{"id":"https://openalex.org/W4388499426","doi":"https://doi.org/10.32996/jmhs.2023.4.6.4","title":"Association between Diabetes Mellitus and Pancreatic Cancer: A Comprehensive Narrative Review","display_name":"Association between Diabetes Mellitus and Pancreatic Cancer: A Comprehensive Narrative Review","publication_year":2023,"publication_date":"2023-11-08","ids":{"openalex":"https://openalex.org/W4388499426","doi":"https://doi.org/10.32996/jmhs.2023.4.6.4"},"language":"en","primary_location":{"id":"doi:10.32996/jmhs.2023.4.6.4","doi":"https://doi.org/10.32996/jmhs.2023.4.6.4","is_oa":true,"landing_page_url":"http://dx.doi.org/10.32996/jmhs.2023.4.6.4","pdf_url":"https://al-kindipublisher.com/index.php/jmhs/article/download/6027/5217","source":{"id":"https://openalex.org/S4210240251","display_name":"Journal of Medical and Health Studies","issn_l":"2710-1452","issn":["2710-1452"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4365383729","host_organization_name":"Al-Kindi Center for Research and Development","host_organization_lineage":["https://openalex.org/P4365383729"],"host_organization_lineage_names":["Al-Kindi Center for Research and Development"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical and Health Studies","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://al-kindipublisher.com/index.php/jmhs/article/download/6027/5217","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057631310","display_name":"Zeryab Shahid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799345741","display_name":"CMH Lahore Medical College and Institute of Dentistry","ror":"https://ror.org/0381dt953","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2799345741"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zeryab Shahid","raw_affiliation_strings":["CMH Lahore Medical and Dental College, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CMH Lahore Medical and Dental College, Lahore, Pakistan","institution_ids":["https://openalex.org/I2799345741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108864333","display_name":"Sehrish Arif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267158","display_name":"FMH College of Medicine & Dentistry","ror":"https://ror.org/01egxa393","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405267158"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sehrish Arif","raw_affiliation_strings":["FMH college of medicine and dentistry, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMH college of medicine and dentistry, Lahore, Pakistan","institution_ids":["https://openalex.org/I4405267158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003076400","display_name":"Himanika Paliwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168974072","display_name":"Government Medical College","ror":"https://ror.org/026b7da27","country_code":"IN","type":"education","lineage":["https://openalex.org/I168974072"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Himanika Paliwal","raw_affiliation_strings":["Government Medical College, Nagpur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Government Medical College, Nagpur, India","institution_ids":["https://openalex.org/I168974072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092501138","display_name":"Rishabh Baskara Salian","orcid":"https://orcid.org/0009-0005-5324-584X","observed_orcids":["https://orcid.org/0009-0005-5324-584X"]},"institutions":[{"id":"https://openalex.org/I4387153400","display_name":"Kasturba Medical College, Mangalore","ror":"https://ror.org/048vk1h54","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460","https://openalex.org/I4387153400"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rishabh Baskara Salian","raw_affiliation_strings":["Kasturba Medical College Mangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kasturba Medical College Mangalore, India","institution_ids":["https://openalex.org/I4387153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037521974","display_name":"Samia Rauf Butt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samia Rauf Butt","raw_affiliation_strings":["University colleges of medicine and dentistry , Lahore ,pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University colleges of medicine and dentistry , Lahore ,pakistan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Faiza Choudhry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1318157472","display_name":"Liaquat University of Medical & Health Sciences","ror":"https://ror.org/015jxh185","country_code":"PK","type":"education","lineage":["https://openalex.org/I1318157472"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Faiza Choudhry","raw_affiliation_strings":["Liaquat university of medical and health sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liaquat university of medical and health sciences","institution_ids":["https://openalex.org/I1318157472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064646592","display_name":"Yetunde