{"id":"https://openalex.org/W4388738301","doi":"https://doi.org/10.1097/01.hs9.0000936168.61107.6f","title":"P10 AN ULTRA-SENSITIVE METHOD FOR SEQUENCING AND MONITORING OF M-PROTEIN IN PERIPHERAL BLOOD (M-INSIGHT)","display_name":"P10 AN ULTRA-SENSITIVE METHOD FOR SEQUENCING AND MONITORING OF M-PROTEIN IN PERIPHERAL BLOOD (M-INSIGHT)","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4388738301","doi":"https://doi.org/10.1097/01.hs9.0000936168.61107.6f"},"language":"en","primary_location":{"id":"doi:10.1097/01.hs9.0000936168.61107.6f","doi":"https://doi.org/10.1097/01.hs9.0000936168.61107.6f","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.hs9.0000936168.61107.6f","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/01.hs9.0000936168.61107.6f","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056468557","display_name":"Vincent Bonifay","orcid":"https://orcid.org/0000-0003-4341-6981","observed_orcids":["https://orcid.org/0000-0003-4341-6981"]},"institutions":[{"id":"https://openalex.org/I4210135100","display_name":"Sebia (France)","ror":"https://ror.org/0382x5c07","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210135100"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V. Bonifay","raw_affiliation_strings":["Sebia, Lisses, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sebia, Lisses, France","institution_ids":["https://openalex.org/I4210135100"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093276553","display_name":"Victor Vimard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135100","display_name":"Sebia (France)","ror":"https://ror.org/0382x5c07","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210135100"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V. Vimard","raw_affiliation_strings":["Sebia, Lisses, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sebia, Lisses, France","institution_ids":["https://openalex.org/I4210135100"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017563261","display_name":"Somayya Noori","orcid":"https://orcid.org/0000-0003-3776-2976","observed_orcids":["https://orcid.org/0000-0003-3776-2976"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"S. Noori","raw_affiliation_strings":["Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068670255","display_name":"Charissa Wijnands","orcid":"https://orcid.org/0000-0001-9057-8751","observed_orcids":["https://orcid.org/0000-0001-9057-8751"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C. Wijnands","raw_affiliation_strings":["Laboratory Medical Immunology, Department of Laboratory Medicine, Radboud university medical center, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Medical Immunology, Department of Laboratory Medicine, Radboud university medical center, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058940187","display_name":"Cyrille Touzeau","orcid":"https://orcid.org/0000-0003-0275-2575","observed_orcids":["https://orcid.org/0000-0003-0275-2575"]},"institutions":[{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Touzeau","raw_affiliation_strings":["Centre Hospitalier Universitaire de Nantes, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire de Nantes, Nantes, France","institution_ids":["https://openalex.org/I3019204325","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030565933","display_name":"Jill Corre","orcid":"https://orcid.org/0000-0003-1580-6106","observed_orcids":["https://orcid.org/0000-0003-1580-6106"]},"institutions":[{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210098740","https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Corre","raw_affiliation_strings":["Unite de Genomique du Myelome, Institut universitaire du cancer de Toulouse Oncopole, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite de Genomique du Myelome, Institut universitaire du cancer de Toulouse Oncopole, Toulouse, France","institution_ids":["https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082698003","display_name":"Aurore Perrot","orcid":"https://orcid.org/0000-0003-0131-8689","observed_orcids":["https://orcid.org/0000-0003-0131-8689"]},"institutions":[{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210098740","https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Perrot","raw_affiliation_strings":["Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France","institution_ids":["https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103143602","display_name":"Philippe Moreau","orcid":"https://orcid.org/0000-0003-1780-8746","observed_orcids":["https://orcid.org/0000-0003-1780-8746"]},"institutions":[{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Moreau","raw_affiliation_strings":["Hematology, University Hospital H\u00f4tel-Dieu, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, University Hospital H\u00f4tel-Dieu, Nantes, France","institution_ids":["https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023937847","display_name":"H\u00e9l\u00e8ne Caillon","orcid":"https://orcid.org/0000-0001-9725-9323","observed_orcids":["https://orcid.org/0000-0001-9725-9323"]},"institutions":[{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H. Caillon","raw_affiliation_strings":["Biochemistry Laboratory, Hospital of Nantes, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Laboratory, Hospital of Nantes, Nantes, France","institution_ids":["https://openalex.org/I3019204325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021139263","display_name":"Thomas