{"id":"https://openalex.org/W4388941299","doi":"https://doi.org/10.3389/fnins.2023.1183312","title":"Apolipoprotein-E deficiency leads to brain network alteration characterized by diffusion MRI and graph theory","display_name":"Apolipoprotein-E deficiency leads to brain network alteration characterized by diffusion MRI and graph theory","publication_year":2023,"publication_date":"2023-11-21","ids":{"openalex":"https://openalex.org/W4388941299","doi":"https://doi.org/10.3389/fnins.2023.1183312","pmid":"https://pubmed.ncbi.nlm.nih.gov/38075287","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10702609"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2023.1183312","doi":"https://doi.org/10.3389/fnins.2023.1183312","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2023.1183312","pdf_url":null,"source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fnins.2023.1183312","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104152105","display_name":"Margaret Caroline Stapleton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Caroline Stapleton","raw_affiliation_strings":["Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103143676","display_name":"Stefan Koch","orcid":"https://orcid.org/0000-0001-6606-6369","observed_orcids":["https://orcid.org/0000-0001-6606-6369"]},"institutions":[{"id":"https://openalex.org/I4405268531","display_name":"NeuroCure Cluster of Excellence","ror":"https://ror.org/0188nsq50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405268531"]},{"id":"https://openalex.org/I4405268574","display_name":"Center for Stroke Research Berlin","ror":"https://ror.org/01cr98995","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405268574"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Paul Koch","raw_affiliation_strings":["Charit\u00e9 3R | Replace, Reduce, Refine, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","Department of Experimental Neurology and Center for Stroke Research Berlin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","NeuroCure Cluster of Excellence and Charit\u00e9 Core Facility 7T Experimental MRIs, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charit\u00e9 3R | Replace, Reduce, Refine, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Experimental Neurology and Center for Stroke Research Berlin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4405268574","https://openalex.org/I7877124"]},{"raw_affiliation_string":"NeuroCure Cluster of Excellence and Charit\u00e9 Core Facility 7T Experimental MRIs, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4405268531","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037249079","display_name":"Devin Raine Everaldo Cortes","orcid":"https://orcid.org/0009-0004-8130-8513","observed_orcids":["https://orcid.org/0009-0004-8130-8513"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devin Raine Everaldo Cortes","raw_affiliation_strings":["Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, United States","Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039797407","display_name":"Samuel K. Wyman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Wyman","raw_affiliation_strings":["Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104103022","display_name":"Kristina Elsa Schwab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristina E. Schwab","raw_affiliation_strings":["Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055826912","display_name":"Susanne G. Mueller","orcid":"https://orcid.org/0000-0002-5053-2211","observed_orcids":["https://orcid.org/0000-0002-5053-2211"]},"institutions":[{"id":"https://openalex.org/I4405268531","display_name":"NeuroCure Cluster of Excellence","ror":"https://ror.org/0188nsq50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405268531"]},{"id":"https://openalex.org/I4405268574","display_name":"Center for Stroke Research Berlin","ror":"https://ror.org/01cr98995","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405268574"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne Mueller","raw_affiliation_strings":["Charit\u00e9 3R | Replace, Reduce, Refine, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","Department of Experimental Neurology and Center for Stroke Research Berlin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","NeuroCure Cluster of Excellence and Charit\u00e9 Core Facility 7T Experimental MRIs, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charit\u00e9 3R | Replace, Reduce, Refine, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Experimental Neurology and Center for Stroke Research Berlin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4405268574","https://openalex.org/I7877124"]},{"raw_affiliation_string":"NeuroCure Cluster of Excellence and Charit\u00e9 Core Facility 7T Experimental MRIs, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4405268531","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000536060","display_name":"Chris G. McKennan","orcid":"https://orcid.org/0000-0003-2096-8257","observed_orcids":["https://orcid.org/0000-0003-2096-8257"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Gordon McKennan","raw_affiliation_strings":["Department of Statistics, University of Pittsburgh, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088966771","display_name":"Philipp Boehm\u2010Sturm","orcid":"https://orcid.org/0000-0001-8777-4823","observed_orcids":["https://orcid.org/0000-0001-8777-4823"]},"institutions":[{"id":"https://openalex.org/I4405268531","display_name":"NeuroCure Cluster of Excellence","ror":"https://ror.org/0188nsq50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405268531"]},{"id":"https://openalex.org/I4405268574","display_name":"Center for Stroke Research