{"id":"https://openalex.org/W43888680","doi":null,"title":"Effects of gamma-hydroxybutyrate (liquid ecstasy) on the eye development of the chick embryo","display_name":"Effects of gamma-hydroxybutyrate (liquid ecstasy) on the eye development of the chick embryo","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W43888680","mag":"43888680"},"language":"en","primary_location":{"id":"mag:43888680","doi":null,"is_oa":false,"landing_page_url":"http://www.eurjanat.com/web/pdfdownload.php?id=08030139","pdf_url":null,"source":{"id":"https://openalex.org/S2764384229","display_name":"European Journal of Anatomy","issn_l":"1136-4890","issn":["1136-4890","2340-311X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","poland-20","russia-white-list-3","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Anatomy","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066974003","display_name":"M T Pascual-Morenilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M T Pascual-Morenilla","raw_affiliation_strings":["[University of Granada]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[University of Granada]","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083155843","display_name":"Miguel Guirao Pi\u00f1eyro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel Guirao-Pi\u00f1eyro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008882861","display_name":"F Robles-Garzon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Robles-Garzon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017906602","display_name":"J A Roda-Moreno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Roda-Moreno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074255531","display_name":"M Lopez-Soler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Lopez-Soler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039700946","display_name":"F Arrebola-Nacle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Arrebola-Nacle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010497868","display_name":"J. A. Casanova Llivina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. A. Casanova-Llivina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077844943","display_name":"O. Roda-Murillo","orcid":"https://orcid.org/0000-0001-8696-6313","observed_orcids":["https://orcid.org/0000-0001-8696-6313"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. Roda-Murillo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8696-6313","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00720115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"3","first_page":"139","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.31709998846054077,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.31709998846054077,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.28519999980926514,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.20319999754428864,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-hydroxybutyric-acid","display_name":"gamma-hydroxybutyric acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/eye-development","display_name":"eye development","score":0.7099999785423279},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.9639999866485596},{"id":"https://openalex.org/keywords/corneal-thickness","display_name":"corneal thickness","score":0.843999981880188},{"id":"https://openalex.org/keywords/lens-diameter","display_name":"lens diameter","score":0.777999997138977},{"id":"https://openalex.org/keywords/prenatal-drug-exposure","display_name":"prenatal drug exposure","score":0.6779999732971191},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.7654916644096375},{"id":"https://openalex.org/C2911064607","wikidata":"https://www.wikidata.org/wiki/Q207920","display_name":"Gamma hydroxybutyrate","level":2,"score":0.6427226662635803},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.6200544834136963},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5969483852386475},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5880764126777649},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5571475028991699},{"id":"https://openalex.org/C114696181","wikidata":"https://www.wikidata.org/wiki/Q5422650","display_name":"Eye development","level":4,"score":0.4527169167995453},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.41884222626686096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34200215339660645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3221580982208252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30437999963760376},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17153477668762207},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13801494240760803},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1004069447517395},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:43888680","doi":null,"is_oa":false,"landing_page_url":"http://www.eurjanat.com/web/pdfdownload.php?id=08030139","pdf_url":null,"source":{"id":"https://openalex.org/S2764384229","display_name":"European Journal of Anatomy","issn_l":"1136-4890","issn":["1136-4890","2340-311X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","poland-20","russia-white-list-3","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Anatomy","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W119161378","https://openalex.org/W1479669382","https://openalex.org/W1997585586","https://openalex.org/W2002169972","https://openalex.org/W2016865305","https://openalex.org/W2019009498","https://openalex.org/W2019429563","https://openalex.org/W2038702925","https://openalex.org/W2046275375","https://openalex.org/W2060116684","https://openalex.org/W2089687062","https://openalex.org/W2090456974","https://openalex.org/W2097437544","https://openalex.org/W2120091443","https://openalex.org/W2140034535","https://openalex.org/W2150472263","https://openalex.org/W2156277612","https://openalex.org/W2170663842","https://openalex.org/W2321482338","https://openalex.org/W2403986085"],"related_works":["https://openalex.org/W2372397054","https://openalex.org/W652509722","https://openalex.org/W7095437549","https://openalex.org/W2094530762","https://openalex.org/W1974620126","https://openalex.org/W2077989453","https://openalex.org/W7132975562","https://openalex.org/W1984792131","https://openalex.org/W2125329047","https://openalex.org/W133426904"],"abstract_inverted_index":{"Gamma-hydroxybutyrate":[0],"(GHB),":[1],"a":[2,16,176],"precursor":[3],"to":[4,34,64,121],"gamma":[5],"aminobutyric":[6],"acid":[7],"(GABA),":[8],"was":[9,119],"initially":[10],"employed":[11],"as":[12,155],"an":[13,47,59],"anesthetic.":[14],"As":[15],"relatively":[17],"novel":[18],"drug,":[19],"few":[20,29],"people":[21],"are":[22],"aware":[23],"of":[24,53,67,79,92,107,130,135,139,143,159,169,179],"its":[25,36,40],"harmful":[26],"effects":[27,38,101],"and":[28,87,99,152,162,164],"studies":[30],"have":[31],"been":[32],"undertaken":[33],"investigate":[35],"long-term":[37],"or":[39,76],"action":[41,52],"on":[42,50,55,181],"developing":[43,57],"tissues.":[44],"We":[45,145],"performed":[46],"experimental":[48],"study":[49],"the":[51,56,65,68,100,150,157,160,166,170],"GHB":[54,82,180],"eye,":[58],"organ":[60],"very":[61],"closely":[62],"related":[63],"development":[66],"CNS.":[69],"Chick":[70],"embryos":[71],"were":[72,102],"treated":[73,151],"with":[74],"20%":[75],"30%":[77],"dilutions":[78],"100":[80],"?l":[81],"at":[83,104],"7":[84],"(30-31":[85],"HH)":[86,90],"11":[88],"(37":[89],"days":[91,106],"incubation":[93,108],"(i.e.,":[94],"two":[95],"doses":[96],"per":[97],"group),":[98],"observed":[103,146],"21":[105],"(45":[109],"HH).":[110],"An":[111],"ophthalmologic":[112],"ultrasonography":[113],"device":[114],"(Hondex":[115],"A/B":[116],"SCAN":[117],"IS-500)":[118],"used":[120],"measure":[122],"different":[123],"eye":[124],"parameters":[125],"(corneal":[126],"thickness;":[127],"posterior":[128],"surface":[129,134],"cornea":[131,161],"-":[132],"anterior":[133],"lens;":[136,140],"anteroposterior":[137,141,167],"diameter":[138,142,168],"eye).":[144],"significant":[147],"differences":[148],"between":[149],"control":[153],"groups":[154],"regards":[156],"thickness":[158],"lens,":[163],"in":[165],"eye.":[171],"The":[172],"present":[173],"results":[174],"demonstrate":[175],"possible":[177],"effect":[178],"development.":[182]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}