{"id":"https://openalex.org/W4388478933","doi":"https://doi.org/10.1039/d3bm01138k","title":"Covalent drugs based on small molecules and peptides for disease theranostics","display_name":"Covalent drugs based on small molecules and peptides for disease theranostics","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4388478933","doi":"https://doi.org/10.1039/d3bm01138k","pmid":"https://pubmed.ncbi.nlm.nih.gov/37975197"},"language":"en","primary_location":{"id":"doi:10.1039/d3bm01138k","doi":"https://doi.org/10.1039/d3bm01138k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d3bm01138k","pdf_url":null,"source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ying-Jin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying-Jin Zhang","raw_affiliation_strings":["CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P.R. China","Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450052, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P.R. China","institution_ids":["https://openalex.org/I4210141483"]},{"raw_affiliation_string":"Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450052, P.R. China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109716760","display_name":"Jian\u2010Xiao Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Xiao Liang","raw_affiliation_strings":["CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P.R. China","Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, No. 19(A) Yuquan Road, Shijingshan District, Beijing 100049, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P.R. China","institution_ids":["https://openalex.org/I4210141483"]},{"raw_affiliation_string":"Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, No. 19(A) Yuquan Road, Shijingshan District, Beijing 100049, P.R. China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080559091","display_name":"Yinsheng Xu","orcid":"https://orcid.org/0000-0002-1887-0632","observed_orcids":["https://orcid.org/0000-0002-1887-0632"]},"institutions":[{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin-Sheng Xu","raw_affiliation_strings":["CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P.R. China","institution_ids":["https://openalex.org/I4210141483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100746010","display_name":"Yixuan Liu","orcid":"https://orcid.org/0000-0002-9522-8651","observed_orcids":["https://orcid.org/0000-0002-9522-8651","https://orcid.org/0000-0001-9471-5493","https://orcid.org/0009-0001-3592-9894","https://orcid.org/0009-0001-7728-1109"]},"institutions":[{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Xuan Liu","raw_affiliation_strings":["CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P.R. China","Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, No. 19(A) Yuquan Road, Shijingshan District, Beijing 100049, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P.R. China","institution_ids":["https://openalex.org/I4210141483"]},{"raw_affiliation_string":"Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, No. 19(A) Yuquan Road, Shijingshan District, Beijing 100049, P.R. China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102318136","display_name":"Ying-Ying Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405278911","display_name":"Laiwu Vocational and Technical College","ror":"https://ror.org/00re8ag58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405278911"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingying Cui","raw_affiliation_strings":["Department of Food and Drug, Laiwu Vocational and Technical, College, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Drug, Laiwu Vocational and Technical, College, Jinan, China","institution_ids":["https://openalex.org/I4405278911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068646559","display_name":"Zeng\u2010Ying Qiao","orcid":"https://orcid.org/0000-0002-9932-7702","observed_orcids":["https://orcid.org/0000-0002-9932-7702"]},"institutions":[{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zeng-Ying Qiao","raw_affiliation_strings":["CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-9932-7702","affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P.R. China","institution_ids":["https://openalex.org/I4210141483"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100446107","display_name":"Hao Wang","orcid":"https://orcid.org/0000-0002-1961-0787","observed_orcids":["https://orcid.org/0000-0002-1961-0787"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hao Wang","raw_affiliation_strings":["CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P.R. China","Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, No. 19(A) Yuquan Road, Shijingshan District, Beijing 100049, P.R. China","Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450052, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-1961-0787","affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P.R. China","institution_ids":["https://openalex.org/I4210141483"]},{"raw_affiliation_string":"Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, No. 19(A) Yuquan Road, Shijingshan District, Beijing 100049, P.R. China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450052, P.R. China","institution_ids":["https://openalex.org/I38877650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068646559","https://openalex.org/A5100446107"],"corresponding_institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210141483","https://openalex.org/I4210165038"],"apc_list":null,"apc_paid":null,"fwci":0.2211,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.15740199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"3","first_page":"564","last_page":"580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-molecule-drugs","display_name":"small molecule drugs","score":0.6179999709129333},{"id":"https://openalex.org/keywords/theranostics","display_name":"theranostics","score":0.8619999885559082},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.5920000076293945},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5960000157356262},{"id":"https://openalex.org/keywords/artificial-intelligence-in-drug-discovery","display_name":"artificial intelligence in drug discovery","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.8960360288619995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6304864883422852},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4742423892021179},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.43337297439575195},{"id":"https://openalex.org/C3018522384","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent