{"id":"https://openalex.org/W4388934098","doi":"https://doi.org/10.1248/yakushi.23-00148","title":"Xanthan Gum-based Food Thickeners Reduce Disintegration Time of Medical and OTC Loxoprofen Sodium Tablets","display_name":"Xanthan Gum-based Food Thickeners Reduce Disintegration Time of Medical and OTC Loxoprofen Sodium Tablets","publication_year":2023,"publication_date":"2023-11-23","ids":{"openalex":"https://openalex.org/W4388934098","doi":"https://doi.org/10.1248/yakushi.23-00148","pmid":"https://pubmed.ncbi.nlm.nih.gov/38008462"},"language":"en","primary_location":{"id":"doi:10.1248/yakushi.23-00148","doi":"https://doi.org/10.1248/yakushi.23-00148","is_oa":true,"landing_page_url":"https://doi.org/10.1248/yakushi.23-00148","pdf_url":"https://www.jstage.jst.go.jp/article/yakushi/advpub/0/advpub_23-00148/_pdf","source":{"id":"https://openalex.org/S2764386467","display_name":"YAKUGAKU ZASSHI","issn_l":"0031-6903","issn":["0031-6903","1347-5231"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"YAKUGAKU ZASSHI","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/yakushi/advpub/0/advpub_23-00148/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033833528","display_name":"Masami Kawahara","orcid":"https://orcid.org/0009-0006-6449-5446","observed_orcids":["https://orcid.org/0009-0006-6449-5446"]},"institutions":[{"id":"https://openalex.org/I195444995","display_name":"Aichi Gakuin University","ror":"https://ror.org/01rwx7470","country_code":"JP","type":"education","lineage":["https://openalex.org/I195444995"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masami Kawahara","raw_affiliation_strings":["Clinical Pharmacy, School of Pharmacy, Aichi-Gakuin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, School of Pharmacy, Aichi-Gakuin University","institution_ids":["https://openalex.org/I195444995"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maika Moriyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195444995","display_name":"Aichi Gakuin University","ror":"https://ror.org/01rwx7470","country_code":"JP","type":"education","lineage":["https://openalex.org/I195444995"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Maika Moriyama","raw_affiliation_strings":["Clinical Pharmacy, School of Pharmacy, Aichi-Gakuin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, School of Pharmacy, Aichi-Gakuin University","institution_ids":["https://openalex.org/I195444995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111079002","display_name":"Misato Fukatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195444995","display_name":"Aichi Gakuin University","ror":"https://ror.org/01rwx7470","country_code":"JP","type":"education","lineage":["https://openalex.org/I195444995"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misato Fukatsu","raw_affiliation_strings":["Clinical Pharmacy, School of Pharmacy, Aichi-Gakuin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, School of Pharmacy, Aichi-Gakuin University","institution_ids":["https://openalex.org/I195444995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025321094","display_name":"Motozumi Ando","orcid":"https://orcid.org/0000-0003-2473-0588","observed_orcids":["https://orcid.org/0000-0003-2473-0588"]},"institutions":[{"id":"https://openalex.org/I195444995","display_name":"Aichi Gakuin University","ror":"https://ror.org/01rwx7470","country_code":"JP","type":"education","lineage":["https://openalex.org/I195444995"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motozumi Ando","raw_affiliation_strings":["Clinical Pharmacy, School of Pharmacy, Aichi-Gakuin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, School of Pharmacy, Aichi-Gakuin University","institution_ids":["https://openalex.org/I195444995"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041725712","display_name":"Norio Watanabe","orcid":"https://orcid.org/0000-0001-9768-993X","observed_orcids":["https://orcid.org/0000-0001-9768-993X"]},"institutions":[{"id":"https://openalex.org/I195444995","display_name":"Aichi Gakuin University","ror":"https://ror.org/01rwx7470","country_code":"JP","type":"education","lineage":["https://openalex.org/I195444995"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Watanabe","raw_affiliation_strings":["Clinical Pharmacy, School of Pharmacy, Aichi-Gakuin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, School of Pharmacy, Aichi-Gakuin University","institution_ids":["https://openalex.org/I195444995"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I195444995"],"apc_list":null,"apc_paid":null,"fwci":0.0867,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.32592663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"144","issue":"2","first_page":"231","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xanthan-gum","display_name":"xanthan gum","score":0.9589999914169312},{"id":"https://openalex.org/keywords/food-thickeners","display_name":"food thickeners","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tablet-disintegration","display_name":"tablet disintegration","score":0.7689999938011169},{"id":"https://openalex.org/keywords/loxoprofen-sodium","display_name":"loxoprofen sodium","score":0.9929999709129333},{"id":"https://openalex.org/keywords/superdisintegrants","display_name":"superdisintegrants","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tablet-coating","display_name":"tablet coating","score":0.5479999780654907},{"id":"https://openalex.org/keywords/tablet-hardness","display_name":"tablet hardness","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C2780100132","wikidata":"https://www.wikidata.org/wiki/Q410768","display_name":"Xanthan gum","level":3,"score":0.7256907820701599},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.5102267265319824},{"id":"https://openalex.org/C199068039","wikidata":"https://www.wikidata.org/wiki/Q574523","display_name":"Immersion (mathematics)","level":2,"score":0.49216359853744507},{"id":"https://openalex.org/C139145706","wikidata":"https://www.wikidata.org/wiki/Q189567","display_name":"Food