{"id":"https://openalex.org/W4388601047","doi":"https://doi.org/10.1093/eurheartj/ehad655.1756","title":"Mitral annulus disjunction: a detailed magnetic resonance study of phenotype and clinical significance","display_name":"Mitral annulus disjunction: a detailed magnetic resonance study of phenotype and clinical significance","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4388601047","doi":"https://doi.org/10.1093/eurheartj/ehad655.1756"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehad655.1756","doi":"https://doi.org/10.1093/eurheartj/ehad655.1756","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehad655.1756","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/44/Supplement_2/ehad655.1756/53607438/ehad655.1756.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/eurheartj/article-pdf/44/Supplement_2/ehad655.1756/53607438/ehad655.1756.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008854672","display_name":"Pedro Cust\u00f3dio","orcid":"https://orcid.org/0000-0002-0069-0844","observed_orcids":["https://orcid.org/0000-0002-0069-0844"]},"institutions":[{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P M Custodio","raw_affiliation_strings":["Barts Health NHS Trust , London , United Kingdom of Great Britain & Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Health NHS Trust , London , United Kingdom of Great Britain & Northern Ireland","institution_ids":["https://openalex.org/I225661044"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P Campos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P Campos","raw_affiliation_strings":["Barts Health NHS Trust , London , United Kingdom of Great Britain & Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Health NHS Trust , London , United Kingdom of Great Britain & Northern Ireland","institution_ids":["https://openalex.org/I225661044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007278959","display_name":"A R Moura","orcid":"https://orcid.org/0000-0001-8010-8780","observed_orcids":["https://orcid.org/0000-0001-8010-8780"]},"institutions":[{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A R Moura","raw_affiliation_strings":["Barts Health NHS Trust , London , United Kingdom of Great Britain & Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Health NHS Trust , London , United Kingdom of Great Britain & Northern Ireland","institution_ids":["https://openalex.org/I225661044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018472539","display_name":"Mohammed Yunus Khanji","orcid":"https://orcid.org/0000-0002-5903-4454","observed_orcids":["https://orcid.org/0000-0002-5903-4454"]},"institutions":[{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Khanji","raw_affiliation_strings":["Barts Health NHS Trust , London , United Kingdom of Great Britain & Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Health NHS Trust , London , United Kingdom of Great Britain & Northern Ireland","institution_ids":["https://openalex.org/I225661044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037924600","display_name":"Jo\u00e3o B. Augusto","orcid":"https://orcid.org/0000-0003-0040-5270","observed_orcids":["https://orcid.org/0000-0003-0040-5270"]},"institutions":[{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J A Bicho","raw_affiliation_strings":["Barts Health NHS Trust , London , United Kingdom of Great Britain & Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Health NHS Trust , London , United Kingdom of Great Britain & Northern Ireland","institution_ids":["https://openalex.org/I225661044"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031484534","display_name":"Lu\u00eds Rocha Lopes","orcid":"https://orcid.org/0000-0002-6408-4667","observed_orcids":["https://orcid.org/0000-0002-6408-4667"]},"institutions":[{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L R Lopes","raw_affiliation_strings":["Barts Health NHS Trust , London , United Kingdom of Great Britain & Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Health NHS Trust , London , United Kingdom of Great Britain & Northern