{"id":"https://openalex.org/W4388766960","doi":"https://doi.org/10.1016/j.ijpharm.2023.123614","title":"Self-emulsifying drug delivery systems (SEDDS) disrupt the gut microbiota and trigger an intestinal inflammatory response in rats","display_name":"Self-emulsifying drug delivery systems (SEDDS) disrupt the gut microbiota and trigger an intestinal inflammatory response in rats","publication_year":2023,"publication_date":"2023-11-17","ids":{"openalex":"https://openalex.org/W4388766960","doi":"https://doi.org/10.1016/j.ijpharm.2023.123614","pmid":"https://pubmed.ncbi.nlm.nih.gov/37979632"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijpharm.2023.123614","doi":"https://doi.org/10.1016/j.ijpharm.2023.123614","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2023.123614","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0378517323010359-ga1_lrg.jpg","source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0378517323010359-ga1_lrg.jpg","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014552906","display_name":"Santhni Subramaniam","orcid":"https://orcid.org/0000-0003-2945-851X","observed_orcids":["https://orcid.org/0000-0003-2945-851X"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Santhni Subramaniam","raw_affiliation_strings":["Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia"],"raw_orcid":"https://orcid.org/0000-0003-2945-851X","affiliations":[{"raw_affiliation_string":"Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028867323","display_name":"Aurelia S. Elz","orcid":"https://orcid.org/0000-0001-6768-8223","observed_orcids":["https://orcid.org/0000-0001-6768-8223"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Aurelia Elz","raw_affiliation_strings":["Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia"],"raw_orcid":"https://orcid.org/0000-0001-6768-8223","affiliations":[{"raw_affiliation_string":"Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025170328","display_name":"Anthony D. Wignall","orcid":"https://orcid.org/0000-0002-6564-7927","observed_orcids":["https://orcid.org/0000-0002-6564-7927"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anthony Wignall","raw_affiliation_strings":["Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088900629","display_name":"Srinivas Kamath","orcid":"https://orcid.org/0000-0002-7502-1581","observed_orcids":["https://orcid.org/0000-0002-7502-1581"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Srinivas Kamath","raw_affiliation_strings":["Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia"],"raw_orcid":"https://orcid.org/0000-0002-7502-1581","affiliations":[{"raw_affiliation_string":"Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092143039","display_name":"Amin Ariaee","orcid":"https://orcid.org/0000-0002-4649-219X","observed_orcids":["https://orcid.org/0000-0002-4649-219X"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Amin Ariaee","raw_affiliation_strings":["Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia"],"raw_orcid":"https://orcid.org/0000-0002-4649-219X","affiliations":[{"raw_affiliation_string":"Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042296051","display_name":"Alexander Hunter","orcid":"https://orcid.org/0000-0003-2448-5164","observed_orcids":["https://orcid.org/0000-0003-2448-5164"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Alexander Hunter","raw_affiliation_strings":["Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093282000","display_name":"Tahlia Newblack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tahlia Newblack","raw_affiliation_strings":["Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052756021","display_name":"Hannah R. Wardill","orcid":"https://orcid.org/0000-0002-6613-3661","observed_orcids":["https://orcid.org/0000-0002-6613-3661"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hannah R. Wardill","raw_affiliation_strings":["Supportive Oncology Research Group, Precision Cancer Medicine (Theme), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide, South Australia, Australia"],"raw_orcid":"https://orcid.org/0000-0002-6613-3661","affiliations":[{"raw_affiliation_string":"Supportive Oncology Research Group, Precision Cancer Medicine (Theme), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide, South Australia, Australia","institution_ids":["https://openalex.org/I4210137740","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023179049","display_name":"Clive A. Prestidge","orcid":"https://orcid.org/0000-0001-5401-7535","observed_orcids":["https://orcid.org/0000-0001-5401-7535"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Clive A. Prestidge","raw_affiliation_strings":["Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia","institution_ids":["https://openalex.org/I170239107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050086795","display_name":"Paul Joyce","orcid":"https://orcid.org/0000-0003-3619-7901","observed_orcids":["https://orcid.org/0000-0003-3619-7901"]},"institutions":[{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107","https://openalex.org/I4405259444"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Paul Joyce","raw_affiliation_strings":["Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia. Electronic address: paul.joyce@unisa.edu.au","Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia"],"raw_orcid":"https://orcid.org/0000-0003-3619-7901","affiliations":[{"raw_affiliation_string":"Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia. Electronic