{"id":"https://openalex.org/W4388701645","doi":"https://doi.org/10.1097/ana.0000000000000938","title":"Effect of Repeated Exposure to Sevoflurane on Electroencephalographic Alpha Oscillation in Pediatric Patients Undergoing Radiation Therapy: A Prospective Observational Study","display_name":"Effect of Repeated Exposure to Sevoflurane on Electroencephalographic Alpha Oscillation in Pediatric Patients Undergoing Radiation Therapy: A Prospective Observational Study","publication_year":2023,"publication_date":"2023-11-13","ids":{"openalex":"https://openalex.org/W4388701645","doi":"https://doi.org/10.1097/ana.0000000000000938","pmid":"https://pubmed.ncbi.nlm.nih.gov/37965706"},"language":"en","primary_location":{"id":"doi:10.1097/ana.0000000000000938","doi":"https://doi.org/10.1097/ana.0000000000000938","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ana.0000000000000938","pdf_url":null,"source":{"id":"https://openalex.org/S23610305","display_name":"Journal of Neurosurgical Anesthesiology","issn_l":"0898-4921","issn":["0898-4921","1537-1921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgical Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013752569","display_name":"Samuel Madariaga","orcid":"https://orcid.org/0000-0001-6516-5867","observed_orcids":["https://orcid.org/0000-0001-6516-5867"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Samuel Madariaga","raw_affiliation_strings":["Centro Nacional de Inteligencia Artificial (CENIA) Chile","Department of Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Inteligencia Artificial (CENIA) Chile","institution_ids":[]},{"raw_affiliation_string":"Department of Neuroscience","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019041854","display_name":"Christ Devia","orcid":"https://orcid.org/0000-0002-2416-0864","observed_orcids":["https://orcid.org/0000-0002-2416-0864"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christ Devia","raw_affiliation_strings":["Centro Nacional de Inteligencia Artificial (CENIA) Chile","Department of Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Inteligencia Artificial (CENIA) Chile","institution_ids":[]},{"raw_affiliation_string":"Department of Neuroscience","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101570451","display_name":"Antonello Penna S.","orcid":"https://orcid.org/0000-0002-8626-4415","observed_orcids":["https://orcid.org/0000-0002-8626-4415"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Antonello Penna","raw_affiliation_strings":["Centro de Investigaci\u00f3n Cl\u00ednica Avanzada (CICA), Faculty of Medicine, University of Chile","Department of Anesthesiology and Perioperative Medicine, University of Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Cl\u00ednica Avanzada (CICA), Faculty of Medicine, University of Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Department of Anesthesiology and Perioperative Medicine, University of Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053873808","display_name":"Jose Ignacio Ega\u00f1a","orcid":"https://orcid.org/0000-0003-1242-0232","observed_orcids":["https://orcid.org/0000-0003-1242-0232"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 I. Ega\u00f1a","raw_affiliation_strings":["Centro Nacional de Inteligencia Artificial (CENIA) Chile","Department of Anesthesiology and Perioperative Medicine, University of Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Inteligencia Artificial (CENIA) Chile","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology and Perioperative Medicine, University of Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091989081","display_name":"Vanessa Lucero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134348","display_name":"National Cancer Institute","ror":"https://ror.org/044ybef51","country_code":"MY","type":"government","lineage":["https://openalex.org/I105292261","https://openalex.org/I4210134348"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["MY","UA","US"],"is_corresponding":false,"raw_author_name":"Vanessa Lucero","raw_affiliation_strings":["Department of Anesthesia, National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, National Cancer Institute","institution_ids":["https://openalex.org/I4210123359","https://openalex.org/I4210134348","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Soledad Ram\u00edrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134348","display_name":"National Cancer Institute","ror":"https://ror.org/044ybef51","country_code":"MY","type":"government","lineage":["https://openalex.org/I105292261","https://openalex.org/I4210134348"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["MY","UA","US"],"is_corresponding":false,"raw_author_name":"Soledad Ram\u00edrez","raw_affiliation_strings":["Department of Anesthesia, National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, National Cancer Institute","institution_ids":["https://openalex.org/I4210123359","https://openalex.org/I4210134348","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079459676","display_name":"Felipe Maldonado","orcid":"https://orcid.org/0000-0002-2633-4717","observed_orcids":["https://orcid.org/0000-0002-2633-4717"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Felipe Maldonado","raw_affiliation_strings":["Department of Anesthesiology and Perioperative Medicine, University of Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Perioperative Medicine, University of Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102579737","display_name":"Macarena