{"id":"https://openalex.org/W4388569017","doi":"https://doi.org/10.18027/2224-5057-2023-13-3-56-63","title":"The choice of treatment for chemorefractory colon cancer","display_name":"The choice of treatment for chemorefractory colon cancer","publication_year":2023,"publication_date":"2023-11-09","ids":{"openalex":"https://openalex.org/W4388569017","doi":"https://doi.org/10.18027/2224-5057-2023-13-3-56-63"},"language":"en","primary_location":{"id":"doi:10.18027/2224-5057-2023-13-3-56-63","doi":"https://doi.org/10.18027/2224-5057-2023-13-3-56-63","is_oa":true,"landing_page_url":"http://dx.doi.org/10.18027/2224-5057-2023-13-3-56-63","pdf_url":"https://www.malignanttumors.org/jour/article/download/1169/813","source":{"id":"https://openalex.org/S4210217917","display_name":"Malignant tumours","issn_l":"2224-5057","issn":["2224-5057","2587-6813"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malignant tumours","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.malignanttumors.org/jour/article/download/1169/813","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093238082","display_name":"Maria S Cheporova","orcid":"https://orcid.org/0009-0003-7514-5220","observed_orcids":["https://orcid.org/0009-0003-7514-5220"]},"institutions":[{"id":"https://openalex.org/I136268261","display_name":"Russian University of Medicine","ror":"https://ror.org/04bgrkn57","country_code":"RU","type":"education","lineage":["https://openalex.org/I136268261"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M.\u200a S. Cheporova","raw_affiliation_strings":["A.\u200aI. Evdokimov Moscow State University of Medicine and Dentistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.\u200aI. Evdokimov Moscow State University of Medicine and Dentistry","institution_ids":["https://openalex.org/I136268261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090599068","display_name":"\u0427\u0435\u043f\u043e\u0440\u043e\u0432 \u0421\u0435\u0440\u0433\u0435\u0439 \u0412\u0430\u043b\u0435\u043d\u0442\u0438\u043d\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0003-2776-4994","observed_orcids":["https://orcid.org/0000-0003-2776-4994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S.\u200a V. Cheporov","raw_affiliation_strings":["Regional Clinical Oncological Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional Clinical Oncological Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052686564","display_name":"Alexey Alexandrovich Tryakin","orcid":"https://orcid.org/0000-0003-2245-214X","observed_orcids":["https://orcid.org/0000-0003-2245-214X"]},"institutions":[{"id":"https://openalex.org/I4210090957","display_name":"Russian Cancer Research Center NN Blokhin","ror":"https://ror.org/00ab9fg88","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210090957"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. A. Tryakin","raw_affiliation_strings":["N.\u200aN. Blokhin Russian Cancer Research Center","N. N. Blokhin Russian Cancer Research Center, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.\u200aN. Blokhin Russian Cancer Research Center","institution_ids":["https://openalex.org/I4210090957"]},{"raw_affiliation_string":"N. N. Blokhin Russian Cancer Research Center, Moscow, Russia","institution_ids":["https://openalex.org/I4210090957"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2406,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47422543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"13","issue":"3","first_page":"56","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8230000138282776},{"id":"https://openalex.org/keywords/regorafenib","display_name":"regorafenib","score":0.8109999895095825},{"id":"https://openalex.org/keywords/anti-egfr-monoclonal-antibody","display_name":"anti-EGFR monoclonal antibody","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.9549999833106995},{"id":"https://openalex.org/keywords/panitumumab","display_name":"panitumumab","score":0.9829999804496765},{"id":"https://openalex.org/keywords/braf-inhibitors","display_name":"BRAF inhibitors","score":0.8149999976158142},{"id":"https://openalex.org/keywords/microsatellite-instability-high","display_name":"microsatellite instability-high","score":0.722000002861023},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/kras-g12c-inhibitors","display_name":"KRAS G12C inhibitors","score":0.9380000233650208},{"id":"https://openalex.org/keywords/stereotactic-radiotherapy","display_name":"stereotactic radiotherapy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8807061910629272},{"id":"https://openalex.org/C2776248978","wikidata":"https://www.wikidata.org/wiki/Q3891664","display_name":"Regorafenib","level":4,"score":0.8487166166305542},{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.7910604476928711},{"id":"https://openalex.org/C2781164504","wikidata":"https://www.wikidata.org/wiki/Q1998021","display_name":"Pertuzumab","level":5,"score":0.7799153327941895},{"id":"https://openalex.org/C2777329042","wikidata":"https://www.wikidata.org/wiki/Q420323","display_name":"Lapatinib","level":5,"score":0.7534496188163757},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.734107255935669},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6994929909706116},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6692392230033875},{"id":"https://openalex.org/C2778332735","wikidata":"https://www.wikidata.org/wiki/Q417775","display_name":"Panitumumab","level":5,"score":0.6500167846679688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.587910532951355},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.5703308582305908},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.5480476021766663},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.5377711057662964},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.5260510444641113},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.48700839281082153},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.472355455160141},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.46285951137542725},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39554888010025024},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.39235183596611023},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2652910351753235},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.190715491771698}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18027/2224-5057-2023-13-3-56-63","doi":"https://doi.org/10.18027/2224-5057-2023-13-3-56-63","is_oa":true,"landing_page_url":"http://dx.doi.org/10.18027/2224-5057-2023-13-3-56-63","pdf_url":"https://www.malignanttumors.org/jour/article/download/1169/813","source":{"id":"https://openalex.org/S4210217917","display_name":"Malignant