Berlin","ror":"https://ror.org/01cr98995","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405268574"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Philipp Boehm-Sturm","raw_affiliation_strings":["Charit\u00e9 3R | Replace, Reduce, Refine, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","Department of Experimental Neurology and Center for Stroke Research Berlin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","NeuroCure Cluster of Excellence and Charit\u00e9 Core Facility 7T Experimental MRIs, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charit\u00e9 3R | Replace, Reduce, Refine, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Experimental Neurology and Center for Stroke Research Berlin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4405268574","https://openalex.org/I7877124"]},{"raw_affiliation_string":"NeuroCure Cluster of Excellence and Charit\u00e9 Core Facility 7T Experimental MRIs, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4405268531","https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022501599","display_name":"Yijen Lin Wu","orcid":"https://orcid.org/0000-0001-9509-5417","observed_orcids":["https://orcid.org/0000-0001-9509-5417"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yijen Lin Wu","raw_affiliation_strings":["Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5022501599","https://openalex.org/A5088966771"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210130600","https://openalex.org/I4210134769","https://openalex.org/I4405268531","https://openalex.org/I4405268574","https://openalex.org/I7877124"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.8961,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.70849159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"17","issue":null,"first_page":"1183312","last_page":"1183312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9430000185966492},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.9509999752044678},{"id":"https://openalex.org/keywords/late-onset-alzheimer-s-disease","display_name":"late-onset Alzheimer's disease","score":0.9509999752044678},{"id":"https://openalex.org/keywords/brain-network-topology","display_name":"brain network topology","score":0.8610000014305115},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"functional connectivity","score":0.6940000057220459},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.906000018119812},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":1.0},{"id":"https://openalex.org/keywords/caudate-putamen","display_name":"caudate-putamen","score":0.9909999966621399},{"id":"https://openalex.org/keywords/network-efficiency","display_name":"network efficiency","score":0.7210000157356262},{"id":"https://openalex.org/keywords/network-segregation","display_name":"network segregation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.5189999938011169},{"id":"https://openalex.org/keywords/diffusion-tensor-imaging","display_name":"diffusion tensor imaging","score":0.7480000257492065},{"id":"https://openalex.org/keywords/graph-theory","display_name":"graph theory","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.789191484451294},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.6502377986907959},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6078757047653198},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.5824068784713745},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.546122670173645},{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.4894603490829468},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.459544837474823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31919723749160767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2400205433368683},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1788705587387085},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.11630302667617798},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnins.2023.1183312","doi":"https://doi.org/10.3389/fnins.2023.1183312","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2023.1183312","pdf_url":null,"source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10702609","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10702609","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:38075287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38075287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3449a712c14044958258e61c0ef0d4c6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3449a712c14044958258e61c0ef0d4c6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 17 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2023.1183312","doi":"https://doi.org/10.3389/fnins.2023.1183312","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2023.1183312","pdf_url":null,"source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1364073712","display_name":"Bioenergetics and Neuronal Network Remodeling in a Rodent Model of Temporal Lobe Epilepsy","funder_award_id":"R21NS121706","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1680808902","display_name":null,"funder_award_id":"EXC 2049","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1717570230","display_name":null,"funder_award_id":"EXC-2049 \u2013 390688,087","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1923547659","display_name":null,"funder_award_id":"EXC-2049","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G2324210374","display_name":"topdownPTSD - Untersuchung und Manipulation der Top-Down-Kontrolle des Erinnerungsengramms der posttraumatischen Belastungsst\u00f6rung","funder_award_id":"01EW1811","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G2589556207","display_name":null,"funder_award_id":"BO4484/2\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3102961367","display_name":"Gating-Free