{"id":"https://openalex.org/W4388731516","doi":"https://doi.org/10.7717/peerj.16342","title":"Integrated single-dose kinome profiling data is predictive of cancer cell line sensitivity to kinase inhibitors","display_name":"Integrated single-dose kinome profiling data is predictive of cancer cell line sensitivity to kinase inhibitors","publication_year":2023,"publication_date":"2023-11-16","ids":{"openalex":"https://openalex.org/W4388731516","doi":"https://doi.org/10.7717/peerj.16342","pmid":"https://pubmed.ncbi.nlm.nih.gov/38025707","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10657565"},"language":"en","primary_location":{"id":"doi:10.7717/peerj.16342","doi":"https://doi.org/10.7717/peerj.16342","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.16342","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7717/peerj.16342","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015090317","display_name":"Chinmaya U. Joisa","orcid":"https://orcid.org/0000-0001-5088-9598","observed_orcids":["https://orcid.org/0000-0001-5088-9598"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chinmaya U. Joisa","raw_affiliation_strings":["Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA","Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5088-9598","affiliations":[{"raw_affiliation_string":"Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137902535"]},{"raw_affiliation_string":"Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, United States of America","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044061634","display_name":"Kevin A. Chen","orcid":"https://orcid.org/0000-0003-1610-5889","observed_orcids":["https://orcid.org/0000-0003-1610-5889"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin A. Chen","raw_affiliation_strings":["Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1610-5889","affiliations":[{"raw_affiliation_string":"Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090261482","display_name":"Matthew E. Berginski","orcid":"https://orcid.org/0000-0002-4798-3273","observed_orcids":["https://orcid.org/0000-0002-4798-3273"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew E. Berginski","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4798-3273","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045554156","display_name":"Brian T. Golitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian T. Golitz","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Eshelman Institute for Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075242451","display_name":"Madison R. Jenner","orcid":"https://orcid.org/0000-0002-3402-8509","observed_orcids":["https://orcid.org/0000-0002-3402-8509"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madison R. Jenner","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006805437","display_name":"Gabriela Herrera Loeza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silvia G. Herrera Loeza","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065098287","display_name":"Jen Jen Yeh","orcid":"https://orcid.org/0000-0003-2542-6211","observed_orcids":["https://orcid.org/0000-0003-2542-6211"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jen Jen Yeh","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029081281","display_name":"Shawn M. Gomez","orcid":"https://orcid.org/0000-0002-8251-4552","observed_orcids":["https://orcid.org/0000-0002-8251-4552"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shawn M. Gomez","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA","Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137902535"]},{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, United States of America","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029081281"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137902535"],"apc_list":{"value":1395,"currency":"USD","value_usd":1395},"apc_paid":{"value":1395,"currency":"USD","value_usd":1395},"fwci":0.8144,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.7195774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"11","issue":null,"first_page":"e16342","last_page":"e16342"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinome-profiling","display_name":"kinome profiling","score":0.9610000252723694},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cancer-cell-line-sensitivity","display_name":"cancer cell line sensitivity","score":0.824999988079071},{"id":"https://openalex.org/keywords/protein-kinase-activity","display_name":"protein kinase activity","score":0.7049999833106995},{"id":"https://openalex.org/keywords/ic50-prediction","display_name":"IC50 prediction","score":0.7120000123977661},{"id":"https://openalex.org/keywords/breast-cancer-cell-lines","display_name":"breast cancer cell lines","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pancreatic-cancer-cell-lines","display_name":"pancreatic cancer cell lines","score":0.9369999766349792},{"id":"https://openalex.org/keywords/patient-derived-cell-lines","display_name":"patient-derived cell lines","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C54174078","wikidata":"https://www.wikidata.org/wiki/Q3197188","display_name":"Kinome","level":3,"score":0.9980130195617676},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6416061520576477},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6174711585044861},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4598544239997864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4228781461715698},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3922904431819916},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3844035863876343},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.344657301902771},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21648883819580078}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.7717/peerj.16342","doi":"https://doi.org/10.7717/peerj.16342","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.16342","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},{"id":"doi:10.1101/2022.12.06.519165","doi":"https://doi.org/10.1101/2022.12.06.519165","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.12.06.519165","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/12/10/2022.12.06.519165.