{"id":"https://openalex.org/W4388422985","doi":"https://doi.org/10.48095/ccgh2023419","title":"Subcutaneous infliximab in the treatment of refractory Crohn\u2018s disease patients \u2013 a pilot study of drug immunogenicity","display_name":"Subcutaneous infliximab in the treatment of refractory Crohn\u2018s disease patients \u2013 a pilot study of drug immunogenicity","publication_year":2023,"publication_date":"2023-10-30","ids":{"openalex":"https://openalex.org/W4388422985","doi":"https://doi.org/10.48095/ccgh2023419"},"language":"en","primary_location":{"id":"doi:10.48095/ccgh2023419","doi":"https://doi.org/10.48095/ccgh2023419","is_oa":false,"landing_page_url":"http://dx.doi.org/10.48095/ccgh2023419","pdf_url":null,"source":{"id":"https://openalex.org/S4210202899","display_name":"Gastroenterologie a hepatologie","issn_l":"1804-7874","issn":["1804-7874","1804-803X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310314279","host_organization_name":"Czech Medical Association of J. E. Purkyn\u011b","host_organization_lineage":["https://openalex.org/P4310314279"],"host_organization_lineage_names":["Czech Medical Association of J. E. Purkyn\u011b"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterologie a hepatologie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058669752","display_name":"Karin \u010cern\u00e1","orcid":"https://orcid.org/0000-0002-0562-6497","observed_orcids":["https://orcid.org/0000-0002-0562-6497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karin \u010cern\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015033532","display_name":"Dana \u010euricov\u00e1","orcid":"https://orcid.org/0000-0002-6090-3522","observed_orcids":["https://orcid.org/0000-0002-6090-3522"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dana \u010euricov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009409396","display_name":"Martin Luk\u00e1\u0161","orcid":"https://orcid.org/0000-0003-3946-3953","observed_orcids":["https://orcid.org/0000-0003-3946-3953"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Luk\u00e1\u0161","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085176483","display_name":"Nad\u011b\u017eda Machkov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nad\u011b\u017eda Machkov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009301755","display_name":"Veronika Hrub\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Veronika Hrub\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042319766","display_name":"Kristyna Kastylova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krist\u00fdna Ka\u0161tylov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029209055","display_name":"Katar\u00edna Mitrov\u00e1","orcid":"https://orcid.org/0000-0002-1836-3745","observed_orcids":["https://orcid.org/0000-0002-1836-3745"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katar\u00edna Mitrov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065792269","display_name":"Marta Kostrejov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Kostrejov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058772393","display_name":"Krist\u00fdna Kub\u00ed\u010dkov\u00e1","orcid":"https://orcid.org/0000-0003-1257-9171","observed_orcids":["https://orcid.org/0000-0003-1257-9171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krist\u00fdna Kub\u00ed\u010dkov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072474972","display_name":"\u0161t\u011bp\u00e1n Peterka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0160t\u011bp\u00e1n Peterka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007787685","display_name":"Martin Kol\u00e1\u0159","orcid":"https://orcid.org/0000-0001-9501-0604","observed_orcids":["https://orcid.org/0000-0001-9501-0604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Kol\u00e1\u0159","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jakub Jirsa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jakub Jirsa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041546771","display_name":"Gabriela Vojt\u011bchov\u00e1","orcid":"https://orcid.org/0000-0002-7911-470X","observed_orcids":["https://orcid.org/0000-0002-7911-470X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriela Vojt\u011bchov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022448896","display_name":"Milan Luk\u00e1\u0161","orcid":"https://orcid.org/0000-0002-1463-3840","observed_orcids":["https://orcid.org/0000-0002-1463-3840"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Milan