-3643","issn":["2666-3643"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO Clinical and Research Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jtocrr.org/article/S2666-3643(23)00154-6/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048979154","display_name":"Katherine E R Smith","orcid":"https://orcid.org/0009-0004-5114-794X","observed_orcids":["https://orcid.org/0009-0004-5114-794X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine E.R. Smith","raw_affiliation_strings":["Department of Oncology, Mayo Clinic, Rochester, Minnesota","Mayo Clinic, Department of Oncology, 200 1 st St SW, Rochester, MN, 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]},{"raw_affiliation_string":"Mayo Clinic, Department of Oncology, 200 1 st St SW, Rochester, MN, 55905","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019119343","display_name":"Stephanie L. Pritzl","orcid":"https://orcid.org/0000-0001-9718-9927","observed_orcids":["https://orcid.org/0000-0001-9718-9927"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie L. Pritzl","raw_affiliation_strings":["Department of Oncology, Mayo Clinic, Rochester, Minnesota","Mayo Clinic, Department of Oncology, 200 1 st St SW, Rochester, MN, 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]},{"raw_affiliation_string":"Mayo Clinic, Department of Oncology, 200 1 st St SW, Rochester, MN, 55905","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101688586","display_name":"Wei Yu","orcid":"https://orcid.org/0000-0001-6963-910X","observed_orcids":["https://orcid.org/0000-0001-6963-910X"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Yu","raw_affiliation_strings":["Genentech Inc., South San Francisco, California","Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110688867","display_name":"Ilze B\u0101ra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilze Bara","raw_affiliation_strings":["Genentech Inc., South San Francisco, California","Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080184636","display_name":"Gita Thanarajasingam","orcid":"https://orcid.org/0000-0003-2144-5415","observed_orcids":["https://orcid.org/0000-0003-2144-5415"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gita Thanarajasingam","raw_affiliation_strings":["Department of Hematology, Mayo Clinic, Rochester, Minnesota","Mayo Clinic, Department of Hematology, 200 1 st St SW, Rochester, MN, 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Department of Hematology, 200 1 st St SW, Rochester, MN, 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062915216","display_name":"Monika D. Kaul","orcid":"https://orcid.org/0009-0002-8039-5665","observed_orcids":["https://orcid.org/0009-0002-8039-5665"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monika D. Kaul","raw_affiliation_strings":["Genentech Inc., South San Francisco, California","Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052459259","display_name":"Kirstin Anne Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirstin A. Williams","raw_affiliation_strings":["Genentech Inc., South San Francisco, California","Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090009905","display_name":"Amylou Constance Dueck","orcid":"https://orcid.org/0000-0002-9912-1085","observed_orcids":["https://orcid.org/0000-0002-9912-1085"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amylou C. Dueck","raw_affiliation_strings":["Department of Quantitative Health Sciences, Mayo Clinic, Phoenix, Arizona","Mayo Clinic, Department of Quantitative Health Sciences, 5881 E. Mayo Blvd, Phoenix, AZ, 85054"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Sciences, Mayo Clinic, Phoenix, Arizona","institution_ids":["https://openalex.org/I4210125099","https://openalex.org/I4210127938"]},{"raw_affiliation_string":"Mayo Clinic, Department of Quantitative Health Sciences, 5881 E. Mayo Blvd, Phoenix, AZ, 85054","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071440718","display_name":"Aaron Scott Mansfield","orcid":"https://orcid.org/0000-0002-9483-6903","observed_orcids":["https://orcid.org/0000-0002-9483-6903"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aaron S. Mansfield","raw_affiliation_strings":["Department of Oncology, Mayo Clinic, Rochester, Minnesota","Mayo Clinic, Department of Oncology, 200 1 st St SW, Rochester, MN, 55905"],"raw_orcid":"https://orcid.org/0000-0002-9483-6903","affiliations":[{"raw_affiliation_string":"Department of Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]},{"raw_affiliation_string":"Mayo Clinic, Department of Oncology, 200 1 st St SW, Rochester, MN, 55905","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5071440718"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":1.093,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.78461625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"4","issue":"12","first_page":"100611","last_page":"100611"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.9860000014305115},{"id":"https://openalex.org/keywords/atezolizumab","display_name":"atezolizumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9860000014305115},{"id":"https://openalex.org/keywords/time-to-onset","display_name":"time to onset","score":0.8009999990463257},{"id":"https://openalex.org/keywords/skin-rash","display_name":"rash","score":0.9079999923706055},{"id":"https://openalex.org/keywords/hepatitis","display_name":"hepatitis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.996999979019165},{"id":"https://openalex.org/keywords/chemoimmunotherapy","display_name":"chemoimmunotherapy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/impower150","display_name":"IMpower150","score":1.0}],"concepts":[{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.9915205240249634},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7046216130256653},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6663962602615356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6263393759727478},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.515872597694397},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4675893485546112},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38910895586013794},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.2915807366371155},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.28309282660484314},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2726086974143982},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jtocrr.2023.100611","doi":"https://doi.org/10.1016/j.jtocrr.2023.100611","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtocrr.2023.100611","pdf_url":"https://www.jtocrr.org/article/S2666-3643(23)00154-6/pdf","source":{"id":"https://openalex.org/S4210220242","display_name":"JTO Clinical and Research Reports","issn_l":"2666-3643","issn":["2666-3643"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO Clinical and Research Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10755354","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10755354","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10755354/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO Clin Res Rep","raw_type":"Text"},{"id":"pmid:38162172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38162172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO clinical and research reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e5e782b7f8e347ce8ef0b2845d17c3ff","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e5e782b7f8e347ce8ef0b2845d17c3ff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JTO Clinical and Research Reports, Vol 4, Iss 12, Pp 100611- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jtocrr.2023.100611","doi":"https://doi.org/10.1016/j.jtocrr.2023.100611","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtocrr.2023.100611","pdf_url":"https://www.jtocrr.org/article/S2666-3643(23)00154-6/pdf","source":{"id":"https://openalex.org/S4210220242","display_name":"JTO Clinical and Research Reports","issn_l":"2666-3643","issn":["2666-3643"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO Clinical and Research Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306769","display_name":"Mesothelioma Applied Research Foundation","ror":"https://ror.org/01d0tvs72"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307779","display_name":"Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320309249","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320317866","display_name":"Verily Life Sciences","ror":"https://ror.org/047305x76"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320333003","display_name":"Chugai Pharmaceutical","ror":"https://ror.org/01vepzj85"},{"id":"https://openalex.org/F4320333265","display_name":"Takeda Oncology","ror":"https://ror.org/05vm7p871"},{"id":"https://openalex.org/F4320333587","display_name":"Sanofi Genzyme","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388948022.pdf","grobid_xml":"https://content.openalex.org/works/W4388948022.