{"id":"https://openalex.org/W4388939802","doi":"https://doi.org/10.1021/acsnano.3c06626","title":"Hepatic Stellate Cell- and Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis","display_name":"Hepatic Stellate Cell- and Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis","publication_year":2023,"publication_date":"2023-11-23","ids":{"openalex":"https://openalex.org/W4388939802","doi":"https://doi.org/10.1021/acsnano.3c06626","pmid":"https://pubmed.ncbi.nlm.nih.gov/37995097"},"language":"en","primary_location":{"id":"doi:10.1021/acsnano.3c06626","doi":"https://doi.org/10.1021/acsnano.3c06626","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.3c06626","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069052024","display_name":"Xia Niu","orcid":"https://orcid.org/0000-0002-9693-7716","observed_orcids":["https://orcid.org/0000-0002-9693-7716"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Niu","raw_affiliation_strings":["Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China"],"raw_orcid":"https://orcid.org/0000-0002-9693-7716","affiliations":[{"raw_affiliation_string":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111079131","display_name":"Yanan Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanan Meng","raw_affiliation_strings":["Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112072819","display_name":"Jinjin Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinjin Cui","raw_affiliation_strings":["Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rui Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Li","raw_affiliation_strings":["Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101800478","display_name":"Xiao Qiang Ding","orcid":"https://orcid.org/0000-0002-5205-5957","observed_orcids":["https://orcid.org/0000-0002-5205-5957"]},"institutions":[{"id":"https://openalex.org/I13850615","display_name":"Kunming Institute of Botany","ror":"https://ror.org/02e5hx313","country_code":"CN","type":"facility","lineage":["https://openalex.org/I13850615","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Ding","raw_affiliation_strings":["State Key Laboratory of Phytochemistry and Plant Resource in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Phytochemistry and Plant Resource in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China","institution_ids":["https://openalex.org/I13850615","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005856863","display_name":"Bingyu Niu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingyu Niu","raw_affiliation_strings":["Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101254074","display_name":"Ge Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ge Chang","raw_affiliation_strings":["Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101687901","display_name":"Ning Xu","orcid":"https://orcid.org/0000-0003-1186-6128","observed_orcids":["https://orcid.org/0000-0003-1186-6128"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Xu","raw_affiliation_strings":["Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049001219","display_name":"Guiling Li","orcid":"https://orcid.org/0000-0001-8585-6286","observed_orcids":["https://orcid.org/0000-0001-8585-6286"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guiling Li","raw_affiliation_strings":["Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410465","display_name":"Yucheng Wang","orcid":"https://orcid.org/0000-0003-2124-594X","observed_orcids":["https://orcid.org/0000-0003-2124-594X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yucheng Wang","raw_affiliation_strings":["Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China"],"raw_orcid":"https://orcid.org/0000-0003-2124-594X","affiliations":[{"raw_affiliation_string":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100444639","display_name":"Lulu Wang","orcid":"https://orcid.org/0000-0002-6969-5811","observed_orcids":["https://orcid.org/0000-0002-6969-5811"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lulu Wang","raw_affiliation_strings":["Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049001219","https://openalex.org/A5100410465","https://openalex.org/A5100444639"],"corresponding_institution_ids":["https://openalex.org/I200296433"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":5.0867,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.97294855,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"17","issue":"23","first_page":"23608","last_page":"23625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8490999937057495,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8490999937057495,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dihydrotanshinone-i","display_name":"dihydrotanshinone I","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/vitamin-a","display_name":"vitamin A","score":0.8230000138282776},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.7319999933242798},{"id":"https://openalex.org/keywords/bile-duct-ligation","display_name":"bile duct ligation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.6579999923706055},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/salvia-miltiorrhiza","display_name":"Salvia miltiorrhiza","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.8601981401443481},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.4953995943069458},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.48829078674316406},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4436093866825104},{"id":"https://openalex.org/C2776332195","wikidata":"https://www.wikidata.org/wiki/Q1000854","display_name":"Salvia miltiorrhiza","level":4,"score":0.4383801221847534},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3828354477882385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37598949670791626},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3746432065963745},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34137022495269775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3407677114009857},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2525095045566559},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.11165916919708252},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010616","descriptor_name":"Phenanthrenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsnano.3c06626","doi":"https://doi.org/10.1021/acsnano.3c06626","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.3c06626","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},{"id":"pmid:37995097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37995097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS