{"id":"https://openalex.org/W4388770907","doi":"https://doi.org/10.21294/1814-4861-2023-22-5-84-95","title":"Results of combined and chemoradiation treatment of patients with thoracic esophageal cancer according to the data of the regional cancer center","display_name":"Results of combined and chemoradiation treatment of patients with thoracic esophageal cancer according to the data of the regional cancer center","publication_year":2023,"publication_date":"2023-11-15","ids":{"openalex":"https://openalex.org/W4388770907","doi":"https://doi.org/10.21294/1814-4861-2023-22-5-84-95"},"language":"en","primary_location":{"id":"doi:10.21294/1814-4861-2023-22-5-84-95","doi":"https://doi.org/10.21294/1814-4861-2023-22-5-84-95","is_oa":true,"landing_page_url":"https://doi.org/10.21294/1814-4861-2023-22-5-84-95","pdf_url":"https://www.siboncoj.ru/jour/article/download/2763/1160","source":{"id":"https://openalex.org/S4210184057","display_name":"Siberian Journal of Oncology","issn_l":"1814-4861","issn":["1814-4861","2312-3168"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312790","host_organization_name":"Tomsk National Research Medical Center of the Russian Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310312790"],"host_organization_lineage_names":["Tomsk National Research Medical Center of the Russian Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Siberian journal of oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.siboncoj.ru/jour/article/download/2763/1160","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091563648","display_name":"\u0415. \u0410. \u0422\u043e\u043d\u0435\u0435\u0432","orcid":"https://orcid.org/0000-0001-8590-2350","observed_orcids":["https://orcid.org/0000-0001-8590-2350"]},"institutions":[{"id":"https://openalex.org/I194437852","display_name":"Ulyanovsk State University","ror":"https://ror.org/02vn11j58","country_code":"RU","type":"education","lineage":["https://openalex.org/I194437852"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. A. Toneev","raw_affiliation_strings":["Regional Clinical Cancer Center; Ulyanovsk State University"],"raw_orcid":"https://orcid.org/0000-0001-8590-2350","affiliations":[{"raw_affiliation_string":"Regional Clinical Cancer Center; Ulyanovsk State University","institution_ids":["https://openalex.org/I194437852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077085011","display_name":"\u041e. \u0412. \u041f\u0438\u043a\u0438\u043d","orcid":"https://orcid.org/0000-0001-6871-6804","observed_orcids":["https://orcid.org/0000-0001-6871-6804"]},"institutions":[{"id":"https://openalex.org/I4210139937","display_name":"P.A. Hertzen Moscow Oncology Research Institute","ror":"https://ror.org/04rbazs75","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117042","https://openalex.org/I4210139937"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"\u041e. V. Pikin","raw_affiliation_strings":["P.A. Hertsen Moscow Oncology Research Institute \u2013 Branch of the National Medical Research Radiological Centre of the Ministryof Health of the Russia"],"raw_orcid":"https://orcid.org/0000-0001-6871-6804","affiliations":[{"raw_affiliation_string":"P.A. Hertsen Moscow Oncology Research Institute \u2013 Branch of the National Medical Research Radiological Centre of the Ministryof Health of the Russia","institution_ids":["https://openalex.org/I4210139937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009521774","display_name":"Natalia Dengina","orcid":"https://orcid.org/0000-0002-6608-2745","observed_orcids":["https://orcid.org/0000-0002-6608-2745"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. V. Dengina","raw_affiliation_strings":["Regional Clinical Cancer Center"],"raw_orcid":"https://orcid.org/0000-0002-6608-2745","affiliations":[{"raw_affiliation_string":"Regional Clinical Cancer Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109737012","display_name":"\u0410. B. Ryabov","orcid":"https://orcid.org/0000-0002-1037-2364","observed_orcids":["https://orcid.org/0000-0002-1037-2364"]},"institutions":[{"id":"https://openalex.org/I4210139937","display_name":"P.A. Hertzen Moscow Oncology Research Institute","ror":"https://ror.org/04rbazs75","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117042","https://openalex.org/I4210139937"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. B. Ryabov","raw_affiliation_strings":["P.A. Hertsen Moscow Oncology Research Institute \u2013 Branch of the National Medical Research Radiological Centre of the Ministryof Health of the Russia; National Medical Research Radiological Centre of the Ministryof Health of the Russia"],"raw_orcid":"https://orcid.org/0000-0002-1037-2364","affiliations":[{"raw_affiliation_string":"P.A. Hertsen Moscow Oncology Research Institute \u2013 Branch of the National Medical Research Radiological Centre of the Ministryof Health of the Russia; National Medical Research Radiological Centre of the Ministryof Health of the Russia","institution_ids":["https://openalex.org/I4210139937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031574013","display_name":"Aleksandr Aleksandrovich Martynov","orcid":"https://orcid.org/0000-0003-4662-9886","observed_orcids":["https://orcid.org/0000-0003-4662-9886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. A. \u041cartynov","raw_affiliation_strings":["Regional Clinical Cancer