tumours","issn_l":"2224-5057","issn":["2224-5057","2587-6813"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malignant tumours","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18027/2224-5057-2023-13-3-56-63","doi":"https://doi.org/10.18027/2224-5057-2023-13-3-56-63","is_oa":true,"landing_page_url":"http://dx.doi.org/10.18027/2224-5057-2023-13-3-56-63","pdf_url":"https://www.malignanttumors.org/jour/article/download/1169/813","source":{"id":"https://openalex.org/S4210217917","display_name":"Malignant tumours","issn_l":"2224-5057","issn":["2224-5057","2587-6813"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malignant tumours","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388569017.pdf","grobid_xml":"https://content.openalex.org/works/W4388569017.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1968209756","https://openalex.org/W2074987421","https://openalex.org/W2115790682","https://openalex.org/W2147834058","https://openalex.org/W2166191933","https://openalex.org/W2229749788","https://openalex.org/W2336815607","https://openalex.org/W2400949262","https://openalex.org/W2470575266","https://openalex.org/W2570166526","https://openalex.org/W2603299281","https://openalex.org/W2612547710","https://openalex.org/W2754547251","https://openalex.org/W2770004975","https://openalex.org/W2784868445","https://openalex.org/W2802514896","https://openalex.org/W2810647922","https://openalex.org/W2898902386","https://openalex.org/W2908755091","https://openalex.org/W2913797367","https://openalex.org/W2921113926","https://openalex.org/W2925220913","https://openalex.org/W2947983188","https://openalex.org/W2952596923","https://openalex.org/W2983284890","https://openalex.org/W2993847643","https://openalex.org/W2997643107","https://openalex.org/W3004698092","https://openalex.org/W3016696879","https://openalex.org/W3030833373","https://openalex.org/W3087229737","https://openalex.org/W3092192928","https://openalex.org/W3119715349","https://openalex.org/W3153839765","https://openalex.org/W3159805754","https://openalex.org/W3195895258","https://openalex.org/W4200037575","https://openalex.org/W4213097104","https://openalex.org/W4220872849","https://openalex.org/W4230445786","https://openalex.org/W4283771992","https://openalex.org/W4285891554","https://openalex.org/W4297986297","https://openalex.org/W4300869975","https://openalex.org/W4310753291","https://openalex.org/W4312094576","https://openalex.org/W4317862745","https://openalex.org/W4317862819","https://openalex.org/W4317862890","https://openalex.org/W4317892007","https://openalex.org/W4319023497","https://openalex.org/W4361868929"],"related_works":["https://openalex.org/W7214146293","https://openalex.org/W4312782504","https://openalex.org/W4386173462","https://openalex.org/W2989628597","https://openalex.org/W2611295065","https://openalex.org/W3054841029","https://openalex.org/W3017607167","https://openalex.org/W2346753238","https://openalex.org/W4390231082","https://openalex.org/W2146383172"],"abstract_inverted_index":{"Metastatic":[0],"colorectal":[1,152],"cancer":[2,153],"(mCRC)":[3],"is":[4,67,87,100,126,159,174],"a":[5,54],"major":[6],"challenge":[7],"in":[8,36,89,136],"the":[9,16,37,45,68,95,101,137,142,166,170,181],"treatment":[10,61,138,171],"of":[11,18,32,42,47,94,139,165,172,184],"malignant":[12],"neoplasms.":[13],"However,":[14],"with":[15,34,62,106,141],"development":[17],"cytotoxic":[19],"chemotherapy,":[20],"targeted":[21],"therapy":[22,43,117,185],"and":[23,39,83,130,156],"local":[24,167],"therapies,":[25],"survival":[26,79],"rates":[27],"have":[28,132],"improved":[29],"significantly.":[30],"Treatment":[31],"patients":[33],"CRC":[35,140],"third":[38],"subsequent":[40],"lines":[41],"suggests":[44],"use":[46],"regorafenib":[48],"/":[49,97],"TAS102,":[50],"as":[51,53,72],"well":[52],"return":[55],"to":[56,77],"previously":[57],"used":[58],"chemotherapy.":[59],"Late-line":[60],"anti-EGFR":[63,85],"antibodies":[64],"(cetuximab,":[65],"panitumumab)":[66],"choice":[69],"for":[70,103,150,169,186],"mCRC":[71,173],"it":[73],"has":[74],"been":[75],"shown":[76],"improve":[78],"rates.":[80],"BRAF":[81,90],"inhibitor":[82],"an":[84],"antibody":[86],"effective":[88],"mutations.":[91],"A":[92],"feature":[93],"HER2":[96],"neu":[98],"mutation":[99],"requirement":[102],"dual":[104],"blockade":[105],"trastuzumab":[107],"+":[108,112,122],"lapatinib":[109],"or":[110,120],"pertuzumab":[111],"trastuzumab.":[113],"For":[114],"MSI-high,":[115],"anti-PD":[116],"(nivolumab,":[118],"pembrolizumab,":[119],"nivolumab":[121],"ipilimumab":[123],"combination":[124],"therapy)":[125],"highly":[127],"effective.":[128],"Adagrasib":[129],"sotorasib":[131],"demonstrated":[133],"their":[134],"value":[135],"KRAS":[143],"G12C":[144],"mutation.":[145],"Two":[146],"inhibitors":[147],"are":[148],"approved":[149],"NTRK-positive":[151],"\u2014":[154],"larotrectinib":[155],"entrectinib.":[157],"It":[158],"also":[160],"worth":[161],"noting":[162],"that":[163],"one":[164],"options":[168],"stereotactic":[175],"radiation":[176],"therapy.":[177],"This":[178],"article":[179],"presents":[180],"current":[182],"possibilities":[183],"chemoresistant":[187],"CRC.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-11T00:00:00"}
