{"id":"https://openalex.org/W4388939898","doi":"https://doi.org/10.3389/fendo.2023.1269139","title":"Pancreas and islet morphology in cystic fibrosis: clues to the etiology of cystic fibrosis-related diabetes","display_name":"Pancreas and islet morphology in cystic fibrosis: clues to the etiology of cystic fibrosis-related diabetes","publication_year":2023,"publication_date":"2023-11-23","ids":{"openalex":"https://openalex.org/W4388939898","doi":"https://doi.org/10.3389/fendo.2023.1269139","pmid":"https://pubmed.ncbi.nlm.nih.gov/38075070","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10704027"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2023.1269139","doi":"https://doi.org/10.3389/fendo.2023.1269139","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2023.1269139","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1269139/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1269139/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sarah S. Malik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah S. Malik","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA, United States","Research Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA, United States","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Research Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210094549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102582676","display_name":"Diksha Padmanabhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]},{"id":"https://openalex.org/I4210144959","display_name":"Seattle Institute for Biomedical and Clinical Research","ror":"https://ror.org/04c91wj10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210144959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diksha Padmanabhan","raw_affiliation_strings":["Research Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States","Seattle Institute for Biomedical and Clinical Research, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210094549"]},{"raw_affiliation_string":"Seattle Institute for Biomedical and Clinical Research, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210144959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072438608","display_name":"Rebecca L. Hull-Meichle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]},{"id":"https://openalex.org/I4210144959","display_name":"Seattle Institute for Biomedical and Clinical Research","ror":"https://ror.org/04c91wj10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210144959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rebecca L. Hull-Meichle","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA, United States","Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, United States","Research Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States","Seattle Institute for Biomedical and Clinical Research, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA, United States","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, United States","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Research Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210094549"]},{"raw_affiliation_string":"Seattle Institute for Biomedical and Clinical Research, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210144959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072438608"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210094549","https://openalex.org/I4210144959"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":2.0108,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.88992016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"14","issue":null,"first_page":"1269139","last_page":"1269139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7002000212669373,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7002000212669373,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.2930000126361847,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cystic-fibrosis-related-diabetes","display_name":"cystic fibrosis-related diabetes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.8730000257492065},{"id":"https://openalex.org/keywords/beta-cell-dysfunction","display_name":"beta-cell dysfunction","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.8149999976158142},{"id":"https://openalex.org/keywords/pancreatic-duct-obstruction","display_name":"pancreatic duct obstruction","score":0.7590000033378601},{"id":"https://openalex.org/keywords/islet-microenvironment","display_name":"islet microenvironment","score":0.7139999866485596},{"id":"https://openalex.org/keywords/islet-amyloid-deposition","display_name":"islet amyloid deposition","score":0.8759999871253967},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.8169999718666077},{"id":"https://openalex.org/keywords/islet-microvasculature","display_name":"islet microvasculature","score":0.8019999861717224},{"id":"https://openalex.org/keywords/autonomic-nerve-fibers","display_name":"autonomic nerve fibers","score":0.9150000214576721},{"id":"https://openalex.org/keywords/islet-fibrosis","display_name":"islet fibrosis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/islet-cell-composition","display_name":"islet cell composition","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.7619317770004272},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.7436192035675049},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.698338508605957},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5963467955589294},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5446516871452332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5079296231269836},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.5006332397460938},{"id":"https://openalex.org/C2778428886","wikidata":"https://www.wikidata.org/wiki/Q420470","display_name":"Cystic