additive","level":2,"score":0.46234312653541565},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.456257164478302},{"id":"https://openalex.org/C187714232","wikidata":"https://www.wikidata.org/wiki/Q2745207","display_name":"Anhydrous","level":2,"score":0.4211553931236267},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31521594524383545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29548579454421997},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2798863649368286},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19994887709617615},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14394459128379822},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.11378610134124756},{"id":"https://openalex.org/C200990466","wikidata":"https://www.wikidata.org/wiki/Q271707","display_name":"Rheology","level":2,"score":0.10787984728813171},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06547945737838745},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005503","descriptor_name":"Food Additives","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005503","descriptor_name":"Food Additives","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005503","descriptor_name":"Food Additives","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010666","descriptor_name":"Phenylpropionates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010666","descriptor_name":"Phenylpropionates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010666","descriptor_name":"Phenylpropionates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/yakushi.23-00148","doi":"https://doi.org/10.1248/yakushi.23-00148","is_oa":true,"landing_page_url":"https://doi.org/10.1248/yakushi.23-00148","pdf_url":"https://www.jstage.jst.go.jp/article/yakushi/advpub/0/advpub_23-00148/_pdf","source":{"id":"https://openalex.org/S2764386467","display_name":"YAKUGAKU ZASSHI","issn_l":"0031-6903","issn":["0031-6903","1347-5231"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"YAKUGAKU ZASSHI","raw_type":"journal-article"},{"id":"pmid:38008462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38008462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","raw_type":"English Abstract"}],"best_oa_location":{"id":"doi:10.1248/yakushi.23-00148","doi":"https://doi.org/10.1248/yakushi.23-00148","is_oa":true,"landing_page_url":"https://doi.org/10.1248/yakushi.23-00148","pdf_url":"https://www.jstage.jst.go.jp/article/yakushi/advpub/0/advpub_23-00148/_pdf","source":{"id":"https://openalex.org/S2764386467","display_name":"YAKUGAKU ZASSHI","issn_l":"0031-6903","issn":["0031-6903","1347-5231"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"YAKUGAKU ZASSHI","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388934098.pdf","grobid_xml":"https://content.openalex.org/works/W4388934098.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W595791996","https://openalex.org/W1993377227","https://openalex.org/W2014672695","https://openalex.org/W2076662527","https://openalex.org/W2121960517","https://openalex.org/W2241877634","https://openalex.org/W2312691345","https://openalex.org/W2328260345","https://openalex.org/W2594564096","https://openalex.org/W2781341509","https://openalex.org/W2890550449","https://openalex.org/W3046885953","https://openalex.org/W3095071174","https://openalex.org/W3109697019","https://openalex.org/W3197777095"],"related_works":["https://openalex.org/W2143265691","https://openalex.org/W4232008048","https://openalex.org/W2064772788","https://openalex.org/W786874010","https://openalex.org/W1994214155","https://openalex.org/W2030815628","https://openalex.org/W1929776281","https://openalex.org/W605513751","https://openalex.org/W2370134021","https://openalex.org/W2391128704"],"abstract_inverted_index":{"Xanthan":[0],"gum-based":[1,43,209],"food":[2,44,99,120,210],"thickeners":[3],"have":[4],"been":[5],"reported":[6],"to":[7,26,36,130,149,214],"potentially":[8,212],"interfere":[9],"with":[10,86,183],"tablet":[11,48,76,127,164,182],"disintegration.":[12,49],"Loxoprofen":[13],"sodium":[14],"(LOX)":[15],"is":[16,24,202],"widely":[17],"used":[18,51],"as":[19,67],"an":[20],"antipyretic":[21],"analgesic":[22],"and":[23,58,82,107,132,137,144,152,176],"expected":[25],"provide":[27],"rapid":[28,215],"pain":[29,216],"relief.":[30],"In":[31],"this":[32],"study,":[33],"we":[34],"aimed":[35],"investigate":[37],"the":[38,68,74,87,98,119,191,196,207],"impact":[39],"of":[40,56,65,178,199],"a":[41,184],"xanthan":[42,208],"thickener":[45,100,121],"on":[46,73],"LOX":[47,66,200],"We":[50],"four":[52],"different":[53,166],"brands":[54,139],"each":[55,61,163],"medical":[57,93,126],"OTC-LOX":[59],"tablets,":[60,110],"containing":[62,165],"60":[63],"mg":[64],"sole":[69],"active":[70],"ingredient.":[71],"Depending":[72],"brand,":[75],"hardness":[77],"varied":[78],"between":[79,173],"50.1-96.6":[80],"N":[81],"was":[83,158,171],"not":[84,95],"associated":[85],"disintegration":[88,128,174,193,197],"time.":[89,194],"Disintegration":[90],"times":[91],"for":[92,108,122,146,218],"tablets":[94,148,201],"immersed":[96,205],"in":[97,118,206],"were":[101,111,140],"536\u00b1215,":[102],"621\u00b1159,":[103],"348\u00b122,":[104],"369\u00b142":[105],"s":[106,134,154],"OTC":[109,147,181],"358\u00b120,":[112],"336\u00b113,":[113],"292\u00b113,":[114],"172\u00b127":[115],"s.":[116],"Immersion":[117],"15":[123],"min":[124],"reduced":[125],"time":[129,175,198],"177\u00b146":[131],"233\u00b1150":[133],"(the":[135,155],"third":[136],"fourth":[138,156],"disintegrated":[141,159],"during":[142,160],"immersion),":[143],"that":[145],"77\u00b140,":[150],"75\u00b1110,":[151],"37\u00b185":[153],"brand":[157],"immersion).":[161],"Despite":[162],"pharmaceutical":[167],"additives,":[168],"no":[169],"correlation":[170],"found":[172],"presence":[177],"superdisintegrants.":[179],"The":[180],"light":[185],"anhydrous":[186],"silicic":[187],"acid":[188],"coating":[189],"exhibited":[190],"shortest":[192],"Thus,":[195],"accelerated":[203],"when":[204],"thickener,":[211],"leading":[213],"relief":[217],"patients.":[219]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-11-24T00:00:00"}