Luk\u00e1\u0161","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1811,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44938847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"77","issue":"5","first_page":"419","last_page":"426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subcutaneous-infliximab","display_name":"subcutaneous infliximab","score":0.9879999756813049},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9330000281333923},{"id":"https://openalex.org/keywords/refractory-crohn-s-disease","display_name":"refractory Crohn's disease","score":0.8889999985694885},{"id":"https://openalex.org/keywords/drug-immunogenicity","display_name":"drug immunogenicity","score":0.878000020980835},{"id":"https://openalex.org/keywords/anti-drug-antibodies","display_name":"anti-drug antibodies","score":0.9649999737739563},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.5519999861717224},{"id":"https://openalex.org/keywords/medication-persistence","display_name":"treatment persistence","score":0.5799999833106995},{"id":"https://openalex.org/keywords/hla-dqa1-05","display_name":"HLA-DQA1*05","score":0.8389999866485596},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.46700000762939453},{"id":"https://openalex.org/keywords/treatment-intensification","display_name":"treatment intensification","score":0.5170000195503235},{"id":"https://openalex.org/keywords/fecal-calprotectin","display_name":"fecal calprotectin","score":0.6880000233650208},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9229999780654907},{"id":"https://openalex.org/keywords/endoscopic-disease-activity","display_name":"endoscopic activity","score":0.5389999747276306},{"id":"https://openalex.org/keywords/ultrasonography","display_name":"ultrasonography","score":0.48899999260902405},{"id":"https://openalex.org/keywords/loss-of-response","display_name":"loss of response","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9271001219749451},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.9228250980377197},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.7366076707839966},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.7296625375747681},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6235573291778564},{"id":"https://openalex.org/C31785415","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough level","level":4,"score":0.6181687712669373},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.49870824813842773},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4975135624408722},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.47991737723350525},{"id":"https://openalex.org/C59491497","wikidata":"https://www.wikidata.org/wiki/Q864715","display_name":"Biosimilar","level":2,"score":0.45142191648483276},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4438624382019043},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43595123291015625},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3713102638721466},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.34231922030448914},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22506213188171387},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19814369082450867},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.07111617922782898},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48095/ccgh2023419","doi":"https://doi.org/10.48095/ccgh2023419","is_oa":false,"landing_page_url":"http://dx.doi.org/10.48095/ccgh2023419","pdf_url":null,"source":{"id":"https://openalex.org/S4210202899","display_name":"Gastroenterologie a hepatologie","issn_l":"1804-7874","issn":["1804-7874","1804-803X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310314279","host_organization_name":"Czech Medical Association of J. E. Purkyn\u011b","host_organization_lineage":["https://openalex.org/P4310314279"],"host_organization_lineage_names":["Czech Medical Association of J. E. Purkyn\u011b"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterologie a hepatologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385252076","https://openalex.org/W4402757216","https://openalex.org/W4391161520","https://openalex.org/W4391218324","https://openalex.org/W4391165556","https://openalex.org/W4318539264","https://openalex.org/W4318184869","https://openalex.org/W4406702393","https://openalex.org/W4214642973","https://openalex.org/W7125095007"],"abstract_inverted_index":{"Introduction:":[0],"Despite":[1],"infliximab":[2,74,197,365,380,394],"(IFX)":[3],"still":[4],"being":[5],"the":[6,29,34,41,56,133,138,143,210,333,350,369,372,401,407],"\u201cgold":[7],"standard\u201d":[8],"of":[9,25,43,49,62,101,104,110,117,132,140,145,153,159,164,189,193,205,212,217,313,329,337,349,379,393,403],"biological":[10,190],"therapy":[11,207,215,395],"for":[12,79],"Crohn\u2019s":[13],"disease":[14,271],"(CD),":[15],"its":[16,85,107],"effectiveness":[17],"may":[18,52,382],"vary":[19],"depending":[20],"on":[21,209,305],"many":[22],"factors.":[23],"One":[24],"these":[26],"factors":[27],"is":[28,40,96,106,396],"individual":[30],"patient\u2019s":[31],"reaction":[32],"to":[33,47,59,64,69,124,136,185,344,364],"drug.":[35,408],"A":[36],"significant":[37,319],"clinical":[38],"problem":[39],"immunogenicity":[42,139],"IFX,":[44],"where":[45,391],"up":[46],"60%":[48],"treated":[50,127,352],"patients":[51,118,177,315,351,399],"develop":[53],"antibodies":[54,149,266,405],"against":[55,406],"drug,":[57],"leading":[58],"a":[60,114,318,384],"loss":[61],"response":[63],"treatment":[65,167,307],"and/or":[66],"adverse":[67],"reactions":[68],"therapy.":[70,374],"Since":[71],"2020,":[72],"subcutaneous":[73,377],"(IFX-SC)":[75],"has":[76],"been":[77],"available":[78],"treating":[80],"CD":[81,121,160,180,330],"patients,":[82],"characterized":[83],"by":[84],"stable":[86],"and":[87,147,156,166,171,224,244,263,269,274,278,298,326,386],"high":[88],"trough":[89,259],"level":[90],"(TL)":[91],"concentration":[92],"in":[93,284,310,321,355,368,389],"blood.":[94],"It":[95],"possible":[97],"that":[98],"one":[99,162,192],"consequence":[100],"this":[102],"property":[103],"IFX-SC":[105,306,354],"lower":[108],"rate":[109],"immunogenicity.":[111],"We":[112],"present":[113],"prospective":[115],"study":[116,134,174],"diagnosed":[119,178],"with":[120,122,128,179,294,317,353,400],"severe":[123],"refractory":[125],"courses,":[126],"IFX-SC.":[129],"The":[130,151,173,376],"aim":[131],"was":[135,195,226,282,308,366],"monitor":[137],"IFX-SC,":[141],"including":[142,398],"dynamics":[144,152],"TL":[146],"anti-drug":[148,265],"(anti-IFX).":[150,267],"clinical,":[154,324],"imaging,":[155,325],"laboratory":[157,327],"markers":[158,328],"over":[161],"year":[163],"monitoring":[165],"are":[168],"described.":[169],"Materials":[170],"methods:":[172],"included":[175],"23":[176,314],"who":[181],"had":[182],"failed":[183],"2":[184],"6":[186],"previous":[187],"lines":[188],"therapy,":[191,334],"which":[194],"intravenous":[196],"(IFX-IV).":[198],"Patients":[199,235],"were":[200,236,276,288],"divided":[201],"into":[202],"two":[203],"arms":[204],"induction":[206],"based":[208],"presence":[211,402],"anti-IFX.":[213],"Maintenance":[214],"consisted":[216],"120":[218],"mg":[219,228],"s.c.":[220,229],"every":[221,230],"14":[222,231],"days,":[223],"intensification":[225],"240":[227],"days":[232],"if":[233],"necessary.":[234],"monitored":[237,323],"at":[238],"weeks":[239],"W0,":[240],"W4,":[241],"W14,":[242],"W30,":[243],"W52,":[245],"recording":[246],"Harvey-Bradshaw":[247],"Index":[248],"(HBI),":[249],"serum":[250,264],"C-reactive":[251],"protein":[252],"(CRP),":[253],"fecal":[254],"calprotectin":[255],"(FC)":[256],"concentrations,":[257],"drug":[258],"levels":[260],"(TL":[261],"IFX)":[262],"Endoscopic":[268],"ultrasonographic":[270],"scores":[272],"(SES-CD":[273],"IUS)":[275],"determined,":[277],"HLA":[279],"DQA1*05":[280],"haplotype":[281],"examined":[283],"all":[285,322],"patients.":[286],"Data":[287],"analyzed":[289],"using":[290],"MedCalc\u00ae":[291],"Statistical":[292],"Software":[293],"non-parametric":[295],"statistical":[296],"methods":[297],"binary":[299],"logistic":[300],"regression.":[301],"Results:":[302],"52-week":[303,373],"persistence":[304],"recorded":[309,367],"13":[311],"out":[312,336],"(56.5%),":[316],"decrease":[320],"activity.":[331],"During":[332],"8":[335],"16":[338],"initially":[339],"anti-IFX":[340,346],"positive":[341],"individuals":[342],"seroconverted":[343],"negative":[345],"(50%).":[347],"None":[348],"W52":[356],"needed":[357],"concomitant":[358],"immunomodulator":[359],"treatment.":[360],"No":[361],"new":[362],"sensitization":[363],"cohort":[370],"during":[371],"Conclusion:":[375],"route":[378],"administration":[381],"be":[383],"suitable":[385],"successful":[387],"solution":[388],"situations":[390],"reinduction":[392],"desired,":[397],"neutralizing":[404]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-11-07T00:00:00"}