{"id":"https://openalex.org/W4388835530","doi":"https://doi.org/10.1016/j.isci.2023.108489","title":"More time to kill: A longer liver stage increases T cell-mediated protection against pre-erythrocytic malaria","display_name":"More time to kill: A longer liver stage increases T cell-mediated protection against pre-erythrocytic malaria","publication_year":2023,"publication_date":"2023-11-20","ids":{"openalex":"https://openalex.org/W4388835530","doi":"https://doi.org/10.1016/j.isci.2023.108489","pmid":"https://pubmed.ncbi.nlm.nih.gov/38162031","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10755051"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2023.108489","doi":"https://doi.org/10.1016/j.isci.2023.108489","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2023.108489","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.isci.2023.108489","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101770551","display_name":"Naveen K. Yadav","orcid":"https://orcid.org/0000-0002-3052-8899","observed_orcids":["https://orcid.org/0000-0002-3052-8899"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naveen Yadav","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038384623","display_name":"Chaitra Parthiban","orcid":"https://orcid.org/0000-0003-0998-7764","observed_orcids":["https://orcid.org/0000-0003-0998-7764"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chaitra Parthiban","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084409415","display_name":"Zachary P. Billman","orcid":"https://orcid.org/0000-0001-7738-5795","observed_orcids":["https://orcid.org/0000-0001-7738-5795"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary P. Billman","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110159471","display_name":"Brad C. Stone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad C. Stone","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Felicia N. Watson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Felicia N. Watson","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045799128","display_name":"Kevin Zhou","orcid":"https://orcid.org/0000-0001-9218-6743","observed_orcids":["https://orcid.org/0000-0001-9218-6743"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Zhou","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068330069","display_name":"Tayla M. Olsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tayla M. Olsen","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071683467","display_name":"Irene Cruz Talavera","orcid":"https://orcid.org/0000-0002-0500-3038","observed_orcids":["https://orcid.org/0000-0002-0500-3038"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene Cruz Talavera","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070774961","display_name":"Annette M. Seilie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annette Mariko Seilie","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060378402","display_name":"Anya C. Kalata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anya C. Kalata","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076825181","display_name":"Jokichi Matsubara","orcid":"https://orcid.org/0009-0008-8005-1727","observed_orcids":["https://orcid.org/0009-0008-8005-1727"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jokichi Matsubara","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046081413","display_name":"Melanie J. Shears","orcid":"https://orcid.org/0000-0002-8226-4354","observed_orcids":["https://orcid.org/0000-0002-8226-4354"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie J. Shears","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113859281","display_name":"Rebekah A. Reynolds","orcid":"https://orcid.org/0000-0002-1141-0932","observed_orcids":["https://orcid.org/0000-0002-1141-0932"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebekah A. Reynolds","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054620494","display_name":"Sean C. Murphy","orcid":"https://orcid.org/0000-0002-2048-0131","observed_orcids":["https://orcid.org/0000-0002-2048-0131"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sean C. Murphy","raw_affiliation_strings":["Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","Department of Microbiology, University of Washington, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2048-0131","affiliations":[{"raw_affiliation_string":"Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Microbiology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054620494"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":{"value":3150,"currency":"USD","value_usd":3150},"fwci":1.4743,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.81721711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":97},"biblio":{"volume":"26","issue":"12","first_page":"108489","last_page":"108489"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/sporozoite-vaccine","display_name":"sporozoite vaccine","score":0.5569999814033508},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9340000152587891},{"id":"https://openalex.org/keywords/malaria-vaccine-development","display_name":"malaria vaccine development","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.7313213348388672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5318809151649475},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.5245052576065063},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5107486248016357},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5079007744789124},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.500525712966919},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.45511654019355774},{"id":"https://openalex.org/C2778675580","wikidata":"https://www.wikidata.org/wiki/Q614956","display_name":"Plasmodium (life