{"id":"https://openalex.org/W4388895929","doi":"https://doi.org/10.1186/s43168-023-00245-y","title":"Quercetin for inhibition of inflammatory responses and oxidative stress in lung injury model: a systematic review and meta-analysis","display_name":"Quercetin for inhibition of inflammatory responses and oxidative stress in lung injury model: a systematic review and meta-analysis","publication_year":2023,"publication_date":"2023-11-22","ids":{"openalex":"https://openalex.org/W4388895929","doi":"https://doi.org/10.1186/s43168-023-00245-y"},"language":"en","primary_location":{"id":"doi:10.1186/s43168-023-00245-y","doi":"https://doi.org/10.1186/s43168-023-00245-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43168-023-00245-y","pdf_url":"https://ejb.springeropen.com/counter/pdf/10.1186/s43168-023-00245-y","source":{"id":"https://openalex.org/S2764714012","display_name":"Egyptian Journal of Bronchology","issn_l":"1687-8426","issn":["1687-8426","2314-8551"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Bronchology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ejb.springeropen.com/counter/pdf/10.1186/s43168-023-00245-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013829668","display_name":"Ghufran Lutfi Ismaeel","orcid":"https://orcid.org/0000-0001-7543-1444","observed_orcids":["https://orcid.org/0000-0001-7543-1444"]},"institutions":[{"id":"https://openalex.org/I4405264678","display_name":"University of Al-Ameed","ror":"https://ror.org/02mpwke65","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405264678"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Ghufran Lutfi Ismaeel","raw_affiliation_strings":["College of Pharmacy, Department of Pharmacology, University of Al-Ameed, Karbala, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Department of Pharmacology, University of Al-Ameed, Karbala, Iraq","institution_ids":["https://openalex.org/I4405264678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010059635","display_name":"Mohanad Ali Abdulhadi","orcid":"https://orcid.org/0000-0001-9846-9760","observed_orcids":["https://orcid.org/0000-0001-9846-9760"]},"institutions":[{"id":"https://openalex.org/I2800838116","display_name":"University of Al Maarif","ror":"https://ror.org/05scxf493","country_code":"IQ","type":"education","lineage":["https://openalex.org/I2800838116"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Mohanad Ali Abdulhadi","raw_affiliation_strings":["Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq","institution_ids":["https://openalex.org/I2800838116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092201906","display_name":"Lubna Raad Al-Ameer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153874","display_name":"Al-Zahraa University for Women","ror":"https://ror.org/05c2btq38","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4387153874"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Lubna R. Al-Ameer","raw_affiliation_strings":["College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq","institution_ids":["https://openalex.org/I4387153874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093315106","display_name":"Sally Salih Jumaa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254421","display_name":"National University of Science and Technology","ror":"https://ror.org/01ss3xk05","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405254421"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Sally Salih Jumaa","raw_affiliation_strings":["College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq","institution_ids":["https://openalex.org/I4405254421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039541150","display_name":"Israa M. Essa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126633494","display_name":"University of Basrah","ror":"https://ror.org/00840ea57","country_code":"IQ","type":"education","lineage":["https://openalex.org/I126633494"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Israa M. Essa","raw_affiliation_strings":["College of Veterinary Medicine Department of Veterinary Parasitology, University of Basrah, Basrah, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine Department of Veterinary Parasitology, University of Basrah, Basrah, Iraq","institution_ids":["https://openalex.org/I126633494"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027119695","display_name":"Abduladheem Turki Jalil","orcid":"https://orcid.org/0000-0001-8403-7465","observed_orcids":["https://orcid.org/0000-0001-8403-7465"]},"institutions":[{"id":"https://openalex.org/I4400573189","display_name":"Al-Mustaqbal University","ror":"https://ror.org/023a3xe97","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4400573189"]}],"countries":["IQ"],"is_corresponding":true,"raw_author_name":"Abduladheem Turki Jalil","raw_affiliation_strings":["Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla, 51001, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla, 51001, Iraq","institution_ids":["https://openalex.org/I4400573189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000646126","display_name":"Abbas Firras Almulla","orcid":"https://orcid.org/0000-0002-7667-6731","observed_orcids":["https://orcid.org/0000-0002-7667-6731","https://orcid.org/0009-0002-7503-1314"]},"institutions":[{"id":"https://openalex.org/I4405259362","display_name":"Islamic University of Najaf","ror":"https://ror.org/024dzaa63","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405259362"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Abbas F. Almulla","raw_affiliation_strings":["Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq","institution_ids":["https://openalex.org/I4405259362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072618152","display_name":"Ronak Taher Ali","orcid":"https://orcid.org/0000-0003-1418-8721","observed_orcids":["https://orcid.org/0000-0003-1418-8721"]},"institutions":[{"id":"https://openalex.org/I102254642","display_name":"University of Kirkuk","ror":"https://ror.org/01pk8rb11","country_code":"IQ","type":"education","lineage":["https://openalex.org/I102254642"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Ronak Taher Ali","raw_affiliation_strings":["College of Medical Technology, Al-Kitab University, Kirkuk, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medical Technology, Al-Kitab