Ireland","institution_ids":["https://openalex.org/I225661044"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I225661044"],"apc_list":{"value":4238,"currency":"EUR","value_usd":4584},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"Supplement_2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.35910001397132874,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.35910001397132874,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.20909999310970306,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.2037000060081482,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitral-annulus-disjunction","display_name":"mitral annulus disjunction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitral-annulus","display_name":"mitral annulus","score":0.703000009059906},{"id":"https://openalex.org/keywords/mitral-valve-prolapse","display_name":"mitral valve prolapse","score":0.7950000166893005},{"id":"https://openalex.org/keywords/ventricular-arrhythmias","display_name":"ventricular arrhythmias","score":0.8240000009536743},{"id":"https://openalex.org/keywords/ventricular-tachycardia","display_name":"ventricular tachycardia","score":0.8389999866485596},{"id":"https://openalex.org/keywords/mitral-annular-dilatation","display_name":"mitral annular dilatation","score":0.6470000147819519},{"id":"https://openalex.org/keywords/left-ventricular-systolic-function","display_name":"left ventricular systolic function","score":0.550000011920929},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.6069999933242798},{"id":"https://openalex.org/keywords/left-ventricular-end-diastolic-volume","display_name":"left ventricular end-diastolic volume","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9455872178077698},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7010473012924194},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6973225474357605},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.6888589262962341},{"id":"https://openalex.org/C2777728562","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral annulus","level":4,"score":0.6268909573554993},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5519291758537292},{"id":"https://openalex.org/C2777274916","wikidata":"https://www.wikidata.org/wiki/Q1913658","display_name":"Papillary muscle","level":2,"score":0.5221260190010071},{"id":"https://openalex.org/C2781030672","wikidata":"https://www.wikidata.org/wiki/Q735652","display_name":"Mitral valve prolapse","level":3,"score":0.48960405588150024},{"id":"https://openalex.org/C2776008845","wikidata":"https://www.wikidata.org/wiki/Q5038325","display_name":"Cardiac magnetic resonance imaging","level":3,"score":0.47332414984703064},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.46945708990097046},{"id":"https://openalex.org/C2776331378","wikidata":"https://www.wikidata.org/wiki/Q56002","display_name":"Ventricular tachycardia","level":2,"score":0.4419912099838257},{"id":"https://openalex.org/C169554166","wikidata":"https://www.wikidata.org/wiki/Q496359","display_name":"Systole","level":4,"score":0.43486836552619934},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.41673222184181213},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.28321248292922974},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2199694812297821},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.10004213452339172}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/eurheartj/ehad655.1756","doi":"https://doi.org/10.1093/eurheartj/ehad655.1756","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehad655.1756","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/44/Supplement_2/ehad655.1756/53607438/ehad655.1756.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/eurheartj/ehad655.1756","doi":"https://doi.org/10.1093/eurheartj/ehad655.1756","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehad655.1756","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/44/Supplement_2/ehad655.1756/53607438/ehad655.1756.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388601047.pdf","grobid_xml":"https://content.openalex.org/works/W4388601047.