{"id":"https://openalex.org/W4388458136","doi":"https://doi.org/10.51737/2766-4589.2023.101","title":"Thrombocytopaenia and Down Syndrome \u2013 What about the Usual Suspects?","display_name":"Thrombocytopaenia and Down Syndrome \u2013 What about the Usual Suspects?","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4388458136","doi":"https://doi.org/10.51737/2766-4589.2023.101"},"language":"en","primary_location":{"id":"doi:10.51737/2766-4589.2023.101","doi":"https://doi.org/10.51737/2766-4589.2023.101","is_oa":false,"landing_page_url":"https://doi.org/10.51737/2766-4589.2023.101","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Suntext Review of Case Reports &amp; Images","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://orbi.uliege.be/bitstream/2268/313035/1/Thrombocytopaenia%20and%20Down%20Syndrome_What%20about%20the%20Usual%20Suspects.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093215132","display_name":"Schmit C\u00e9line","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Schmit C\u00e9line","raw_affiliation_strings":["Department of Pediatrics, Centre Hospitalier Universitaire de Liege, University of Lige, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Centre Hospitalier Universitaire de Liege, University of Lige, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093215133","display_name":"Geurten Claire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geurten Claire","raw_affiliation_strings":["Department of Pediatrics, division of Pediatric Hematology and Oncology, Centre Hospitalier Universitaire de Lige, University of Lige, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, division of Pediatric Hematology and Oncology, Centre Hospitalier Universitaire de Lige, University of Lige, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046470677","display_name":"Beno\u00eet Florkin","orcid":"https://orcid.org/0000-0001-7318-8348","observed_orcids":["https://orcid.org/0000-0001-7318-8348"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florkin Benoit","raw_affiliation_strings":["Department of Pediatrics, division of Pediatric Hematology and Oncology, Centre Hospitalier Universitaire de Lige, University of Lige, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, division of Pediatric Hematology and Oncology, Centre Hospitalier Universitaire de Lige, University of Lige, Belgium","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111383820","display_name":"Marie Francoise Dresse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dresse Marie- Fran\u00e7oise","raw_affiliation_strings":["Department of Pediatrics, division of Pediatric Hematology and Oncology, Centre Hospitalier Universitaire de Lige, University of Lige, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, division of Pediatric Hematology and Oncology, Centre Hospitalier Universitaire de Lige, University of Lige, Belgium","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"04","issue":"06","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.05050000175833702,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.9670000076293945},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9049999713897705},{"id":"https://openalex.org/keywords/immune-thrombotic-thrombocytopenic-purpura","display_name":"immune-mediated thrombotic thrombocytopenic purpura","score":0.9700000286102295},{"id":"https://openalex.org/keywords/acquired-ttp","display_name":"acquired TTP","score":0.8450000286102295},{"id":"https://openalex.org/keywords/adamts13-inhibitor","display_name":"ADAMTS13 inhibitor","score":0.7699999809265137},{"id":"https://openalex.org/keywords/plasmapheresis","display_name":"plasmapheresis","score":0.777999997138977},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hemolytic-anemia","display_name":"hemolytic anemia","score":0.8880000114440918},{"id":"https://openalex.org/keywords/upper-respiratory-tract-infection","display_name":"upper respiratory tract infection","score":0.765999972820282},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.8059999942779541},{"id":"https://openalex.org/keywords/pediatric-thrombosis","display_name":"pediatric thrombosis","score":0.6010000109672546},{"id":"https://openalex.org/keywords/differential-diagnosis-of-thrombocytopenia","display_name":"differential diagnosis of thrombocytopenia","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3799980878829956},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33045369386672974}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.51737/2766-4589.2023.101","doi":"https://doi.org/10.51737/2766-4589.2023.101","is_oa":false,"landing_page_url":"https://doi.org/10.51737/2766-4589.2023.101","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Suntext Review of Case Reports &amp; Images","raw_type":"journal-article"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/313035","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/313035","pdf_url":"https://orbi.uliege.be/bitstream/2268/313035/1/Thrombocytopaenia%20and%20Down%20Syndrome_What%20about%20the%20Usual%20Suspects.pdf","source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Suntext Reviews, 4 (7), 1-4 (2023-09-04)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"pmh:oai:orbi.ulg.ac.be:2268/313035","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/313035","pdf_url":"https://orbi.uliege.be/bitstream/2268/313035/1/Thrombocytopaenia%20and%20Down%20Syndrome_What%20about%20the%20Usual%20Suspects.pdf","source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Suntext Reviews, 4 (7), 1-4 (2023-09-04)","raw_type":"http://purl.org/coar/resource_type/c_6501"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388458136.pdf","grobid_xml":"https://content.openalex.org/works/W4388458136.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1988386441","https://openalex.org/W2006906895","https://openalex.org/W2010802708","https://openalex.org/W2032268179","https://openalex.org/W2317056394","https://openalex.org/W2580773246","https://openalex.org/W2582683896","https://openalex.org/W2766826848","https://openalex.org/W2793580293","https://openalex.org/W2890014169","https://openalex.org/W2910737538","https://openalex.org/W3014111030","https://openalex.org/W3133741137"],"related_works":["https://openalex.org/W303457254","https://openalex.org/W2955741835","https://openalex.org/W1971352783","https://openalex.org/W4401103696","https://openalex.org/W4281673547","https://openalex.org/W2923102969","https://openalex.org/W2065908257","https://openalex.org/W2808596725","https://openalex.org/W2013641463","https://openalex.org/W2296863327"],"abstract_inverted_index":{"Down":[0,42,200,223],"syndrome":[1,43,201],"is":[2,152,190],"a":[3,9],"chromosomal":[4],"disorder":[5],"renowned":[6],"for":[7,62],"conferring":[8],"predisposition":[10],"to":[11,24,34,170,180,192,205],"auto-immune":[12],"and":[13,65,100,127,143,165,183],"hematological":[14,16],"conditions;":[15],"abnormalities":[17],"in":[18,157,199,220],"this":[19,188],"population":[20],"should":[21,31],"prompt":[22],"investigations":[23],"exclude":[25],"malignancy,":[26],"but":[27,124],"comprehensive":[28],"differential":[29],"diagnosis":[30],"be":[32,167],"broadened":[33],"other":[35,213],"pathologies.":[36],"A":[37,69],"15":[38],"months-old":[39],"infant":[40],"with":[41,45,122,141,222],"presented":[44],"isolated":[46],"moderate":[47],"thrombocytopenia":[48],"during":[49],"an":[50,116,153],"episode":[51],"of":[52,85,108,135,139,147,162,173,187,215,217],"upper":[53],"respiratory":[54],"tract":[55],"infection.":[56,117],"Clinical":[57],"examination":[58],"was":[59,98],"unremarkable":[60],"except":[61],"mild":[63],"hepatomegaly":[64],"diffuse":[66],"petechial":[67],"rash.":[68],"bone":[70],"marrow":[71],"aspiration":[72],"showed":[73,79],"no":[74],"malignant":[75],"infiltration.":[76],"Intravenous":[77],"immunoglobulins":[78],"little":[80],"benefit":[81],"over":[82],"the":[83,86,106,145,171],"course":[84],"following":[87],"7":[88],"days.":[89],"The":[90],"patient":[91],"secondarily":[92],"developed":[93],"hemolytic":[94],"anemia.":[95],"ADAMTS13":[96],"activity":[97],"undetectable,":[99],"plasmatic":[101],"inhibitors":[102],"were":[103,120],"detected":[104],"confirming":[105],"hypothesis":[107],"immune":[109,206,218],"thrombotic":[110],"thrombocytopenic":[111],"purpura":[112],"(TTP),":[113],"triggered":[114],"by":[115],"Daily":[118],"plasmapheresis":[119],"started":[121],"immediate":[123],"short-lived":[125],"benefit,":[126],"TTP":[128,151,219],"persistently":[129],"recurred":[130],"every":[131],"48h":[132],"after":[133],"interruption":[134],"exchanges,":[136],"warranting":[137],"initiation":[138],"treatment":[140],"Rituximab":[142],"enabling":[144],"achievement":[146],"long-term":[148,194],"remission.":[149],"Acquired":[150],"extremely":[154],"rare":[155],"entity":[156,189],"children":[158],"below":[159],"9":[160],"years":[161],"age":[163],"(<1/1.000.000),":[164],"can":[166],"life-threatening":[168],"due":[169],"formation":[172],"micro":[174],"thrombi":[175],"occluding":[176],"terminal":[177],"circulation":[178],"leading":[179],"organ":[181],"damage":[182],"dysfunction.":[184],"Prompt":[185],"recognition":[186],"important":[191],"avoid":[193],"damages.":[195],"Altered":[196],"IFN":[197],"signaling":[198],"could":[202],"theoretically":[203],"predispose":[204],"TTP,":[207],"although":[208],"we":[209],"couldn\u2019t":[210],"find":[211],"any":[212],"report":[214],"cases":[216],"patients":[221],"syndrome.":[224]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-11-08T00:00:00"}