fibrosis transmembrane conductance regulator","level":3,"score":0.4898087680339813},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.4254509210586548},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42450448870658875},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.422088623046875},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4138167202472687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3436839282512665}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2023.1269139","doi":"https://doi.org/10.3389/fendo.2023.1269139","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2023.1269139","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1269139/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10704027","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10704027","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10704027/pdf/fendo-14-1269139.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmid:38075070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38075070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0b938453eae94ecda480ced02c4cc63f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0b938453eae94ecda480ced02c4cc63f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2023.1269139","doi":"https://doi.org/10.3389/fendo.2023.1269139","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2023.1269139","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1269139/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7443692255","display_name":"Drug Action, Metabolism and Kinetics Training Grant","funder_award_id":"T32GM007750","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7640278689","display_name":null,"funder_award_id":"I01 BX004063","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G9000868740","display_name":"Center for Cystic Fibrosis Translational Research in the Post-CFTR modulator Era","funder_award_id":"P30DK089507","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388939898.pdf","grobid_xml":"https://content.openalex.org/works/W4388939898.grobid-xml"},"referenced_works_count":150,"referenced_works":["https://openalex.org/W19538232","https://openalex.org/W1489292216","https://openalex.org/W1500760933","https://openalex.org/W1559981541","https://openalex.org/W1704077777","https://openalex.org/W1838707203","https://openalex.org/W1967766455","https://openalex.org/W1983525614","https://openalex.org/W1987537937","https://openalex.org/W1999522662","https://openalex.org/W2001686756","https://openalex.org/W2001819739","https://openalex.org/W2004140559","https://openalex.org/W2012034410","https://openalex.org/W2015044617","https://openalex.org/W2019196493","https://openalex.org/W2023195670","https://openalex.org/W2023478520","https://openalex.org/W2026429762","https://openalex.org/W2027140244","https://openalex.org/W2032595821","https://openalex.org/W2033209163","https://openalex.org/W2034946303","https://openalex.org/W2035902793","https://openalex.org/W2039090061","https://openalex.org/W2039735560","https://openalex.org/W2040574917","https://openalex.org/W2049699523","https://openalex.org/W2050859161","https://openalex.org/W2052588826","https://openalex.org/W2053220154","https://openalex.org/W2053873040","https://openalex.org/W2056784230","https://openalex.org/W2059516713","https://openalex.org/W2060325544","https://openalex.org/W2060722104","https://openalex.org/W2063123264","https://openalex.org/W2066759164","https://openalex.org/W2069045404","https://openalex.org/W2078857918","https://openalex.org/W2082293476","https://openalex.org/W2090434487","https://openalex.org/W2103879666","https://openalex.org/W2105748867","https://openalex.org/W2108841123","https://openalex.org/W2114854928","https://openalex.org/W2116490273","https://openalex.org/W2117792576","https://openalex.org/W2121576595","https://openalex.org/W2121996960","https://openalex.org/W2128867464","https://openalex.org/W2131867652","https://openalex.org/W2135261427","https://openalex.org/W2136989779","https://openalex.org/W2137140254","https://openalex.org/W2141441022","https://openalex.org/W2143247822","https://openalex.org/W2146114441","https://openalex.org/W2147095419","https://openalex.org/W2147821592","https://openalex.org/W2150323171","https://openalex.org/W2150461406","https://openalex.org/W2158141897","https://openalex.org/W2169273342","https://openalex.org/W2183555230","https://openalex.org/W2186359677","https://openalex.org/W2254054106","https://openalex.org/W2288780584","https://openalex.org/W2321266618","https://openalex.org/W2333780784","https://openalex.org/W2410852719","https://openalex.org/W2484917035","https://openalex.org/W2496297269","https://openalex.org/W2518974058","https://openalex.org/W2520537726","https://openalex.org/W2523369352","https://openalex.org/W2546711934","https://openalex.org/W2549063564","https://openalex.org/W2551389730","https://openalex.org/W2566820606","https://openalex.org/W2590750824","https://openalex.org/W2592847274","https://openalex.org/W2606611764","https://openalex.org/W2618452469","https://openalex.org/W2738293628","https://openalex.org/W2739924830","https://openalex.org/W2754660380","https://openalex.org/W2760296413