{"id":"https://openalex.org/W4388564245","doi":"https://doi.org/10.26508/lsa.202302051","title":"Visualization of conformational transition of GRP94 in solution","display_name":"Visualization of conformational transition of GRP94 in solution","publication_year":2023,"publication_date":"2023-11-10","ids":{"openalex":"https://openalex.org/W4388564245","doi":"https://doi.org/10.26508/lsa.202302051","pmid":"https://pubmed.ncbi.nlm.nih.gov/37949474","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10638095"},"language":"en","primary_location":{"id":"doi:10.26508/lsa.202302051","doi":"https://doi.org/10.26508/lsa.202302051","is_oa":true,"landing_page_url":"https://doi.org/10.26508/lsa.202302051","pdf_url":"https://www.life-science-alliance.org/content/lsa/7/2/e202302051.full.pdf","source":{"id":"https://openalex.org/S4210202458","display_name":"Life Science Alliance","issn_l":"2575-1077","issn":["2575-1077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Science Alliance","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.life-science-alliance.org/content/lsa/7/2/e202302051.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004504784","display_name":"S. F. Sun","orcid":"https://orcid.org/0009-0008-9066-9061","observed_orcids":["https://orcid.org/0009-0008-9066-9061"]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shangwu Sun","raw_affiliation_strings":["Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University",", Shanghai, China"],"raw_orcid":"https://orcid.org/0009-0008-9066-9061","affiliations":[{"raw_affiliation_string":"Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University","institution_ids":["https://openalex.org/I30809798"]},{"raw_affiliation_string":", Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032188592","display_name":"Rui Zhu","orcid":"https://orcid.org/0009-0009-6899-8392","observed_orcids":["https://orcid.org/0009-0009-6899-8392"]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Zhu","raw_affiliation_strings":["Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University",", Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University","institution_ids":["https://openalex.org/I30809798"]},{"raw_affiliation_string":", Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103045541","display_name":"Mengyao Zhu","orcid":"https://orcid.org/0009-0002-1315-9830","observed_orcids":["https://orcid.org/0009-0002-1315-9830"]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyao Zhu","raw_affiliation_strings":["Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University",", Shanghai, China"],"raw_orcid":"https://orcid.org/0009-0002-1315-9830","affiliations":[{"raw_affiliation_string":"Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University","institution_ids":["https://openalex.org/I30809798"]},{"raw_affiliation_string":", Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103135066","display_name":"Qi Wang","orcid":"https://orcid.org/0000-0003-0783-4588","observed_orcids":["https://orcid.org/0000-0003-0783-4588"]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Wang","raw_affiliation_strings":["Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University",", Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0003-0783-4588","affiliations":[{"raw_affiliation_string":"Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University","institution_ids":["https://openalex.org/I30809798"]},{"raw_affiliation_string":", Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100368158","display_name":"Na Li","orcid":"https://orcid.org/0000-0002-8476-511X","observed_orcids":["https://orcid.org/0000-0002-8476-511X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210111959","display_name":"Shanghai Advanced Research Institute","ror":"https://ror.org/02br7py06","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210111959"]},{"id":"https://openalex.org/I4210114190","display_name":"Shanghai Zhangjiang Laboratory","ror":"https://ror.org/0208qbg77","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210114190"]},{"id":"https://openalex.org/I4405256935","display_name":"Zhangjiang Laboratory","ror":"https://ror.org/04pmg2p90","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405256935"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Na Li","raw_affiliation_strings":["National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute (Zhangjiang Laboratory), Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-8476-511X","affiliations":[{"raw_affiliation_string":"National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute (Zhangjiang Laboratory), Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210111959","https://openalex.org/I4210114190","https://openalex.org/I4405256935"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044040961","display_name":"Bei Yang","orcid":"https://orcid.org/0000-0001-5389-3859","observed_orcids":["https://orcid.org/0000-0001-5389-3859"]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bei Yang","raw_affiliation_strings":["Shanghai Clinical Research and Trial Center, Shanghai, China","Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine, ShanghaiTech University","Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University",", Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0001-5389-3859","affiliations":[{"raw_affiliation_string":"Shanghai Clinical Research and Trial Center, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine, ShanghaiTech