{"id":"https://openalex.org/W4388737270","doi":null,"title":"Addition of adipose tissue-derived mesenchymal stem cells improves empagliflozin therapy for alleviating hyperglycemia--induced neuropathy.","display_name":"Addition of adipose tissue-derived mesenchymal stem cells improves empagliflozin therapy for alleviating hyperglycemia--induced neuropathy.","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4388737270","pmid":"https://pubmed.ncbi.nlm.nih.gov/37969202","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10641353"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10641353","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10641353","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10641353/pdf/ajtr0015-6264.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10641353/pdf/ajtr0015-6264.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042465484","display_name":"Hung-Sheng Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hung-Sheng Lin","raw_affiliation_strings":["Division of Neurology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101035200","display_name":"Chien\u2010Hui Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chien-Hui Yang","raw_affiliation_strings":["Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042455926","display_name":"Tsung\u2010Cheng Yin","orcid":"https://orcid.org/0000-0002-2468-6196","observed_orcids":["https://orcid.org/0000-0002-2468-6196"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tsung-Cheng Yin","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001850751","display_name":"Pei\u2010Hsun Sung","orcid":"https://orcid.org/0000-0002-1989-9752","observed_orcids":["https://orcid.org/0000-0002-1989-9752"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pei-Hsun Sung","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001141477","display_name":"John Y. Chiang","orcid":"https://orcid.org/0000-0002-8719-4017","observed_orcids":["https://orcid.org/0000-0002-8719-4017"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"John Y Chiang","raw_affiliation_strings":["Department of Computer Science and Engineering, National Sun Yat-Sen University Kaohsiung 80424, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, National Sun Yat-Sen University Kaohsiung 80424, Taiwan","institution_ids":["https://openalex.org/I142974352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059047610","display_name":"Pei\u2010Lin Shao","orcid":"https://orcid.org/0000-0001-6920-0447","observed_orcids":["https://orcid.org/0000-0001-6920-0447"]},"institutions":[{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pei-Lin Shao","raw_affiliation_strings":["Department of Nursing, Asia University Taichung 41354, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Asia University Taichung 41354, Taiwan","institution_ids":["https://openalex.org/I143578492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104314316","display_name":"Yi-Ling Chen","orcid":"https://orcid.org/0000-0002-9789-2441","observed_orcids":["https://orcid.org/0000-0002-9789-2441"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Ling Chen","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101770561","display_name":"Chi\u2010Ruei Huang","orcid":"https://orcid.org/0000-0001-9646-8852","observed_orcids":["https://orcid.org/0000-0001-9646-8852"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chi-Ruei Huang","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028066500","display_name":"Hon\u2010Kan Yip","orcid":"https://orcid.org/0000-0002-6305-5717","observed_orcids":["https://orcid.org/0000-0002-6305-5717"]},"institutions":[{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]},{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hon-Kan Yip","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan","Department of Nursing, Asia University Taichung 41354, Taiwan","Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital Kaohsiung 83301, Taiwan","School of Medicine, College of Medicine, Chang Gung University Taoyuan 333, Taiwan","Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital Kaohsiung 83301, Taiwan","Department of Medical Research, China Medical University Hospital, China Medical University Taichung 40402, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210093821"]},{"raw_affiliation_string":"Department of Nursing, Asia University Taichung 41354, Taiwan","institution_ids":["https://openalex.org/I143578492"]},{"raw_affiliation_string":"Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]},{"raw_affiliation_string":"School of Medicine, College of Medicine, Chang Gung University Taoyuan 333, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]},{"raw_affiliation_string":"Department of Medical Research, China Medical University Hospital, China Medical University Taichung 40402, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085808541","display_name":"Kuan\u2010Hung Chen","orcid":"https://orcid.org/0000-0002-2527-2825","observed_orcids":["https://orcid.org/0000-0002-2527-2825"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuan-Hung Chen","raw_affiliation_strings":["Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210093821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3534,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.5947646,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"15","issue":"10","first_page":"6264","last_page":"6285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.039400000125169754,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/empagliflozin","display_name":"empagliflozin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diabetic-neuropathy","display_name":"diabetic neuropathy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7770000100135803},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.8100000023841858},{"id":"https://openalex.org/keywords/voltage-gated-sodium-channels","display_name":"voltage-gated sodium channels","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mitochondrial-cytochrome-c","display_name":"mitochondrial cytochrome