Ishola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87477611","display_name":"Igbinedion University","ror":"https://ror.org/041rwsw06","country_code":"NG","type":"education","lineage":["https://openalex.org/I87477611"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Yetunde Ishola","raw_affiliation_strings":["Oba Okunade Sijuade college of health science Igbinedion University Okada Edo State Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oba Okunade Sijuade college of health science Igbinedion University Okada Edo State Nigeria","institution_ids":["https://openalex.org/I87477611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021229498","display_name":"Zain Ul Ab\u0131d\u0131n","orcid":"https://orcid.org/0000-0003-1713-2141","observed_orcids":["https://orcid.org/0000-0003-1713-2141"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zain ul Abidin","raw_affiliation_strings":["Mount Sinai Hospital Jackson Park"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai Hospital Jackson Park","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014386050","display_name":"Zahra Nazir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800672702","display_name":"Combined Military Hospital","ror":"https://ror.org/05mya2w74","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2800672702"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zahra Nazir","raw_affiliation_strings":["Combined Military Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Combined Military Hospital","institution_ids":["https://openalex.org/I2800672702"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"6","first_page":"25","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.1005999967455864,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9279999732971191},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7639999985694885},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-axis","display_name":"insulin-like growth factor axis","score":0.968999981880188},{"id":"https://openalex.org/keywords/impaired-glucose-metabolism","display_name":"impaired glucose metabolism","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.6029999852180481},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.7687918543815613},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6825652718544006},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6793771386146545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6321874856948853},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6319113373756409},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.605676531791687},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5425937175750732},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5385056734085083},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.506990909576416},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.5021591186523438},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4657256305217743},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42056241631507874},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.4131351411342621},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40935659408569336},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3761754631996155},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3546266555786133},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.14897915720939636},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.13522592186927795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11702147126197815}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.32996/jmhs.2023.4.6.4","doi":"https://doi.org/10.32996/jmhs.2023.4.6.4","is_oa":true,"landing_page_url":"http://dx.doi.org/10.32996/jmhs.2023.4.6.4","pdf_url":"https://al-kindipublisher.com/index.php/jmhs/article/download/6027/5217","source":{"id":"https://openalex.org/S4210240251","display_name":"Journal of Medical and Health Studies","issn_l":"2710-1452","issn":["2710-1452"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4365383729","host_organization_name":"Al-Kindi Center for Research and Development","host_organization_lineage":["https://openalex.org/P4365383729"],"host_organization_lineage_names":["Al-Kindi Center for Research and Development"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical and Health Studies","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.32996/jmhs.2023.4.6.4","doi":"https://doi.org/10.32996/jmhs.2023.4.6.4","is_oa":true,"landing_page_url":"http://dx.doi.org/10.32996/jmhs.2023.4.6.4","pdf_url":"https://al-kindipublisher.com/index.php/jmhs/article/download/6027/5217","source":{"id":"https://openalex.org/S4210240251","display_name":"Journal of Medical and Health Studies","issn_l":"2710-1452","issn":["2710-1452"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4365383729","host_organization_name":"Al-Kindi Center for Research and Development","host_organization_lineage":["https://openalex.org/P4365383729"],"host_organization_lineage_names":["Al-Kindi Center for Research and Development"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical and Health Studies","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388499426.pdf","grobid_xml":"https://content.openalex.org/works/W4388499426.