{"id":"https://openalex.org/W4388739849","doi":"https://doi.org/10.14797/mdcvj.1295","title":"Bridging the Translational Gap in Heart Failure Research: Using Human iPSC-derived Cardiomyocytes to Accelerate Therapeutic Insights","display_name":"Bridging the Translational Gap in Heart Failure Research: Using Human iPSC-derived Cardiomyocytes to Accelerate Therapeutic Insights","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4388739849","doi":"https://doi.org/10.14797/mdcvj.1295","pmid":"https://pubmed.ncbi.nlm.nih.gov/38028973","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10655754"},"language":"en","primary_location":{"id":"doi:10.14797/mdcvj.1295","doi":"https://doi.org/10.14797/mdcvj.1295","is_oa":true,"landing_page_url":"https://doi.org/10.14797/mdcvj.1295","pdf_url":"https://storage.googleapis.com/jnl-up-j-mdbcj-files/journals/1/articles/1295/65561616ba3b9.pdf","source":{"id":"https://openalex.org/S2764606495","display_name":"Methodist DeBakey Cardiovascular Journal","issn_l":"1947-6094","issn":["1947-6094","1947-6108"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methodist DeBakey Cardiovascular Journal","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://storage.googleapis.com/jnl-up-j-mdbcj-files/journals/1/articles/1295/65561616ba3b9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071494455","display_name":"Leslye Venegas-Zamora","orcid":"https://orcid.org/0000-0002-7726-8801","observed_orcids":["https://orcid.org/0000-0002-7726-8801"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL","US"],"is_corresponding":false,"raw_author_name":"Leslye Venegas-Zamora","raw_affiliation_strings":["Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Santiago, Chile","Houston Methodist Research Institute, Houston, Texas, US","Weill Cornell Medical College, New York, New York, US","0628-000X Houston Methodist Research Institute, Houston, Texas, US; Weill Cornell Graduate School of Medical Sciences, New York, New York, US"],"raw_orcid":"https://orcid.org/0000-0002-7726-8801","affiliations":[{"raw_affiliation_string":"Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, Texas, US","institution_ids":["https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Weill Cornell Medical College, New York, New York, US","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"0628-000X Houston Methodist Research Institute, Houston, Texas, US; Weill Cornell Graduate School of Medical Sciences, New York, New York, US","institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053092460","display_name":"Matthew J. Fiedler","orcid":"https://orcid.org/0000-0003-0628-000X","observed_orcids":["https://orcid.org/0000-0003-0628-000X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL","US"],"is_corresponding":false,"raw_author_name":"Matthew Fiedler","raw_affiliation_strings":["Houston Methodist Research Institute, Houston, Texas, US","Weill Cornell Graduate School of Medical Sciences, New York, New York, US","Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Santiago, Chile","Weill Cornell Medical College, New York, New York, US","0628-000X Houston Methodist Research Institute, Houston, Texas, US; Weill Cornell Graduate School of Medical Sciences, New York, New York, US"],"raw_orcid":"https://orcid.org/0000-0003-0628-000X","affiliations":[{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, Texas, US","institution_ids":["https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Weill Cornell Graduate School of Medical Sciences, New York, New York, US","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Weill Cornell Medical College, New York, New York, US","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"0628-000X Houston Methodist Research Institute, Houston, Texas, US; Weill Cornell Graduate School of Medical Sciences, New York, New York, US","institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William Perez","orcid":"https://orcid.org/0000-0003-0344-4160","observed_orcids":["https://orcid.org/0000-0003-0344-4160"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL","US"],"is_corresponding":false,"raw_author_name":"William Perez","raw_affiliation_strings":["Houston Methodist Research Institute, Houston, Texas, US","Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Santiago, Chile","Weill Cornell Medical College, New York, New York, US","0628-000X Houston Methodist Research Institute, Houston, Texas, US; Weill Cornell Graduate School of Medical