University","institution_ids":["https://openalex.org/I30809798"]},{"raw_affiliation_string":"Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University","institution_ids":["https://openalex.org/I30809798"]},{"raw_affiliation_string":", Shanghai, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5044040961","https://openalex.org/A5100368158"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I30809798","https://openalex.org/I4210111959","https://openalex.org/I4210114190","https://openalex.org/I4405256935"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":0.2225,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.36004079,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"7","issue":"2","first_page":"e202302051","last_page":"e202302051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grp94","display_name":"GRP94","score":1.0},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.7599999904632568},{"id":"https://openalex.org/keywords/atp-hydrolysis","display_name":"ATP hydrolysis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/chaperone-mechanism","display_name":"chaperone mechanism","score":0.7580000162124634},{"id":"https://openalex.org/keywords/apo-conformation","display_name":"apo conformation","score":0.5059999823570251},{"id":"https://openalex.org/keywords/adp-binding","display_name":"ADP binding","score":0.9079999923706055},{"id":"https://openalex.org/keywords/hydrogen-deuterium-exchange","display_name":"hydrogen-deuterium exchange","score":0.6489999890327454},{"id":"https://openalex.org/keywords/solution-structure","display_name":"solution structure","score":0.4000000059604645},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-chaperone","display_name":"endoplasmic reticulum chaperone","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C141315368","wikidata":"https://www.wikidata.org/wiki/Q4654881","display_name":"ATP hydrolysis","level":4,"score":0.6745202541351318},{"id":"https://openalex.org/C2776196297","wikidata":"https://www.wikidata.org/wiki/Q17138781","display_name":"Twist","level":2,"score":0.6625864505767822},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.6043742895126343},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5771160125732422},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5601924657821655},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.542941153049469},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.5343329906463623},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.49474474787712097},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.4684593379497528},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4191417098045349},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.372795045375824},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3178575038909912},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20758378505706787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19494938850402832},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19176986813545227},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.15678590536117554},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000266","descriptor_name":"Adenylyl Imidodiphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.26508/lsa.202302051","doi":"https://doi.org/10.26508/lsa.202302051","is_oa":true,"landing_page_url":"https://doi.org/10.26508/lsa.202302051","pdf_url":"https://www.life-science-alliance.org/content/lsa/7/2/e202302051.full.pdf","source":{"id":"https://openalex.org/S4210202458","display_name":"Life Science Alliance","issn_l":"2575-1077","issn":["2575-1077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Science Alliance","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10638095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10638095","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10638095/pdf/LSA-2023-02051.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sci Alliance","raw_type":"Text"},{"id":"pmid:37949474","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37949474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life science alliance","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3d895101c2b1445cb230c82cf7a5daff","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3d895101c2b1445cb230c82cf7a5daff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life Science Alliance, Vol 7, Iss 2, p e202302051 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.26508/lsa.202302051","doi":"https://doi.org/10.26508/lsa.202302051","is_oa":true,"landing_page_url":"https://doi.org/10.26508/lsa.202302051","pdf_url":"https://www.life-science-alliance.org/content/lsa/7/2/e202302051.full.pdf","source":{"id":"https://openalex.org/S4210202458","display_name":"Life Science Alliance","issn_l":"2575-1077","issn":["2575-1077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Science Alliance","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1861951465","display_name":null,"funder_award_id":"21ZR1471600","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G232349065","display_name":null,"funder_award_id":"U2230115","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2656536957","display_name":null,"funder_award_id":"21ZR1471600","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4307240154","display_name":null,"funder_award_id":"23ZR1442500","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G5090432375","display_name":"3C\u86cb\u767d\u8c03\u63a7\u80a0\u9053\u75c5\u6bd2\u5c5e\u75c5\u6bd2\u57fa\u56e0\u7ec4\u590d\u5236\u7684\u5206\u5b50\u673a\u5236\u7814\u7a76\u4e0e\u76f8\u5e94\u6291\u5236\u5242\u7b5b\u9009","funder_award_id":"32070170","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5598132200","display_name":null,"funder_award_id":"16PJ1407500","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G7103648002","display_name":null,"funder_award_id":"16PJ1407500, 