{"id":"https://openalex.org/W4388734271","doi":"https://doi.org/10.3390/v15112263","title":"Phenotypic Characterization of Recombinant Marek\u2019s Disease Virus in Live Birds Validates Polymorphisms Associated with Virulence","display_name":"Phenotypic Characterization of Recombinant Marek\u2019s Disease Virus in Live Birds Validates Polymorphisms Associated with Virulence","publication_year":2023,"publication_date":"2023-11-16","ids":{"openalex":"https://openalex.org/W4388734271","doi":"https://doi.org/10.3390/v15112263","pmid":"https://pubmed.ncbi.nlm.nih.gov/38005939","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10674313"},"language":"en","primary_location":{"id":"doi:10.3390/v15112263","doi":"https://doi.org/10.3390/v15112263","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v15112263","pdf_url":"https://www.mdpi.com/1999-4915/15/11/2263/pdf?version=1700136938","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4915/15/11/2263/pdf?version=1700136938","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086503140","display_name":"Taejoong Kim","orcid":"https://orcid.org/0000-0002-5699-998X","observed_orcids":["https://orcid.org/0000-0002-5699-998X"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210141533","display_name":"U.S. National Poultry Research Center","ror":"https://ror.org/03sc3bx43","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210141533"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Taejoong Kim","raw_affiliation_strings":["Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA"],"raw_orcid":"https://orcid.org/0000-0002-5699-998X","affiliations":[{"raw_affiliation_string":"Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I4210141533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058819214","display_name":"Cari J. Hearn","orcid":"https://orcid.org/0000-0003-1309-4547","observed_orcids":["https://orcid.org/0000-0003-1309-4547"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210141533","display_name":"U.S. National Poultry Research Center","ror":"https://ror.org/03sc3bx43","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210141533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cari J. Hearn","raw_affiliation_strings":["Avian Diseases and Oncology Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 4279 E. Mount Hope Road, East Lansing, MI 48823, USA"],"raw_orcid":"https://orcid.org/0000-0003-1309-4547","affiliations":[{"raw_affiliation_string":"Avian Diseases and Oncology Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 4279 E. Mount Hope Road, East Lansing, MI 48823, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110799159","display_name":"Jody K. Mays","orcid":"https://orcid.org/0000-0003-4871-5024","observed_orcids":["https://orcid.org/0000-0003-4871-5024"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210141533","display_name":"U.S. National Poultry Research Center","ror":"https://ror.org/03sc3bx43","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210141533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jody Mays","raw_affiliation_strings":["Avian Diseases and Oncology Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 4279 E. Mount Hope Road, East Lansing, MI 48823, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Avian Diseases and Oncology Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 4279 E. Mount Hope Road, East Lansing, MI 48823, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027285159","display_name":"Deborah Velez\u2010Irizarry","orcid":"https://orcid.org/0000-0001-8107-5175","observed_orcids":["https://orcid.org/0000-0001-8107-5175"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210141533","display_name":"U.S. National Poultry Research Center","ror":"https://ror.org/03sc3bx43","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210141533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Velez-Irizarry","raw_affiliation_strings":["Avian Diseases and Oncology Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 4279 E. Mount Hope Road, East Lansing, MI 48823, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Avian Diseases and Oncology Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 4279 E. Mount Hope Road, East Lansing, MI 48823, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047098034","display_name":"Sanjay M. Reddy","orcid":"https://orcid.org/0000-0001-9304-8887","observed_orcids":["https://orcid.org/0000-0001-9304-8887"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay M. Reddy","raw_affiliation_strings":["Department of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030297307","display_name":"Stephen J. Spatz","orcid":"https://orcid.org/0000-0002-1545-5855","observed_orcids":["https://orcid.org/0000-0002-1545-5855"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210141533","display_name":"U.S. National Poultry Research Center","ror":"https://ror.org/03sc3bx43","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210141533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Spatz","raw_affiliation_strings":["Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I4210141533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064384439","display_name":"Hans