{"id":"https://openalex.org/W4388588663","doi":"https://doi.org/10.1093/neuonc/noad179.0931","title":"EXTH-78. CRISPROFF EPIGENOME EDITING AND FUNCTIONAL GENOMICS DEFINE MEDIATORS OF CHEMOTHERAPY RESISTANCE IN GLIOBLASTOMA","display_name":"EXTH-78. CRISPROFF EPIGENOME EDITING AND FUNCTIONAL GENOMICS DEFINE MEDIATORS OF CHEMOTHERAPY RESISTANCE IN GLIOBLASTOMA","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4388588663","doi":"https://doi.org/10.1093/neuonc/noad179.0931"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noad179.0931","doi":"https://doi.org/10.1093/neuonc/noad179.0931","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noad179.0931","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10639587/pdf/noad179.0931.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072719730","display_name":"Katie Y. Lin","orcid":"https://orcid.org/0000-0003-2000-2073","observed_orcids":["https://orcid.org/0000-0003-2000-2073"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie Lin","raw_affiliation_strings":["University of California, San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017305667","display_name":"Laine Goudy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laine Goudy","raw_affiliation_strings":["University of California, San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086432402","display_name":"Joanna Pak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna Pak","raw_affiliation_strings":["UCSF , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSF , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009680909","display_name":"Kyla J. Foster","orcid":"https://orcid.org/0000-0002-8452-6397","observed_orcids":["https://orcid.org/0000-0002-8452-6397"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyla Foster","raw_affiliation_strings":["University of California, San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Emily Payne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Payne","raw_affiliation_strings":["UCSF , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSF , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047028132","display_name":"Tomoko Ozawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomoko Ozawa","raw_affiliation_strings":["UCSF , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSF , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055183757","display_name":"John de Groot","orcid":"https://orcid.org/0000-0003-1454-6461","observed_orcids":["https://orcid.org/0000-0003-1454-6461"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John de Groot","raw_affiliation_strings":["University of California, San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079425092","display_name":"Harish N. Vasudevan","orcid":"https://orcid.org/0000-0001-9633-1100","observed_orcids":["https://orcid.org/0000-0001-9633-1100"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harish Vasudevan","raw_affiliation_strings":["UCSF , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSF , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007540843","display_name":"David Ronan Raleigh","orcid":"https://orcid.org/0000-0001-9299-8864","observed_orcids":["https://orcid.org/0000-0001-9299-8864"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Raleigh","raw_affiliation_strings":["University of California, San Francisco , San Francisco, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco, CA , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035219354","display_name":"Luke A. Gilbert","orcid":"https://orcid.org/0000-0001-5854-0825","observed_orcids":["https://orcid.org/0000-0001-5854-0825"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke Gilbert","raw_affiliation_strings":["University of California, San Francisco , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006262715","display_name":"Mitchel Stuart Berger","orcid":"https://orcid.org/0000-0003-1983-4892","observed_orcids":["https://orcid.org/0000-0003-1983-4892"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchel Berger","raw_affiliation_strings":["University of California, San Francisco , San Francisco, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco , San Francisco, CA , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":null,"display_name":"John Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Liu","raw_affiliation_strings":["UCSF , San Francisco , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSF , San Francisco , USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"Supplement_5","first_page":"v242","last_page":"v242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9300000071525574},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8209999799728394},{"id":"https://openalex.org/keywords/mgmt-promoter-methylation","display_name":"MGMT promoter methylation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/epigenome-editing","display_name":"epigenome editing","score":0.9399999976158142},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.7630000114440918},{"id":"https://openalex.org/keywords/lomustine","display_name":"lomustine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.8500000238418579},{"id":"https://openalex.org/keywords/crispr-interference-screen","display_name":"CRISPR interference screen","score":0.7620000243186951},{"id":"https://openalex.org/keywords/dna-repair-pathways","display_name":"DNA repair pathways","score":0.6259999871253967},{"id":"https://openalex.org/keywords/fanconi-anemia-pathway","display_name":"Fanconi anemia pathway","score":0.9139999747276306},{"id":"https://openalex.org/keywords/atr-pathway","display_name":"ATR