{"id":"https://openalex.org/W4388539425","doi":"https://doi.org/10.1093/jas/skad281.204","title":"238 Leucine Supplementation Enhances Protein Synthesis in Lean Tissue Through a Sestrin2-GATOR2 and Raga-mTORC1 Signaling Pathway in a Preterm Piglet Model","display_name":"238 Leucine Supplementation Enhances Protein Synthesis in Lean Tissue Through a Sestrin2-GATOR2 and Raga-mTORC1 Signaling Pathway in a Preterm Piglet Model","publication_year":2023,"publication_date":"2023-11-06","ids":{"openalex":"https://openalex.org/W4388539425","doi":"https://doi.org/10.1093/jas/skad281.204"},"language":"en","primary_location":{"id":"doi:10.1093/jas/skad281.204","doi":"https://doi.org/10.1093/jas/skad281.204","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jas/skad281.204","pdf_url":"https://academic.oup.com/jas/article-pdf/101/Supplement_3/168/52957240/skad281.204.pdf","source":{"id":"https://openalex.org/S72684844","display_name":"Journal of Animal Science","issn_l":"0021-8812","issn":["0021-8812","1525-3015","1525-3163","1544-7847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jas/article-pdf/101/Supplement_3/168/52957240/skad281.204.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047020092","display_name":"Erin A Posey","orcid":"https://orcid.org/0000-0001-5847-3714","observed_orcids":["https://orcid.org/0000-0001-5847-3714"]},"institutions":[{"id":"https://openalex.org/I1288380561","display_name":"Animal and Plant Health Inspection Service","ror":"https://ror.org/0599wfz09","country_code":"US","type":"government","lineage":["https://openalex.org/I1288380561","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin A Posey","raw_affiliation_strings":["USDA/APHIS, National Veterinary Services Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA/APHIS, National Veterinary Services Laboratories","institution_ids":["https://openalex.org/I1288380561","https://openalex.org/I1336096307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104076402","display_name":"Agus Suryawan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210141908","display_name":"Children's Nutrition Research Center at Baylor College of Medicine","ror":"https://ror.org/03s936v76","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141908","https://openalex.org/I4210145274"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agus Suryawan","raw_affiliation_strings":["USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210141908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101745125","display_name":"Hanh V. Nguyen","orcid":"https://orcid.org/0000-0003-2747-5295","observed_orcids":["https://orcid.org/0000-0003-2747-5295"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210141908","display_name":"Children's Nutrition Research Center at Baylor College of Medicine","ror":"https://ror.org/03s936v76","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141908","https://openalex.org/I4210145274"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanh Nguyen","raw_affiliation_strings":["USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210141908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068081240","display_name":"Christina M. Sciarrillo","orcid":"https://orcid.org/0000-0002-2354-1534","observed_orcids":["https://orcid.org/0000-0002-2354-1534"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Sciarrillo","raw_affiliation_strings":["NIDDK, National Institutes of Health (NIH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIDDK, National Institutes of Health (NIH)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Barbara Stoll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210141908","display_name":"Children's Nutrition Research Center at Baylor College of Medicine","ror":"https://ror.org/03s936v76","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141908","https://openalex.org/I4210145274"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Stoll","raw_affiliation_strings":["USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210141908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034157193","display_name":"Caitlin E. Vonderohe","orcid":"https://orcid.org/0000-0001-9457-984X","observed_orcids":["https://orcid.org/0000-0001-9457-984X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210141908","display_name":"Children's Nutrition Research Center at Baylor College of Medicine","ror":"https://ror.org/03s936v76","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141908","https://openalex.org/I4210145274"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin Vonderohe","raw_affiliation_strings":["USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210141908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086975889","display_name":"Douglas