{"id":"https://openalex.org/W4388530263","doi":"https://doi.org/10.1097/mbc.0000000000001249","title":"Glanzmann's thrombasthenia associated with gastrointestinal angiodysplasias successfully treated with bevacizumab","display_name":"Glanzmann's thrombasthenia associated with gastrointestinal angiodysplasias successfully treated with bevacizumab","publication_year":2023,"publication_date":"2023-10-20","ids":{"openalex":"https://openalex.org/W4388530263","doi":"https://doi.org/10.1097/mbc.0000000000001249","pmid":"https://pubmed.ncbi.nlm.nih.gov/37942747"},"language":"en","primary_location":{"id":"doi:10.1097/mbc.0000000000001249","doi":"https://doi.org/10.1097/mbc.0000000000001249","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mbc.0000000000001249","pdf_url":null,"source":{"id":"https://openalex.org/S118812467","display_name":"Blood Coagulation & Fibrinolysis","issn_l":"0957-5235","issn":["0957-5235","1473-5733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Coagulation & Fibrinolysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107719426","display_name":"Agustina Saladino","orcid":"https://orcid.org/0009-0006-6099-9794","observed_orcids":["https://orcid.org/0009-0006-6099-9794"]},"institutions":[{"id":"https://openalex.org/I2802359038","display_name":"Hospital Italiano de Buenos Aires","ror":"https://ror.org/00bq4rw46","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I2802359038"]},{"id":"https://openalex.org/I4210163230","display_name":"Universidad Hospital Italiano","ror":"https://ror.org/05x6bj397","country_code":"AR","type":"education","lineage":["https://openalex.org/I4210163230"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Agustina Saladino","raw_affiliation_strings":["Argentine Rendu Study Group","Hospital Italiano de Buenos Aires","Instituto Universitario Hospital Italiano de Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Argentine Rendu Study Group","institution_ids":[]},{"raw_affiliation_string":"Hospital Italiano de Buenos Aires","institution_ids":["https://openalex.org/I2802359038"]},{"raw_affiliation_string":"Instituto Universitario Hospital Italiano de Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2802359038","https://openalex.org/I4210163230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101787558","display_name":"Mar\u00eda Laura Gonz\u00e1lez","orcid":"https://orcid.org/0000-0003-0469-7469","observed_orcids":["https://orcid.org/0000-0003-0469-7469"]},"institutions":[{"id":"https://openalex.org/I2802359038","display_name":"Hospital Italiano de Buenos Aires","ror":"https://ror.org/00bq4rw46","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I2802359038"]},{"id":"https://openalex.org/I4210163230","display_name":"Universidad Hospital Italiano","ror":"https://ror.org/05x6bj397","country_code":"AR","type":"education","lineage":["https://openalex.org/I4210163230"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mar\u00eda L. Gonzalez","raw_affiliation_strings":["Argentine Rendu Study Group","Gastroenterology Department","Hereditary Hemorrhagic Telangiectasia Unit","Hospital Italiano de Buenos Aires","Instituto Universitario Hospital Italiano de Buenos Aires, Argentina","Argentine Rendu Study Group; Gastroenterology Department; Hereditary Hemorrhagic Telangiectasia Unit; Instituto Universitario Hospital Italiano de Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Argentine Rendu Study Group","institution_ids":[]},{"raw_affiliation_string":"Gastroenterology Department","institution_ids":[]},{"raw_affiliation_string":"Hereditary Hemorrhagic Telangiectasia Unit","institution_ids":[]},{"raw_affiliation_string":"Hospital Italiano de Buenos Aires","institution_ids":["https://openalex.org/I2802359038"]},{"raw_affiliation_string":"Instituto Universitario Hospital Italiano de Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2802359038","https://openalex.org/I4210163230"]},{"raw_affiliation_string":"Argentine Rendu Study Group; Gastroenterology Department; Hereditary Hemorrhagic Telangiectasia Unit; Instituto Universitario Hospital Italiano de Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2802359038","https://openalex.org/I4210163230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027824995","display_name":"Fernando Andr\u00e9s Chuliber","orcid":"https://orcid.org/0000-0001-8625-8624","observed_orcids":["https://orcid.org/0000-0001-8625-8624"]},"institutions":[{"id":"https://openalex.org/I2802359038","display_name":"Hospital Italiano de Buenos Aires","ror":"https://ror.org/00bq4rw46","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I2802359038"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Fernando A. Chuliber","raw_affiliation_strings":["Hematology Department","Hospital Italiano de Buenos