{"id":"https://openalex.org/W4388911540","doi":"https://doi.org/10.1080/07391102.2023.2280779","title":"Network pharmacology, molecular docking-driven, Qbd-Engineered antifungal in-situ gel loaded with voriconazole nanostructured lipid carriers","display_name":"Network pharmacology, molecular docking-driven, Qbd-Engineered antifungal in-situ gel loaded with voriconazole nanostructured lipid carriers","publication_year":2023,"publication_date":"2023-11-21","ids":{"openalex":"https://openalex.org/W4388911540","doi":"https://doi.org/10.1080/07391102.2023.2280779","pmid":"https://pubmed.ncbi.nlm.nih.gov/37990482"},"language":"en","primary_location":{"id":"doi:10.1080/07391102.2023.2280779","doi":"https://doi.org/10.1080/07391102.2023.2280779","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2023.2280779","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037267044","display_name":"Abhishek Tiwari","orcid":"https://orcid.org/0000-0003-1221-4754","observed_orcids":["https://orcid.org/0000-0003-1221-4754"]},"institutions":[{"id":"https://openalex.org/I2801192375","display_name":"IFTM University","ror":"https://ror.org/02v2sn747","country_code":"IN","type":"education","lineage":["https://openalex.org/I2801192375"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Abhishek Tiwari","raw_affiliation_strings":["Department of Pharmacy, Pharmacy Academy, IFTM University","Department of Pharmacy, Pharmacy Academy, IFTM University, Moradabad, India"],"raw_orcid":"https://orcid.org/0000-0003-1221-4754","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Pharmacy Academy, IFTM University","institution_ids":["https://openalex.org/I2801192375"]},{"raw_affiliation_string":"Department of Pharmacy, Pharmacy Academy, IFTM University, Moradabad, India","institution_ids":["https://openalex.org/I2801192375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063020151","display_name":"Varsha Tiwari","orcid":"https://orcid.org/0000-0002-2293-8943","observed_orcids":["https://orcid.org/0000-0002-2293-8943"]},"institutions":[{"id":"https://openalex.org/I2801192375","display_name":"IFTM University","ror":"https://ror.org/02v2sn747","country_code":"IN","type":"education","lineage":["https://openalex.org/I2801192375"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Varsha Tiwari","raw_affiliation_strings":["Department of Pharmacy, Pharmacy Academy, IFTM University","Department of Pharmacy, Pharmacy Academy, IFTM University, Moradabad, India"],"raw_orcid":"https://orcid.org/0000-0002-2293-8943","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Pharmacy Academy, IFTM University","institution_ids":["https://openalex.org/I2801192375"]},{"raw_affiliation_string":"Department of Pharmacy, Pharmacy Academy, IFTM University, Moradabad, India","institution_ids":["https://openalex.org/I2801192375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007400741","display_name":"Binita Palaria","orcid":"https://orcid.org/0000-0003-4604-4933","observed_orcids":["https://orcid.org/0000-0003-4604-4933"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Binita Palaria","raw_affiliation_strings":["Department of Pharmacy, Devsthali Vidyapeeth College of Pharmacy","Department of Pharmacy, Devsthali Vidyapeeth College of Pharmacy, Rudrapur, India"],"raw_orcid":"https://orcid.org/0000-0003-4604-4933","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Devsthali Vidyapeeth College of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacy, Devsthali Vidyapeeth College of Pharmacy, Rudrapur, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072456538","display_name":"Ramsha Aslam","orcid":"https://orcid.org/0000-0002-3712-4416","observed_orcids":["https://orcid.org/0000-0002-3712-4416"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramsha Aslam","raw_affiliation_strings":["Department of Pharmacy, Devsthali Vidyapeeth College of Pharmacy","Department of Pharmacy, Devsthali Vidyapeeth College of Pharmacy, Rudrapur, India"],"raw_orcid":"https://orcid.org/0000-0002-3712-4416","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Devsthali Vidyapeeth College of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacy, Devsthali Vidyapeeth College of Pharmacy, Rudrapur, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080588119","display_name":"Manish Kumar","orcid":"https://orcid.org/0000-0003-2042-1243","observed_orcids":["https://orcid.org/0000-0003-2042-1243","https://orcid.org/0009-0006-6546-8888"]},"institutions":[{"id":"https://openalex.org/I4405258160","display_name":"CT University","ror":"https://ror.org/007czgh25","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210094618","https://openalex.org/I4405258160"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manish Kumar","raw_affiliation_strings":["School of Pharmaceutical Sciences, C.T. University","School of Pharmaceutical