{"id":"https://openalex.org/W4388916248","doi":"https://doi.org/10.52711/0974-360x.2023.00705","title":"Nephroprotective effects of Hydroalcoholic Extracts of Four selected Indian Medicinal Plants in Gentamicin-induced Nephrotoxic Wistar Rats","display_name":"Nephroprotective effects of Hydroalcoholic Extracts of Four selected Indian Medicinal Plants in Gentamicin-induced Nephrotoxic Wistar Rats","publication_year":2023,"publication_date":"2023-09-30","ids":{"openalex":"https://openalex.org/W4388916248","doi":"https://doi.org/10.52711/0974-360x.2023.00705"},"language":"en","primary_location":{"id":"doi:10.52711/0974-360x.2023.00705","doi":"https://doi.org/10.52711/0974-360x.2023.00705","is_oa":false,"landing_page_url":"https://doi.org/10.52711/0974-360x.2023.00705","pdf_url":null,"source":{"id":"https://openalex.org/S4210228335","display_name":"Research Journal of Pharmacy and Technology","issn_l":"0974-360X","issn":["0974-360X","0974-3618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacy and Technology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4388916248"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078700197","display_name":"Sarita Chaurasia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74885063","display_name":"Sharda University","ror":"https://ror.org/03b6ffh07","country_code":"IN","type":"education","lineage":["https://openalex.org/I74885063"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sarita Chaurasia","raw_affiliation_strings":["Research Scholar, School of Pharmacy, Sharda University, Greater Noida - 201306, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Scholar, School of Pharmacy, Sharda University, Greater Noida - 201306, Uttar Pradesh, India","institution_ids":["https://openalex.org/I74885063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085499822","display_name":"Saroj Yadav","orcid":"https://orcid.org/0000-0001-8408-9919","observed_orcids":["https://orcid.org/0000-0001-8408-9919"]},"institutions":[{"id":"https://openalex.org/I74885063","display_name":"Sharda University","ror":"https://ror.org/03b6ffh07","country_code":"IN","type":"education","lineage":["https://openalex.org/I74885063"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saroj Yadav","raw_affiliation_strings":["Associate Professor, School of Pharmacy, Sharda University, Greater Noida - 201306, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, School of Pharmacy, Sharda University, Greater Noida - 201306, Uttar Pradesh, India","institution_ids":["https://openalex.org/I74885063"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025246136","display_name":"P. Mani Chandrika","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Mani Chandrika","raw_affiliation_strings":["Principal, Department of Pharmacy, Bojjam Narasimhulu Pharmacy College for Women,  Hyderabad - 500049, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Principal, Department of Pharmacy, Bojjam Narasimhulu Pharmacy College for Women,  Hyderabad - 500049, Telangana, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5109,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.53900618,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"4307","last_page":"4313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gentamicin-induced-nephrotoxicity","display_name":"gentamicin nephrotoxicity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/aminoglycoside-nephrotoxicity","display_name":"aminoglycoside nephrotoxicity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/medicinal-plant-extracts","display_name":"medicinal plant extracts","score":0.6629999876022339},{"id":"https://openalex.org/keywords/hydroalcoholic-extract","display_name":"hydroalcoholic extract","score":0.8130000233650208},{"id":"https://openalex.org/keywords/ficus-religiosa","display_name":"Ficus religiosa","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tinospora-cordifolia","display_name":"Tinospora cordifolia","score":1.0},{"id":"https://openalex.org/keywords/moringa-oleifera","display_name":"Moringa oleifera","score":1.0},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.7889999747276306},{"id":"https://openalex.org/keywords/blood-urea-nitrogen","display_name":"blood urea nitrogen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kidney-histopathology","display_name":"kidney histopathology","score":0.7879999876022339},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8560000061988831},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ayurvedic-medicinal-plants","display_name":"Ayurvedic medicinal plants","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C2778523797","wikidata":"https://www.wikidata.org/wiki/Q3595912","display_name":"Tinospora cordifolia","level":2,"score":0.9370629191398621},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.8081796169281006},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.7672090530395508},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.7635927200317383},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6214771866798401},{"id":"https://openalex.org/C2776836740","wikidata":"https://www.wikidata.org/wiki/Q310468","display_name":"Moringa","level":2,"score":0.5469106435775757},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5355669260025024},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.4994673728942871},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.49091559648513794},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43356990814208984},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.40941309928894043},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3691422939300537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23197272419929504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17339244484901428},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08890217542648315}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.52711/0974-360x.2023.00705","doi":"https://doi.org/10.52711/0974-360x.2023.00705","is_oa":false,"landing_page_url":"https://doi.org/10.52711/0974-360x.2023.00705","pdf_url":null,"source":{"id":"https://openalex.org/S4210228335","display_name":"Research