Center"],"raw_orcid":"https://orcid.org/0000-0003-4662-9886","affiliations":[{"raw_affiliation_string":"Regional Clinical Cancer Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071125046","display_name":"Alexandra Galchin","orcid":"https://orcid.org/0000-0002-9350-6785","observed_orcids":["https://orcid.org/0000-0002-9350-6785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0410. V. Galchin","raw_affiliation_strings":["Regional Clinical Cancer Center"],"raw_orcid":"https://orcid.org/0000-0002-9350-6785","affiliations":[{"raw_affiliation_string":"Regional Clinical Cancer Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. N. Isaev","orcid":"https://orcid.org/0000-0001-9903-1816","observed_orcids":["https://orcid.org/0000-0001-9903-1816"]},"institutions":[{"id":"https://openalex.org/I194437852","display_name":"Ulyanovsk State University","ror":"https://ror.org/02vn11j58","country_code":"RU","type":"education","lineage":["https://openalex.org/I194437852"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. N. Isaev","raw_affiliation_strings":["Ulyanovsk State University"],"raw_orcid":"https://orcid.org/0000-0001-9903-1816","affiliations":[{"raw_affiliation_string":"Ulyanovsk State University","institution_ids":["https://openalex.org/I194437852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071835836","display_name":"A. A. Firstov","orcid":"https://orcid.org/0000-0002-2551-9795","observed_orcids":["https://orcid.org/0000-0002-2551-9795"]},"institutions":[{"id":"https://openalex.org/I194437852","display_name":"Ulyanovsk State University","ror":"https://ror.org/02vn11j58","country_code":"RU","type":"education","lineage":["https://openalex.org/I194437852"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. A. Firstov","raw_affiliation_strings":["Ulyanovsk State University"],"raw_orcid":"https://orcid.org/0000-0002-2551-9795","affiliations":[{"raw_affiliation_string":"Ulyanovsk State University","institution_ids":["https://openalex.org/I194437852"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115645568","display_name":"Daniil Dmitrievich Prokhorov","orcid":"https://orcid.org/0000-0002-0827-0115","observed_orcids":["https://orcid.org/0000-0002-0827-0115"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210127240","display_name":"Samara State Medical University","ror":"https://ror.org/02z5czc07","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210127240"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. D. Prohorov","raw_affiliation_strings":["Samara State Medical University of the Ministry of Health of Russia"],"raw_orcid":"https://orcid.org/0000-0002-0827-0115","affiliations":[{"raw_affiliation_string":"Samara State Medical University of the Ministry of Health of Russia","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210127240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0682,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.73904947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"22","issue":"5","first_page":"84","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11658","display_name":"Esophageal and GI Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thoracic-esophageal-cancer","display_name":"thoracic esophageal cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/concurrent-chemoradiotherapy","display_name":"concurrent chemoradiotherapy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/esophagectomy","display_name":"esophagectomy","score":0.8510000109672546},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.8420000076293945},{"id":"https://openalex.org/keywords/clinical-complete-response","display_name":"clinical complete response","score":0.8149999976158142},{"id":"https://openalex.org/keywords/treatment-related-complications","display_name":"treatment complications","score":0.5899999737739563},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.8989999890327454},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7630000114440918},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.9509999752044678},{"id":"https://openalex.org/keywords/locally-advanced-esophageal-cancer","display_name":"locally advanced esophageal cancer","score":0.9570000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9514336585998535},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.7985174655914307},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.6582319736480713},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5508924126625061},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5468946099281311},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5367257595062256},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5016989707946777},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.42705482244491577},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3741440176963806}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21294/1814-4861-2023-22-5-84-95","doi":"https://doi.org/10.21294/1814-4861-2023-22-5-84-95","is_oa":true,"landing_page_url":"https://doi.org/10.21294/1814-4861-2023-22-5-84-95","pdf_url":"https://www.siboncoj.ru/jour/article/download/2763/1160","source":{"id":"https://openalex.org/S4210184057","display_name":"Siberian Journal of Oncology","issn_l":"1814-4861","issn":["1814-4861","2312-3168"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312790","host_organization_name":"Tomsk National Research Medical Center of the