address: paul.joyce@unisa.edu.au","institution_ids":["https://openalex.org/I170239107"]},{"raw_affiliation_string":"Centre for Pharmaceutical Innovation (CPI), UniSA Clinical & Health Sciences, University of South Australia, South Australia, Australia","institution_ids":["https://openalex.org/I170239107"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050086795"],"corresponding_institution_ids":["https://openalex.org/I170239107"],"apc_list":{"value":4050,"currency":"USD","value_usd":4050},"apc_paid":{"value":4050,"currency":"USD","value_usd":4050},"fwci":3.5507,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.95132739,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"648","issue":null,"first_page":"123614","last_page":"123614"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.045499999076128006,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-emulsifying-drug-delivery-systems","display_name":"self-emulsifying drug delivery systems","score":1.0},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8870000243186951},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/surfactant-toxicity","display_name":"surfactant toxicity","score":0.6610000133514404},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.6899999976158142},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mucosal-injury","display_name":"mucosal injury","score":0.6809999942779541},{"id":"https://openalex.org/keywords/citrulline","display_name":"citrulline","score":0.9580000042915344},{"id":"https://openalex.org/keywords/enterocyte-mass","display_name":"enterocyte mass","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mucosal-barrier-integrity","display_name":"mucosal integrity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/poorly-water-soluble-drugs","display_name":"poorly water-soluble drugs","score":0.8960000276565552},{"id":"https://openalex.org/keywords/oral-drug-absorption","display_name":"oral drug absorption","score":0.6380000114440918},{"id":"https://openalex.org/keywords/alpha-and-beta-diversity","display_name":"alpha and beta diversity","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7767881751060486},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.7219025492668152},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.6123454570770264},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.596847653388977},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48240482807159424},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4557064175605774},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3917478919029236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3579757809638977},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2908380627632141},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004655","descriptor_name":"Emulsions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ijpharm.2023.123614","doi":"https://doi.org/10.1016/j.ijpharm.2023.123614","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2023.123614","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0378517323010359-ga1_lrg.jpg","source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:37979632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37979632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:urm_publish:9916812631501831","doi":null,"is_oa":true,"landing_page_url":"https://find.library.unisa.edu.au/discovery/fulldisplay/alma9916812631501831/61USOUTHAUS_INST:ROR","pdf_url":null,"source":{"id":"https://openalex.org/S4306402528","display_name":"UniSA Research Outputs Repository (University of South Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170239107","host_organization_name":"University of South Australia","host_organization_lineage":["https://openalex.org/I170239107"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/141395","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2440/141395","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dx.doi.org/10.1016/j.ijpharm.2023.123614","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1016/j.ijpharm.2023.123614","doi":"https://doi.org/10.1016/j.ijpharm.2023.123614","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2023.123614","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0378517323010359-ga1_lrg.jpg","source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1460065051","display_name":null,"funder_award_id":"2022-CF-EMCR-004-25314","funder_id":"https://openalex.org/F4320311494","funder_display_name":"Hospital Research Foundation"},{"id":"https://openalex.org/G4930903517","display_name":null,"funder_award_id":"C-F-EMCR-007","funder_id":"https://openalex.org/F4320311494","funder_display_name":"Hospital Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320311494","display_name":"Hospital Research Foundation","ror":"https://ror.org/043ae3f44"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388766960.pdf","grobid_xml":"https://content.openalex.org/works/W4388766960.