pathway","score":0.6549999713897705},{"id":"https://openalex.org/keywords/rev1","display_name":"Rev1","score":0.6650000214576721},{"id":"https://openalex.org/keywords/fancd2","display_name":"FANCD2","score":0.675000011920929},{"id":"https://openalex.org/keywords/fanci","display_name":"FANCI","score":0.8550000190734863},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.899499773979187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7140512466430664},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6489042639732361},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6406599879264832},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.569084107875824},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5358124375343323},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.4957674443721771},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.47827160358428955},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.47774308919906616},{"id":"https://openalex.org/C189235521","wikidata":"https://www.wikidata.org/wiki/Q4087270","display_name":"Bisulfite sequencing","level":5,"score":0.4441242218017578},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.2921281158924103},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2224765419960022},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17586126923561096},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14948615431785583}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noad179.0931","doi":"https://doi.org/10.1093/neuonc/noad179.0931","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noad179.0931","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10639587","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10639587","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10639587/pdf/noad179.0931.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10639587","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10639587","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10639587/pdf/noad179.0931.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388588663.pdf","grobid_xml":"https://content.openalex.org/works/W4388588663.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387207931","https://openalex.org/W4407943033","https://openalex.org/W4404236687","https://openalex.org/W4391397381","https://openalex.org/W7062031793","https://openalex.org/W4386175017","https://openalex.org/W4416140902","https://openalex.org/W4409177842","https://openalex.org/W4388588702","https://openalex.org/W7135092697"],"abstract_inverted_index":{"Abstract":[0],"Alkylating":[1],"chemotherapies":[2],"exhibit":[3],"survival":[4],"benefit":[5],"for":[6,41,64],"patients":[7],"with":[8,129,141,227,234,280],"glioblastoma":[9],"(GBM).":[10],"CRISPRoff":[11,50,93,152,215,236],"is":[12,39],"a":[13,60,286],"programmable":[14],"epigenetic":[15],"memory":[16],"writer":[17],"that":[18],"stably":[19,52],"and":[20,38,95,104,106,115,139,158,170,181,196,199,212,244,247,253,267,289],"heritably":[21],"silences":[22],"genes":[23],"through":[24,55,90],"DNA":[25,261],"methylation.":[26],"Epigenetic":[27],"silencing":[28,131],"of":[29,83,92,132,194,208,216,251],"MGMT":[30,54,98,133,154,156,209,217,243],"via":[31],"promoter":[32,57],"methylation":[33,58],"predicts":[34],"response":[35],"to":[36,51,67,77,165,168,173,204,231,284],"chemotherapy":[37],"prognostic":[40],"overall":[42],"survival.":[43],"Here,":[44],"we":[45,275],"performed":[46,89,148],"epigenome":[47,278],"editing":[48,87,279],"using":[49,149],"silence":[53],"induced":[56],"as":[59],"therapeutically":[61],"tractable":[62],"approach":[63],"potentiating":[65],"GBM":[66,84,100,108,127,176,186],"chemotherapy.":[68],"We":[69],"then":[70],"used":[71],"genome-wide":[72,282],"CRISPR":[73,150],"interference":[74],"(CRISPRi)":[75],"screens":[76,146,241],"broadly":[78],"define":[79],"novel":[80,287],"chemosensitizing":[81],"targets":[82],"cells.":[85,109,177],"Epigenome":[86],"was":[88],"electroporation":[91],"mRNA":[94,157],"sgRNAs":[96],"into":[97],"hypomethylated":[99],"cell":[101,264],"lines":[102],"(LN18":[103],"T98G)":[105],"primary":[107],"Whole":[110],"genome":[111],"bisulfite":[112],"sequencing,":[113],"RT-qPCR,":[114],"western":[116],"blot":[117],"assessed":[118],"gene":[119,197],"silencing.":[120],"Cell":[121],"viability":[122],"assays":[123],"measured":[124],"drug":[125,200],"sensitivity.":[126],"xenografts":[128,220],"CRISPRoff-induced":[130],"were":[134,147,202],"intracranially":[135],"transplanted":[136],"in":[137,175,183,210,213,218,224],"mice":[138],"treated":[140],"temozolomide.":[142],"Genome-wide":[143],"functional":[144],"genomics":[145],"interference.":[151],"against":[153,292],"reduced":[155],"protein":[159],"levels":[160],"by":[161],"99.97%,":[162],"generating":[163],"up":[164],"150-fold":[166],"sensitization":[167,172,201],"temozolomide":[169,228,232,252],"9-fold":[171],"lomustine":[174,254],"Silencing":[178],"remained":[179],"stable":[180],"heritable":[182],"clonally":[184],"isolated":[185],"cells":[187],"at":[188],"145":[189],"days":[190],"after":[191],"transient":[192],"delivery":[193],"CRISPRoff,":[195],"repression":[198],"equivalent":[203],"Cas9-mediated":[205],"homozygous":[206],"deletion":[207],"vitro":[211],"vivo.":[214],"intracranial":[219],"exhibited":[221],"significant":[222],"reduction":[223],"tumor":[225],"growth":[226],"treatment":[229,233],"compared":[230],"control":[235],"(p":[237],"=":[238],"0.0047).":[239],"CRISPRi":[240],"validated":[242],"defined":[245],"266":[246],"238":[248],"additional":[249],"modifiers":[250],"response,":[255],"respectively,":[256],"including":[257],"the":[258],"ATR":[259],"(BRCA2),":[260],"repair":[262],"(REV1),":[263],"cycle":[265],"(PSMD13),":[266],"Fanconi":[268],"anemia":[269],"pathways":[270],"(FANCI,":[271],"FANCD2).":[272],"In":[273],"summary,":[274],"integrate":[276],"targeted":[277],"unbiased":[281],"approaches":[283],"establish":[285],"discovery":[288],"therapeutic":[290],"platform":[291],"glioblastoma.":[293]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-11-12T00:00:00"}