Sciences, New York, New York, US"],"raw_orcid":"https://orcid.org/0000-0003-0344-4160","affiliations":[{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, Texas, US","institution_ids":["https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Weill Cornell Medical College, New York, New York, US","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"0628-000X Houston Methodist Research Institute, Houston, Texas, US; Weill Cornell Graduate School of Medical Sciences, New York, New York, US","institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I4405286254"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062067826","display_name":"Francisco J Altamirano","orcid":"https://orcid.org/0000-0002-1612-2729","observed_orcids":["https://orcid.org/0000-0002-1612-2729"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL","US"],"is_corresponding":true,"raw_author_name":"Francisco Altamirano","raw_affiliation_strings":["Houston Methodist Research Institute, Houston, Texas, US","Weill Cornell Medical College, New York, New York, US","Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Santiago, Chile","0628-000X Houston Methodist Research Institute, Houston, Texas, US; Weill Cornell Graduate School of Medical Sciences, New York, New York, US"],"raw_orcid":"https://orcid.org/0000-0002-1612-2729","affiliations":[{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, Texas, US","institution_ids":["https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Weill Cornell Medical College, New York, New York, US","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"0628-000X Houston Methodist Research Institute, Houston, Texas, US; Weill Cornell Graduate School of Medical Sciences, New York, New York, US","institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I4405286254"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062067826"],"corresponding_institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I4405286254","https://openalex.org/I69737025"],"apc_list":null,"apc_paid":null,"fwci":0.096,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.05783855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"19","issue":"5","first_page":"5","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":1.0},{"id":"https://openalex.org/keywords/human-induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"human induced pluripotent stem cell-derived cardiomyocytes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.7879999876022339},{"id":"https://openalex.org/keywords/ischemic-heart-failure","display_name":"ischemic heart failure","score":0.8489999771118164},{"id":"https://openalex.org/keywords/engineered-heart-tissue","display_name":"engineered heart tissue","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cardiomyocyte-maturation","display_name":"cardiomyocyte maturation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cardiomyocyte-dysfunction","display_name":"cardiomyocyte dysfunction","score":0.859000027179718},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.6209999918937683},{"id":"https://openalex.org/keywords/limitations-of-animal-models","display_name":"animal model limitations","score":0.7170000076293945},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7602198123931885},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.7086370587348938},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6532468199729919},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5669801235198975},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45967012643814087},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44650816917419434},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44072476029396057},{"id":"https://openalex.org/C174348530","wikidata":"https://www.wikidata.org/wiki/Q188635","display_name":"Bridging (networking)","level":2,"score":0.4196532964706421},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41717109084129333},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1829225718975067},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1555536687374115},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.13789698481559753},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.12346789240837097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11088204383850098},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10537922382354736},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.14797/mdcvj.1295","doi":"https://doi.org/10.14797/mdcvj.1295","is_oa":true,"landing_page_url":"https://doi.org/10.14797/mdcvj.1295","pdf_url":"https://storage.googleapis.com/jnl-up-j-mdbcj-files/journals/1/articles/1295/65561616ba3b9.pdf","source":{"id":"https://openalex.org/S2764606495","display_name":"Methodist DeBakey Cardiovascular Journal","issn_l":"1947-6094","issn":["1947-6094","1947-6108"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methodist DeBakey Cardiovascular Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10655754","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10655754","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10655754/pdf/mdcvj-19-5-1295.