binding","level":3,"score":0.41411957144737244},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23510447144508362},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12082099914550781}],"mesh":[{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/d3bm01138k","doi":"https://doi.org/10.1039/d3bm01138k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d3bm01138k","pdf_url":null,"source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},{"id":"pmid:37975197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37975197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4072387575","display_name":null,"funder_award_id":"XDB36000000","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G4430307170","display_name":null,"funder_award_id":"Z211100002121148","funder_id":"https://openalex.org/F4320334978","funder_display_name":"Beijing Nova Program"},{"id":"https://openalex.org/G4436172131","display_name":null,"funder_award_id":"2021YFB3801002","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7441525990","display_name":null,"funder_award_id":"22222503","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320334978","display_name":"Beijing Nova Program","ror":"https://ror.org/034k14f91"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335892","display_name":"Youth Innovation Promotion Association","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W1983865998","https://openalex.org/W1989822059","https://openalex.org/W2010654750","https://openalex.org/W2011281389","https://openalex.org/W2028161249","https://openalex.org/W2037392993","https://openalex.org/W2042799385","https://openalex.org/W2044430464","https://openalex.org/W2048234380","https://openalex.org/W2052030759","https://openalex.org/W2060215679","https://openalex.org/W2064517127","https://openalex.org/W2088518810","https://openalex.org/W2093986197","https://openalex.org/W2099798519","https://openalex.org/W2101486946","https://openalex.org/W2134967712","https://openalex.org/W2147199669","https://openalex.org/W2158534713","https://openalex.org/W2170298138","https://openalex.org/W2264363593","https://openalex.org/W2284923715","https://openalex.org/W2296618733","https://openalex.org/W2300615341","https://openalex.org/W2317417725","https://openalex.org/W2396813504","https://openalex.org/W2407117297","https://openalex.org/W2518405147","https://openalex.org/W2560263664","https://openalex.org/W2582190190","https://openalex.org/W2619923059","https://openalex.org/W2622009965","https://openalex.org/W2693081864","https://openalex.org/W2787149025","https://openalex.org/W2793965939","https://openalex.org/W2810612816","https://openalex.org/W2888929903","https://openalex.org/W2904842851","https://openalex.org/W2918370785","https://openalex.org/W2949252818","https://openalex.org/W2979836494","https://openalex.org/W2982321167","https://openalex.org/W2982602983","https://openalex.org/W2983852549","https://openalex.org/W2994916398","https://openalex.org/W3001630456","https://openalex.org/W3084402429","https://openalex.org/W3089819726","https://openalex.org/W3092280809","https://openalex.org/W3096244860","https://openalex.org/W3097379035","https://openalex.org/W3118407888","https://openalex.org/W3123671769","https://openalex.org/W3129641179","https://openalex.org/W3160814986","https://openalex.org/W3161651131","https://openalex.org/W3165143074","https://openalex.org/W3166196440","https://openalex.org/W3172081492","https://openalex.org/W3176313619","https://openalex.org/W3188410974","https://openalex.org/W3207920936","https://openalex.org/W4200510858","https://openalex.org/W4205797641","https://openalex.org/W4206094329","https://openalex.org/W4220910940","https://openalex.org/W4225410161","https://openalex.org/W4237526537","https://openalex.org/W4283660454","https://openalex.org/W4283707692","https://openalex.org/W4283710994","https://openalex.org/W4291667405","https://openalex.org/W4293793251","https://openalex.org/W4295456329","https://openalex.org/W4295755745","https://openalex.org/W4297200884","https://openalex.org/W4300963584","https://openalex.org/W4306165745","https://openalex.org/W4306630516","https://openalex.org/W4308694108","https://openalex.org/W4309047423","https://openalex.org/W4310943225","https://openalex.org/W4313418831","https://openalex.org/W4315707232","https://openalex.org/W4317870869","https://openalex.org/W4319826818","https://openalex.org/W4367156322","https://openalex.org/W4386420442"],"related_works":["https://openalex.org/W7160393178","https://openalex.org/W3108346969","https://openalex.org/W4408672873","https://openalex.org/W4399951700","https://openalex.org/W7212293151","https://openalex.org/W3211722196","https://openalex.org/W4405819339","https://openalex.org/W2996107378","https://openalex.org/W2523153670","https://openalex.org/W4380301919"],"abstract_inverted_index":{"Biomacromolecules,":[0],"such":[1,49],"as":[2,22,50],"proteins,":[3],"nucleic":[4],"acids":[5],"and":[6,15,40,53,60,69,89,112,127],"polysaccharides,":[7],"are":[8],"widely":[9],"distributed":[10],"in":[11,35,94,97],"the":[12,23,78,101,109,113,121],"human":[13],"body,":[14],"some":[16,47],"of":[17,25,74,80,103,115,123],"them":[18],"have":[19,46,62,85,90],"been":[20,91],"recognized":[21],"targets":[24,34,61],"drugs":[26,45,59,84,126],"for":[27,134],"disease":[28],"theranostics.":[29],"Drugs":[30],"typically":[31],"act":[32],"on":[33],"two":[36],"ways:":[37],"non-covalent":[38,72],"bond":[39],"covalent":[41,83,104,116,124],"bond.":[42],"Non-covalent":[43],"bond-based":[44],"disadvantages,":[48],"structural":[51],"instability":[52],"environmental":[54],"sensitivity.":[55],"Covalent":[56],"interactions":[57,73],"between":[58],"a":[63,131],"longer":[64],"action":[65],"time,":[66],"higher":[67],"affinity":[68],"controllability":[70],"than":[71],"conventional":[75],"drugs.":[76,117],"With":[77],"development":[79],"artificial":[81],"intelligence,":[82],"received":[86],"more":[87],"attention":[88],"developed":[92],"rapidly":[93],"pharmaceutical":[95],"research":[96],"recent":[98],"years.":[99],"From":[100],"perspective":[102],"drugs,":[105],"this":[106],"review":[107],"summarizes":[108],"design":[110],"methods":[111],"effects":[114],"Finally,":[118],"we":[119],"discuss":[120],"application":[122],"peptide":[125],"expect":[128],"to":[129],"provide":[130],"new":[132],"reference":[133],"cancer":[135],"treatment.":[136]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-08T00:00:00"}