G. Burrin","orcid":"https://orcid.org/0000-0002-8792-3339","observed_orcids":["https://orcid.org/0000-0002-8792-3339"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210141908","display_name":"Children's Nutrition Research Center at Baylor College of Medicine","ror":"https://ror.org/03s936v76","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141908","https://openalex.org/I4210145274"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doug Burrin","raw_affiliation_strings":["USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210141908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042594822","display_name":"Marta L. Fiorotto","orcid":"https://orcid.org/0000-0001-8475-4704","observed_orcids":["https://orcid.org/0000-0001-8475-4704"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210141908","display_name":"Children's Nutrition Research Center at Baylor College of Medicine","ror":"https://ror.org/03s936v76","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141908","https://openalex.org/I4210145274"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta Fiorotto","raw_affiliation_strings":["USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210141908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045762120","display_name":"Teresa A. Davis","orcid":"https://orcid.org/0000-0002-4610-9795","observed_orcids":["https://orcid.org/0000-0002-4610-9795"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210141908","display_name":"Children's Nutrition Research Center at Baylor College of Medicine","ror":"https://ror.org/03s936v76","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141908","https://openalex.org/I4210145274"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa A Davis","raw_affiliation_strings":["USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210141908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1557371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"101","issue":"Supplement_3","first_page":"168","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leucine-supplementation","display_name":"leucine supplementation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/mtorc1-signaling","display_name":"mTORC1 signaling","score":0.9399999976158142},{"id":"https://openalex.org/keywords/sestrin2","display_name":"Sestrin2","score":0.8510000109672546},{"id":"https://openalex.org/keywords/gator2","display_name":"GATOR2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/raga","display_name":"raga","score":0.9660000205039978},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.652999997138977},{"id":"https://openalex.org/keywords/extrauterine-growth-restriction","display_name":"extrauterine growth restriction","score":0.8820000290870667},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.8109999895095825},{"id":"https://openalex.org/keywords/longissimus-muscle","display_name":"longissimus dorsi","score":0.7120000123977661},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.9390000104904175},{"id":"https://openalex.org/keywords/s6k1-phosphorylation","display_name":"S6K1 phosphorylation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/4e-bp1","display_name":"4E-BP1","score":0.9430000185966492},{"id":"https://openalex.org/keywords/translation-initiation","display_name":"translation initiation","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.7387721538543701},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.728500485420227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5489972233772278},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5374045968055725},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4525635838508606},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.44702082872390747},{"id":"https://openalex.org/C120863210","wikidata":"https://www.wikidata.org/wiki/Q17064264","display_name":"Lean body mass","level":3,"score":0.4303883910179138},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4265868067741394},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3831367492675781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3779134750366211},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.33656203746795654},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.2480468451976776},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24109572172164917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19758760929107666},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.18619492650032043}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/jas/skad281.204","doi":"https://doi.org/10.1093/jas/skad281.204","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jas/skad281.204","pdf_url":"https://academic.oup.com/jas/article-pdf/101/Supplement_3/168/52957240/skad281.204.pdf","source":{"id":"https://openalex.org/S72684844","display_name":"Journal of Animal Science","issn_l":"0021-8812","issn":["0021-8812","1525-3015","1525-3163","1544-7847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10633050","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10633050","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10633050/pdf/skad281.204.