Ganga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134348","display_name":"National Cancer Institute","ror":"https://ror.org/044ybef51","country_code":"MY","type":"government","lineage":["https://openalex.org/I105292261","https://openalex.org/I4210134348"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["MY","UA","US"],"is_corresponding":false,"raw_author_name":"Macarena Ganga","raw_affiliation_strings":["Department of Anesthesia, National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, National Cancer Institute","institution_ids":["https://openalex.org/I4210123359","https://openalex.org/I4210134348","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085964422","display_name":"Nicol\u00e1s Valls","orcid":"https://orcid.org/0000-0002-3664-5770","observed_orcids":["https://orcid.org/0000-0002-3664-5770"]},"institutions":[{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134348","display_name":"National Cancer Institute","ror":"https://ror.org/044ybef51","country_code":"MY","type":"government","lineage":["https://openalex.org/I105292261","https://openalex.org/I4210134348"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["MY","UA","US"],"is_corresponding":false,"raw_author_name":"Nicol\u00e1s Valls","raw_affiliation_strings":["Department of Anesthesia, National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, National Cancer Institute","institution_ids":["https://openalex.org/I4210123359","https://openalex.org/I4210134348","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044916385","display_name":"Nicol\u00e1s Villablanca","orcid":"https://orcid.org/0000-0001-5742-9658","observed_orcids":["https://orcid.org/0000-0001-5742-9658"]},"institutions":[{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134348","display_name":"National Cancer Institute","ror":"https://ror.org/044ybef51","country_code":"MY","type":"government","lineage":["https://openalex.org/I105292261","https://openalex.org/I4210134348"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["MY","UA","US"],"is_corresponding":false,"raw_author_name":"Nicol\u00e1s Villablanca","raw_affiliation_strings":["Department of Anesthesia, National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, National Cancer Institute","institution_ids":["https://openalex.org/I4210123359","https://openalex.org/I4210134348","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075387353","display_name":"Tom\u00e1s Stamm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134348","display_name":"National Cancer Institute","ror":"https://ror.org/044ybef51","country_code":"MY","type":"government","lineage":["https://openalex.org/I105292261","https://openalex.org/I4210134348"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["MY","UA","US"],"is_corresponding":false,"raw_author_name":"Tom\u00e1s Stamm","raw_affiliation_strings":["Department of Anesthesia, National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, National Cancer Institute","institution_ids":["https://openalex.org/I4210123359","https://openalex.org/I4210134348","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005240128","display_name":"Patrick L. Purdon","orcid":"https://orcid.org/0000-0003-0080-3340","observed_orcids":["https://orcid.org/0000-0003-0080-3340"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick L. Purdon","raw_affiliation_strings":["Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101233787","display_name":"Rodrigo Guti\u00e9rrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL","US"],"is_corresponding":false,"raw_author_name":"Rodrigo Guti\u00e9rrez","raw_affiliation_strings":["Centro de Investigaci\u00f3n Cl\u00ednica Avanzada (CICA), Faculty of Medicine, University of Chile","Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA","Department of Anesthesiology and Perioperative Medicine, University of Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Cl\u00ednica Avanzada (CICA), Faculty of Medicine, University of Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Anesthesiology and Perioperative Medicine, University of Chile","institution_ids":["https://openalex.org/I69737025"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5013752569","https://openalex.org/A5019041854","https://openalex.org/A5053873808"],"corresponding_institution_ids":["https://openalex.org/I69737025"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"2","first_page":"125","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sevoflurane","display_name":"sevoflurane","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pediatric-anesthesia","display_name":"pediatric anesthesia","score":0.7080000042915344},{"id":"https://openalex.org/keywords/spectral-edge-frequency","display_name":"spectral edge frequency","score":0.7680000066757202},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.578000009059906},{"id":"https://openalex.org/keywords/induction-period","display_name":"induction