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methodist Debakey Cardiovasc J","raw_type":"Text"},{"id":"pmid:38028973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38028973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methodist DeBakey cardiovascular journal","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0201b92853e64511a8325d3d67b47e4e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0201b92853e64511a8325d3d67b47e4e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Methodist DeBakey Cardiovascular Journal, Vol 19, Iss 5, Pp 5-15 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.14797/mdcvj.1295","doi":"https://doi.org/10.14797/mdcvj.1295","is_oa":true,"landing_page_url":"https://doi.org/10.14797/mdcvj.1295","pdf_url":"https://storage.googleapis.com/jnl-up-j-mdbcj-files/journals/1/articles/1295/65561616ba3b9.pdf","source":{"id":"https://openalex.org/S2764606495","display_name":"Methodist DeBakey Cardiovascular Journal","issn_l":"1947-6094","issn":["1947-6094","1947-6108"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methodist DeBakey Cardiovascular Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4882419867","display_name":null,"funder_award_id":"ANID 21200450","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G9000857382","display_name":"Training in Cardiovascular Physiology and Pharmacology","funder_award_id":"T32HL007444","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000871585","display_name":"Mechanisms driving cardiac dysfunction in Autosomal Dominant Polycystic Kidney Disease","funder_award_id":"R01HL158703","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000874252","display_name":"UCSD Future Faculty of Cardiovascular Sciences (FOCUS)","funder_award_id":"R25HL145817","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320319253","display_name":"Agen\u021bia Na\u021bional\u0103 pentru Cercetare \u0219i Dezvoltare","ror":"https://ror.org/04kp6rb84"},{"id":"https://openalex.org/F4320331146","display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","ror":"https://ror.org/05btm5233"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333841","display_name":"Houston Methodist Research Institute","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320338463","display_name":"CHIST-ERA","ror":"https://ror.org/00rbzpz17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388739849.pdf","grobid_xml":"https://content.openalex.org/works/W4388739849.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W207992492","https://openalex.org/W1593379380","https://openalex.org/W1821665499","https://openalex.org/W1867433030","https://openalex.org/W1876131152","https://openalex.org/W1975484052","https://openalex.org/W1994446230","https://openalex.org/W2009163517","https://openalex.org/W2033142987","https://openalex.org/W2036156636","https://openalex.org/W2038221909","https://openalex.org/W2042091538","https://openalex.org/W2059219385","https://openalex.org/W2066390373","https://openalex.org/W2071568942","https://openalex.org/W2085927442","https://openalex.org/W2106540045","https://openalex.org/W2119106132","https://openalex.org/W2122349854","https://openalex.org/W2122530165","https://openalex.org/W2125987139","https://openalex.org/W2128085444","https://openalex.org/W2142147247","https://openalex.org/W2145411235","https://openalex.org/W2152205887","https://openalex.org/W2166305181","https://openalex.org/W2232883894","https://openalex.org/W2271175958","https://openalex.org/W2406621385","https://openalex.org/W2580792129","https://openalex.org/W2587731622","https://openalex.org/W2606688972","https://openalex.org/W2744628121","https://openalex.org/W2764024258","https://openalex.org/W2788496190","https://openalex.org/W2792750072","https://openalex.org/W2794616878","https://openalex.org/W2801396581","https