{"id":"https://openalex.org/W4388565640","doi":"https://doi.org/10.33380/2305-2066-2023-12-4-1577","title":"Composition and Technology Development for Obtaining Amorphous Solid Dispersion of Ebastine by Hot Melt Extrusion to Increase Dissolution Rate","display_name":"Composition and Technology Development for Obtaining Amorphous Solid Dispersion of Ebastine by Hot Melt Extrusion to Increase Dissolution Rate","publication_year":2023,"publication_date":"2023-11-10","ids":{"openalex":"https://openalex.org/W4388565640","doi":"https://doi.org/10.33380/2305-2066-2023-12-4-1577"},"language":"en","primary_location":{"id":"doi:10.33380/2305-2066-2023-12-4-1577","doi":"https://doi.org/10.33380/2305-2066-2023-12-4-1577","is_oa":true,"landing_page_url":"https://doi.org/10.33380/2305-2066-2023-12-4-1577","pdf_url":"https://www.pharmjournal.ru/jour/article/download/1648/1189","source":{"id":"https://openalex.org/S4210178334","display_name":"Drug development & registration","issn_l":"2305-2066","issn":["2305-2066","2658-5049"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug development & registration","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.pharmjournal.ru/jour/article/download/1648/1189","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090941746","display_name":"\u041a\u043e\u043d\u0441\u0442\u0430\u043d\u0442\u0438\u043d \u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0440\u043e\u0432\u0438\u0447 \u0413\u0443\u0441\u0435\u0432","orcid":"https://orcid.org/0000-0003-1922-3282","observed_orcids":["https://orcid.org/0000-0003-1922-3282"]},"institutions":[{"id":"https://openalex.org/I4210103400","display_name":"Saint - Petersburg State Chemical Pharmaceutical Academy","ror":"https://ror.org/01nrsdg41","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210103400"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"K. A. Gusev","raw_affiliation_strings":["Saint-Petersburg State Chemical and Pharmaceutical University"],"raw_orcid":"https://orcid.org/0000-0003-1922-3282","affiliations":[{"raw_affiliation_string":"Saint-Petersburg State Chemical and Pharmaceutical University","institution_ids":["https://openalex.org/I4210103400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057858840","display_name":"A. R. Aliev","orcid":"https://orcid.org/0000-0003-0010-0119","observed_orcids":["https://orcid.org/0000-0003-0010-0119"]},"institutions":[{"id":"https://openalex.org/I4210103400","display_name":"Saint - Petersburg State Chemical Pharmaceutical Academy","ror":"https://ror.org/01nrsdg41","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210103400"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. R. Aliev","raw_affiliation_strings":["Saint-Petersburg State Chemical and Pharmaceutical University"],"raw_orcid":"https://orcid.org/0000-0003-0010-0119","affiliations":[{"raw_affiliation_string":"Saint-Petersburg State Chemical and Pharmaceutical University","institution_ids":["https://openalex.org/I4210103400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015210539","display_name":"Yu. E. Generalova","orcid":"https://orcid.org/0000-0002-2573-6036","observed_orcids":["https://orcid.org/0000-0002-2573-6036"]},"institutions":[{"id":"https://openalex.org/I4210103400","display_name":"Saint - Petersburg State Chemical Pharmaceutical Academy","ror":"https://ror.org/01nrsdg41","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210103400"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yu. E. Generalova","raw_affiliation_strings":["Saint-Petersburg State Chemical and Pharmaceutical University"],"raw_orcid":"https://orcid.org/0000-0002-2573-6036","affiliations":[{"raw_affiliation_string":"Saint-Petersburg State Chemical and Pharmaceutical University","institution_ids":["https://openalex.org/I4210103400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013946145","display_name":"\u0410\u043a\u0441\u0435\u043d\u043e\u0432\u0430 \u041d\u0430\u0434\u0435\u0436\u0434\u0430 \u0410\u043d\u0430\u0442\u043e\u043b\u044c\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0003-0527-8899","observed_orcids":["https://orcid.org/0000-0003-0527-8899"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]},{"id":"https://openalex.org/I2801076587","display_name":"Semenov Institute of Chemical Physics","ror":"https://ror.org/01jemb993","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I2801076587","https://openalex.org/I4210145551"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. \u0410. Aksenova","raw_affiliation_strings":["I. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University); N. N. Semenov Institute of Chemical Physics, RAS"],"raw_orcid":"https://orcid.org/0000-0003-0527-8899","affiliations":[{"raw_affiliation_string":"I. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University); N. N. Semenov Institute of Chemical Physics, RAS","institution_ids":["https://openalex.org/I17877952","https://openalex.org/I2801076587","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093237218","display_name":"G. V. Rechkalov","orcid":"https://orcid.org/0009-0004-0608-1611","observed_orcids":["https://orcid.org/0009-0004-0608-1611"]},"institutions":[{"id":"https://openalex.org/I4210103400","display_name":"Saint - Petersburg State Chemical Pharmaceutical Academy","ror":"https://ror.org/01nrsdg41","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210103400"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G. V. Rechkalov","raw_affiliation_strings":["Saint-Petersburg State Chemical and Pharmaceutical University"],"raw_orcid":"https://orcid.org/0009-0004-0608-1611","affiliations":[{"raw_affiliation_string":"Saint-Petersburg State Chemical and Pharmaceutical University","institution_ids":["https://openalex.org/I4210103400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080296843","display_name":"D. N. Maimistov","orcid":"https://orcid.org/0000-0001-8070-1699","observed_orcids":["https://orcid.org/0000-0001-8070-1699"]},"institutions":[{"id":"https://openalex.org/I4210103400","display_name":"Saint - Petersburg State Chemical Pharmaceutical Academy","ror":"https://ror.org/01nrsdg41","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210103400"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. N. Maimistov","raw_affiliation_strings":["Saint-Petersburg State Chemical and Pharmaceutical University"],"raw_orcid":"https://orcid.org/0000-0001-8070-1699","affiliations":[{"raw_affiliation_string":"Saint-Petersburg State Chemical and Pharmaceutical University","institution_ids":["https://openalex.org/I4210103400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044254744","display_name":"Galina M. Alekseeva","orcid":"https://orcid.org/0009-0008-6343-0450","observed_orcids":["https://orcid.org/0009-0008-6343-0450"]},"institutions":[{"id":"https://openalex.org/I4210103400","display_name":"Saint - Petersburg State Chemical Pharmaceutical Academy","ror":"https://ror.org/01nrsdg41","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210103400"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G. M. Alekseeva","raw_affiliation_strings":["Saint-Petersburg State Chemical and Pharmaceutical University"],"raw_orcid":"https://orcid.org/0009-0008-6343-0450","affiliations":[{"raw_affiliation_string":"Saint-Petersburg State Chemical and Pharmaceutical University","institution_ids":["https://openalex.org/I4210103400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055785185","display_name":"\u0415\u043b\u0435\u043d\u0430 \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440\u043e\u0432\u043d\u0430 \u0424\u043b\u0438\u0441\u044e\u043a","orcid":"https://orcid.org/0000-0001-8077-2462","observed_orcids":["https://orcid.org/0000-0001-8077-2462"]},"institutions":[{"id":"https://openalex.org/I4210103400","display_name":"Saint - Petersburg State Chemical Pharmaceutical Academy","ror":"https://ror.org/01nrsdg41","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210103400"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. V. Flisyuk","raw_affiliation_strings":["Saint-Petersburg State Chemical and Pharmaceutical University"],"raw_orcid":"https://orcid.org/0000-0001-8077-2462","affiliations":[{"raw_affiliation_string":"Saint-Petersburg State Chemical and Pharmaceutical University","institution_ids":["https://openalex.org/I4210103400"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4082,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.46083536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ebastine","display_name":"ebastine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amorphous-solid-dispersions","display_name":"amorphous solid dispersions","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hot-melt-extrusion","display_name":"melt extrusion","score":1.0},{"id":"https://openalex.org/keywords/dissolution-rate","display_name":"dissolution rate","score":0.6819999814033508},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7210000157356262},{"id":"https://openalex.org/keywords/low-water-solubility","display_name":"low water solubility","score":0.7360000014305115},{"id":"https://openalex.org/keywords/antihistamines","display_name":"antihistamines","score":0.7950000166893005},{"id":"https://openalex.org/keywords/impurity-concentration","display_name":"impurity concentration","score":0.6629999876022339},{"id":"https://openalex.org/keywords/glass-transition","display_name":"glass transition","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2778958987","wikidata":"https://www.wikidata.org/wiki/Q139143","display_name":"Extrusion","level":2,"score":0.7428578734397888},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7307175397872925},{"id":"https://openalex.org/C56052488","wikidata":"https://www.wikidata.org/wiki/Q103382","display_name":"Amorphous solid","level":2,"score":0.6404353380203247},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6104246377944946},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.5743805170059204},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.5673764944076538},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.4863798916339874},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.47699931263923645},{"id":"https://openalex.org/C18337273","wikidata":"https://www.wikidata.org/wiki/Q1590264","display_name":"Die swell","level":3,"score":0.4685044586658478},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3543717861175537},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2283223271369934},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1972070038318634},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10853788256645203},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.059722334146499634},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.05191364884376526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05170103907585144},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.33380/2305-2066-2023-12-4-1577","doi":"https://doi.org/10.33380/2305-2066-2023-12-4-1577","is_oa":true,"landing_page_url":"https://doi.org/10.33380/2305-2066-2023-12-4-1577","pdf_url":"https://www.pharmjournal.ru/jour/article/download/1648/1189","source":{"id":"https://openalex.org/S4210178334","display_name":"Drug