{"id":"https://openalex.org/W4388424129","doi":"https://doi.org/10.1158/2767-9764.24512230.v1","title":"Figure S2 from PRMT5 Inhibitors Regulate DNA Damage Repair Pathways in Cancer Cells and Improve Response to PARP Inhibition and Chemotherapies","display_name":"Figure S2 from PRMT5 Inhibitors Regulate DNA Damage Repair Pathways in Cancer Cells and Improve Response to PARP Inhibition and Chemotherapies","publication_year":2023,"publication_date":"2023-11-06","ids":{"openalex":"https://openalex.org/W4388424129","doi":"https://doi.org/10.1158/2767-9764.24512230.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.24512230.v1","doi":"https://doi.org/10.1158/2767-9764.24512230.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.24512230.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.24512230.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052263916","display_name":"Jack Carter","orcid":"https://orcid.org/0000-0002-7784-7897","observed_orcids":["https://orcid.org/0000-0002-7784-7897"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jack Carter","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7784-7897","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091867223","display_name":"Michael Hulse","orcid":"https://orcid.org/0000-0002-6691-365X","observed_orcids":["https://orcid.org/0000-0002-6691-365X","https://orcid.org/0009-0000-7928-1842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Hulse","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6691-365X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017032244","display_name":"Monisha Sivakumar","orcid":"https://orcid.org/0009-0002-8937-4289","observed_orcids":["https://orcid.org/0009-0002-8937-4289"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monisha Sivakumar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-8937-4289","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030876681","display_name":"Jessica Burtell","orcid":"https://orcid.org/0000-0002-7763-6379","observed_orcids":["https://orcid.org/0000-0002-7763-6379"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica Burtell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7763-6379","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062031656","display_name":"Venkat Thodima","orcid":"https://orcid.org/0000-0002-0939-3707","observed_orcids":["https://orcid.org/0000-0002-0939-3707"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Venkat Thodima","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0939-3707","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064147672","display_name":"Min Wang","orcid":"https://orcid.org/0009-0004-9364-1284","observed_orcids":["https://orcid.org/0009-0004-9364-1284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-9364-1284","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034853468","display_name":"Anjana Agarwal","orcid":"https://orcid.org/0009-0008-7625-1240","observed_orcids":["https://orcid.org/0009-0008-7625-1240"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anjana Agarwal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-7625-1240","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049083963","display_name":"Komali Vykuntam","orcid":"https://orcid.org/0009-0004-4538-4535","observed_orcids":["https://orcid.org/0009-0004-4538-4535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Komali Vykuntam","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-4538-4535","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086821262","display_name":"Jacob Spruance","orcid":"https://orcid.org/0000-0003-2744-8123","observed_orcids":["https://orcid.org/0000-0003-2744-8123"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacob Spruance","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2744-8123","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060435781","display_name":"Neha Bhagwat","orcid":"https://orcid.org/0009-0002-5766-0272","observed_orcids":["https://orcid.org/0009-0002-5766-0272"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neha Bhagwat","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-5766-0272","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004443645","display_name":"Joseph D. Rager","orcid":"https://orcid.org/0009-0004-6008-9630","observed_orcids":["https://orcid.org/0009-0004-6008-9630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Rager","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-6008-9630","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036665836","display_name":"Bruce Ruggeri","orcid":"https://orcid.org/0009-0002-0095-873X","observed_orcids":["https://orcid.org/0009-0002-0095-873X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce Ruggeri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-0095-873X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018193992","display_name":"Peggy Scherle","orcid":"https://orcid.org/0000-0003-0783-6815","observed_orcids":["https://orcid.org/0000-0003-0783-6815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peggy Scherle","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0783-6815","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023093205","display_name":"Koichi Ito","orcid":"https://orcid.org/0000-0003-1421-3122","observed_orcids":["https://orcid.org/0000-0003-1421-3122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koichi Ito","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1421-3122","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prmt5-inhibitors","display_name":"PRMT5 inhibitors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8220000267028809},{"id":"https://openalex.org/keywords/parp-inhibition","display_name":"PARP inhibition","score":0.8519999980926514},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.7604926228523254},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6553220152854919},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5141475796699524},{"id":"https://openalex.org/C2909513124","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA Damage Repair","level":4,"score":0.5009074211120605},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3465622663497925},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34471914172172546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33891573548316956},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24368849396705627},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.05287653207778931}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.24512230.v1","doi":"https://doi.org/10.1158/2767-9764.24512230.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.24512230.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.24512230.v1","doi":"https://doi.org/10.1158/2767-9764.24512230.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.24512230.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388411483","https://openalex.org/W4388424298","https://openalex.org/W4388423425","https://openalex.org/W4388422886","https://openalex.org/W4388423210","https://openalex.org/W4388424081","https://openalex.org/W4388411538","https://openalex.org/W4388424187","https://openalex.org/W4387799386","https://openalex.org/W3180719856"],"abstract_inverted_index":{"C220":[0],"broadly":[1],"suppresses":[2],"DDR":[3],"gene":[4],"expression":[5],"in":[6],"cancer":[7],"cells":[8],"and":[9],"reduces":[10],"DNA":[11],"repair.":[12]},"counts_by_year":[],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2023-11-07T00:00:00"}
