{"id":"https://openalex.org/W4388862016","doi":"https://doi.org/10.3897/pharmacia.70.e111923","title":"Analysis of the pharmacotherapeutic effectiveness of the tyrosine kinase inhibitors therapy in patients with Chronic Myeloid Leukemia in a single hematology center in Plovdiv, Bulgaria","display_name":"Analysis of the pharmacotherapeutic effectiveness of the tyrosine kinase inhibitors therapy in patients with Chronic Myeloid Leukemia in a single hematology center in Plovdiv, Bulgaria","publication_year":2023,"publication_date":"2023-11-21","ids":{"openalex":"https://openalex.org/W4388862016","doi":"https://doi.org/10.3897/pharmacia.70.e111923"},"language":"en","primary_location":{"id":"doi:10.3897/pharmacia.70.e111923","doi":"https://doi.org/10.3897/pharmacia.70.e111923","is_oa":true,"landing_page_url":"https://doi.org/10.3897/pharmacia.70.e111923","pdf_url":null,"source":{"id":"https://openalex.org/S4210231629","display_name":"Pharmacia","issn_l":"0428-0296","issn":["0428-0296","2603-557X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacia","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4388862016"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3897/pharmacia.70.e111923","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060993952","display_name":"Veselina Goranova\u2010Marinova","orcid":"https://orcid.org/0000-0002-7811-162X","observed_orcids":["https://orcid.org/0000-0002-7811-162X"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Veselina Goranova-Marinova","raw_affiliation_strings":["Medical University Plovdiv, Plovdiv, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University Plovdiv, Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101570333","display_name":"Daniela Grekova","orcid":"https://orcid.org/0000-0002-4105-9485","observed_orcids":["https://orcid.org/0000-0002-4105-9485"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Daniela Grekova","raw_affiliation_strings":["Medical University Plovdiv, Plovdiv, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0002-4105-9485","affiliations":[{"raw_affiliation_string":"Medical University Plovdiv, Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021336614","display_name":"Vania Bozhidarova Georgieva","orcid":"https://orcid.org/0000-0001-6387-2402","observed_orcids":["https://orcid.org/0000-0001-6387-2402"]},"institutions":[{"id":"https://openalex.org/I4210108077","display_name":"Prof. Assen Zlatarov University","ror":"https://ror.org/020ak9w19","country_code":"BG","type":"education","lineage":["https://openalex.org/I4210108077"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Vania Georgieva","raw_affiliation_strings":["Prof. Assen Zlatarov University, Burgas, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0001-6387-2402","affiliations":[{"raw_affiliation_string":"Prof. Assen Zlatarov University, Burgas, Bulgaria","institution_ids":["https://openalex.org/I4210108077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084962402","display_name":"Kalina Andreevska","orcid":"https://orcid.org/0000-0001-6709-816X","observed_orcids":["https://orcid.org/0000-0001-6709-816X"]},"institutions":[{"id":"https://openalex.org/I58918642","display_name":"Sofia University \"St. Kliment Ohridski\"","ror":"https://ror.org/02jv3k292","country_code":"BG","type":"education","lineage":["https://openalex.org/I58918642"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Kalina Andreevska","raw_affiliation_strings":["Sofia University \"St. Kliment Ohridski\", Sofia, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0001-6709-816X","affiliations":[{"raw_affiliation_string":"Sofia University \"St. Kliment Ohridski\", Sofia, Bulgaria","institution_ids":["https://openalex.org/I58918642"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020012160","display_name":"Yana Gvozdeva","orcid":"https://orcid.org/0000-0002-7622-6060","observed_orcids":["https://orcid.org/0000-0002-7622-6060"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Yana Gvozdeva","raw_affiliation_strings":["Medical University Plovdiv, Plovdiv, Bulgaria","Research Institute at Medical University of Plovdiv, Plovdiv, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0002-7622-6060","affiliations":[{"raw_affiliation_string":"Medical University Plovdiv, Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]},{"raw_affiliation_string":"Research Institute at Medical University of Plovdiv, Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037715563","display_name":"Margarita I. Kassarova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Margarita Kassarova","raw_affiliation_strings":["Medical University Plovdiv, Plovdiv, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University Plovdiv, Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057360885","display_name":"Zhanet G. Grudeva-Popova","orcid":"https://orcid.org/0000-0003-4698-8600","observed_orcids":["https://orcid.org/0000-0003-4698-8600"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Zhanet Grudeva-Popova","raw_affiliation_strings":["Medical University Plovdiv, Plovdiv, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University Plovdiv, Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":100,"currency":"EUR","value_usd":107},"apc_paid":{"value":100,"currency":"EUR","value_usd":107},"fwci":0.9375,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.73413927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"70","issue":"4","first_page":"1355","last_page":"1362"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9639999866485596},{"id":"https://openalex.org/keywords/second-generation-tkis","display_name":"second-generation TKIs","score":0.8519999980926514},{"id":"https://openalex.org/keywords/bcr-abl1","display_name":"BCR-ABL1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6800000071525574},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6650000214576721},{"id":"https://openalex.org/keywords/molecular-monitoring","display_name":"molecular monitoring","score":0.8859999775886536},{"id":"https://openalex.org/keywords/chronic-phase","display_name":"chronic