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400510343","https://openalex.org/W4200259016","https://openalex.org/W2891096905","https://openalex.org/W4400316243","https://openalex.org/W2964996243","https://openalex.org/W4380794492","https://openalex.org/W4411709004","https://openalex.org/W4377983931","https://openalex.org/W3206156313","https://openalex.org/W2906250501"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,171,288,382],"clinical":[3,35,351],"significance":[4],"and":[5,34,58,79,84,101,222,350,388],"arrhythmogenic":[6],"propensity":[7],"of":[8,41,86,126,160,260,290,312,326,333,341,371,376,379,384],"mitral":[9,27,81],"annulus":[10,194],"disjunction":[11],"(MAD)":[12],"are":[13],"not":[14,301,366],"well":[15],"established.":[16],"Our":[17],"aim":[18],"was":[19,65,68,94,107,138,144,155,165,174,214,227,254,263,270,293],"to":[20,104,360,368,392],"characterize":[21],"MAD":[22,46,67,106,137,153,201,210,277,320,342,361],"in":[23,30,97,140,198,207,229,274,304,395],"all-comers,":[24],"analyzing":[25],"the":[26,75,80,98,105,175,186,331,338,369],"valve":[28,192,355],"apparatus":[29],"detail,":[31],"scar":[32],"burden":[33],"outcomes.":[36,352],"Methods":[37],"Single-center":[38],"retrospective":[39],"analysis":[40,267,286,346],"all":[42],"consecutive":[43],"patients":[44,128,199,231,235,275,310,343],"with":[45,180,200,209,216,233,243,276,295],"described":[47],"by":[48,185],"cardiovascular":[49,313,389],"magnetic":[50],"resonance":[51],"(CMR)":[52],"between":[53,74],"2010-2022.":[54],"Medical":[55],"history,":[56],"imaging":[57],"arrhythmia":[59],"data":[60],"were":[61,114,130,148],"analysed.":[62],"Cardiovascular":[63],"mortality":[64],"assessed.":[66,95],"defined":[69],"as":[70,109,133],"a":[71,161,374],"separation":[72],"\u22652mm":[73],"left":[76,87],"ventricular":[77,120,386],"myocardium":[78],"annulus.":[82],"Presence":[83],"pattern":[85],"ventricle":[88],"(LV)":[89],"late":[90],"gadolinium":[91],"enhancement":[92],"(LGE)":[93],"Scar":[96,363],"papillary":[99],"muscles":[100],"areas":[102],"adjacent":[103],"identified":[108,132],"MAD-related.":[110],"Ventricular":[111],"arrhythmias":[112,387],"(VA)":[113],"grouped":[115],"into":[116],"non-sustained":[117,268,291],"(ectopies>10%/24h":[118],"or":[119,122,248,321],"tachycardia)":[121],"sustained.":[123],"Results":[124],"Out":[125],"341":[127],"who":[129],"initially":[131],"possibly":[134],"having":[135],"MAD,":[136,183,372],"confirmed":[139],"222.":[141],"Mean":[142,151],"age":[143],"49.2\u00b119.3":[145],"years,":[146],"126":[147],"male":[149],"(56.8%).":[150],"longitudinal":[152],"extent":[154,245,370],"5\u00b12.6mm,":[156],"while":[157,203],"circumferential":[158,249],"involvement":[159],"single":[162],"segment":[163,177],"(60\u00ba)":[164],"most":[166],"commonly":[167],"seen":[168],"(n=99,":[169],"44.6%).":[170],"inferior":[172],"wall":[173,188],"affected":[176],"(n=116,":[178],"52.2%)":[179],"more":[181,272],"extensive":[182,319],"followed":[184],"inferolateral":[187],"(n=71,":[189],"32%).":[190],"Mitral":[191,354],"(MV)":[193],"expanded":[195],"during":[196],"systole":[197],"\u22656mm,":[202],"annular":[204],"contraction":[205],"occurred":[206],"those":[208],"<6mm.":[211],"Annular":[212],"expansion":[213],"associated":[215,294],"MV":[217],"prolapse":[218],"(p=0.003),":[219],"billowing":[220],"(p=0.018)":[221],"curling":[223],"(p<0.001).":[224],"LV":[225,297],"LGE":[226,298,303],"present":[228],"82":[230],"(36.9%),":[232],"23":[234],"(10.4%)":[236],"showing":[237],"MAD-related":[238,302,322],"LGE,":[239,349],"but":[240,300,316,373],"no":[241],"association":[242],"disease":[244],"(MAD":[246],"length":[247],"involvement).":[250],"Median":[251],"follow-up":[252],"time":[253],"1392":[255],"(872-1922)":[256],"days.":[257],"No":[258],"episode":[259],"sustained":[261,385],"VA":[262,269,292],"observed.":[264],"In":[265],"univariable":[266],"significantly":[271],"prevalent":[273],"\u22656mm":[278],"(p=0.002),":[279],"although":[280],"this":[281,336,396],"tendency":[282],"faded":[283],"after":[284],"multivariate":[285],"(p=0.053).":[287],"presence":[289],"global":[296],"(p=0.005),":[299],"isolation":[305],"-":[306],"Table":[307],"1.":[308],"Three":[309],"died":[311,325],"causes":[314],"(1.4%),":[315],"none":[317],"had":[318],"LGE.":[323],"None":[324],"sudden":[327],"cardiac":[328],"arrest.":[329],"To":[330],"best":[332],"our":[334],"knowledge,":[335],"is":[337,358,364],"biggest":[339],"dataset":[340],"that":[344],"simultaneously":[345],"phenotype,":[347],"including":[348],"Conclusion":[353],"dysfunction":[356],"(prolapse/billowing)":[357],"linked":[359],"severity.":[362],"common,":[365],"related":[367],"predictor":[375],"VAs":[377],"independently":[378],"its":[380],"location.":[381],"risk":[383],"death":[390],"appears":[391],"be":[393],"low":[394],"all-comers":[397],"population.Table":[398],"1":[399]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-11-12T00:00:00"}