nano","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1093040371","display_name":null,"funder_award_id":"2022-I2M-1-016","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G4914425894","display_name":null,"funder_award_id":"2022-I2M-JB-012","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G5153934310","display_name":null,"funder_award_id":"2021-I2M-1-070","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G5590802287","display_name":null,"funder_award_id":"3332022151","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G8003938212","display_name":null,"funder_award_id":"P2022-KF01","funder_id":"https://openalex.org/F4320326888","funder_display_name":"State Key Laboratory of Phytochemistry and Plant Resources in West China"},{"id":"https://openalex.org/G830817890","display_name":null,"funder_award_id":"2022-I2M-2-002","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320326888","display_name":"State Key Laboratory of Phytochemistry and Plant Resources in West China","ror":"https://ror.org/05wk7t803"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1437602880","https://openalex.org/W1994302891","https://openalex.org/W2066273470","https://openalex.org/W2097817969","https://openalex.org/W2147060719","https://openalex.org/W2148392644","https://openalex.org/W2188192437","https://openalex.org/W2565367159","https://openalex.org/W2757909794","https://openalex.org/W2771374783","https://openalex.org/W2804285404","https://openalex.org/W2806730922","https://openalex.org/W2807412877","https://openalex.org/W2885395493","https://openalex.org/W2909605537","https://openalex.org/W2916995073","https://openalex.org/W2943201830","https://openalex.org/W2950360205","https://openalex.org/W2979268390","https://openalex.org/W2980614519","https://openalex.org/W2992864763","https://openalex.org/W2999829053","https://openalex.org/W3000265439","https://openalex.org/W3005709647","https://openalex.org/W3009834370","https://openalex.org/W3045420839","https://openalex.org/W3047943181","https://openalex.org/W3088449656","https://openalex.org/W3115933192","https://openalex.org/W3118423163","https://openalex.org/W3128402462","https://openalex.org/W3157089588","https://openalex.org/W3170157724","https://openalex.org/W3195163478","https://openalex.org/W3196958551","https://openalex.org/W3201265314","https://openalex.org/W3206994391","https://openalex.org/W3213621514","https://openalex.org/W4200012230","https://openalex.org/W4214947110","https://openalex.org/W4223944873","https://openalex.org/W4225125073","https://openalex.org/W4226219510","https://openalex.org/W4242279979","https://openalex.org/W4281552134","https://openalex.org/W4281687987","https://openalex.org/W4283593125","https://openalex.org/W4285105556","https://openalex.org/W4293457648","https://openalex.org/W4293865792","https://openalex.org/W4296216075","https://openalex.org/W4311664384","https://openalex.org/W4318027779"],"related_works":["https://openalex.org/W4404691375","https://openalex.org/W4413406830","https://openalex.org/W2804285404","https://openalex.org/W7163873028","https://openalex.org/W2960880851","https://openalex.org/W4403703614","https://openalex.org/W2108497863","https://openalex.org/W3009834370","https://openalex.org/W7164679495","https://openalex.org/W4223944873"],"abstract_inverted_index":{"Liver":[0],"fibrosis":[1,65,261],"is":[2],"a":[3,26,51,138,187,255],"major":[4],"contributor":[5],"to":[6,33,82,206,215],"the":[7,45,56,68,74,98,108,156,166,171,198,216,219,223,236,239,268],"morbidity":[8],"and":[9,87,121,164,197,266],"mortality":[10],"associated":[11],"with":[12,132,179],"liver":[13,64,101,111,173,242,260,269],"diseases,":[14],"yet":[15],"effective":[16],"treatment":[17],"options":[18],"remain":[19],"limited.":[20],"Hepatic":[21],"stellate":[22],"cells":[23],"(HSCs)":[24],"are":[25],"promising":[27,256],"target":[28],"for":[29,91,125,259],"hepatic":[30],"fibrogenesis":[31],"due":[32,81],"their":[34],"pivotal":[35],"role":[36],"in":[37,62,71,159,170,174,190,203,235],"disease":[38],"progression.":[39],"Our":[40,145],"previous":[41],"research":[42],"has":[43,185,230],"demonstrated":[44],"potential":[46],"of":[47,77,89,100,110,168,200,218,241],"Dihydrotanshinone":[48],"I":[49],"(DHI),":[50],"lipophilic":[52],"component":[53],"derived":[54],"from":[55,104],"natural":[57],"herb":[58],"Salvia":[59],"miltiorrhiza":[60],"Bunge,":[61],"treating":[63],"by":[66,127,262],"inhibiting":[67],"YAP/TEAD2":[69,220],"interaction":[70],"HSCs.":[72,92],"However,":[73],"clinical":[75],"application":[76],"DHI":[78,126,169],"faces":[79],"challenges":[80],"its":[83],"poor":[84],"aqueous":[85],"solubility":[86],"lack":[88],"specificity":[90],"Additionally,":[93],"recent":[94],"studies":[95],"have":[96,117],"implicated":[97],"impact":[99],"microbiota,":[102,106],"distinct":[103],"gut":[105],"on":[107],"pathogenesis":[109],"diseases.":[112],"In":[113],"this":[114],"study,":[115],"we":[116],"developed":[118],"an":[119],"HSC-":[120],"microbiome-specific":[122],"delivery":[123],"system":[124],"conjugating":[128],"prebiotic-like":[129],"cyclodextrin":[130],"(CD)":[131],"vitamin":[133],"A,":[134],"utilizing":[135],"PEG2000":[136],"as":[137],"linker":[139],"(V":[140],"A":[141,150,181,225,250],"P":[142,151,182,226,251],"2000":[143,152,183,227,252],"@CD).":[144],"results":[146],"demonstrate":[147],"that":[148,248],"V":[149],"@CD":[153,184,228,253],"markedly":[154],"enhances":[155,165],"cellular":[157],"uptake":[158],"human":[160],"HSC":[161],"line":[162],"LX-2":[163],"deposition":[167],"fibrotic":[172],"vivo":[175],".":[176],"Subsequently,":[177],"intervention":[178,229],"DHI-V":[180,224,249],"shown":[186],"notable":[188],"reduction":[189],"bile":[191,207],"duct-like":[192],"structure":[193],"proliferation,":[194],"collagen":[195],"accumulation,":[196],"expression":[199],"fibrogenesis-associated":[201],"genes":[202],"rats":[204],"subjected":[205],"duct":[208],"ligation.":[209],"These":[210],"effects":[211],"may":[212],"be":[213],"attributed":[214],"regulation":[217],"interaction.":[221],"Importantly,":[222],"also":[231],"restored":[232],"microbial":[233,270],"homeostasis":[234],"liver,":[237],"promoting":[238],"amelioration":[240],"inflammation.":[243],"Overall,":[244],"our":[245],"findings":[246],"indicate":[247],"represents":[254],"therapeutic":[257],"approach":[258],"specifically":[263],"targeting":[264],"HSCs":[265],"restoring":[267],"balance.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-11-24T00:00:00"}