Russian Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310312790"],"host_organization_lineage_names":["Tomsk National Research Medical Center of the Russian Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Siberian journal of oncology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:0add944a45c74112bb63acf09acd558d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0add944a45c74112bb63acf09acd558d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0421\u0438\u0431\u0438\u0440\u0441\u043a\u0438\u0439 \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b, Vol 22, Iss 5, Pp 84-95 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.21294/1814-4861-2023-22-5-84-95","doi":"https://doi.org/10.21294/1814-4861-2023-22-5-84-95","is_oa":true,"landing_page_url":"https://doi.org/10.21294/1814-4861-2023-22-5-84-95","pdf_url":"https://www.siboncoj.ru/jour/article/download/2763/1160","source":{"id":"https://openalex.org/S4210184057","display_name":"Siberian Journal of Oncology","issn_l":"1814-4861","issn":["1814-4861","2312-3168"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312790","host_organization_name":"Tomsk National Research Medical Center of the Russian Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310312790"],"host_organization_lineage_names":["Tomsk National Research Medical Center of the Russian Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Siberian journal of oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388770907.pdf","grobid_xml":"https://content.openalex.org/works/W4388770907.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1965623412","https://openalex.org/W2127356591","https://openalex.org/W2497800384","https://openalex.org/W2531468279","https://openalex.org/W2762361020","https://openalex.org/W2980485478","https://openalex.org/W3012572041","https://openalex.org/W3036358233","https://openalex.org/W3154482193","https://openalex.org/W3166655131","https://openalex.org/W4288058676"],"related_works":["https://openalex.org/W1969183945","https://openalex.org/W1964459162","https://openalex.org/W121742132","https://openalex.org/W2769754705","https://openalex.org/W1968027910","https://openalex.org/W6996138601","https://openalex.org/W154441457","https://openalex.org/W2248528782","https://openalex.org/W3029476762","https://openalex.org/W2015731659"],"abstract_inverted_index":{"Background.":[0],"esophageal":[1,50,70,96,264],"cancer":[2,71,77,97,265],"(ec)":[3],"is":[4,17,277,296],"one":[5],"of":[6,11,20,28,36,65,79,137,140,144,156,198,208,256],"the":[7,12,18,29,34,75,135,231,289,300],"most":[8],"aggressive":[9],"malignancies":[10],"gastrointestinal":[13],"tract.":[14],"chemoradiation":[15,37],"therapy":[16,38],"standard":[19],"care":[21],"for":[22,85,286],"locally":[23],"advanced":[24],"ec.":[25],"The":[26,115,166,196,216,242,254],"purpose":[27],"study":[30],"was":[31,147,203,227,239],"to":[32,59,107,128,132,176,282,292,298],"evaluate":[33],"efficacy":[35],"given":[39],"alone":[40],"and":[41,53,102,134,174,180,191,230,248,258,284],"in":[42,46,74,112,149,161,171,220,235,260,269,272],"combination":[43,255],"with":[44,48,68,222,237,262],"surgery":[45,177,213,259,287],"patients":[47,67,82,98,125,151,163,172,210,221,236,261],"thoracic":[49,69,95,263],"cancer.":[51],"Material":[52],"Methods.":[54],"From":[55],"January":[56],"1,":[57],"2012":[58],"december":[60],"31,":[61],"2021,":[62],"a":[63,278],"total":[64],"940":[66],"were":[72,83,109,126,159,178,189,246],"registered":[73],"regional":[76],"registry,":[78],"which":[80],"178":[81],"selected":[84],"concurrent":[86],"chemoradiotherapy":[87,257],"(CRT)":[88],"at":[89],"clinical":[90,223,280],"stages":[91],"I\u2013III.":[92],"thirty":[93],"seven":[94],"who":[99,211],"received":[100],"CRT":[101,283],"required":[103],"treatment":[104,130],"interruption":[105],"due":[106,131],"complications":[108,139,155],"not":[110],"included":[111,118],"our":[113,273],"analysis.":[114],"final":[116],"analysis":[117],"141":[119],"patients.":[120],"Results.":[121],"37":[122],"(20.7":[123],"%)":[124],"unable":[127],"complete":[129,200,224,279],"intolerance":[133],"development":[136],"severe":[138],"CRT.":[141],"Hematological":[142],"toxicity":[143],"grade":[145,157],"3-4":[146],"noted":[148,160],"21":[150,247],"(14.8":[152],"%).":[153,165],"Non-hematological":[154],"2-4":[158],"109":[162],"(77.3":[164],"5-year":[167,186],"relapse-free":[168],"survival":[169,187,218,233,244,271],"rates":[170,188,245],"undergoing":[173],"non-undergoing":[175],"23.0":[179],"25.0":[181],"%,":[182,193,250],"respectively":[183,194,251],"(p=0.018).":[184],"Overall":[185],"24":[190],"27":[192],"(p=0.020).":[195],"rate":[197],"pathological":[199],"response":[201,225,281],"(pcR)":[202],"43.5":[204],"%":[205],"(in":[206],"20":[207],"46":[209],"underwent":[212],"after":[214],"CRT).":[215],"median":[217,232],"time":[219,234],"(ccR)":[226],"24.0":[228],"months":[229],"pcR":[238],"29.0":[240],"months.":[241],"3-year":[243],"45":[249],"(p=0.050).":[252],"Conclusion.":[253],"demonstrated":[266],"an":[267],"increase":[268],"overall":[270],"study.":[274],"if":[275],"there":[276],"contraindications":[285],"or":[288],"patient\u2019s":[290],"refusal":[291],"undergo":[293],"surgery,":[294],"it":[295],"advisable":[297],"use":[299],"\u201cwait":[301],"&":[302],"watch\u201d":[303],"tactic.":[304]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2023-11-18T00:00:00"}