://openalex.org/W2809990901","https://openalex.org/W2833376036","https://openalex.org/W2892212668","https://openalex.org/W2896847375","https://openalex.org/W2947343895","https://openalex.org/W2954018739","https://openalex.org/W2975681149","https://openalex.org/W2982101288","https://openalex.org/W2989977822","https://openalex.org/W2998521009","https://openalex.org/W3000441751","https://openalex.org/W3004299218","https://openalex.org/W3006530715","https://openalex.org/W3015284544","https://openalex.org/W3020716964","https://openalex.org/W3030645235","https://openalex.org/W3034958226","https://openalex.org/W3040598213","https://openalex.org/W3046077377","https://openalex.org/W3080633652","https://openalex.org/W3093926067","https://openalex.org/W3127229298","https://openalex.org/W3136226423","https://openalex.org/W3161466741","https://openalex.org/W3164422518","https://openalex.org/W3203729610","https://openalex.org/W3205540207","https://openalex.org/W4200249847","https://openalex.org/W4210412258","https://openalex.org/W4220946720","https://openalex.org/W4232767515","https://openalex.org/W4281776060","https://openalex.org/W4281799836","https://openalex.org/W4283164327","https://openalex.org/W4287960369","https://openalex.org/W4288431983","https://openalex.org/W4293116285","https://openalex.org/W4308793203","https://openalex.org/W4385800894"],"related_works":["https://openalex.org/W3102554657","https://openalex.org/W7164298356","https://openalex.org/W2025187846","https://openalex.org/W2751515929","https://openalex.org/W4403604589","https://openalex.org/W2403120760","https://openalex.org/W2620563284","https://openalex.org/W7172535598","https://openalex.org/W2174470530","https://openalex.org/W1969743736"],"abstract_inverted_index":{"Heart":[0],"failure":[1],"(HF)":[2],"remains":[3,22],"a":[4,18,76,130,153,174],"leading":[5],"cause":[6],"of":[7,27,48,84,142,164,173,196,206],"death":[8],"worldwide,":[9],"with":[10,123,152,187],"increasing":[11],"prevalence":[12],"and":[13,30,87,93,112,126,140,144,166,183,209],"burden.":[14],"Despite":[15],"extensive":[16],"research,":[17,190],"cure":[19],"for":[20,54,97],"HF":[21,150,158],"elusive.":[23],"Traditionally,":[24],"the":[25,45,82,95,138,171,193],"study":[26,83,149],"HF's":[28],"pathogenesis":[29],"therapies":[31],"has":[32],"relied":[33],"heavily":[34],"on":[35,156],"animal":[36,182],"experimentation.":[37],"However,":[38],"these":[39],"models":[40],"have":[41],"limitations":[42,141],"in":[43,52,181],"recapitulating":[44],"full":[46],"spectrum":[47],"human":[49,64,85,197],"HF,":[50],"resulting":[51],"challenges":[53],"clinical":[55,167,189],"translation.":[56],"To":[57],"address":[58],"this":[59,207],"translational":[60],"gap,":[61],"research":[62,98],"employing":[63],"cells,":[65],"especially":[66],"cardiomyocytes":[67],"derived":[68],"from":[69],"human-induced":[70],"pluripotent":[71],"stem":[72],"cells":[73,80],"(hiPSC-CMs),":[74],"offers":[75,129],"promising":[77],"solution.":[78],"These":[79],"facilitate":[81],"genetic":[86],"molecular":[88],"mechanisms":[89],"driving":[90],"cardiomyocyte":[91,117],"dysfunction":[92],"pave":[94],"way":[96],"tailored":[99],"to":[100,115,148,160,191,211],"individual":[101],"patients.":[102],"Further,":[103],"engineered":[104],"heart":[105],"tissues":[106],"combine":[107],"hiPSC-CMs,":[108],"other":[109],"cell":[110],"types,":[111],"scaffold-based":[113],"approaches":[114],"improve":[116,203],"maturation.":[118],"Their":[119],"tridimensional":[120],"architecture,":[121],"complemented":[122],"mechanical,":[124],"chemical,":[125],"electrical":[127],"cues,":[128],"more":[131,212],"physiologically":[132],"relevant":[133],"environment.":[134],"This":[135],"review":[136],"explores":[137],"advantages":[139],"conventional":[143],"innovative":[145],"methods":[146],"used":[147],"pathogenesis,":[151],"primary":[154],"focus":[155],"ischemic":[157],"due":[159],"its":[161],"relative":[162],"ease":[163],"modeling":[165],"relevance.":[168],"We":[169],"emphasize":[170],"importance":[172],"collaborative":[175],"approach":[176,201],"that":[177],"integrates":[178],"insights":[179],"obtained":[180],"hiPSC-CMs-based":[184],"models,":[185],"along":[186],"rigorous":[188],"dissect":[192],"mechanistic":[194],"underpinnings":[195],"HF.":[198],"Such":[199],"an":[200],"could":[202],"our":[204],"understanding":[205],"disease":[208],"lead":[210],"effective":[213],"treatments.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-17T00:00:00"}