phase","score":0.8029999732971191},{"id":"https://openalex.org/keywords/blast-crisis","display_name":"blast crisis","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.942874014377594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7653038501739502},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.7567578554153442},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7019914388656616},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.6362776160240173},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.4664821922779083},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.45062851905822754},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.41857460141181946},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35466572642326355},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08314526081085205}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3897/pharmacia.70.e111923","doi":"https://doi.org/10.3897/pharmacia.70.e111923","is_oa":true,"landing_page_url":"https://doi.org/10.3897/pharmacia.70.e111923","pdf_url":null,"source":{"id":"https://openalex.org/S4210231629","display_name":"Pharmacia","issn_l":"0428-0296","issn":["0428-0296","2603-557X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacia","raw_type":"journal-article"},{"id":"pmh:10.3897/pharmacia.70.e111923","doi":null,"is_oa":true,"landing_page_url":"https://pharmacia.pensoft.net/article/111923/","pdf_url":null,"source":{"id":"https://openalex.org/S199213172","display_name":"ZooKeys","issn_l":"1313-2970","issn":["1313-2970","1313-2989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacia 70(4): 1355-1362","raw_type":"Research Article"},{"id":"pmh:oai:doaj.org/article:296bf2f76db640ebb5570c1bcd917154","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/296bf2f76db640ebb5570c1bcd917154","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacia, Vol 70, Iss 4, Pp 1355-1362 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3897/pharmacia.70.e111923","doi":"https://doi.org/10.3897/pharmacia.70.e111923","is_oa":true,"landing_page_url":"https://doi.org/10.3897/pharmacia.70.e111923","pdf_url":null,"source":{"id":"https://openalex.org/S4210231629","display_name":"Pharmacia","issn_l":"0428-0296","issn":["0428-0296","2603-557X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W123163326","https://openalex.org/W1587979812","https://openalex.org/W1894088929","https://openalex.org/W1968747503","https://openalex.org/W1987593147","https://openalex.org/W1989610523","https://openalex.org/W2014316424","https://openalex.org/W2025935458","https://openalex.org/W2028669471","https://openalex.org/W2035375550","https://openalex.org/W2091653492","https://openalex.org/W2100943317","https://openalex.org/W2107268345","https://openalex.org/W2109292561","https://openalex.org/W2117634410","https://openalex.org/W2128738046","https://openalex.org/W2151486690","https://openalex.org/W2261840157","https://openalex.org/W2329648702","https://openalex.org/W2549961409","https://openalex.org/W2737594272","https://openalex.org/W2802371729","https://openalex.org/W4253420620"],"related_works":["https://openalex.org/W2586061800","https://openalex.org/W3034822000","https://openalex.org/W2953285070","https://openalex.org/W4405049534","https://openalex.org/W2315118341","https://openalex.org/W2763262996","https://openalex.org/W4229980099","https://openalex.org/W2398378854","https://openalex.org/W2952920627","https://openalex.org/W7203770956"],"abstract_inverted_index":{"Aim.":[0],"The":[1,108,141],"aim":[2],"of":[3,31,84,135,215],"this":[4],"study":[5,69],"is":[6,119,128,189],"to":[7,12,25,191],"evaluate":[8],"treatment":[9,214],"retrospectively,":[10],"response":[11,159],"the":[13,28,37,63,68,125,170,213],"therapy":[14,139],"and":[15,24,56,60,70,77,102,124,151,180],"outcomes":[16],"in":[17,67,93,99,105,147,169,176,186,206,212,217],"patients":[18,48,79,131,149,167,216],"with":[19,49,80,162,178],"chronic":[20,94],"myeloid":[21],"leukemia":[22],"(CML)":[23],"what":[26],"extent":[27],"European":[29],"recommendations":[30],"LeukemiaNET":[32],"(ELN)":[33],"are":[34,209],"followed":[35],"at":[36,62],"Hematology":[38],"Clinic,":[39],"University":[40],"Hospital":[41],"\u201cSt.":[42],"Georgi\u201d,":[43],"MU":[44],"Plovdiv.":[45],"Methods.":[46],"All":[47,130],"Ph+,":[50],"BCR-ABL1+":[51],"CML":[52],"who":[53],"were":[54,65,71,88,92],"treated":[55,168],"observed":[57],"between":[58],"01.01.2018":[59],"12.31.2022":[61],"clinic":[64,172],"included":[66],"analyzed":[72],"retrospectively.":[73],"Results.":[74],"One":[75],"hundred":[76],"eighty-eight":[78],"a":[81,155,200],"mean":[82],"age":[83],"61.26":[85],"(21\u201391)":[86],"years":[87],"analyzed.":[89],"151":[90],"(80.3%)":[91],"phase":[95],"(CP),":[96],"27":[97],"(14.4%)":[98],"accelerating":[100],"one":[101],"10":[103],"(5.3%)":[104],"blast":[106],"crisis.":[107],"actual":[109],"overall":[110],"survival":[111,184],"rate":[112,127],"was":[113,145,160],"79.26%,":[114],"while":[115],"for":[116,203],"CP":[117],"it":[118],"very":[120],"high":[121],"\u2013":[122],"86.75%,":[123],"mortality":[126],"20.74%.":[129],"received":[132,154],"some":[133],"form":[134],"tyrosine":[136],"kinase":[137],"inhibitors":[138],"(TKIs-therapy).":[140],"first":[142],"line":[143],"TKI":[144],"imatinib":[146],"120":[148],"(64%),":[150],"68":[152],"(36%)":[153],"second-generation":[156],"TKI.":[157],"Treatment":[158],"monitored":[161],"TKIs":[163],"by":[164],"RT-qPCR.":[165],"Conclusion.CML":[166],"hematology":[171],"receive":[173],"standard":[174],"care":[175,188],"accordance":[177],"ELN":[179],"BMSH":[181],"recommendations.":[182],"Overall":[183],"(OS)":[185],"routine":[187],"comparable":[190],"published":[192],"data":[193],"from":[194],"international":[195],"studies.":[196],"Molecular":[197],"monitoring":[198],"provides":[199],"good":[201],"basis":[202],"disease":[204],"control":[205],"CP.":[207],"There":[208],"unmet":[210],"needs":[211],"advanced":[218],"stages.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-22T00:00:00"}