H. Cheng","orcid":"https://orcid.org/0000-0003-2071-4644","observed_orcids":["https://orcid.org/0000-0003-2071-4644"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210141533","display_name":"U.S. National Poultry Research Center","ror":"https://ror.org/03sc3bx43","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210141533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans H. Cheng","raw_affiliation_strings":["Avian Diseases and Oncology Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 4279 E. Mount Hope Road, East Lansing, MI 48823, USA"],"raw_orcid":"https://orcid.org/0000-0003-2071-4644","affiliations":[{"raw_affiliation_string":"Avian Diseases and Oncology Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 4279 E. Mount Hope Road, East Lansing, MI 48823, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141533"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023558807","display_name":"John R. Dunn","orcid":"https://orcid.org/0000-0002-7287-0916","observed_orcids":["https://orcid.org/0000-0002-7287-0916"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210141533","display_name":"U.S. National Poultry Research Center","ror":"https://ror.org/03sc3bx43","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210141533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Dunn","raw_affiliation_strings":["Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA"],"raw_orcid":"https://orcid.org/0000-0002-7287-0916","affiliations":[{"raw_affiliation_string":"Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I4210141533"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5086503140"],"corresponding_institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I4210141533"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":0.5675,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.59306206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"15","issue":"11","first_page":"2263","last_page":"2263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/marek-s-disease-virus","display_name":"Marek's disease virus","score":1.0},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.7680000066757202},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9539999961853027},{"id":"https://openalex.org/keywords/nonsynonymous-snps","display_name":"non-synonymous SNPs","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pathotyping","display_name":"pathotyping","score":0.6370000243186951},{"id":"https://openalex.org/keywords/very-virulent-marek-s-disease-virus","display_name":"very virulent Marek's disease virus","score":0.8709999918937683},{"id":"https://openalex.org/keywords/recombinant-viruses","display_name":"recombinant virus","score":0.8429999947547913},{"id":"https://openalex.org/keywords/open-reading-frames","display_name":"open reading frames","score":0.6019999980926514},{"id":"https://openalex.org/keywords/icp4","display_name":"ICP4","score":0.7440000176429749},{"id":"https://openalex.org/keywords/live-birds","display_name":"live birds","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.9617022275924683},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7790443897247314},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6139861345291138},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6006253957748413},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5825849771499634},{"id":"https://openalex.org/C149904235","wikidata":"https://www.wikidata.org/wiki/Q7049620","display_name":"Nonsynonymous substitution","level":4,"score":0.5811176300048828},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.532299280166626},{"id":"https://openalex.org/C2777852405","wikidata":"https://www.wikidata.org/wiki/Q53843869","display_name":"Marek's disease","level":3,"score":0.5202723145484924},{"id":"https://openalex.org/C2780530800","wikidata":"https://www.wikidata.org/wiki/Q7072921","display_name":"ORFS","level":5,"score":0.5058307647705078},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4645756185054779},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.431146502494812},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3829970359802246},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.12899145483970642},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.05443459749221802}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008380","descriptor_name":"Marek Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008381","descriptor_name":"Herpesvirus 2, Gallid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025922","descriptor_name":"Mardivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/v15112263","doi":"https://doi.org/10.3390/v15112263","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v15112263","pdf_url":"https://www.mdpi.com/1999-4915/15/11/2263/pdf?version=1700136938","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10674313","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10674313","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10674313/pdf/viruses-15-02263.