{"id":"https://openalex.org/W4388700780","doi":"https://doi.org/10.1038/s41598-023-46511-3","title":"Polysorbate 80 surface modified SLNs of formoterol suppress SNCA gene and mitochondrial oxidative stress in mice model of Parkinson\u2019s disease","display_name":"Polysorbate 80 surface modified SLNs of formoterol suppress SNCA gene and mitochondrial oxidative stress in mice model of Parkinson\u2019s disease","publication_year":2023,"publication_date":"2023-11-15","ids":{"openalex":"https://openalex.org/W4388700780","doi":"https://doi.org/10.1038/s41598-023-46511-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/37968340","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10651909"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-46511-3","doi":"https://doi.org/10.1038/s41598-023-46511-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-46511-3","pdf_url":"https://www.nature.com/articles/s41598-023-46511-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-46511-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043723173","display_name":"Piyong Sola","orcid":"https://orcid.org/0000-0003-3503-7316","observed_orcids":["https://orcid.org/0000-0003-3503-7316"]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Piyong Sola","raw_affiliation_strings":["Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, 643001, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, 643001, Tamil Nadu, India","institution_ids":["https://openalex.org/I126824641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036895663","display_name":"Kusuma Kumari Garikapati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kusuma Kumari Garikapati","raw_affiliation_strings":["Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, 643001, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, 643001, Tamil Nadu, India","institution_ids":["https://openalex.org/I126824641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027192697","display_name":"Praveen Thaggikuppe Krishnamurthy","orcid":"https://orcid.org/0000-0003-2666-0878","observed_orcids":["https://orcid.org/0000-0003-2666-0878"]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Praveen Thaggikuppe Krishnamurthy","raw_affiliation_strings":["Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, 643001, Tamil Nadu, India. praveentk7812@gmail.com","Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, 643001, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, 643001, Tamil Nadu, India. praveentk7812@gmail.com","institution_ids":["https://openalex.org/I126824641"]},{"raw_affiliation_string":"Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, 643001, Tamil Nadu, India","institution_ids":["https://openalex.org/I126824641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109500901","display_name":"Mamta Kumari","orcid":"https://orcid.org/0000-0002-9917-2077","observed_orcids":["https://orcid.org/0000-0002-9917-2077"]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mamta Kumari","raw_affiliation_strings":["Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, 643001, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, 643001, Tamil Nadu, India","institution_ids":["https://openalex.org/I126824641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027192697"],"corresponding_institution_ids":["https://openalex.org/I126824641"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":0.8592,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.61817741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"19942","last_page":"19942"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.22439999878406525,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.11630000174045563,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/formoterol","display_name":"formoterol","score":0.9769999980926514},{"id":"https://openalex.org/keywords/solid-lipid-nanoparticles","display_name":"solid lipid nanoparticles","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tween-80","display_name":"Tween 80","score":0.9459999799728394},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8240000009536743},{"id":"https://openalex.org/keywords/beta-2-adrenergic-agonists","display_name":"beta2-adrenergic agonists","score":0.8330000042915344},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.8640000224113464},{"id":"https://openalex.org/keywords/mitochondrial-oxidative-stress","display_name":"mitochondrial oxidative stress","score":0.8870000243186951},{"id":"https://openalex.org/keywords/rotenone-induced-neurotoxicity","display_name":"rotenone-induced neurotoxicity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9670000076293945},{"id":"https://openalex.org/keywords/brain-bioavailability","display_name":"brain bioavailability","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7009999752044678},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8009305000305176},{"id":"https://openalex.org/C2779871671","wikidata":"https://www.wikidata.org/wiki/Q637247","display_name":"Formoterol","level":4,"score":0.4894064962863922},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.48108479380607605},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.43447983264923096},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43106958270072937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4107198119163513},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35732394456863403},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3508721590042114},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20109280943870544},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18342313170433044},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.143668532371521},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.07382556796073914},{"id":"https://openalex.org/C2776136866","wikidata":"https://www.wikidata.org/wiki/Q422212","display_name":"Budesonide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011136","descriptor_name":"Polysorbates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012402","descriptor_name":"Rotenone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-023-46511-3","doi":"https://doi.org/10.1038/s41598-023-46511-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-46511-3","pdf_url":"https://www.nature.com/articles/s41598-023-46511-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10651909","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10651909","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10651909/pdf/41598_2023_Article_46511.