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10657565","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10657565","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10657565/pdf/peerj-11-16342.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"Text"},{"id":"pmid:38025707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38025707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8bc2b6d4dbfe4288a0ab2733a2068d82","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8bc2b6d4dbfe4288a0ab2733a2068d82","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PeerJ, Vol 11, p e16342 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7717/peerj.16342","doi":"https://doi.org/10.7717/peerj.16342","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.16342","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4558306147","display_name":"MICROFABRICATED INSTRUMENTATION TO MEASURE SPHINGOLIPID SIGNALING IN HUMAN ACUTE MYELOID LEUKEMIA","funder_award_id":"R01CA233811","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4962532565","display_name":"Predictive Modeling of the EGFR-MAPK pathway for Triple Negative Breast Cancer Patients","funder_award_id":"U01CA238475","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5706969922","display_name":"Illuminating Function of the Understudied Druggable Kinome","funder_award_id":"U24DK116204","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000919498","display_name":"Integrating tumor and stroma to understand and predict treatment response","funder_award_id":"U01CA274298","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388731516.pdf","grobid_xml":"https://content.openalex.org/works/W4388731516.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W2002069093","https://openalex.org/W2002143632","https://openalex.org/W2108933868","https://openalex.org/W2110071511","https://openalex.org/W2122825543","https://openalex.org/W2153080167","https://openalex.org/W2157395790","https://openalex.org/W2160811827","https://openalex.org/W2294990791","https://openalex.org/W2295598076","https://openalex.org/W2603489941","https://openalex.org/W2606715885","https://openalex.org/W2768921712","https://openalex.org/W2769263100","https://openalex.org/W2773242491","https://openalex.org/W2788451340","https://openalex.org/W2889326414","https://openalex.org/W2937295472","https://openalex.org/W2951428751","https://openalex.org/W2975481196","https://openalex.org/W3000653492","https://openalex.org/W3003119869","https://openalex.org/W3006807889","https://openalex.org/W3013093838","https://openalex.org/W3031592812","https://openalex.org/W3093660856","https://openalex.org/W3094568106","https://openalex.org/W3107527779","https://openalex.org/W3119588688","https://openalex.org/W3196809995","https://openalex.org/W3211988828","https://openalex.org/W4200242163","https://openalex.org/W4285606919","https://openalex.org/W4294541781","https://openalex.org/W4294576509","https://openalex.org/W4321436530","https://openalex.org/W4401966767"],"related_works":["https://openalex.org/W4321436530","https://openalex.org/W4414558342","https://openalex.org/W6925408937","https://openalex.org/W2992253338","https://openalex.org/W4401966767","https://openalex.org/W37577663","https://openalex.org/W3184867843","https://openalex.org/W3135649715","https://openalex.org/W2795491140","https://openalex.org/W4385740997"],"abstract_inverted_index":{"Abstract":[0],"Protein":[1],"kinase":[2,72,100],"activity":[3],"forms":[4],"the":[5,21,60,78,90,97,208],"backbone":[6],"of":[7,17,36,62,93,111,163,168,172,181,228,235],"cellular":[8,108,237],"information":[9],"transfer,":[10],"acting":[11],"both":[12],"individually":[13],"and":[14,54,80,103,118,136,170,174,183,206],"as":[15,32,44],"part":[16],"a":[18,33,46,160,179],"broader":[19],"network,":[20],"kinome.":[22],"Correspondingly,":[23],"their":[24,58,104],"central":[25],"role":[26,50],"in":[27,51,77,86,122,201,215],"signaling":[28],"implicates":[29],"kinome":[30,132,229],"dysfunction":[31],"common":[34],"driver":[35],"cancer,":[37],"where":[38],"numerous":[39],"kinases":[40,65,185],"have":[41],"been":[42],"identified":[43],"having":[45],"causal":[47],"or":[48],"modulating":[49],"cancer":[52,203,218],"development":[53,61],"progression.":[55],"Driven":[56],"by":[57,197,211],"importance,":[59],"therapies":[63],"targeting":[64],"has":[66],"rapidly":[67],"grown,":[68],"with":[69,143],"over":[70,81],"70":[71],"inhibitors":[73],"approved":[74],"for":[75,114],"use":[76,137],"clinic":[79],"double":[82],"this":[83,126,155],"number":[84],"currently":[85],"clinical":[87],"trials.":[88],"Given":[89],"growing":[91],"importance":[92,113],"kinase-targeted":[94],"therapies,":[95],"linking":[96],"relationship":[98],"between":[99],"inhibitor":[101],"treatment":[102,116,146],"effects":[105,200],"on":[106,154],"downstream":[107,236],"phenotype":[109],"is":[110,232],"clear":[112],"understanding":[115],"mechanisms":[117],"streamlining":[119],"compound":[120],"screening":[121],"therapy":[123],"development.":[124],"In":[125],"work,":[127],"we":[128,192],"combine":[129],"two":[130],"large-scale":[131],"profiling":[133],"data":[134,156],"sets":[135],"them":[138],"to":[139,177],"link":[140],"inhibitor-kinome":[141],"interactions":[142],"cell":[144,189,204,219],"line":[145],"responses":[147],"(AUC/IC50).":[148],"We":[149],"then":[150],"built":[151],"computational":[152],"models":[153,195],"set":[157,180],"that":[158,186,225],"achieve":[159],"high":[161],"degree":[162],"prediction":[164],"accuracy":[165],"(R":[166],"2":[167],"0.7":[169],"RMSE":[171],"0.9),":[173],"were":[175],"able":[176],"identify":[178],"well-characterized":[182],"understudied":[184],"significantly":[187],"affect":[188],"responses.":[190],"Further,":[191],"validated":[193],"these":[194,222],"experimentally":[196],"testing":[198],"predicted":[199],"breast":[202],"lines,":[205],"extended":[207],"model":[209],"scope":[210],"performing":[212],"additional":[213],"validation":[214],"patient-derived":[216],"pancreatic":[217],"lines.":[220],"Overall,":[221],"results":[223],"demonstrate":[224],"broad":[226],"quantification":[227],"inhibition":[230],"state":[231],"highly":[233],"predictive":[234],"phenotypes.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-17T00:00:00"}