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Anim Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/jas/skad281.204","doi":"https://doi.org/10.1093/jas/skad281.204","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jas/skad281.204","pdf_url":"https://academic.oup.com/jas/article-pdf/101/Supplement_3/168/52957240/skad281.204.pdf","source":{"id":"https://openalex.org/S72684844","display_name":"Journal of Animal Science","issn_l":"0021-8812","issn":["0021-8812","1525-3015","1525-3163","1544-7847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6875},{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388539425.pdf","grobid_xml":"https://content.openalex.org/works/W4388539425.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4296630514","https://openalex.org/W4296963695","https://openalex.org/W4282829734","https://openalex.org/W3169644994","https://openalex.org/W4385366913","https://openalex.org/W4400149508","https://openalex.org/W4390084215","https://openalex.org/W3206111499","https://openalex.org/W2275260036","https://openalex.org/W2904348169"],"abstract_inverted_index":{"Abstract":[0],"Extrauterine":[1],"growth":[2,15],"restriction":[3],"is":[4,10],"common":[5],"in":[6,36,87,90,195,221,253,273,281,300],"preterm":[7,92,305],"infants":[8],"and":[9,16,34,54,108,116,140,164,189,215,224,243,245,256,276,313,323],"associated":[11],"with":[12,230,262,284],"reduced":[13],"lean":[14,88],"long-term":[17],"morbidities.":[18],"We":[19],"previously":[20],"showed":[21],"that":[22,35,70,293],"leucine":[23,294],"(Leu)":[24],"acts":[25],"as":[26,144],"a":[27,80,106,145,308],"nutrient":[28],"signal":[29],"to":[30,63,83,131],"stimulate":[31],"protein":[32,55,85,107,119,271,330],"synthesis,":[33],"neonatal":[37],"pigs":[38,199,232,264,286],"born":[39],"at":[40,99],"term":[41],"intermittent":[42],"parenteral":[43],"Leu":[44,132],"pulses":[45],"during":[46,73],"continuous":[47,74],"feeding":[48,75],"increases":[49],"skeletal":[50,301,321],"muscle":[51,191,223,226,255,258,275,278,302,322,329],"mTORC1":[52,77,165,205],"signaling":[53,78,163],"synthesis.":[56,331],"The":[57],"objective":[58],"of":[59,67,160,174,204,209,227,237,241,247,259,270,303],"this":[60],"study":[61],"was":[62,184,193,213,219],"determine":[64],"the":[65,68,91,175,207,210,216,239,248,304,314],"validity":[66],"hypothesis":[69],"leu":[71],"pulsing":[72],"enhances":[76,296],"via":[79,307],"Sestrin-mediated":[81],"pathway":[82,310],"increase":[84],"synthesis":[86,272],"tissue":[89],"piglet.":[93],"Pigs":[94,124],"delivered":[95],"by":[96,327],"cesarean":[97],"section":[98],"105":[100],"d":[101],"gestation":[102],"were":[103,128,142,167,251,279],"continuously":[104],"fed":[105],"energy":[109],"balanced":[110],"milk-replacer":[111],"diet":[112],"[195":[113],"kcal":[114],"ME":[115],"13.5":[117],"g":[118],"(kg":[120],"body":[121,182,324],"weight;":[122],"BW)-1\u00b7d-1)].":[123],"(n":[125],"=":[126,201],"11-12)":[127],"randomly":[129],"assigned":[130],"(LEU)":[133],"or":[134],"Alanine":[135],"(ALA,":[136],"isonitrogenous":[137],"control)":[138],"groups":[139],"treatments":[141],"administered":[143],"pulse":[146,177],"(1.6":[147],"mmol\u00b7kg":[148],"BW-1\u00b7h-1)":[149],"for":[150,156],"1":[151],"h":[152,155],"every":[153],"4":[154],"21":[157],"d.":[158],"Indices":[159],"amino":[161],"acid":[162],"activation":[166],"determined":[168],"postprandially,":[169],"60":[170],"min":[171],"after":[172],"initiation":[173,299],"last":[176],"on":[178],"day":[179],"24.":[180],"Final":[181],"weight":[183,192,325],"greater":[185,220,252,280],"(P":[186,200,233,265,287],"<":[187,234,266,288],"0.05)":[188],"longissimus":[190,222,254,274],"heavier":[194],"LEU":[196,228,260,282],"than":[197],"ALA":[198,231,263,285],"0.01).":[202],"Upstream":[203],"activation,":[206],"abundance":[208,246],"Sestrin2-GATOR2":[211],"complex":[212,218,250],"less":[214],"RagA-mTORC1":[217],"gastrocnemius":[225,257,277],"compared":[229,261,283],"0.05).":[235,267,289],"Downstream":[236],"mTORC1,":[238],"phosphorylation":[240],"S6K1":[242],"4EBP1":[244],"eIF4E-eIF4G":[249],"Fractional":[268],"rates":[269],"These":[290],"results":[291],"show":[292],"supplementation":[295],"mTORC1-activated":[297],"translation":[298],"piglet":[306],"Leu-sensing":[309],"mediated":[311],"bySestrin2":[312],"Rag":[315],"proteins.":[316],"This":[317],"leucine-mediated":[318],"cascade":[319],"promotes":[320],"gain":[326],"increasing":[328]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-11-10T00:00:00"}