","https://openalex.org/W2769097325","https://openalex.org/W2771340583","https://openalex.org/W2772262575","https://openalex.org/W2789888964","https://openalex.org/W2790518348","https://openalex.org/W2792126427","https://openalex.org/W2802569467","https://openalex.org/W2804214868","https://openalex.org/W2807014976","https://openalex.org/W2810918014","https://openalex.org/W2886352538","https://openalex.org/W2888375595","https://openalex.org/W2908458492","https://openalex.org/W2913363240","https://openalex.org/W2913441707","https://openalex.org/W2921508185","https://openalex.org/W2924778481","https://openalex.org/W2929384359","https://openalex.org/W2933251983","https://openalex.org/W2934694739","https://openalex.org/W2942831377","https://openalex.org/W2951582017","https://openalex.org/W2952529739","https://openalex.org/W2956895234","https://openalex.org/W2964214839","https://openalex.org/W2970979696","https://openalex.org/W2978801662","https://openalex.org/W2979759357","https://openalex.org/W2982470664","https://openalex.org/W2982511231","https://openalex.org/W2985405196","https://openalex.org/W2991267152","https://openalex.org/W2995142178","https://openalex.org/W2999142685","https://openalex.org/W3003270600","https://openalex.org/W3013491981","https://openalex.org/W3024452115","https://openalex.org/W3026376247","https://openalex.org/W3076637040","https://openalex.org/W3091872874","https://openalex.org/W3121859101","https://openalex.org/W3124881250","https://openalex.org/W3142277933","https://openalex.org/W3156231493","https://openalex.org/W3160311361","https://openalex.org/W3179991420","https://openalex.org/W3195453623","https://openalex.org/W3213882079","https://openalex.org/W4200329341","https://openalex.org/W4205139704","https://openalex.org/W4211056322","https://openalex.org/W4220765530","https://openalex.org/W4281720887","https://openalex.org/W4283591844","https://openalex.org/W4284714303","https://openalex.org/W4287009074","https://openalex.org/W4310289611","https://openalex.org/W4320507087","https://openalex.org/W4381378488","https://openalex.org/W4382182595","https://openalex.org/W6849874600","https://openalex.org/W6991663719"],"related_works":["https://openalex.org/W2913363240","https://openalex.org/W3205257587","https://openalex.org/W2802569467","https://openalex.org/W3190485987","https://openalex.org/W4409617482","https://openalex.org/W4281720887","https://openalex.org/W7038880159","https://openalex.org/W2808735519","https://openalex.org/W4417414588","https://openalex.org/W3178048754"],"abstract_inverted_index":{"(which":[0],"encodes":[1],"the":[2,40,44,47,59,71,82,189,206,231],"CF":[3,20,60,184,232],"transmembrane":[4],"conductance":[5],"regulator":[6],"ion":[7],"channel).":[8],"Cystic":[9],"fibrosis":[10,105],"related":[11],"diabetes":[12],"(CFRD)":[13],"occurs":[14],"in":[15,39,58,76,90,97,129,135,168],"40-50%":[16],"of":[17,49,73,86,102,145,152,188,195,216,230],"adults":[18],"with":[19,24,78],"and":[21,28,93,106,121,132,138,158,225,243],"is":[22,70,165,173,185,235],"associated":[23],"significantly":[25],"increased":[26,166],"morbidity":[27],"mortality.":[29],"CFRD":[30],"arises":[31],"from":[32,36,214],"insufficient":[33],"insulin":[34],"release":[35],"\u03b2":[37,50,130,207],"cells":[38,131],"pancreatic":[41],"islet,":[42],"but":[43],"mechanisms":[45],"underlying":[46],"loss":[48,151],"cell":[51,140,219],"function":[52,88,224],"remain":[53,114],"understudied.":[54],"Widespread":[55],"pathological":[56,179],"changes":[57,180,197],"pancreas":[61,69,74,233],"provide":[62],"clues":[63],"to":[64,100,200,237,241],"these":[65,178,196,217],"mechanisms.":[66],"The":[67,142],"exocrine":[68],"epicenter":[72],"pathology":[75,80],"CF,":[77],"ductal":[79,91],"being":[81],"initiating":[83],"event.":[84],"Loss":[85],"CFTR":[87],"results":[89],"plugging":[92],"subsequent":[94],"obliteration.":[95],"This":[96],"turn":[98],"leads":[99],"destruction":[101],"acinar":[103],"cells,":[104],"fatty":[107],"replacement.":[108],"Despite":[109],"this":[110],"adverse":[111],"environment,":[112],"islets":[113],"relatively":[115],"well":[116],"preserved.":[117],"However,":[118],"islet":[119,170],"composition":[120],"arrangement":[122],"are":[123,198],"abnormal,":[124],"including":[125],"a":[126,174,186,202],"modest":[127],"decrease":[128],"an":[133],"increase":[134],"\u03b1,":[136],"\u03b4":[137],"\u03b3":[139],"abundance.":[141],"small":[143],"amount":[144],"available":[146],"data":[147],"suggest":[148],"that":[149,183],"substantial":[150],"pancreatic/islet":[153],"microvasculature,":[154],"autonomic":[155],"nerve":[156],"fibers":[157],"intra-islet":[159],"macrophages":[160],"occur.":[161],"Conversely,":[162],"T-cell":[163],"infiltration":[164],"and,":[167],"CFRD,":[169],"amyloid":[171],"deposition":[172],"frequent":[175],"occurrence.":[176],"Together,":[177],"clearly":[181],"demonstrate":[182],"disease":[187],"pancreas/islet":[190],"microenvironment.":[191],"Any":[192],"or":[193],"all":[194,215],"likely":[199],"have":[201],"dramatic":[203],"effect":[204],"on":[205,211],"cell,":[208],"which":[209],"relies":[210],"positive":[212],"signals":[213],"neighboring":[218],"types":[220],"for":[221],"its":[222],"normal":[223],"survival.":[226],"A":[227],"thorough":[228],"characterization":[229],"microenvironment":[234],"needed":[236],"develop":[238],"better":[239],"therapies":[240],"treat,":[242],"ultimately":[244],"prevent":[245],"CFRD.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2023-11-24T00:00:00"}