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W2610389172","https://openalex.org/W2743419024","https://openalex.org/W2805354595","https://openalex.org/W2946386783","https://openalex.org/W2962502275","https://openalex.org/W2974280214","https://openalex.org/W3009082159","https://openalex.org/W3010374810","https://openalex.org/W3017217098","https://openalex.org/W3045946240","https://openalex.org/W3095154565","https://openalex.org/W3110066265","https://openalex.org/W3110814768","https://openalex.org/W3148902978","https://openalex.org/W3155554393","https://openalex.org/W3179734443","https://openalex.org/W3185428150","https://openalex.org/W3193480132","https://openalex.org/W3210474759","https://openalex.org/W4200327459","https://openalex.org/W4205177974","https://openalex.org/W4205465153","https://openalex.org/W4226329559","https://openalex.org/W4293724290","https://openalex.org/W4306692674","https://openalex.org/W4321003638","https://openalex.org/W4362474345","https://openalex.org/W4366606693","https://openalex.org/W6852464553"],"related_works":["https://openalex.org/W4321003638","https://openalex.org/W3083367621","https://openalex.org/W3171739548","https://openalex.org/W4403335990","https://openalex.org/W3083281449","https://openalex.org/W2788599721","https://openalex.org/W4389487189","https://openalex.org/W2995594742","https://openalex.org/W2761732633","https://openalex.org/W4401955627"],"abstract_inverted_index":{"Introduction:":[0],"Immune-related":[1],"adverse":[2,132,243],"events":[3,80,244],"(irAEs)":[4],"due":[5],"to":[6,137,184,194,245],"immune":[7],"checkpoint":[8],"inhibitors":[9],"can":[10,235],"have":[11],"complicated":[12],"clinical":[13,49,209,237],"courses.":[14],"We":[15,206],"comprehensively":[16],"evaluated":[17],"the":[18,44,52,97,109,121,141,144,156,171,189,203],"timing,":[19],"trajectory,":[20],"and":[21,26,47,76,92,104,151,161,226,239],"incidence":[22,173,222],"of":[23,54,61,78,155,169,202,223,228,242],"both":[24],"single":[25],"multiple":[27,79,224],"irAEs":[28,147,160,196,212,229],"for":[29,174,200,211],"NSCLC":[30,58],"treated":[31,89,215],"with":[32,68,90,216],"atezolizumab.":[33],"Methods:":[34],"Data":[35],"were":[36,81,88,95,148],"pooled":[37],"from":[38,182],"2457":[39],"patients":[40,87,94,113,125,157,214],"who":[41],"participated":[42],"in":[43,56,73,96,198,213,220,231],"IMpower130,":[45],"IMpower132,":[46],"IMpower150":[48],"trials":[50],"investigating":[51],"use":[53],"atezolizumab":[55,91,110,142],"metastatic":[57],"as":[59],"part":[60],"a":[62],"chemoimmunotherapy":[63],"regimen.":[64],"Longitudinal":[65],"irAE":[66,176],"data":[67],"landmark":[69],"analysis,":[70],"time-to-onset,":[71,221],"changes":[72],"grading":[74],"severity,":[75],"occurrence":[77],"summarized.":[82],"Results:":[83],"In":[84,108,120,140],"general,":[85],"1557":[86],"900":[93],"control":[98,122],"groups.":[99],"Median":[100,179],"follow-up":[101],"was":[102,135,177],"32.3":[103],"23.5":[105],"months,":[106],"respectively.":[107],"group,":[111,123,143],"753":[112],"(48.4%)":[114],"experienced":[115,127,158,163],"at":[116,128],"least":[117,129],"one":[118,130],"irAE.":[119,139,191],"289":[124],"(32.1%)":[126],"nonimmune":[131],"event":[133],"that":[134],"attributed":[136],"an":[138],"most":[145],"common":[146],"rash,":[149],"hepatitis,":[150],"hypothyroidism.":[152],"Furthermore,":[153],"13%":[154],"two":[159],"4%":[162],"three":[164],"irAEs.":[165],"Within":[166],"5":[167],"months":[168,186],"treatment,":[170],"cumulative":[172],"any":[175],"39.2%.":[178],"time-to-onset":[180],"varied":[181],"1":[183,193],"10":[185],"based":[187],"on":[188],"specific":[190],"Grade":[192],"2":[195],"increased":[197],"severity":[199],"33%":[201],"patients.":[204],"Conclusions:":[205],"identified":[207],"dynamic":[208],"patterns":[210],"atezolizumab,":[217],"including":[218],"variations":[219],"irAEs,":[225],"frequency":[227],"increasing":[230],"severity.":[232],"These":[233],"results":[234],"guide":[236],"management":[238],"future":[240],"reporting":[241],"enable":[246],"comprehensive":[247],"longitudinal":[248],"analyses.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-11-24T00:00:00"}