Sciences, C.T. University, Ludhiana, India"],"raw_orcid":"https://orcid.org/0000-0003-2042-1243","affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, C.T. University","institution_ids":[]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, C.T. University, Ludhiana, India","institution_ids":["https://openalex.org/I4405258160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011386787","display_name":"Neeraj Kumar","orcid":"https://orcid.org/0000-0001-5508-0616","observed_orcids":["https://orcid.org/0000-0001-5508-0616"]},"institutions":[{"id":"https://openalex.org/I4405252731","display_name":"Bhupal Nobles University","ror":"https://ror.org/01qaf6z41","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405252731"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neeraj Kumar","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Bhupal Nobles\u2019 College of Pharmacy, Bhupal Nobles\u2019 University","Department of Pharmaceutical Chemistry, Bhupal Nobles' College of Pharmacy, Bhupal Nobles' University, Udaipur, India"],"raw_orcid":"https://orcid.org/0000-0001-5508-0616","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Bhupal Nobles\u2019 College of Pharmacy, Bhupal Nobles\u2019 University","institution_ids":["https://openalex.org/I4405252731"]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Bhupal Nobles' College of Pharmacy, Bhupal Nobles' University, Udaipur, India","institution_ids":["https://openalex.org/I4405252731"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037267044"],"corresponding_institution_ids":["https://openalex.org/I2801192375"],"apc_list":null,"apc_paid":null,"fwci":0.7233,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.61193511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"43","issue":"1","first_page":"305","last_page":"324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voriconazole","display_name":"voriconazole","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nanostructured-lipid-carriers","display_name":"nanostructured lipid carriers","score":0.9750000238418579},{"id":"https://openalex.org/keywords/in-situ-gel","display_name":"in situ gel","score":0.859000027179718},{"id":"https://openalex.org/keywords/antifungal-drug-delivery","display_name":"antifungal drug delivery","score":0.8610000014305115},{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.8460000157356262},{"id":"https://openalex.org/keywords/fungal-infection","display_name":"fungal infection","score":0.4399999976158142},{"id":"https://openalex.org/keywords/ergosterol-biosynthesis","display_name":"ergosterol biosynthesis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/dihydrofolate-reductase","display_name":"dihydrofolate reductase","score":0.8669999837875366},{"id":"https://openalex.org/keywords/acetolactate-synthase","display_name":"acetolactate synthase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/protein-farnesyltransferase","display_name":"farnesyltransferase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/endoglucanase","display_name":"endoglucanase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C2777910421","wikidata":"https://www.wikidata.org/wiki/Q143263","display_name":"Ergosterol","level":2,"score":0.5420668125152588},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46723824739456177},{"id":"https://openalex.org/C2779969316","wikidata":"https://www.wikidata.org/wiki/Q414996","display_name":"Lanosterol","level":4,"score":0.46490585803985596},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4516250491142273},{"id":"https://openalex.org/C2780690907","wikidata":"https://www.wikidata.org/wiki/Q412236","display_name":"Voriconazole","level":3,"score":0.4410886764526367},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.4163309931755066},{"id":"https://openalex.org/C2781320022","wikidata":"https://www.wikidata.org/wiki/Q417149","display_name":"Dihydrofolate reductase","level":3,"score":0.41530314087867737},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40352991223335266},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.352936714887619},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32554399967193604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3169076442718506},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20957186818122864},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.17140114307403564},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.14380010962486267},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.08584260940551758},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.0791628360748291},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065819","descriptor_name":"Voriconazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D065819","descriptor_name":"Voriconazole","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/07391102.2023.2280779","doi":"https://doi.org/10.1080/07391102.2023.2280779","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2023.2280779","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},{"id":"pmid:37990482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37990482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomolecular structure & dynamics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1652163807","https://openalex.org/W1714079339","https://openalex.org/W1785785141","https://openalex.org/W1976359124","https://openalex.org/W1981833691","https://openalex.org/W2028517473","https://openalex.org/W2064185190","https://openalex.org/W2107998478","https://openalex.org/W2110831416","https://openalex.org/W2133463731","https://openalex.org/W2134122507","https://openalex.org/W2144149632","https://openalex.org/W2156339880","https://openalex.org/W2400984848","https://openalex.org/W2470059686","https://openalex.org/W2591533405","https://openalex.org/W2781877382","https://openalex.org/W2794591995","https://openalex.org/W2927115307","https://openalex.org/W2947344879","https://openalex.org/W3006902785","https://openalex.org/W3032047811","https://openalex.org/W3136125550","https://openalex.org/W3208072175","https://openalex.org/W3210893320","https://openalex.org/W4212855414","https://openalex.org/W4237233916","https://openalex.org/W4378746707","https://openalex.org/W4379769603","https://openalex.org/W4385840353"],"related_works":["https://openalex.org/W4366524502","https://openalex.org/W4365518522","https://openalex.org/W2940932035","https://openalex.org/W7165362841","https://openalex.org/W7091589559","https://openalex.org/W2528269894","https://openalex.org/W3092318962","https://openalex.org/W6977186893","https://openalex.org/W4415204539","https://openalex.org/W3207971894"],"abstract_inverted_index":{"Fungal":[0],"infections":[1],"(FIs)":[2],"affect":[3],"majority":[4],"of":[5,16,86,90,123,150,164,170,174,177],"the":[6,9,42,84,108,119,151,175,194,243],"population,":[7],"but":[8],"current":[10],"treatments":[11],"face":[12],"challenges":[13],"in":[14,121],"terms":[15,122],"their":[17],"effectiveness.":[18],"This":[19],"study":[20,155],"focused":[21],"on":[22],"specific":[23],"fungal":[24],"targets,":[25],"including":[26,77,203],"dihydrofolate":[27],"reductase":[28,239],"(DHFR),":[29],"acetohydroxy-acid":[30],"synthase":[31],"(AHAS),":[32],"farnesyltransferase":[33],"and":[34,51,71,81,144,166,237],"endoglucanase.":[35],"The":[36,88,148,172],"docking":[37],"studies":[38],"were":[39,100,118],"conducted":[40],"with":[41,48,193],"drug":[43,132,146,167],"voriconazole":[44],"(VCZ),":[45],"comparing":[46],"it":[47],"Fluconazole":[49],"(FCZ)":[50],"Amphotericin":[52],"B":[53,223],"(ATB)":[54],"against":[55],"11":[56],"protein":[57,211],"data":[58],"bank":[59],"(PDB)":[60],"IDs":[61],"(IDYR,":[62],"3NZB,":[63],"6DEQ,":[64],"1KS5,":[65],"7T0C,":[66],"1FY4,":[67],"5AJH,":[68],"7R79,":[69],"6TZ6":[70],"6IDY).":[72],"Molecular":[73],"dynamics":[74],"(MD)":[75],"analysis,":[76],"RMSD,":[78],"RMSF,":[79],"PCA":[80],"FEL,":[82],"confirmed":[83],"stability":[85],"VCZ.":[87],"solubility":[89],"VCZ":[91,191],"was":[92,107],"a":[93,248],"problem,":[94],"so":[95],"nanostructured":[96],"lipid":[97],"carriers":[98],"(NLCs)":[99],"developed":[101],"to":[102,186,251],"improve":[103],"ocular":[104,253],"penetration.":[105],"VCF5":[106],"optimized":[109,244],"formulation":[110],"by":[111,255],"using":[112],"32":[113],"full":[114],"factorial":[115],"design.":[116],"VCZF5-NLCs":[117],"best":[120],"nanoparticle":[124],"size":[125],"(126.6":[126],"nm),":[127],"Zeta":[128],"potential":[129],"(33.5":[130],"mV),":[131],"content":[133],"(DC;":[134],"97.38":[135],"\u00b1":[136,142],"0.210),":[137],"encapsulation":[138],"efficiency":[139],"(EE;":[140],"88.01":[141],"0.272)":[143],"extended":[145],"release.":[147],"results":[149,173],"ex-vivo":[152],"corneal":[153],"diffusion":[154],"indicate":[156],"that":[157,180],"VCZ-NLC-loaded":[158],"in-situ":[159],"gel":[160],"(VCZ-NLC-IG3)":[161],"exhibited":[162],"DC":[163],"88.25%":[165],"entrapment":[168],"(DE)":[169],"74.2%.":[171],"zone":[176],"inhibition":[178],"indicated":[179],"VCZ-NLC-IG3":[181],"had":[182],"superior":[183],"efficacy":[184],"compared":[185],"ATB.":[187],"Network":[188],"pharmacology":[189],"showed":[190],"interacts":[192],"genes":[195],"which":[196],"are":[197],"responsible":[198],"for":[199],"fungus":[200],"ergosterol":[201,209],"biosynthesis,":[202],"lanosterol":[204],"14-alpha":[205],"demethylase":[206],"inhibitors":[207],"(ERG11),":[208],"biosynthesis":[210],"5":[212],"(ERG5),":[213],"dimethylallyltransferase":[214],"2":[215],"(DIT2),":[216],"ketosynthase":[217],"(KCN),":[218],"methylsterol":[219],"monooxygenase":[220],"(MSMO1),":[221],"lamin":[222],"receptor":[224],"(LBR),":[225],"squalene":[226],"epoxidase":[227],"(SQLE),":[228],"3-hydroxy-3-methylglutaryl-coenzyme":[229,233],"A":[230,234],"Reductase":[231],"(MGCR),":[232],"Synthase":[235],"(HMGCS)":[236],"3-keto-steroid":[238],"(HSD17B7).":[240],"In":[241],"conclusion,":[242],"VCZ-loaded":[245],"NLCs":[246],"present":[247],"promising":[249],"approach":[250],"treat":[252],"FIs.Communicated":[254],"Ramaswamy":[256],"H.":[257],"Sarma":[258]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-11-23T00:00:00"}