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:37968340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37968340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bcc67ac13c084193bb46b3c6b1fac74b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bcc67ac13c084193bb46b3c6b1fac74b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-46511-3","doi":"https://doi.org/10.1038/s41598-023-46511-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-46511-3","pdf_url":"https://www.nature.com/articles/s41598-023-46511-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5372427655","display_name":null,"funder_award_id":"01/09/2019","funder_id":"https://openalex.org/F4320313289","funder_display_name":"Lady Tata Memorial Trust"},{"id":"https://openalex.org/G6253782340","display_name":null,"funder_award_id":"SR/FST/LSI-574/2013","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F4320313289","display_name":"Lady Tata Memorial Trust","ror":"https://ror.org/019yg2621"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388700780.pdf","grobid_xml":"https://content.openalex.org/works/W4388700780.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1497063116","https://openalex.org/W1926220930","https://openalex.org/W1963490643","https://openalex.org/W1982240516","https://openalex.org/W1984879946","https://openalex.org/W1993760429","https://openalex.org/W1995422243","https://openalex.org/W1999134373","https://openalex.org/W2011934424","https://openalex.org/W2012557172","https://openalex.org/W2018121350","https://openalex.org/W2027692613","https://openalex.org/W2045344585","https://openalex.org/W2069976868","https://openalex.org/W2072229818","https://openalex.org/W2080691054","https://openalex.org/W2089357832","https://openalex.org/W2091977884","https://openalex.org/W2099318703","https://openalex.org/W2109442469","https://openalex.org/W2112326782","https://openalex.org/W2139835982","https://openalex.org/W2161410503","https://openalex.org/W2162838846","https://openalex.org/W2270622139","https://openalex.org/W2322297176","https://openalex.org/W2343469774","https://openalex.org/W2395300225","https://openalex.org/W2418560736","https://openalex.org/W2584311212","https://openalex.org/W2595124104","https://openalex.org/W2605158646","https://openalex.org/W2612832381","https://openalex.org/W2753292637","https://openalex.org/W2754736381","https://openalex.org/W2770537873","https://openalex.org/W2803001759","https://openalex.org/W3025422232","https://openalex.org/W3033040200","https://openalex.org/W3207106677","https://openalex.org/W4283022816"],"related_works":["https://openalex.org/W4388588285","https://openalex.org/W3033040200","https://openalex.org/W2008264823","https://openalex.org/W4299865718","https://openalex.org/W7043324916","https://openalex.org/W2027692613","https://openalex.org/W4388018302","https://openalex.org/W7007978020","https://openalex.org/W3127260144","https://openalex.org/W7161693970"],"abstract_inverted_index":{"The":[0,93,120,137,171,204],"present":[1,205],"study":[2,124,206],"hypothesises":[3],"that":[4,35],"the":[5,70,97,126,144,153,162,166,176,193,209],"selective":[6],"brain":[7,36,167,198,210],"\u03b22":[8],"receptor":[9],"activation":[10],"through":[11],"\u03b22-adrenoreceptor":[12],"agonist":[13],"(\u03b22ARA),":[14],"Formoterol":[15,40,49],"(FMT),":[16],"suppresses":[17],"SNCA":[18,98],"gene":[19],"expression,":[20,99],"a":[21,133,149,181,200],"pathological":[22],"hallmark":[23],"of":[24,39,48,125,143,169,175,196,217],"Parkinson's":[25],"disease":[26],"(PD)":[27],"in":[28,107,116,146,152,178,187],"brain.":[29],"Further,":[30,192],"it":[31],"is":[32],"also":[33,164],"hypothesized":[34],"targeted":[37,211],"delivery":[38,212],"via":[41],"polysorbate-80":[42],"surface":[43],"modified":[44],"solid":[45],"lipid":[46],"nanoparticles":[47],"(FMT-SLNs-PS80)":[50],"can":[51],"improve":[52],"its":[53],"stability,":[54],"therapeutic":[55,215],"efficacy":[56,173,216],"and":[57,78,90,103,112,139,189,213],"avoid/reduce":[58],"peripheral":[59],"off-target":[60],"side":[61],"effects.":[62],"FMT-SLNs-PS80":[63],"was":[64,72],"prepared":[65],"by":[66,74,80],"solvent":[67],"injection":[68],"method,":[69],"formulation":[71,127,145,163,177],"optimized":[73],"using":[75,128],"Box-Behnken":[76],"design":[77],"characterized":[79],"measuring":[81],"drug":[82],"content,":[83],"entrapment":[84],"efficacy,":[85],"particle":[86],"size,":[87],"zeta":[88],"potentials":[89],"poly":[91],"dispersibility.":[92],"FMT-SLNs-PS80,":[94],"significantly":[95],"decreases":[96],"mitochondrial":[100],"membrane":[101],"damage":[102],"rotenone":[104],"induced":[105],"changes":[106,186],"oxidative":[108],"(SOD,":[109],"CAT,":[110],"GSH":[111],"ROS)":[113],"stress":[114],"markers":[115],"SH-SY5Y":[117],"cell":[118],"lines.":[119],"ex":[121],"vivo":[122],"permeation":[123],"everted":[129],"chicken":[130],"ileum":[131],"exhibited":[132],"steady":[134],"state":[135],"flux.":[136],"pharmacokinetic":[138],"tissue":[140],"distribution":[141],"studies":[142,174],"rats":[147],"showed":[148,180],"significant":[150,182,201],"improvement":[151],"kinetic":[154],"parameters":[155],"when":[156],"compared":[157],"to":[158],"na\u00efve":[159],"FMT,":[160],"further":[161],"improved":[165],"bioavailability":[168],"FMT.":[170],"anti-Parkinson's":[172,214],"mice":[179,197],"neuroprotection":[183],"against":[184],"rotenone-induced":[185],"behavioural":[188],"biochemical":[190],"parameters.":[191],"histopathological":[194],"analysis":[195],"confirms":[199],"neuroprotective":[202],"benefit.":[203],"successfully":[207],"establishes":[208],"FMT-SLNs-PS80.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-11-16T00:00:00"}