Aires"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department","institution_ids":[]},{"raw_affiliation_string":"Hospital Italiano de Buenos Aires","institution_ids":["https://openalex.org/I2802359038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068949287","display_name":"Marcelo Martin Serra","orcid":"https://orcid.org/0000-0002-9912-9503","observed_orcids":["https://orcid.org/0000-0002-9912-9503"]},"institutions":[{"id":"https://openalex.org/I2802359038","display_name":"Hospital Italiano de Buenos Aires","ror":"https://ror.org/00bq4rw46","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I2802359038"]},{"id":"https://openalex.org/I4210163230","display_name":"Universidad Hospital Italiano","ror":"https://ror.org/05x6bj397","country_code":"AR","type":"education","lineage":["https://openalex.org/I4210163230"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Marcelo M. Serra","raw_affiliation_strings":["Argentine Rendu Study Group","Hereditary Hemorrhagic Telangiectasia Unit","Hospital Italiano de Buenos Aires","Instituto Universitario Hospital Italiano de Buenos Aires, Argentina","Internal Medicine Department"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Argentine Rendu Study Group","institution_ids":[]},{"raw_affiliation_string":"Hereditary Hemorrhagic Telangiectasia Unit","institution_ids":[]},{"raw_affiliation_string":"Hospital Italiano de Buenos Aires","institution_ids":["https://openalex.org/I2802359038"]},{"raw_affiliation_string":"Instituto Universitario Hospital Italiano de Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2802359038","https://openalex.org/I4210163230"]},{"raw_affiliation_string":"Internal Medicine Department","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068949287"],"corresponding_institution_ids":["https://openalex.org/I2802359038","https://openalex.org/I4210163230"],"apc_list":null,"apc_paid":null,"fwci":1.125,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.76968947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"34","issue":"8","first_page":"545","last_page":"548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.5957000255584717,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.5957000255584717,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.21089999377727509,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.17759999632835388,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glanzmann-thrombasthenia","display_name":"Glanzmann thrombasthenia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gastrointestinal-angiodysplasia","display_name":"gastrointestinal angiodysplasia","score":0.9679999947547913},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9750000238418579},{"id":"https://openalex.org/keywords/gastrointestinal-bleeding","display_name":"gastrointestinal bleeding","score":0.8989999890327454},{"id":"https://openalex.org/keywords/melena","display_name":"melena","score":0.7369999885559082},{"id":"https://openalex.org/keywords/iron-deficiency-anemia","display_name":"iron deficiency anemia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hereditary-hemorrhagic-telangiectasia","display_name":"hereditary hemorrhagic telangiectasia","score":0.8640000224113464},{"id":"https://openalex.org/keywords/platelet-dysfunction","display_name":"platelet dysfunction","score":0.6029999852180481},{"id":"https://openalex.org/keywords/gp-iib-iiia","display_name":"GPIIb/IIIa","score":0.8330000042915344},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9476479887962341},{"id":"https://openalex.org/C2777424391","wikidata":"https://www.wikidata.org/wiki/Q1163908","display_name":"Melena","level":2,"score":0.880357027053833},{"id":"https://openalex.org/C2778281985","wikidata":"https://www.wikidata.org/wiki/Q539491","display_name":"Angiodysplasia","level":2,"score":0.8178004026412964},{"id":"https://openalex.org/C2776330896","wikidata":"https://www.wikidata.org/wiki/Q1634800","display_name":"Telangiectasia","level":2,"score":0.713253378868103},{"id":"https://openalex.org/C2911156200","wikidata":"https://www.wikidata.org/wiki/Q1529258","display_name":"Thrombasthenia","level":4,"score":0.6166871786117554},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.6124721765518188},{"id":"https://openalex.org/C2778080469","wikidata":"https://www.wikidata.org/wiki/Q1495657","display_name":"Gastrointestinal bleeding","level":2,"score":0.5656049847602844},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5249093770980835},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.5112519264221191},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5056955814361572},{"id":"https://openalex.org/C2778792578","wikidata":"https://www.wikidata.org/wiki/Q4121501","display_name":"Argon plasma