period","score":0.6880000233650208},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9248733520507812},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.8031634092330933},{"id":"https://openalex.org/C2781453256","wikidata":"https://www.wikidata.org/wiki/Q419394","display_name":"Sevoflurane","level":2,"score":0.7839311361312866},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.685490071773529},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6702127456665039},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5447713732719421},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.4514365792274475},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.41272592544555664},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23786437511444092},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.20873063802719116}],"mesh":[{"descriptor_ui":"D000077149","descriptor_name":"Sevoflurane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008738","descriptor_name":"Methyl Ethers","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/ana.0000000000000938","doi":"https://doi.org/10.1097/ana.0000000000000938","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ana.0000000000000938","pdf_url":null,"source":{"id":"https://openalex.org/S23610305","display_name":"Journal of Neurosurgical Anesthesiology","issn_l":"0898-4921","issn":["0898-4921","1537-1921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgical Anesthesiology","raw_type":"journal-article"},{"id":"pmid:37965706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37965706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurosurgical anesthesiology","raw_type":"Observational Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1950544107","https://openalex.org/W1971158662","https://openalex.org/W1978956684","https://openalex.org/W1993222366","https://openalex.org/W2002996884","https://openalex.org/W2015304937","https://openalex.org/W2025401173","https://openalex.org/W2032869546","https://openalex.org/W2044670283","https://openalex.org/W2088475496","https://openalex.org/W2094480329","https://openalex.org/W2095232157","https://openalex.org/W2129838520","https://openalex.org/W2151442629","https://openalex.org/W2159642468","https://openalex.org/W2275737843","https://openalex.org/W2616971107","https://openalex.org/W2738237448","https://openalex.org/W2800199651","https://openalex.org/W2961103009","https://openalex.org/W2974124135","https://openalex.org/W2978116648","https://openalex.org/W2981152026","https://openalex.org/W3025945084","https://openalex.org/W3054218374","https://openalex.org/W3080201065","https://openalex.org/W3090895598","https://openalex.org/W3093390547","https://openalex.org/W3132857833","https://openalex.org/W4205684527","https://openalex.org/W4291824638","https://openalex.org/W4296949396","https://openalex.org/W4362559754"],"related_works":["https://openalex.org/W3093615399","https://openalex.org/W2078754771","https://openalex.org/W2891257140","https://openalex.org/W1979020936","https://openalex.org/W1987318559","https://openalex.org/W4256576169","https://openalex.org/W2046726750","https://openalex.org/W2008890394","https://openalex.org/W3151112112","https://openalex.org/W2358336077"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pharmacological":[1],"tolerance":[2,39,216],"is":[3],"defined":[4],"as":[5,235],"a":[6,12,101,157,223,228,236],"decrease":[7],"in":[8,40,48,74,156,189,230],"the":[9,17,21,25,66,92,95,109,122,148,151,174,186,195,231],"effect":[10],"of":[11,54,68,125,159,176,191,198,225,238],"drug":[13],"over":[14],"time,":[15],"or":[16,194],"need":[18],"to":[19,23,36,90,107,135,217],"increase":[20],"dose":[22],"achieve":[24],"same":[26],"effect.":[27],"It":[28],"has":[29],"not":[30,183,214],"been":[31],"established":[32],"whether":[33],"repeated":[34,208],"exposure":[35,210],"sevoflurane":[37,62,69],"induces":[38],"children.":[41],"METHODS:":[42],"We":[43,82],"conducted":[44],"an":[45],"observational":[46],"study":[47],"children":[49,118,206],"younger":[50],"than":[51],"6":[52],"years":[53],"age":[55],"scheduled":[56],"for":[57,211],"multiple":[58],"radiotherapy":[59,112,126,145,199,212],"sessions":[60,113,127],"with":[61,173],"anesthesia.":[63],"To":[64],"evaluate":[65,91,108],"development":[67],"tolerance,":[70],"we":[71,220],"analyzed":[72],"changes":[73],"electroencephalographic":[75],"spectral":[76,166],"power":[77,164,234],"at":[78],"induction,":[79],"across":[80],"sessions.":[81,98,146,178,200],"fitted":[83],"individual":[84],"and":[85,97,114,121,144,165],"group-level":[86],"linear":[87,102,152],"regression":[88],"models":[89],"correlation":[93,140],"between":[94,111,141],"outcomes":[96],"In":[99],"addition,":[100],"mixed-effect":[103,153],"model":[104,154],"was":[105,130,138],"used":[106],"association":[110],"outcomes.":[115],"RESULTS:":[116],"Eighteen":[117],"were":[119,170],"included":[120],"median":[123],"number":[124,175,197],"per":[128],"child":[129],"28":[131],"(interquartile":[132],"range:":[133],"10":[134],"33).":[136],"There":[137],"no":[139],"induction":[142],"time":[143],"At":[147],"group":[149,224],"level,":[150],"showed,":[155],"subgroup":[158,181],"patients,":[160],"that":[161,205,222,246],"alpha":[162,232],"relative":[163,233],"edge":[167],"frequency":[168],"95":[169],"inversely":[171],"correlated":[172],"anesthesia":[177,209],"Nonetheless,":[179],"this":[180],"did":[182],"differ":[184],"from":[185],"other":[187],"subjects":[188],"terms":[190],"age,":[192],"sex,":[193],"total":[196],"CONCLUSIONS:":[201],"Our":[202],"results":[203,242],"suggest":[204],"undergoing":[207],"do":[213],"develop":[215],"sevoflurane.":[218],"However,":[219],"found":[221],"patients":[226],"exhibited":[227],"reduction":[229],"function":[237],"anesthetic":[239],"exposure.":[240],"These":[241],"may":[243],"have":[244],"implications":[245],"justify":[247],"further":[248],"studies.":[249]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-16T00:00:00"}