23ZR1442500","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G7278041808","display_name":"\u759f\u75be\u4f20\u64ad\u963b\u65ad\u75ab\u82d7\u5019\u9009\u514d\u75ab\u539fPfs28\u7684\u6297\u539f\u7279\u6027\u63a2\u7a76","funder_award_id":"23ZR1442500","funder_id":"https://openalex.org/F4320309612","funder_display_name":"Natural Science Foundation of Shanghai"},{"id":"https://openalex.org/G7460363223","display_name":null,"funder_award_id":"31600619","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8381332826","display_name":"\u57fa\u4e8e\u751f\u7269\u5c0f\u89d2\u6563\u5c04\u7684\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u523a\u7a81\u86cb\u767d\u4e0e\u523a\u7a81\u86cb\u767d\u53d7\u4f53ACE2 \u590d\u5408\u4f53\u52a8\u6001\u7ed3\u6784\u7814\u7a76","funder_award_id":"21ZR1471600","funder_id":"https://openalex.org/F4320309612","funder_display_name":"Natural Science Foundation of Shanghai"}],"funders":[{"id":"https://openalex.org/F4320309612","display_name":"Natural Science Foundation of Shanghai","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320327675","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388564245.pdf","grobid_xml":"https://content.openalex.org/works/W4388564245.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1858631806","https://openalex.org/W1970081412","https://openalex.org/W1977038370","https://openalex.org/W1981346588","https://openalex.org/W1982126789","https://openalex.org/W1995130557","https://openalex.org/W2003439582","https://openalex.org/W2003801319","https://openalex.org/W2010942421","https://openalex.org/W2012274597","https://openalex.org/W2012778514","https://openalex.org/W2015613793","https://openalex.org/W2038441129","https://openalex.org/W2061912829","https://openalex.org/W2062058722","https://openalex.org/W2063992197","https://openalex.org/W2085898992","https://openalex.org/W2090940245","https://openalex.org/W2100455255","https://openalex.org/W2108906526","https://openalex.org/W2114078851","https://openalex.org/W2118891938","https://openalex.org/W2120702846","https://openalex.org/W2131991936","https://openalex.org/W2132629607","https://openalex.org/W2137212933","https://openalex.org/W2147024375","https://openalex.org/W2147891181","https://openalex.org/W2164352013","https://openalex.org/W2164361934","https://openalex.org/W2171125452","https://openalex.org/W2336550720","https://openalex.org/W2467034934","https://openalex.org/W2474143322","https://openalex.org/W2489181495","https://openalex.org/W2587625522","https://openalex.org/W2753348948","https://openalex.org/W2754267313","https://openalex.org/W2790774674","https://openalex.org/W2804822363","https://openalex.org/W2900310995","https://openalex.org/W2952729952","https://openalex.org/W2952948481","https://openalex.org/W3006470483","https://openalex.org/W3031963365","https://openalex.org/W4210602420"],"related_works":["https://openalex.org/W1970081412","https://openalex.org/W2952948481","https://openalex.org/W2061912829","https://openalex.org/W2164352013","https://openalex.org/W4379981039","https://openalex.org/W2738288503","https://openalex.org/W2056309239","https://openalex.org/W2045160328","https://openalex.org/W4405269000","https://openalex.org/W2002647662"],"abstract_inverted_index":{"GRP94,":[0],"an":[1,75],"ER":[2],"paralog":[3],"of":[4,20,33,46,70,99,106,122,126,163],"the":[5,16,29,36,79,97,103,107,114,117,161],"heat-shock":[6],"protein":[7],"90":[8],"family,":[9],"binds":[10],"and":[11,18,56,119,129,145],"hydrolyses":[12],"ATP":[13,37,143,156,169],"to":[14,139,152],"chaperone":[15],"folding":[17],"maturation":[19],"its":[21,47,66],"selected":[22],"clients.":[23],"Compared":[24],"with":[25],"other":[26,94,172],"hsp90":[27,95,173],"proteins,":[28,96],"in-solution":[30],"conformational":[31,134],"dynamics":[32],"GRP94":[34,72,164],"along":[35],"hydrolysis":[38,170],"cycle":[39],"are":[40],"less":[41],"understood,":[42],"hindering":[43],"our":[44],"understanding":[45],"chaperoning":[48],"mechanism.":[49],"Leveraging":[50],"small-angle":[51],"X-ray":[52],"scattering,":[53],"negative-staining":[54],"EM,":[55],"hydrogen-deuterium":[57],"exchange":[58],"coupled":[59],"mass-spec,":[60],"here":[61],"we":[62],"show":[63],"that":[64],"in":[65,82,165],"apo":[67],"form,":[68],"\u223c60%":[69],"mouse":[71],"(mGRP94)":[73],"populates":[74],"\"extended\"":[76,118],"conformation,":[77],"whereas":[78],"rest":[80],"exist":[81],"either":[83],"\"close":[84,140,150],"V\"":[85,88,138,141,151,154],"or":[86],"\"twist":[87,137,153],"like":[89],"\"compact\"":[90,120],"conformations.":[91],"Different":[92],"from":[93,136,149,171],"presence":[98],"AMPPNP":[100],"only":[101],"impacts":[102],"relative":[104],"abundance":[105],"two":[108],"compact":[109],"conformations,":[110],"rather":[111],"than":[112],"shifting":[113],"equilibrium":[115],"between":[116],"conformations":[121],"mGRP94.":[123],"HDX-MS":[124],"study":[125],"apo,":[127],"AMPPNP-bound,":[128],"ADP-bound":[130],"mGRP94":[131],"suggests":[132],"a":[133,146],"transition":[135,148,167],"upon":[142,155],"binding":[144],"back":[147],"hydrolysis.":[157],"These":[158],"results":[159],"illustrate":[160],"dissimilarities":[162],"conformation":[166],"during":[168],"paralogs.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-11-11T00:00:00"}