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"Text"},{"id":"pmid:38005939","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38005939","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f5d8fa81c9184324b90272b298de58e6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f5d8fa81c9184324b90272b298de58e6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Viruses, Vol 15, Iss 11, p 2263 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/v15112263","doi":"https://doi.org/10.3390/v15112263","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v15112263","pdf_url":"https://www.mdpi.com/1999-4915/15/11/2263/pdf?version=1700136938","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2558733699","display_name":null,"funder_award_id":"6040-32000-083-000D","funder_id":"https://openalex.org/F4320332605","funder_display_name":"Agricultural Research Service"},{"id":"https://openalex.org/G5502514442","display_name":null,"funder_award_id":"2022-67015-36334","funder_id":"https://openalex.org/F4320306114","funder_display_name":"U.S. Department of Agriculture"},{"id":"https://openalex.org/G828965058","display_name":null,"funder_award_id":"2022-67015-36334","funder_id":"https://openalex.org/F4320332299","funder_display_name":"National Institute of Food and Agriculture"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320332605","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388734271.pdf","grobid_xml":"https://content.openalex.org/works/W4388734271.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W156627268","https://openalex.org/W1777421604","https://openalex.org/W1779437710","https://openalex.org/W1967837085","https://openalex.org/W1979266917","https://openalex.org/W1994882633","https://openalex.org/W2014089936","https://openalex.org/W2031841357","https://openalex.org/W2038574803","https://openalex.org/W2043104356","https://openalex.org/W2046262535","https://openalex.org/W2047509761","https://openalex.org/W2050122265","https://openalex.org/W2050351056","https://openalex.org/W2051051370","https://openalex.org/W2070429838","https://openalex.org/W2075931546","https://openalex.org/W2087148357","https://openalex.org/W2092300628","https://openalex.org/W2114287465","https://openalex.org/W2116137883","https://openalex.org/W2131271579","https://openalex.org/W2140215721","https://openalex.org/W2150131459","https://openalex.org/W2407449024","https://openalex.org/W2502341263","https://openalex.org/W2564838249","https://openalex.org/W2579513749","https://openalex.org/W2737250094","https://openalex.org/W2740565815","https://openalex.org/W2949877438","https://openalex.org/W2964849163","https://openalex.org/W2979869287","https://openalex.org/W3010198994","https://openalex.org/W3081631659","https://openalex.org/W3108632576","https://openalex.org/W3110778414","https://openalex.org/W3195527340"],"related_works":["https://openalex.org/W4414545241","https://openalex.org/W2949877438","https://openalex.org/W4411929630","https://openalex.org/W2050122265","https://openalex.org/W4399897197","https://openalex.org/W2051051370","https://openalex.org/W7130561246","https://openalex.org/W7171727958","https://openalex.org/W2038574803","https://openalex.org/W1997957814"],"abstract_inverted_index":{"2,":[0],"also":[1],"known":[2],"as":[3,164],"Marek's":[4],"disease":[5],"virus":[6],"(MDV),":[7],"is":[8,190],"the":[9,50,78,85,99,109,114,121,127,129,140,183],"causative":[10],"pathogen":[11],"and":[12,31,47,74,112,197,204],"has":[13],"been":[14],"categorized":[15],"based":[16],"on":[17],"its":[18],"virulence":[19,162],"rank":[20,126],"into":[21],"four":[22],"pathotypes:":[23],"mild":[24],"(m),":[25],"virulent":[26,29,33],"(v),":[27],"very":[28,32],"(vv),":[30],"plus":[34],"(vv+).":[35],"A":[36],"prior":[37],"comparative":[38],"genomics":[39],"study":[40],"suggested":[41],"that":[42,105,150,177],"several":[43],"single-nucleotide":[44],"polymorphisms":[45],"(SNPs)":[46],"genes":[48],"in":[49,61,98,135,152,172,182],"MDV":[51,184],"genome":[52,89,185],"are":[53,159,167,179],"associated":[54,160,186,206],"with":[55,95,161,187,207],"virulence,":[56,84,128,188],"including":[57],"nonsynonymous":[58],"(ns)":[59],"SNPs":[60,151,205],"eight":[62],"open":[63],"reading":[64],"frames":[65],"(ORF):":[66],"UL22,":[67],"UL36,":[68],"UL37,":[69],"UL41,":[70],"UL43,":[71],"R-LORF8,":[72],"R-LORF7,":[73],"ICP4.":[75],"To":[76],"validate":[77],"contribution":[79],"of":[80,116,156,201],"these":[81,106,145,157],"nsSNPs":[82],"to":[83,125,139,170],"vv+MDV":[86,131],"strain":[87],"686":[88,132],"was":[90],"modified":[91,130],"by":[92],"replacing":[93],"nucleotides":[94],"those":[96],"observed":[97],"vMDV":[100,174],"strains.":[101],"Pathogenicity":[102],"studies":[103],"indicated":[104],"substitutions":[107],"reduced":[108],"MD":[110],"incidence":[111],"increased":[113],"survival":[115],"challenged":[117],"birds.":[118],"Furthermore,":[119],"using":[120],"best-fit":[122],"pathotyping":[123],"method":[124],"viruses":[133],"resulted":[134],"a":[136,165,173],"pathotype":[137],"similar":[138],"vvMDV":[141],"Md5":[142],"strain.":[143],"Thus,":[144],"results":[146],"support":[147],"our":[148,198],"hypothesis":[149],"one":[153],"or":[154],"more":[155],"ORFs":[158],"but,":[163],"group,":[166],"not":[168,191],"sufficient":[169],"result":[171],"pathotype,":[175],"suggesting":[176],"there":[178],"additional":[180,202],"variants":[181,203],"which":[189],"surprising":[192],"given":[193],"this":[194],"complex":[195],"phenotype":[196],"previous":[199],"finding":[200],"virulence.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-11-17T00:00:00"}