c","score":0.6159999966621399},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C2775887513","wikidata":"https://www.wikidata.org/wiki/Q5373824","display_name":"Empagliflozin","level":4,"score":0.9296715259552002},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.629259467124939},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5559466481208801},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5483778119087219},{"id":"https://openalex.org/C2780652884","wikidata":"https://www.wikidata.org/wiki/Q5323607","display_name":"EMPA","level":3,"score":0.52271968126297},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4988291263580322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4976854622364044},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4739518165588379},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4579128623008728},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4001810550689697},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3484877049922943},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3228190541267395},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.29271218180656433},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12147274613380432},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10023447871208191},{"id":"https://openalex.org/C199289684","wikidata":"https://www.wikidata.org/wiki/Q83353","display_name":"Mineralogy","level":1,"score":0.0},{"id":"https://openalex.org/C138411078","wikidata":"https://www.wikidata.org/wiki/Q911272","display_name":"Electron microprobe","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10641353","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10641353","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10641353/pdf/ajtr0015-6264.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:37969202","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37969202","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10641353","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10641353","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10641353/pdf/ajtr0015-6264.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321524","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46"},{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"},{"id":"https://openalex.org/F4320335753","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388737270.pdf","grobid_xml":"https://content.openalex.org/works/W4388737270.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W12670753","https://openalex.org/W1968561916","https://openalex.org/W2000229809","https://openalex.org/W2012282857","https://openalex.org/W2018639383","https://openalex.org/W2021523660","https://openalex.org/W2042291132","https://openalex.org/W2081225883","https://openalex.org/W2081321708","https://openalex.org/W2102114196","https://openalex.org/W2104818454","https://openalex.org/W2111458789","https://openalex.org/W2116500923","https://openalex.org/W2153791907","https://openalex.org/W2162902338","https://openalex.org/W2273304042","https://openalex.org/W2278128380","https://openalex.org/W2296986887","https://openalex.org/W2340569448","https://openalex.org/W2561689434","https://openalex.org/W2619089544","https://openalex.org/W2653398740","https://openalex.org/W2791011305","https://openalex.org/W2810428191","https://openalex.org/W2811133902","https://openalex.org/W2898616650","https://openalex.org/W2900442056","https://openalex.org/W2910075829","https://openalex.org/W2912762225","https://openalex.org/W2980525909","https://openalex.org/W3096498336","https://openalex.org/W3131813085","https://openalex.org/W4200241802","https://openalex.org/W4229020262","https://openalex.org/W4253987421","https://openalex.org/W4303946612"],"related_works":["https://openalex.org/W3195330962","https://openalex.org/W2372020989","https://openalex.org/W4389566941","https://openalex.org/W4283715214","https://openalex.org/W2745476215","https://openalex.org/W2619089544","https://openalex.org/W2898381376","https://openalex.org/W4392581737","https://openalex.org/W7119421293","https://openalex.org/W2618657847"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1],"examined":[2],"the":[3,57,93,156,206],"impact":[4],"of":[5,31,60,65,96,103,109,158,179,189,197,203,212,225],"adipose-derived":[6],"mesenchymal":[7],"stem":[8],"cell":[9],"(ADMSC)-facilitated":[10],"empagliflozin":[11,39],"(EMPA)":[12],"therapy":[13,216],"for":[14,222],"alleviating":[15],"hyperglycemic":[16],"induced":[17],"neuropathy":[18,21],"[i.e.,":[19],"diabetic":[20],"(DN)].":[22],"METHODS:":[23],"cells":[24],"by":[25,44],"vein":[26],"transfusion":[27],"at":[28],"time":[29],"intervals":[30],"1/3/5":[32],"weeks":[33],"after":[34,46,153],"DN":[35,47,154],"induction)/5":[36],"(DN":[37],"+":[38,40,78,88,90,126,133,135,142,144],"ADMSCs)":[41],"and":[42,62,70,100,128,167,182,186,214],"sacrificed":[43],"day-42":[45],"induction.":[48],"RESULTS:":[49],"results":[50],"showed":[51],"that,":[52],"compared":[53],"to":[54,219],"N2a":[55,77,87,121,125,132,141],"cells,":[56,122],"cellular":[58,94,177],"levels":[59,95,102,178,188,196],"senescence/DNA-damage":[61],"protein":[63,101,187],"expressions":[64],"oxidative-stress":[66],"(OS),":[67],"apoptotic,":[68],"autophagic":[69],"inflammatory":[71],"biomarkers":[72,193],"were":[73,83,118,162],"significantly":[74,84,129,168],"higher":[75,130],"in":[76,86,120,124,131,140,164,194],"glucose":[79,89,127,134,143],"(25":[80],"mM)":[81],"but":[82],"reversed":[85],"ADMSCs,":[91],"whereas":[92],"mitochondrial":[97],"cytochrome":[98],"C":[99],"anti-oxidants":[104],"displayed":[105],"an":[106,200],"opposite":[107],"pattern":[108],"OS":[110],"(all":[111,148,174,208],"P<0.001).":[112,149],"The":[113,176],"above-mentioned":[114],"parameters":[115],"(i.e.,":[116],"OS/apoptosis/fibrosis/autophagy/DNA-damage)":[117],"lowest":[119],"highest":[123,163],"EMPA":[136,145,213],"(50":[137],"\u03bcM)":[138,147],"than":[139],"(150":[146],"By":[150],"days":[151],"7/14/21/28/35/42":[152],"induction,":[155],"values":[157],"thermal":[159],"paw-withdrawal-latency":[160],"(TPWL)/mechanical-paw-withdrawal-threshold":[161],"group":[165],"1":[166],"progressively":[169],"increased":[170],"from":[171],"groups":[172,207],"2/4/3/5":[173],"P<0.0001).":[175,209],"unmyelinated":[180],"C-":[181],"myelinated":[183],"A-\u03b4":[184],"fibers,":[185],"OS/apoptotic/DNA-damaged/fibrotic/autophagic/inflammatory/pain-facilitated/voltage-gated":[190],"sodium":[191],"channel":[192],"L4-L5":[195],"dorsal-root-ganglia":[198],"exhibited":[199],"contradictory":[201],"manner":[202],"TPWL":[204],"among":[205],"CONCLUSIONS:":[210],"Combination":[211],"ADMSC":[215],"was":[217],"superior":[218],"either":[220],"alone":[221],"improving":[223],"outcomes":[224],"DN.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-11-17T00:00:00"}