cycle)","level":3,"score":0.4269251227378845},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4236396551132202},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.42225149273872375},{"id":"https://openalex.org/C180032290","wikidata":"https://www.wikidata.org/wiki/Q1664296","display_name":"Inoculation","level":2,"score":0.42119884490966797},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3923473060131073},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2994850277900696},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.20843970775604248},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09716871380805969},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08782389760017395},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.isci.2023.108489","doi":"https://doi.org/10.1016/j.isci.2023.108489","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2023.108489","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.4397207","doi":"https://doi.org/10.2139/ssrn.4397207","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4397207","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10755051","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10755051","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10755051/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Text"},{"id":"pmid:38162031","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38162031","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:785bc2f629ce4eeb89ee479e29c9795b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/785bc2f629ce4eeb89ee479e29c9795b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, Vol 26, Iss 12, Pp 108489- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2023.108489","doi":"https://doi.org/10.1016/j.isci.2023.108489","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2023.108489","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G189162732","display_name":"Identification of responding CD8+ T cells and novel protective epitopes following","funder_award_id":"K08AI097238","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4536318664","display_name":"Liver resident memory for malaria","funder_award_id":"R01AI141857","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320311684","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/01njes783"},{"id":"https://openalex.org/F4320312687","display_name":"Children\u2019s Hospital of Wisconsin Research Institute","ror":"https://ror.org/058g1h315"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388835530.pdf","grobid_xml":"https://content.openalex.org/works/W4388835530.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1532851064","https://openalex.org/W1603402405","https://openalex.org/W1967351936","https://openalex.org/W1990423632","https://openalex.org/W2004979064","https://openalex.org/W2006786031","https://openalex.org/W2016749309","https://openalex.org/W2017552802","https://openalex.org/W2029128803","https://openalex.org/W2060192818","https://openalex.org/W2109963121","https://openalex.org/W2110745776","https://openalex.org/W2119855808","https://openalex.org/W2120160949","https://openalex.org/W2121412731","https://openalex.org/W2129895984","https://openalex.org/W2133945584","https://openalex.org/W2134168246","https://openalex.org/W2134916334","https://openalex.org/W2136187101","https://openalex.org/W2136878748","https://openalex.org/W2137022726","https://openalex.org/W2138891368","https://openalex.org/W2140468443","https://openalex.org/W2140673578","https://openalex.org/W2141856380","https://openalex.org/W2144049034","https://openalex.org/W2146175972","https://openalex.org/W2163861382","https://openalex.org/W2319745231","https://openalex.org/W2344418834","https://openalex.org/W2346928357","https://openalex.org/W2525642000","https://openalex.org/W2611631225","https://openalex.org/W2755393274","https://openalex.org/W2766359681","https://openalex.org/W2769766013","https://openalex.org/W2782270041","https://openalex.org/W2789026035","https://openalex.org/W2789171034","https://openalex.org/W2888613674","https://openalex.org/W2921569643","https://openalex.org/W2922405355","https://openalex.org/W2971688962","https://openalex.org/W3002271205","https://openalex.org/W3082174280","https://openalex.org/W3207444781","https://openalex.org/W3210708964","https://openalex.org/W4214712369","https://openalex.org/W4311821456","https://openalex.org/W4321378731"],"related_works":["https://openalex.org/W4360897849","https://openalex.org/W2123094518","https://openalex.org/W2967581371","https://openalex.org/W2012497305","https://openalex.org/W4362522730","https://openalex.org/W2772623565","https://openalex.org/W2123955674","https://openalex.org/W1967772965","https://openalex.org/W2058414194","https://openalex.org/W2579911248"],"abstract_inverted_index":{"Liver":[0],"stage":[1],"(LS)":[2],"Plasmodia":[3],"mature":[4],"in":[5,8,14,102,111,128],"2-2.5":[6],"days":[7,13,46,76],"rodents":[9],"compared":[10],"to":[11,67],"5-6":[12],"humans.":[15],"Plasmodium-specific":[16],"CD8+":[17,31,97,124],"T":[18,32,69,98,125],"cell":[19,70,99,126],"expansion":[20,127],"differs":[21],"across":[22],"these":[23],"varied":[24],"timespans.":[25],"To":[26],"mimic":[27],"the":[28,94,103,131],"kinetics":[29,122],"of":[30,34,47,63,105,123],"cells":[33],"human":[35],"Plasmodium":[36],"infection,":[37],"a":[38,59],"two-dose":[39,91,106,147],"challenge":[40,87,95,148],"mouse":[41],"model":[42,119],"that":[43,82,117],"achieved":[44],"4-5":[45],"LS":[48],"exposure":[49],"was":[50],"developed.":[51],"In":[52],"this":[53,118,146],"model,":[54],"mice":[55,108],"were":[56],"inoculated":[57],"with":[58,78],"non-protective,":[60],"low":[61],"dose":[62],"late-arresting,":[64],"genetically-attenuated":[65],"sporozoites":[66],"initiate":[68],"activation":[71],"and":[72,137],"then":[73],"re-inoculated":[74],"2-3":[75],"later":[77],"wild-type":[79],"sporozoites.":[80],"Vaccines":[81],"partially":[83],"protected":[84,89],"against":[85,90],"traditional":[86],"completely":[88],"challenge.":[92],"During":[93],"period,":[96],"frequencies":[100],"increased":[101],"livers":[104],"challenged":[107,113],"but":[109],"not":[110],"traditionally":[112],"mice,":[114],"further":[115],"suggesting":[116],"better":[120],"recapitulates":[121],"humans":[129],"during":[130],"P.":[132],"falciparum":[133],"LS.":[134],"Vaccine":[135],"development":[136],"antigen":[138],"discovery":[139],"efforts":[140],"may":[141],"be":[142],"aided":[143],"by":[144],"using":[145],"strategy.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-11-21T00:00:00"}