Dejoie","orcid":"https://orcid.org/0000-0002-5080-6585","observed_orcids":["https://orcid.org/0000-0002-5080-6585"]},"institutions":[{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"T. Dejoie","raw_affiliation_strings":["Biochemistry Laboratory, Hospital of Nantes, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Laboratory, Hospital of Nantes, Nantes, France","institution_ids":["https://openalex.org/I3019204325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067643421","display_name":"Theo M. Luider","orcid":"https://orcid.org/0000-0003-1962-561X","observed_orcids":["https://orcid.org/0000-0003-1962-561X"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"T. Luider","raw_affiliation_strings":["Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045556768","display_name":"Martijn M. VanDuijn","orcid":"https://orcid.org/0000-0002-6654-994X","observed_orcids":["https://orcid.org/0000-0002-6654-994X"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. VanDuijn","raw_affiliation_strings":["Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042368190","display_name":"Joannes F.M. Jacobs","orcid":"https://orcid.org/0000-0002-6208-6386","observed_orcids":["https://orcid.org/0000-0002-6208-6386"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. Jacobs","raw_affiliation_strings":["Laboratory Medical Immunology, Department of Laboratory Medicine, Radboud university medical center, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Medical Immunology, Department of Laboratory Medicine, Radboud university medical center, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003213355","display_name":"Alain J. van Gool","orcid":"https://orcid.org/0000-0003-0010-5286","observed_orcids":["https://orcid.org/0000-0003-0010-5286"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. Van Gool","raw_affiliation_strings":["Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud university medical center, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud university medical center, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"last","author":{"id":null,"display_name":"P. Sonigo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135100","display_name":"Sebia (France)","ror":"https://ror.org/0382x5c07","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210135100"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Sonigo","raw_affiliation_strings":["Sebia, Lisses, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sebia, Lisses, France","institution_ids":["https://openalex.org/I4210135100"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2480,"currency":"USD","value_usd":2480},"apc_paid":{"value":2480,"currency":"USD","value_usd":2480},"fwci":null,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"S2","first_page":"15","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/m-protein","display_name":"M protein","score":0.7929999828338623},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.9290000200271606},{"id":"https://openalex.org/keywords/targeted-mass-spectrometry","display_name":"targeted mass spectrometry","score":0.7699999809265137},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.44200000166893005},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.6589999794960022},{"id":"https://openalex.org/keywords/monoclonal-antibody-therapy","display_name":"monoclonal antibody therapy","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.748430609703064},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6371553540229797},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5258089900016785},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5211098790168762},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.488844096660614},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.47236210107803345},{"id":"https://openalex.org/C188758523","wikidata":"https://www.wikidata.org/wiki/Q6947334","display_name":"Myeloma protein","level":3,"score":0.454303115606308},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3660152554512024},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3049483299255371},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22813451290130615},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1097/01.hs9.0000936168.61107.6f","doi":"https://doi.org/10.1097/01.hs9.0000936168.61107.6f","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.hs9.0000936168.61107.6f","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10171567","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10171567","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10171567/pdf/hs9-7-15a.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemasphere","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5319e8f9a28442508e363cb79e5475bf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5319e8f9a28442508e363cb79e5475bf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HemaSphere, Vol 7, Iss S2, Pp 15-15 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1097/01.hs9.0000936168.61107.6f","doi":"https://doi.org/10.1097/01.hs9.0000936168.61107.6f","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.hs9.0000936168.61107.6f","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388738301.pdf","grobid_xml":"https://content.openalex.org/works/W4388738301.