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W877762747","https://openalex.org/W1517725301","https://openalex.org/W1965658479","https://openalex.org/W1983766165","https://openalex.org/W1999971484","https://openalex.org/W2011068615","https://openalex.org/W2025226890","https://openalex.org/W2025931589","https://openalex.org/W2028381865","https://openalex.org/W2031177552","https://openalex.org/W2041016731","https://openalex.org/W2049875108","https://openalex.org/W2066927092","https://openalex.org/W2072944905","https://openalex.org/W2088222708","https://openalex.org/W2089926889","https://openalex.org/W2101223910","https://openalex.org/W2104878413","https://openalex.org/W2108833494","https://openalex.org/W2129064965","https://openalex.org/W2134657806","https://openalex.org/W2149848289","https://openalex.org/W2151100255","https://openalex.org/W2314428349","https://openalex.org/W2371568955","https://openalex.org/W2428352895","https://openalex.org/W2553390583","https://openalex.org/W2567305286","https://openalex.org/W2603041755","https://openalex.org/W2619161623","https://openalex.org/W2734566240","https://openalex.org/W2770966235","https://openalex.org/W2792021903","https://openalex.org/W2792105006","https://openalex.org/W2792335666","https://openalex.org/W2892573222","https://openalex.org/W2903342493","https://openalex.org/W2948289250","https://openalex.org/W3024321726","https://openalex.org/W3026885758","https://openalex.org/W3092266691","https://openalex.org/W3092595393","https://openalex.org/W3113591600","https://openalex.org/W3113863643","https://openalex.org/W3127975357","https://openalex.org/W3128013585","https://openalex.org/W3139243481","https://openalex.org/W3146898691","https://openalex.org/W3192282135","https://openalex.org/W3192465278","https://openalex.org/W3200743777","https://openalex.org/W3202085543","https://openalex.org/W3212632306","https://openalex.org/W4210377299","https://openalex.org/W4281609143","https://openalex.org/W4310788486","https://openalex.org/W4377862020","https://openalex.org/W4380318669","https://openalex.org/W4383186796","https://openalex.org/W4387007908","https://openalex.org/W6676128747","https://openalex.org/W6810750738"],"related_works":["https://openalex.org/W7097702879","https://openalex.org/W4372342192","https://openalex.org/W4308941206","https://openalex.org/W2182509231","https://openalex.org/W7110513496","https://openalex.org/W2182810846","https://openalex.org/W3082158726","https://openalex.org/W1523400819","https://openalex.org/W2338941473","https://openalex.org/W2593641876"],"abstract_inverted_index":{"Self-emulsifying":[0],"drug":[1,32],"delivery":[2],"systems":[3],"(i.e.":[4,126],"SEDDS,":[5],"SMEDDS":[6],"and":[7,14,54,71,130,146,161,216,235],"SNEDDS)":[8],"are":[9,231],"widely":[10],"employed":[11],"as":[12],"solubility":[13],"bioavailability":[15],"enhancing":[16],"formulation":[17],"strategies":[18],"for":[19,26,41,118,226,239],"poorly":[20],"water-soluble":[21],"drugs.":[22],"Despite":[23],"the":[24,39,61,64,81,86,93,100,106,135,144,149,189,196,237,249],"capacity":[25,40],"SEDDS":[27,84,104,121,234,247],"to":[28,38,50,79,98,134,143,175],"effectively":[29],"facilitate":[30],"oral":[31,114],"absorption,":[33],"tolerability":[34],"concerns":[35],"exist":[36],"due":[37],"high":[42],"concentrations":[43],"of":[44,63,83,95,103,109,148,177,183,192,213,246],"surfactants":[45],"(typically":[46],"present":[47],"within":[48,195],"SEDDS)":[49],"induce":[51],"gastrointestinal":[52,250],"toxicity":[53],"mucosal":[55,72,199,217],"irritation.":[56],"With":[57],"new":[58],"knowledge":[59],"surrounding":[60],"role":[62],"gut":[65,87,107,150,184],"microbiota":[66,108,185],"in":[67,156,171,206,252],"modulating":[68],"intestinal":[69],"inflammation":[70],"injury,":[73],"there":[74],"is":[75,92],"a":[76,123,154,210,253],"clear":[77],"need":[78,238],"determine":[80],"impact":[82,102],"on":[85,105,248],"microbiota.":[88],"The":[89],"current":[90],"study":[91],"first":[94],"its":[96],"kind":[97],"demonstrate":[99],"detrimental":[101],"Sprague-Dawley":[110],"rats,":[111],"following":[112],"daily":[113],"administration":[115],"(100":[116],"mg/kg)":[117],"21":[119],"days.":[120],"comprising":[122],"lipid":[124],"phase":[125],"Type":[127],"I,":[128],"II":[129],"III":[131],"formulations":[132],"according":[133],"Lipid":[136],"Formulation":[137],"Classification":[138],"Scheme)":[139],"induced":[140],"significant":[141,169,204],"changes":[142],"composition":[145],"diversity":[147,163,173],"microbiota,":[151],"evidenced":[152],"through":[153],"reduction":[155],"operational":[157],"taxonomic":[158],"units":[159],"(OTUs)":[160],"alpha":[162],"(Shannon's":[164],"index),":[165],"along":[166],"with":[167,188,233],"statistically":[168],"shifts":[170],"beta":[172],"(according":[174],"PERMANOVA":[176],"multi-dimensional":[178],"Bray-Curtis":[179],"plots).":[180],"Key":[181],"signatures":[182],"dysbiosis":[186],"correlated":[187],"increased":[190],"expression":[191],"pro-inflammatory":[193],"cytokines":[194],"jejunum,":[197],"while":[198],"injury":[200],"was":[201],"characterised":[202],"by":[203],"reductions":[205],"plasma":[207],"citrulline":[208],"levels,":[209],"validated":[211],"biomarker":[212],"enterocyte":[214],"mass":[215],"barrier":[218],"integrity.":[219],"These":[220],"findings":[221],"have":[222],"potential":[223],"clinical":[224,254],"ramifications":[225],"chronically":[227],"administered":[228],"drugs":[229],"that":[230,242],"formulated":[232],"stresses":[236],"further":[240],"studies":[241],"investigate":[243],"dose-dependent":[244],"effects":[245],"microenvironment":[251],"setting.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-11-18T00:00:00"}