Ultra-Fast Fetal Cardiac MRI with Sub-Nyquist Sampling for Live in Utero Imaging and Cardiovascular Phenotyping of Fetal Mice","funder_award_id":"R21EB023507","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G5065494170","display_name":"Multi-modal Imaging Investigation of Cardio-Neural Development in a Mouse Model with Hypoplastic Left Heart Syndrome","funder_award_id":"18CDA34140024","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6118380013","display_name":"EXC 2049: Comprehensive approaches to neurological and psychiatric disorders \"NeuroCure\"","funder_award_id":"390688087","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6219790147","display_name":null,"funder_award_id":"390688087","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G7627931934","display_name":null,"funder_award_id":"01EW1811","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1967061503","https://openalex.org/W1973065853","https://openalex.org/W1987293003","https://openalex.org/W1987444426","https://openalex.org/W1987924998","https://openalex.org/W1993629125","https://openalex.org/W1999653836","https://openalex.org/W2002558640","https://openalex.org/W2006599070","https://openalex.org/W2028674750","https://openalex.org/W2032356857","https://openalex.org/W2040546047","https://openalex.org/W2062108627","https://openalex.org/W2068198745","https://openalex.org/W2070851582","https://openalex.org/W2088351746","https://openalex.org/W2097112082","https://openalex.org/W2105172870","https://openalex.org/W2110065044","https://openalex.org/W2110431535","https://openalex.org/W2112090702","https://openalex.org/W2116649573","https://openalex.org/W2120741776","https://openalex.org/W2132071754","https://openalex.org/W2133287637","https://openalex.org/W2139158372","https://openalex.org/W2139285419","https://openalex.org/W2147413218","https://openalex.org/W2154566941","https://openalex.org/W2162684274","https://openalex.org/W2162988216","https://openalex.org/W2167822639","https://openalex.org/W2169359444","https://openalex.org/W2308383021","https://openalex.org/W2465339739","https://openalex.org/W2491120843","https://openalex.org/W2514570136","https://openalex.org/W2548785077","https://openalex.org/W2549366107","https://openalex.org/W2558302966","https://openalex.org/W2559764604","https://openalex.org/W2563000655","https://openalex.org/W2594878999","https://openalex.org/W2600002013","https://openalex.org/W2601005007","https://openalex.org/W2617543827","https://openalex.org/W2748647778","https://openalex.org/W2789577735","https://openalex.org/W2793043361","https://openalex.org/W2883974615","https://openalex.org/W2889571849","https://openalex.org/W2944325086","https://openalex.org/W2956927868","https://openalex.org/W2965401191","https://openalex.org/W2986720939","https://openalex.org/W3007183066","https://openalex.org/W3021105102","https://openalex.org/W3139368685","https://openalex.org/W4210462365","https://openalex.org/W4220688076","https://openalex.org/W4230920194","https://openalex.org/W4256094090","https://openalex.org/W4313331687"],"related_works":["https://openalex.org/W4385554390","https://openalex.org/W1913608598","https://openalex.org/W398823648","https://openalex.org/W2804282571","https://openalex.org/W2065565403","https://openalex.org/W4410765089","https://openalex.org/W2888586037","https://openalex.org/W2986720939","https://openalex.org/W2030574287","https://openalex.org/W7007906772"],"abstract_inverted_index":{"Late-onset":[0],"Alzheimer\u2019s":[1],"disease":[2],"(LOAD)":[3],"is":[4,23,37,182],"a":[5,24,50],"major":[6],"health":[7],"concern":[8],"for":[9,28],"senior":[10],"citizens,":[11],"characterized":[12],"by":[13,81],"memory":[14],"loss,":[15],"confusion,":[16],"and":[17,71,90,107,127,133,135,158,175],"impaired":[18],"cognitive":[19],"abilities.":[20],"Apolipoprotein-E":[21],"(ApoE)":[22],"well-known":[25],"risk":[26],"factor":[27],"LOAD,":[29],"though":[30],"exactly":[31],"how":[32],"ApoE":[33,42,66,119,156,181],"affects":[34],"LOAD":[35,45,191],"risks":[36,192],"unknown.":[38],"We":[39,58],"hypothesize":[40],"that":[41,150,180],"attenuation":[43],"of":[44,99,118,138,164],"resiliency":[46],"or":[47],"vulnerability":[48],"has":[49],"neurodevelopmental":[51],"origin":[52],"via":[53,193],"changing":[54,194],"brain":[55,61,86,109,151,185,195],"network":[56,62,87,125,128,152,169,186,196],"architecture.":[57],"investigated":[59],"the":[60,102,115,131,136,139,168,172],"structure":[63],"in":[64,97,144,155,167,171,184],"adult":[65],"knock":[67],"out":[68],"(ApoE":[69],"KO)":[70],"wild-type":[72],"(WT)":[73],"mice":[74,160],"with":[75],"diffusion":[76],"tensor":[77],"imaging":[78],"(DTI)":[79],"followed":[80],"graph":[82,116],"theory":[83,117],"to":[84,142],"delineate":[85],"topology.":[88],"Left":[89],"right":[91],"hemisphere":[92],"connectivity":[93],"revealed":[94],"significant":[95],"differences":[96],"number":[98],"connections":[100],"between":[101,130],"hippocampus,":[103,173],"amygdala,":[104,174],"caudate":[105,176],"putamen":[106],"other":[108],"regions.":[110],"Network":[111],"topology":[112],"based":[113],"on":[114],"KO":[120,157],"demonstrated":[121],"decreased":[122],"functional":[123],"integration,":[124],"efficiency,":[126],"segregation":[129],"hippocampus":[132],"amygdala":[134],"rest":[137],"brain,":[140],"compared":[141],"those":[143],"WT":[145,159],"counterparts.":[146],"Our":[147],"data":[148],"show":[149],"developed":[153],"differently":[154],"at":[161],"5":[162],"months":[163],"age,":[165],"especially":[166],"reflected":[170],"putamen.":[177],"This":[178],"indicates":[179],"involved":[183],"development":[187],"which":[188],"might":[189],"modulate":[190],"structures.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-24T00:00:00"}
