{"id":"https://openalex.org/W4388588682","doi":"https://doi.org/10.1093/neuonc/noad179.0872","title":"EXTH-18. DEVELOPMENT OF A TRANSGENIC MOUSE MODEL ENABLING COMPARATIVE ANALYSIS OF CHIMERIC ANTIGEN RECEPTOR (CAR)-EXPRESSING IMMUNE CELL POPULATIONS FOR CANCER IMMUNOTHERAPY","display_name":"EXTH-18. DEVELOPMENT OF A TRANSGENIC MOUSE MODEL ENABLING COMPARATIVE ANALYSIS OF CHIMERIC ANTIGEN RECEPTOR (CAR)-EXPRESSING IMMUNE CELL POPULATIONS FOR CANCER IMMUNOTHERAPY","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4388588682","doi":"https://doi.org/10.1093/neuonc/noad179.0872","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10639655"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noad179.0872","doi":"https://doi.org/10.1093/neuonc/noad179.0872","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad179.0872","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_5/v227/53254967/noad179.0872.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_5/v227/53254967/noad179.0872.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089237578","display_name":"Ryusuke Hatae","orcid":"https://orcid.org/0000-0001-5636-8064","observed_orcids":["https://orcid.org/0000-0001-5636-8064"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryusuke Hatae","raw_affiliation_strings":["Department of Neurological Surgery, University of California San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048998314","display_name":"Payal B. Watchmaker","orcid":"https://orcid.org/0000-0002-0944-3890","observed_orcids":["https://orcid.org/0000-0002-0944-3890"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Payal Watchmaker","raw_affiliation_strings":["University of California, San Francisco , San Francisco, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco, CA , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086865229","display_name":"Akane Yamamichi","orcid":"https://orcid.org/0000-0002-8141-7339","observed_orcids":["https://orcid.org/0000-0002-8141-7339"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akane Yamamichi","raw_affiliation_strings":["Department of Neurological Surgery, University of California San Francisco , San Francisco, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California San Francisco , San Francisco, CA , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066366100","display_name":"Keith Kyewalabye","orcid":"https://orcid.org/0000-0003-3645-6328","observed_orcids":["https://orcid.org/0000-0003-3645-6328"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Kyewalabye","raw_affiliation_strings":["University of California, San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109170102","display_name":"Kaori Okada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaori Okada","raw_affiliation_strings":["University of California, San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057957356","display_name":"Su Myat Phyu","orcid":"https://orcid.org/0000-0003-1775-6966","observed_orcids":["https://orcid.org/0000-0003-1775-6966"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Su Phyu","raw_affiliation_strings":["Department of Neurological Surgery, University of California San Francisco , San Francisco, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California San Francisco , San Francisco, CA , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080261596","display_name":"Yitzhar E. Goretsky","orcid":"https://orcid.org/0009-0001-1227-9059","observed_orcids":["https://orcid.org/0009-0001-1227-9059"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yitzhar Goretsky","raw_affiliation_strings":["University of California, San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026537267","display_name":"Tiffany Chen","orcid":"https://orcid.org/0000-0003-2546-2941","observed_orcids":["https://orcid.org/0000-0003-2546-2941"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiffany Chen","raw_affiliation_strings":["University of California, San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080637764","display_name":"Pavlina Chuntova","orcid":"https://orcid.org/0000-0002-5356-9909","observed_orcids":["https://orcid.org/0000-0002-5356-9909"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavlina Chuntova","raw_affiliation_strings":["Department of Neurological Surgery, University of California San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101822595","display_name":"Masaki Terabe","orcid":"https://orcid.org/0000-0002-1777-0189","observed_orcids":["https://orcid.org/0000-0002-1777-0189"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masaki Terabe","raw_affiliation_strings":["National Cancer Institute, NIH , Bethesda, MD , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, NIH , Bethesda, MD , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058793243","display_name":"Hideho Okada","orcid":"https://orcid.org/0000-0003-0076-9920","observed_orcids":["https://orcid.org/0000-0003-0076-9920"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hideho Okada","raw_affiliation_strings":["University of California, San Francisco , San Francisco, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco, CA , USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"Supplement_5","first_page":"v227","last_page":"v227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.8309999704360962},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.9049999713897705},{"id":"https://openalex.org/keywords/egfrviii","display_name":"EGFRvIII","score":0.9490000009536743},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/car-nk-cells","display_name":"CAR-NK cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/car-macrophages","display_name":"CAR