{"id":"https://openalex.org/W4388708396","doi":null,"title":"Understanding the molecular stability of viral capsids from a physics perspective","display_name":"Understanding the molecular stability of viral capsids from a physics perspective","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4388708396"},"language":"en","primary_location":{"id":"pmh:oai:HAL:hal-04281837v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04281837","pdf_url":"https://hal.science/hal-04281837v1/file/Castelnovo_preprint.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.researchtrends.net/tia/abstract.asp?in=0&vn=19&tid=38&aid=7173&pub=2022&type=3","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hal.science/hal-04281837v1/file/Castelnovo_preprint.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049870815","display_name":"Martin Castelnovo","orcid":"https://orcid.org/0000-0003-1118-7360","observed_orcids":["https://orcid.org/0000-0003-1118-7360"]},"institutions":[{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210096929","display_name":"Laboratoire de Physique de l'ENS de Lyon","ror":"https://ror.org/00w5ay796","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I112936343","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210096929","https://openalex.org/I4405259976","https://openalex.org/I4405263940","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Castelnovo, Martin","raw_affiliation_strings":["Phys-ENS - Laboratoire de Physique de l'ENS Lyon (46 all\u00e9e d'Italie 69007 Lyon - France)","Laboratoire de Physique de l'ENS Lyon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phys-ENS - Laboratoire de Physique de l'ENS Lyon (46 all\u00e9e d'Italie 69007 Lyon - France)","institution_ids":["https://openalex.org/I4210096929"]},{"raw_affiliation_string":"Laboratoire de Physique de l'ENS Lyon","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I4210096929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013521286","display_name":"Fabien Montel","orcid":"https://orcid.org/0000-0001-5430-864X","observed_orcids":["https://orcid.org/0000-0001-5430-864X"]},"institutions":[{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210096929","display_name":"Laboratoire de Physique de l'ENS de Lyon","ror":"https://ror.org/00w5ay796","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I112936343","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210096929","https://openalex.org/I4405259976","https://openalex.org/I4405263940","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Montel, Fabien","raw_affiliation_strings":["Phys-ENS - Laboratoire de Physique de l'ENS Lyon (46 all\u00e9e d'Italie 69007 Lyon - France)","Laboratoire de Physique de l'ENS Lyon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phys-ENS - Laboratoire de Physique de l'ENS Lyon (46 all\u00e9e d'Italie 69007 Lyon - France)","institution_ids":["https://openalex.org/I4210096929"]},{"raw_affiliation_string":"Laboratoire de Physique de l'ENS Lyon","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I4210096929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059700169","display_name":"Cendrine Faivre-Moskalenko","orcid":"https://orcid.org/0000-0002-2686-0995","observed_orcids":["https://orcid.org/0000-0002-2686-0995"]},"institutions":[{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210096929","display_name":"Laboratoire de Physique de l'ENS de Lyon","ror":"https://ror.org/00w5ay796","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I112936343","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210096929","https://openalex.org/I4405259976","https://openalex.org/I4405263940","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Faivre-Moskalenko, Cendrine","raw_affiliation_strings":["Phys-ENS - Laboratoire de Physique de l'ENS Lyon (46 all\u00e9e d'Italie 69007 Lyon - France)","Laboratoire de Physique de l'ENS Lyon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phys-ENS - Laboratoire de Physique de l'ENS Lyon (46 all\u00e9e d'Italie 69007 Lyon - France)","institution_ids":["https://openalex.org/I4210096929"]},{"raw_affiliation_string":"Laboratoire de Physique de l'ENS Lyon","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I4210096929"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12632619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":null,"first_page":"39","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-capsid","display_name":"viral capsid","score":0.9940000176429749},{"id":"https://openalex.org/keywords/molecular-stability","display_name":"molecular stability","score":0.8479999899864197},{"id":"https://openalex.org/keywords/protein-self-assembly","display_name":"protein self-assembly","score":0.9539999961853027},{"id":"https://openalex.org/keywords/capsid-disassembly","display_name":"capsid disassembly","score":0.921999990940094},{"id":"https://openalex.org/keywords/capsid-protein","display_name":"capsid protein","score":0.6039999723434448},{"id":"https://openalex.org/keywords/structural-integrity","display_name":"structural integrity","score":0.6240000128746033},{"id":"https://openalex.org/keywords/microenvironment","display_name":"microenvironment","score":0.4860000014305115},{"id":"https://openalex.org/keywords/external-disturbances","display_name":"external disturbances","score":0.753000020980835},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.8809999823570251},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.7408937215805054},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.6719363927841187},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.46340489387512207},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4503367245197296},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.4139050841331482},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39724814891815186},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3723868429660797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21745935082435608},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1978403627872467},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17360076308250427},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.06387808918952942},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:HAL:hal-04281837v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04281837","pdf_url":"https://hal.science/hal-04281837v1/file/Castelnovo_preprint.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.researchtrends.net/tia/abstract.asp?in=0&vn=19&tid=38&aid=7173&pub=2022&type=3","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:HAL:hal-04281837v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04281837","pdf_url":"https://hal.science/hal-04281837v1/file/Castelnovo_preprint.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.researchtrends.net/tia/abstract.asp?in=0&vn=19&tid=38&aid=7173&pub=2022&type=3","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388708396.pdf","grobid_xml":"https://content.openalex.org/works/W4388708396.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2343837063","https://openalex.org/W4405922306","https://openalex.org/W75460301","https://openalex.org/W2064524294","https://openalex.org/W1984909504","https://openalex.org/W1975706199","https://openalex.org/W1996767976","https://openalex.org/W2058582048","https://openalex.org/W3152075478","https://openalex.org/W4211037153"],"abstract_inverted_index":{"During":[0],"its":[1,45],"replication":[2],"cycle,":[3],"viral":[4,40],"capsids":[5,76],"undergo":[6],"various":[7],"transformations":[8],"going":[9],"from":[10],"protein":[11],"selfassembly":[12],"to":[13,19],"disassembly.":[14],"The":[15],"micro-environment":[16],"is":[17],"thought":[18],"play":[20],"a":[21],"major":[22],"role":[23],"in":[24,64],"triggering":[25],"these":[26],"transformations.":[27],"In":[28,50],"this":[29],"work,":[30],"we":[31],"review":[32],"the":[33,37,54,62],"current":[34],"understanding":[35],"of":[36,39],"correlation":[38],"capsid":[41,59],"molecular":[42],"stability":[43],"with":[44],"physical":[46],"and":[47,61,84],"chemical":[48],"environment.":[49],"particular,":[51],"by":[52,90],"analyzing":[53],"forces":[55],"that":[56],"act":[57],"on":[58],"proteins":[60],"ways":[63],"which":[65],"they":[66,86],"are":[67],"held":[68],"together,":[69],"one":[70],"can":[71],"gain":[72],"insight":[73],"into":[74],"how":[75,85],"maintain":[77],"their":[78],"structural":[79],"integrity":[80],"under":[81],"different":[82],"conditions":[83],"may":[87],"be":[88],"affected":[89],"external":[91],"perturbations":[92],"such":[93],"as":[94],"mutations,":[95],"drug":[96],"treatments,":[97],"or":[98],"mechanical":[99],"triggers.":[100]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-11-16T00:00:00"}