University, Kirkuk, Iraq","institution_ids":["https://openalex.org/I102254642"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5027119695"],"corresponding_institution_ids":["https://openalex.org/I4400573189"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.1951,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.1840796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"17","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.5375999808311462,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.5375999808311462,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.4083999991416931,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.968999981880188},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/flavan-3-ols","display_name":"flavan-3-ols","score":0.9150000214576721},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neutrophil-migration","display_name":"neutrophil migration","score":0.7739999890327454},{"id":"https://openalex.org/keywords/alveolar-capillary-permeability","display_name":"alveolar-capillary permeability","score":0.9049999713897705},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8489471673965454},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7464636564254761},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.646344006061554},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5475763082504272},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.5354412198066711},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4772786498069763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45713767409324646},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42982059717178345},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4250290095806122},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.41793856024742126},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4158133864402771}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s43168-023-00245-y","doi":"https://doi.org/10.1186/s43168-023-00245-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43168-023-00245-y","pdf_url":"https://ejb.springeropen.com/counter/pdf/10.1186/s43168-023-00245-y","source":{"id":"https://openalex.org/S2764714012","display_name":"Egyptian Journal of Bronchology","issn_l":"1687-8426","issn":["1687-8426","2314-8551"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Bronchology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:fd8915fb92cf4defa1acd11f94dac368","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fd8915fb92cf4defa1acd11f94dac368","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Egyptian Journal of Bronchology, Vol 17, Iss 1, Pp 1-8 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s43168-023-00245-y","doi":"https://doi.org/10.1186/s43168-023-00245-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43168-023-00245-y","pdf_url":"https://ejb.springeropen.com/counter/pdf/10.1186/s43168-023-00245-y","source":{"id":"https://openalex.org/S2764714012","display_name":"Egyptian Journal of Bronchology","issn_l":"1687-8426","issn":["1687-8426","2314-8551"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Bronchology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388895929.pdf","grobid_xml":"https://content.openalex.org/works/W4388895929.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W94494873","https://openalex.org/W2001908902","https://openalex.org/W2005501262","https://openalex.org/W2008906556","https://openalex.org/W2029974691","https://openalex.org/W2122814783","https://openalex.org/W2159763561","https://openalex.org/W2297606889","https://openalex.org/W2313803608","https://openalex.org/W2618683072","https://openalex.org/W2791517480","https://openalex.org/W2872234236","https://openalex.org/W2899643240","https://openalex.org/W3014825395","https://openalex.org/W3023282079","https://openalex.org/W3130077984","https://openalex.org/W3197052160","https://openalex.org/W3203180487","https://openalex.org/W4212865324","https://openalex.org/W4282931334","https://openalex.org/W4283795763","https://openalex.org/W4286561088","https://openalex.org/W4287378225","https://openalex.org/W4293051475","https://openalex.org/W4306362307","https://openalex.org/W4307303927","https://openalex.org/W4307906043","https://openalex.org/W4364375469","https://openalex.org/W4385724761","https://openalex.org/W4385950855","https://openalex.org/W4389516078"],"related_works":["https://openalex.org/W7061507980","https://openalex.org/W4407076784","https://openalex.org/W332040658","https://openalex.org/W4387736369","https://openalex.org/W4391386101","https://openalex.org/W2385354515","https://openalex.org/W4408124169","https://openalex.org/W4414429331","https://openalex.org/W2296014169","https://openalex.org/W2989942363"],"abstract_inverted_index":{"Abstract":[0],"Acute":[1],"lung":[2,64,170],"injury":[3,65,171],"(ALI)":[4],"is":[5],"a":[6,46,59,174],"life-threatening":[7],"clinical":[8],"syndrome":[9],"with":[10,87,102,125],"high":[11],"morbidity":[12],"and":[13,34,49,74,110,117,145],"mortality.":[14],"The":[15],"main":[16],"pathological":[17],"features":[18],"of":[19,29,56,62,72,91,163],"ALI":[20,92,179],"are":[21],"increased":[22],"alveolar-capillary":[23],"membrane":[24],"permeability,":[25],"edema,":[26],"uncontrolled":[27],"migration":[28],"neutrophils":[30],"to":[31,51,80],"the":[32,53,82,103,108,114,121,128,161,183],"lungs,":[33],"diffuse":[35],"alveolar":[36],"damage,":[37],"resulting":[38],"in":[39,58,95,120,127,169,178],"acute":[40,63],"hypoxemic":[41],"respiratory":[42],"failure.":[43],"We":[44,98],"performed":[45],"systematic":[47],"review":[48],"meta-analysis":[50],"elucidate":[52],"antioxidant":[54],"activities":[55],"flavanols":[57,165],"rat":[60,89],"model":[61],"(ALI).":[66],"PubMed,":[67],"EMBASE,":[68],"Scopus,":[69],"ProQuest,":[70],"Web":[71],"Science,":[73],"Google":[75],"Scholar":[76],"databases":[77],"were":[78,93],"searched":[79],"obtain":[81],"relevant":[83],"papers.":[84],"Nine":[85],"studies":[86],"343":[88],"models":[90],"included":[94],"this":[96],"study.":[97],"investigated":[99],"oxidative":[100,118,167],"stress":[101,119,168],"corresponding":[104],"95%":[105,111,135,148],"CI.":[106],"Estimating":[107],"correlation":[109],"CIs":[112],"for":[113,192],"inflammatory":[115],"agents":[116],"intervention":[122],"group,":[123],"compared":[124],"that":[126],"control":[129],"group":[130],"(ALI),":[131],"respectively":[132],"(correlation:":[133,146],"0.635;":[134],"CI,":[136,149],"0.560\u20130.699,":[137],"P":[138,151],"value":[139,152],"=":[140,153],"0.000,":[141],"Z":[142,155],"value=":[143,156],"12.648)":[144],"0.317;":[147],"0.189\u20130.434,":[150],"0.00,":[154],"4.7).":[157],"In":[158],"conclusion,":[159],"investigating":[160],"effects":[162],"different":[164],"on":[166,186],"may":[172],"provide":[173],"useful":[175],"therapeutic":[176],"strategy":[177],"mouse":[180],"models.":[181],"However,":[182],"final":[184],"conclusion":[185],"treatment":[187],"efficacy":[188],"should":[189],"be":[190],"sufficient":[191],"prospective":[193],"controlled":[194],"randomized":[195],"trials.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-23T00:00:00"}