development & registration","issn_l":"2305-2066","issn":["2305-2066","2658-5049"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug development & registration","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:d33d26183258451a85d80f5ef230f390","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d33d26183258451a85d80f5ef230f390","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0420\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u043a\u0430 \u0438 \u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0430\u0446\u0438\u044f \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u0441\u0440\u0435\u0434\u0441\u0442\u0432, Vol 12, Iss 4, Pp 126-135 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.33380/2305-2066-2023-12-4-1577","doi":"https://doi.org/10.33380/2305-2066-2023-12-4-1577","is_oa":true,"landing_page_url":"https://doi.org/10.33380/2305-2066-2023-12-4-1577","pdf_url":"https://www.pharmjournal.ru/jour/article/download/1648/1189","source":{"id":"https://openalex.org/S4210178334","display_name":"Drug development & registration","issn_l":"2305-2066","issn":["2305-2066","2658-5049"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug development & registration","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388565640.pdf","grobid_xml":"https://content.openalex.org/works/W4388565640.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W2015165507","https://openalex.org/W2112722416","https://openalex.org/W3011439989","https://openalex.org/W3017929586","https://openalex.org/W3082048885","https://openalex.org/W3087158880","https://openalex.org/W3118936317","https://openalex.org/W3194311454","https://openalex.org/W4200195180","https://openalex.org/W4303685208","https://openalex.org/W4310250794","https://openalex.org/W4316464364"],"related_works":["https://openalex.org/W3174512657","https://openalex.org/W7215476582","https://openalex.org/W2991964884","https://openalex.org/W7217059165","https://openalex.org/W4404313692","https://openalex.org/W3122582431","https://openalex.org/W4310250794","https://openalex.org/W2956394223","https://openalex.org/W7154609857","https://openalex.org/W2990626107"],"abstract_inverted_index":{"Introduction.":[0],"Ebastine":[1,18],"is":[2,45,247],"a":[3,109,231],"second-generation":[4],"antihistamine":[5],"drug":[6],"available":[7],"in":[8,26,72,151,200,208,241],"the":[9,49,76,139,152,204,209,250,255],"form":[10],"of":[11,34,51,58,70,138,148,156,167,171,182,189,196,206,215],"orally":[12],"disintegrating":[13],"tablets":[14],"and":[15,28,60,79,82,133,163],"film-coated":[16],"tablets.":[17],"substance":[19],"exhibits":[20],"high":[21],"bioavailability,":[22],"but":[23],"low":[24,53],"solubility":[25],"water":[27],"gastrointestinal":[29],"tract":[30],"media.":[31],"The":[32,135,146,165,179,187,212],"technology":[33,63,166],"solid":[35,68,154,169,191,221,232],"dispersions":[36],"based":[37,223],"on":[38,108,224],"polymer":[39],"carriers":[40],"by":[41,123,144,160,173,234],"hot":[42,174,235],"melt":[43,175,236,251],"extrusion":[44,176,237],"proposed":[46],"to":[47,64,74,202,227],"solve":[48],"problem":[50],"ebastine":[52,71,157,172,183,197,216,239],"solubility.":[54],"Aim.":[55],"Composition":[56],"development":[57],"extrudate":[59],"its":[61],"production":[62],"create":[65],"an":[66],"amorphous":[67,153,168,220],"dispersion":[69,155,170,192,222,233],"oder":[73],"increase":[75],"recovery":[77],"rate":[78],"bioavailability.":[80],"Materials":[81],"methods.":[83],"Ebastin":[84],"micronized":[85],"(JSC":[86],"\"Active":[87],"Component\",":[88],"Russia);":[89],"ebastin":[90],"crystalline":[91],"(Arevipharma":[92],"GmbH,":[93],"Germany);":[94],"VIVAPHARM\u00ae":[95],"PVP/VA":[96],"64":[97],"(JRS":[98],"Pharma":[99],"GMbH":[100],"&":[101],"Co.":[102],"KG,":[103],"Germany).":[104,119],"Extrudates":[105,120],"were":[106,121,184],"obtained":[107],"HAAKE\u2122":[110],"miniCTW":[111],"co-rotating":[112],"twin-screw":[113],"laboratory":[114],"extruder":[115],"(Thermo":[116],"Fisher":[117],"Scientific,":[118],"studied":[122],"differential":[124],"scanning":[125],"calorimetry,":[126],"synchronous":[127],"thermal":[128],"analysis,":[129],"powder":[130],"X-ray":[131],"diffraction":[132],"FTIR-spectroscopy.":[134],"quantitative":[136],"content":[137,147,205,240],"active":[140],"ingredient":[141],"was":[142,158,177,198],"determined":[143,159],"spectrophotometry.":[145],"related":[149],"impurities":[150,207],"HPLC.":[161],"Results":[162],"discussion.":[164],"developed.":[178],"pharmacokinetic":[180],"properties":[181],"significantly":[185],"improved.":[186],"process":[188],"obtaining":[190],"with":[193,238],"20":[194,228],"%":[195,246],"optimized":[199],"order":[201],"reduce":[203],"extrudate.":[210],"Conclusion.":[211],"maximum":[213],"concentration":[214],"for":[217],"proper":[218],"quality":[219],"PVP/VA64":[225,242],"amounted":[226],"%.":[229],"Obtaining":[230],"higher":[243],"than":[244],"30":[245],"impossible":[248],"because":[249],"does":[252],"not":[253],"possess":[254],"glass":[256],"transition":[257],"property.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2023-11-11T00:00:00"}