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W182079344","https://openalex.org/W962625150","https://openalex.org/W1212651875","https://openalex.org/W1535686293","https://openalex.org/W1964048135","https://openalex.org/W1969074752","https://openalex.org/W1988782755","https://openalex.org/W2007483732","https://openalex.org/W2063524566","https://openalex.org/W2063877293","https://openalex.org/W2066809635","https://openalex.org/W2080247949","https://openalex.org/W2083904574","https://openalex.org/W2094883382","https://openalex.org/W2098082928","https://openalex.org/W2112981414","https://openalex.org/W2119184048","https://openalex.org/W2131396697","https://openalex.org/W2134616748","https://openalex.org/W2136383161","https://openalex.org/W2155146717","https://openalex.org/W2156029787","https://openalex.org/W2159946871","https://openalex.org/W2164215069","https://openalex.org/W2171182790","https://openalex.org/W2176775938","https://openalex.org/W2344249756","https://openalex.org/W2510275243","https://openalex.org/W2554987853","https://openalex.org/W2560633348","https://openalex.org/W2571110330","https://openalex.org/W2615250694","https://openalex.org/W2759631471","https://openalex.org/W2770664083","https://openalex.org/W2790192191","https://openalex.org/W2796978679","https://openalex.org/W2803190522","https://openalex.org/W2809306781","https://openalex.org/W2810335607","https://openalex.org/W2896684572","https://openalex.org/W2910163665","https://openalex.org/W2925901874","https://openalex.org/W2949192712","https://openalex.org/W2958198954","https://openalex.org/W2971654036","https://openalex.org/W2982377416","https://openalex.org/W3048739465","https://openalex.org/W3086743075","https://openalex.org/W3116521081","https://openalex.org/W3165179628","https://openalex.org/W3169182937","https://openalex.org/W3173305737","https://openalex.org/W3175508381","https://openalex.org/W3182981546","https://openalex.org/W3192441941","https://openalex.org/W3196153281","https://openalex.org/W3202441000","https://openalex.org/W4281381857","https://openalex.org/W4297962897","https://openalex.org/W6609246899"],"related_works":["https://openalex.org/W2344249756","https://openalex.org/W3162886926","https://openalex.org/W4283390176","https://openalex.org/W2971654036","https://openalex.org/W2136383161","https://openalex.org/W1486092148","https://openalex.org/W2979929407","https://openalex.org/W2579159366","https://openalex.org/W4394743685","https://openalex.org/W6920978337"],"abstract_inverted_index":{"Pancreatic":[0],"cancer":[1,34,37],"(PC)":[2],"is":[3,24,28],"extremely":[4],"aggressive,":[5],"with":[6,127],"symptoms":[7],"occurring":[8],"only":[9],"in":[10,118],"the":[11,39,75,89,92,95,100,105,111,141],"advanced":[12],"stage.":[13],"The":[14,70],"relationship":[15],"between":[16,147],"Type":[17],"2":[18],"Diabetes":[19],"Mellitus":[20],"(T2DM)":[21],"and":[22,49,67,107,110,121,149,160],"PC":[23,148],"complex.":[25],"However,":[26],"it":[27],"unclear":[29],"whether":[30,36],"long-standing":[31],"diabetes":[32,135],"causes":[33],"or":[35],"proceeds":[38],"development":[40],"of":[41,94,98,102,104,114,125,134],"impaired":[42],"glucose":[43],"metabolism.":[44,122],"PubMed,":[45],"Google":[46],"Scholar,":[47],"Scopus":[48],"Cochrane":[50],"library":[51],"were":[52],"consulted":[53],"to":[54,87,143,152],"look":[55],"for":[56],"relevant":[57],"literature.":[58],"We":[59,139],"narrowed":[60],"down":[61],"20":[62],"articles":[63],"after":[64],"implementing":[65],"inclusion":[66],"exclusion":[68],"criteria.":[69],"database":[71],"was":[72],"searched":[73],"using":[74],"keywords":[76],"\u201cPancreatic":[77],"Cancer\u201d":[78],"AND":[79],"\u201cDiabetes":[80],"Mellitus.\u201d":[81],"This":[82],"narrative":[83],"literature":[84,90,142],"review":[85],"aims":[86],"analyze":[88],"on":[91],"analysis":[93],"metabolic":[96,115,145],"association":[97],"T2DM,":[99],"risk":[101],"carcinogenesis":[103],"pancreas":[106],"their":[108],"association,":[109],"current":[112],"understanding":[113],"pathways":[116],"involved":[117],"cellular":[119],"growth":[120,162],"About":[123],"80%":[124],"patients":[126],"pancreatic":[128],"disease":[129],"have":[130],"a":[131],"previous":[132],"diagnosis":[133],"within":[136],"five":[137],"years.":[138],"explored":[140],"find":[144],"associations":[146],"T2DM":[150],"due":[151],"insulin":[153],"resistance,":[154],"hyperinsulinemia,":[155],"hyperglycemia,":[156],"low-grade":[157],"chronic":[158],"inflammation,":[159],"insulin-like":[161],"factor":[163],"axis":[164],"alteration.":[165]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-11-09T00:00:00"}