macrophages","score":0.9629999995231628},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.8889999985694885},{"id":"https://openalex.org/keywords/syngeneic-mouse-model","display_name":"syngeneic mouse model","score":0.6830000281333923},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.6940000057220459},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6320000290870667},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.8548617362976074},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6204958558082581},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.5186595320701599},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4975488483905792},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.496263325214386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4743201434612274},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4158247411251068},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.41154223680496216},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4101583659648895},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.39747491478919983},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3345468044281006},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2839432656764984},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noad179.0872","doi":"https://doi.org/10.1093/neuonc/noad179.0872","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad179.0872","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_5/v227/53254967/noad179.0872.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10639655","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10639655","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10639655/pdf/noad179.0872.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noad179.0872","doi":"https://doi.org/10.1093/neuonc/noad179.0872","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad179.0872","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_5/v227/53254967/noad179.0872.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388588682.pdf","grobid_xml":"https://content.openalex.org/works/W4388588682.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3188482034","https://openalex.org/W4409629841","https://openalex.org/W4409377812","https://openalex.org/W2114147900","https://openalex.org/W4414792424","https://openalex.org/W2918886343","https://openalex.org/W4388047733","https://openalex.org/W4313383159","https://openalex.org/W2142616877","https://openalex.org/W2767628744"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"reported":[2],"the":[3,11,25,52,55,59,69,136,168,205,239],"creation":[4],"of":[5,20,39,54,71,119,172,208,234],"C57BL/6J-background":[6],"transgenic":[7,226],"(Tg)":[8],"mice":[9,30,62,64,107,157],"carrying":[10,65],"anti-epidermal":[12],"growth":[13],"factor":[14],"receptor":[15],"(EGFR)vIII-CAR":[16],"with":[17,31,63,124,258],"CD3z-CD28-4-1BB":[18,211],"downstream":[19],"a":[21,91,153,242],"Lox-Stop-Lox":[22],"cassette":[23],"in":[24,43,74,104,141,156,169,188,191],"Rosa26":[26],"locus.":[27],"Breeding":[28],"these":[29],"CD4-Cre":[32],"Tg":[33,61],"allows":[34],"rigorous":[35,230],"and":[36,86,106,133,190,231],"reproducible":[37,232],"evaluation":[38],"CAR-T":[40,102,250,254],"cell":[41],"therapy":[42],"syngeneic":[44],"models":[45],"(Chuntova":[46],"et":[47],"al.":[48],"Neuro-Onc":[49],"2022).":[50],"As":[51],"extension":[53],"approach,":[56],"we":[57,80,184,194,203],"crossed":[58],"EGFRvIII-CAR":[60],"Vav-Cre,":[66],"which":[67],"allowed":[68],"expression":[70],"anti-EGFRvIII":[72],"CAR":[73,209,223],"all":[75],"hematopoietic":[76,236],"cells.":[77,237],"In":[78,182],"particular,":[79],"evaluated":[81],"CAR-T,":[82],"CAR-NKT,":[83],"CAR-NK":[84,88,148,173,256],"cells,":[85,99,127,147,257],"CAR-macrophages.":[87],"cells":[89,103,115,149,174],"displayed":[90],"robust":[92],"antigen-specific":[93],"cytolytic":[94],"activity":[95],"against":[96,145],"EGFRvIII-expressing":[97,110,125],"SB28":[98,111,126,146],"comparable":[100],"to":[101,151,212,218],"vitro":[105,142,189],"bearing":[108,158],"intracerebral":[109,159],"gliomas.":[112],"Remarkably,":[113],"CAR-NKT":[114,252],"produced":[116],"higher":[117],"levels":[118],"inflammatory":[120],"cytokines":[121],"when":[122],"co-cultured":[123],"such":[128,178,248],"as":[129,179,249],"IFN-g,":[130],"Perforin,":[131],"IL4,":[132],"IL17.":[134],"On":[135],"other":[137],"hand,":[138],"despite":[139],"their":[140],"cytotoxic":[143],"effects":[144],"failed":[150],"mediate":[152],"therapeutic":[154],"response":[155],"glioma.":[160],"Future":[161],"studies":[162],"will":[163],"be":[164],"directed":[165],"at":[166],"improving":[167],"vivo":[170],"persistence":[171],"using":[175],"engineered":[176],"cytokines,":[177],"IL-2":[180],"superkine.":[181],"addition,":[183],"extensively":[185],"investigated":[186],"CAR-macrophages":[187],"vivo.":[192],"Unfortunately,":[193],"did":[195],"not":[196],"observe":[197],"significant":[198],"CAR-specific":[199],"anti-tumor":[200],"effects.":[201],"Consequently,":[202],"modified":[204],"intracellular":[206],"domain":[207],"from":[210],"CD3z":[213],"alone.":[214],"This":[215,225],"alteration":[216],"led":[217],"increased":[219],"TNF-\u03b1":[220],"production":[221],"through":[222],"signaling.":[224],"mouse":[227],"model":[228,240],"offers":[229],"evaluations":[233],"CAR-expressing":[235],"Furthermore,":[238],"provides":[241],"platform":[243],"for":[244,261],"developing":[245],"combination":[246],"therapies,":[247],"plus":[251,255],"or":[253],"potential":[259],"implications":[260],"enhanced":[262],"cancer":[263],"treatment":[264],"strategies.":[265]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-11-12T00:00:00"}