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403071270","https://openalex.org/W4405051559","https://openalex.org/W4389221171","https://openalex.org/W7205417608","https://openalex.org/W3178434373","https://openalex.org/W4405052087","https://openalex.org/W4376106107","https://openalex.org/W4417012496","https://openalex.org/W7223450081","https://openalex.org/W7135204709"],"abstract_inverted_index":{"With":[0],"the":[1,68,128,138,145,149,184,217,227,236,251,331,342,349,361,370,381,478,500],"improvement":[2],"of":[3,9,17,20,39,97,130,148,186,216,221,326,330,363,459],"therapy":[4,18],"(monoclonal":[5],"antibody,":[6],"CAR-T),":[7],"detection":[8,157],"minimal":[10],"residual":[11],"disease":[12,27,91],"(MRD)":[13],"and":[14,66,93,108,205,213,268,307,313,334,463,470,481,496],"early":[15,95],"restart":[16],"is":[19,100,201,375,485],"high":[21,135,428],"importance":[22],"to":[23,33,119,169,203,209,234,249,285,304,308,341,368,377,380,392,468,494],"manage":[24],"multiple":[25],"myeloma":[26,224],"(MM).":[28],"Most":[29],"sensitive":[30,466],"MRD":[31,173,190,438],"assays":[32],"date":[34],"are":[35,151,259,390],"based":[36,289,318,492],"on":[37,76,90,290,319,406,446],"quantification":[38],"clonal":[40,310],"plasmocytes":[41],"by":[42,125,158,278,337,404,415,434,441,454],"next":[43,442],"generation":[44,443],"sequencing":[45,287,444],"or":[46],"flow":[47],"cytometry":[48],"in":[49,132,395],"bone":[50,84,447],"marrow":[51,85,448],"aspirates.":[52],"However,":[53],"such":[54,59],"methods":[55],"have":[56,180],"shown":[57],"limitations":[58],"as":[60,116,487],"being":[61],"invasive":[62],"with":[63,83,134,253,360,409,430,499],"sample":[64,408],"heterogeneity":[65],"lacking":[67,131],"possibility":[69,118,501],"for":[70,105,153,502],"frequent":[71,503],"sampling.":[72],"Frequent":[73],"MM":[74,106],"monitoring":[75,215],"blood":[77,491],"at":[78,172],"equivalent":[79],"sensitivity":[80,133,429,452],"than":[81,328],"achieved":[82,453],"could":[86],"provide":[87],"actionable":[88],"information":[89],"activity":[92],"detect":[94],"signs":[96],"progression.":[98],"M-protein":[99,150,171,252,350,394,400,412,431,498],"a":[101,117,240,324,407,410,426,437],"well-established":[102],"biomarker":[103],"used":[104,202,233,303,391],"diagnostic":[107],"monitoring.":[109],"Mass":[110],"spectrometry":[111,255,339],"(MS)":[112],"has":[113,127,166],"been":[114,167,181],"introduced":[115],"monitor":[120,497],"M-protein.":[121,218],"Intact":[122],"protein":[123,472],"measurement":[124],"MS":[126,473],"drawback":[129],"interference":[136],"from":[137,144,163,177,226,256,293,345,385],"polyclonal":[139],"background.":[140],"Clonotypic":[141,388],"peptides":[142,208,317,356,389],"originating":[143],"variable":[146],"region":[147],"unique":[152],"each":[154],"patient.":[155],"Their":[156],"MS,":[159],"which":[160,281],"circumvent":[161],"interferences":[162],"other":[164],"immunoglobulins,":[165],"demonstrated":[168],"quantify":[170],"level.":[174],"Several":[175],"studies":[176],"our":[178],"group":[179],"published":[182],"showing":[183],"use":[185,362],"targeted":[187],"mass":[188,254,279,338],"spectrometry-based":[189],"blood-test":[191],"(M-InSight)":[192],"that":[193,258],"detects":[194],"clonotypic":[195,207,316,355],"peptides.":[196],"In":[197,476],"this":[198],"study,":[199],"M-InSight":[200,238,435,483],"sequence":[204,250,351,495],"select":[206,369],"allow":[210],"highly":[211],"specific":[212,379],"ultra-sensitive":[214,489],"Therapy":[219],"response":[220],"41":[222,274],"Multiple":[223],"patients":[225,275,382],"IFM-2009":[228],"clinical":[229],"trial":[230],"(NCT01191060)":[231],"was":[232,282,302,352,461],"evaluate":[235],"assay.":[237],"uses":[239],"novel":[241],"de":[242],"novo":[243],"approach":[244],"using":[245,300],"Peaks":[246],"Ab":[247],"software":[248],"serum":[257,397],"further":[260,358],"assembled":[261],"into":[262],"full":[263],"length":[264],"HC":[265,335],"(Heavy":[266],"Chain)":[267],"LC":[269,333],"(Light":[270],"chain)":[271],"sequences.":[272],"All":[273],"were":[276,357,402],"sequenced":[277,336],"spectrometry,":[280],"then":[283],"compared":[284,340,467],"RNA":[286,297,346],"data":[288,343,445],"tala":[291],"cDNA":[292],"all":[294],"expressed":[295],"genes.":[296],"assembly":[298],"pipeline":[299],"Trust4":[301],"construct":[305],"clonotypes":[306],"identify":[309],"molecular":[311],"fingerprints":[312],"finally":[314],"their":[315],"transcriptomic":[320],"datasets.":[321],"Results":[322,424],"showed":[323,425],"coverage":[325],"more":[327,465],"90%":[329],"entire":[332],"obtain":[344],"sequencing.":[347],"Once":[348],"obtained,":[353],"several":[354],"chosen":[359,376],"an":[364,416,488],"in-house":[365],"bioinformatics":[366],"algorithm":[367],"best":[371,451],"candidate.":[372],"Each":[373],"peptide":[374],"be":[378],"(CDR":[383],"region)":[384],"both":[386],"chains.":[387],"quantitate":[393],"patients\u2019":[396],"after":[398],"treatment.":[399],"concentrations":[401],"determined":[403,440],"calibration":[405],"known":[411],"concentration":[413],"quantified":[414],"agarose":[417],"gel":[418],"electrophoresis":[419],"system":[420],"(Hydrasys":[421],"2,":[422],"Sebia).":[423],"very":[427],"still":[432],"detectable":[433],"despite":[436],"negativity":[439],"aspirate.":[449],"The":[450],"M-InSight,":[455],"detecting":[456],"0.2":[457],"mg/L":[458],"M-protein,":[460],"1000-":[462],"100-fold":[464],"SPE":[469],"intact":[471],"method,":[474],"respectively.":[475],"conclusion,":[477],"newly":[479],"developed":[480],"validated":[482],"assay":[484,493],"presented":[486],"fully":[490],"non-invasive":[504],"analysis.":[505]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-11-17T00:00:00"}