Journal of Pharmacy and Technology","issn_l":"0974-360X","issn":["0974-360X","0974-3618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacy and Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W326580705","https://openalex.org/W582656698","https://openalex.org/W1554276281","https://openalex.org/W1966253411","https://openalex.org/W1972363217","https://openalex.org/W1995448440","https://openalex.org/W2002384775","https://openalex.org/W2006258314","https://openalex.org/W2014589068","https://openalex.org/W2030835039","https://openalex.org/W2033041758","https://openalex.org/W2038628940","https://openalex.org/W2040134804","https://openalex.org/W2051142023","https://openalex.org/W2058627757","https://openalex.org/W2061485058","https://openalex.org/W2067479751","https://openalex.org/W2073521714","https://openalex.org/W2084862624","https://openalex.org/W2087464776","https://openalex.org/W2098466711","https://openalex.org/W2101956379","https://openalex.org/W2103061782","https://openalex.org/W2181571954","https://openalex.org/W2263434320","https://openalex.org/W2764154690","https://openalex.org/W2766930705","https://openalex.org/W2767436976","https://openalex.org/W2921989155","https://openalex.org/W2928187289","https://openalex.org/W2945772133","https://openalex.org/W2951046757","https://openalex.org/W2972733442","https://openalex.org/W2987928061","https://openalex.org/W2995705260","https://openalex.org/W3015568285","https://openalex.org/W3040941096","https://openalex.org/W3131111094","https://openalex.org/W3153157171","https://openalex.org/W3195293722","https://openalex.org/W4220652020","https://openalex.org/W4239060919","https://openalex.org/W4240269235","https://openalex.org/W4281707383","https://openalex.org/W7014939369"],"related_works":["https://openalex.org/W2742494788","https://openalex.org/W2945772133","https://openalex.org/W4285419295","https://openalex.org/W4224248235","https://openalex.org/W4289516141","https://openalex.org/W4409918650","https://openalex.org/W2955343319","https://openalex.org/W2553713680","https://openalex.org/W2602998426","https://openalex.org/W7164221117"],"abstract_inverted_index":{"All":[0],"the":[1,23,41,63,148,155,192,206],"selected":[2,69],"Indian":[3,70],"medicinal":[4,71],"plants,":[5],"Ficus":[6,87],"religiosa;":[7],"Tinospora":[8,91,198,225],"cordifolia;":[9],"Moringa":[10,95],"oleifera;":[11],"Boerhaevia":[12,100,203,228],"diffusa":[13,101,204,229],"have":[14,19],"profound":[15],"pharmacological":[16],"uses":[17],"which":[18,247],"been":[20],"proved":[21],"by":[22,121],"study":[24,58],"of":[25,43,67,83,86,90,94,99,108,144,150,195,197,202,208,224,234],"Ayurvedic":[26],"literature.":[27],"An":[28],"Aminoglycoside":[29],"like":[30],"Gentamicin":[31,51],"is":[32,52],"a":[33,231],"broad-spectrum":[34],"antibiotic":[35],"in":[36,74,78,117,163,183,213,241,254,257],"combination":[37],"with":[38,50,142,186,191],"beta-lactams":[39],"for":[40,250],"treatment":[42,190],"systemic":[44],"infection.":[45],"The":[46,56,221],"major":[47],"risk":[48],"associated":[49],"nephrotoxicity":[53,256],"and":[54,97,110,170,200,227,244],"ototoxicity":[55],"present":[57],"was":[59,236],"done":[60],"to":[61,113,176,215,238],"evaluate":[62,114],"comparative":[64],"Nephroprotective":[65,115],"effects":[66],"four":[68],"plant":[72,217],"extracts":[73,82],"albino":[75,118],"Wistar":[76,119],"rats":[77,120,156,184],"Gentamicin-induced":[79,255],"nephrotoxicity.":[80],"Hydroalcoholic":[81,193,222],"stem":[84,89,196],"bark":[85],"religiosa,":[88],"cordifolia,":[92],"leaves":[93],"oleifera":[96],"roots":[98],"were":[102,157,174],"used":[103],"at":[104,230],"two":[105],"doses":[106],"levels":[107],"200,":[109],"400mg/kg":[111,235],"respectively":[112],"activity":[116,212],"interfering":[122],"Body":[123],"weight,":[124],"Blood":[125],"urea":[126,172],"nitrogen":[127,173],"(BUN),":[128],"Serum":[129,133],"creatinine":[130],"(Serum":[131],"Creatinine),":[132],"total":[134],"proteins,":[135],"Urine":[136,138,166],"volume,":[137],"creatinine,":[139,167],"Creatinine":[140],"clearance":[141],"Histopathology":[143],"Kidney.":[145],"To":[146],"observe":[147],"effect":[149,207],"various":[151],"treatments":[152],"on":[153],"animals":[154],"divided":[158],"into":[159],"Eleven":[160],"groups,":[161],"Six":[162],"each":[164],"group.":[165],"serum":[168],"urea,":[169],"blood":[171],"found":[175,237],"be":[177,239],"significantly":[178],"(P":[179],"<":[180],"0.001)":[181],"increased":[182],"treated":[185,219],"only":[187],"gentamicin;":[188],"whereas":[189],"extract":[194,218,223],"cordifolia":[199,226],"root":[201],"reversed":[205],"gentamicin":[209],"indicating":[210],"nephroprotective":[211,252],"compared":[214],"other":[216,245],"animals.":[220],"dose":[232],"level":[233],"rich":[240],"flavonoids,":[242],"polyphenolics,":[243],"phytoconstituents":[246],"are":[248],"responsible":[249],"good":[251],"action":[253],"rats.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2023-11-23T00:00:00"}