coagulation","level":3,"score":0.48975300788879395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4721434414386749},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4342944622039795},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.30383872985839844},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.22061309218406677},{"id":"https://openalex.org/C2778451229","wikidata":"https://www.wikidata.org/wiki/Q212809","display_name":"Endoscopy","level":2,"score":0.09049537777900696},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001791","descriptor_name":"Blood Platelet Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006471","descriptor_name":"Gastrointestinal Hemorrhage","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006471","descriptor_name":"Gastrointestinal Hemorrhage","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008595","descriptor_name":"Menorrhagia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013915","descriptor_name":"Thrombasthenia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D013915","descriptor_name":"Thrombasthenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016888","descriptor_name":"Angiodysplasia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016888","descriptor_name":"Angiodysplasia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019039","descriptor_name":"Platelet Glycoprotein GPIIb-IIIa Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035583","descriptor_name":"Rare Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/mbc.0000000000001249","doi":"https://doi.org/10.1097/mbc.0000000000001249","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mbc.0000000000001249","pdf_url":null,"source":{"id":"https://openalex.org/S118812467","display_name":"Blood Coagulation & Fibrinolysis","issn_l":"0957-5235","issn":["0957-5235","1473-5733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Coagulation & Fibrinolysis","raw_type":"journal-article"},{"id":"pmid:37942747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37942747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1980907603","https://openalex.org/W1994481502","https://openalex.org/W2031077989","https://openalex.org/W2057205964","https://openalex.org/W2532322090","https://openalex.org/W2919881019","https://openalex.org/W2990094239","https://openalex.org/W3004539106","https://openalex.org/W3009338033","https://openalex.org/W3013494283","https://openalex.org/W3043395065","https://openalex.org/W3094955757","https://openalex.org/W4211136726","https://openalex.org/W4234008004","https://openalex.org/W4289349909","https://openalex.org/W6808446463"],"related_works":["https://openalex.org/W4404232572","https://openalex.org/W3012828504","https://openalex.org/W4387750850","https://openalex.org/W1980907603","https://openalex.org/W7151594316","https://openalex.org/W2460804401","https://openalex.org/W2778772512","https://openalex.org/W23446343","https://openalex.org/W7118070404","https://openalex.org/W3013494283"],"abstract_inverted_index":{"Glanzmann's":[0],"Thrombasthenia":[1],"(GT)":[2],"is":[3,37],"a":[4,10,38,56,68,108,116,128],"rare":[5,39],"hemorrhagic":[6,96],"condition":[7,43],"caused":[8],"by":[9,93],"platelet":[11],"surface":[12],"receptor":[13],"disorder":[14],"of":[15,21,26,41,58,131],"the":[16,42,51,89,94],"glycoprotein":[17],"(GP)":[18],"IIb/IIIa.":[19],"Symptoms":[20],"GT":[22],"are":[23],"various":[24],"forms":[25],"hemorrhages,":[27],"such":[28],"as":[29,55,113,115],"purpura,":[30],"epistaxis":[31],"and":[32,44,80],"menorrhagia.":[33],"Gastrointestinal":[34],"bleeding":[35],"(GIB)":[36],"expression":[40],"may":[45],"occur":[46],"due":[47],"to":[48,75],"traumas":[49],"in":[50,111,118],"GI":[52],"tract":[53],"or":[54],"consequence":[57],"gastrointestinal":[59],"angiodysplasia":[60],"(GIADs).":[61],"In":[62],"this":[63],"case":[64,122],"report,":[65],"we":[66],"present":[67],"middle-aged":[69],"woman":[70],"with":[71,77,135,138],"recurrent":[72],"GIB":[73],"consequent":[74],"GIADs":[76],"persistent":[78],"melena":[79],"iron":[81],"deficiency":[82],"anemia.":[83],"After":[84],"several":[85],"unsuccessful":[86],"therapeutic":[87],"interventions,":[88],"patient":[90],"was":[91],"studied":[92],"hereditary":[95],"telangiectasia's":[97],"(HHT":[98],"-":[99],"Osler-Weber-Rendu":[100],"disease)":[101],"unit,":[102],"where":[103],"she":[104],"received":[105],"bevacizumab,":[106],"showing":[107],"complete":[109],"improvement":[110],"symptoms":[112],"well":[114],"reduction":[117],"her":[119],"GIADs.":[120,139],"This":[121],"shows":[123],"that":[124],"bevacizumab":[125],"could":[126],"be":[127],"possible":[129],"line":[130],"treatment":[132],"for":[133],"patients":[134],"coagulation":[136],"disorders":[137]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-10T00:00:00"}