{"id":"https://openalex.org/W4388422331","doi":"https://doi.org/10.14309/ajg.0000000000002569","title":"Carvedilol Plus NUC for Patients With HBV-Compensated Cirrhosis Under Virological Suppression: A Randomized Open-Label Trial","display_name":"Carvedilol Plus NUC for Patients With HBV-Compensated Cirrhosis Under Virological Suppression: A Randomized Open-Label Trial","publication_year":2023,"publication_date":"2023-11-06","ids":{"openalex":"https://openalex.org/W4388422331","doi":"https://doi.org/10.14309/ajg.0000000000002569","pmid":"https://pubmed.ncbi.nlm.nih.gov/37929952"},"language":"en","primary_location":{"id":"doi:10.14309/ajg.0000000000002569","doi":"https://doi.org/10.14309/ajg.0000000000002569","is_oa":false,"landing_page_url":"https://doi.org/10.14309/ajg.0000000000002569","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4388422331"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110973946","display_name":"Bingqiong Wang","orcid":"https://orcid.org/0009-0005-3439-6810","observed_orcids":["https://orcid.org/0009-0005-3439-6810"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingqiong Wang","raw_affiliation_strings":["Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049626085","display_name":"Jialing Zhou","orcid":"https://orcid.org/0000-0001-5075-6656","observed_orcids":["https://orcid.org/0000-0001-5075-6656"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jialing Zhou","raw_affiliation_strings":["Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101660323","display_name":"Xiaoning Wu","orcid":"https://orcid.org/0000-0001-5416-712X","observed_orcids":["https://orcid.org/0000-0001-5416-712X"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoning Wu","raw_affiliation_strings":["Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;"],"raw_orcid":"https://orcid.org/0000-0001-5416-712X","affiliations":[{"raw_affiliation_string":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010609515","display_name":"Yameng Sun","orcid":"https://orcid.org/0000-0003-2981-9936","observed_orcids":["https://orcid.org/0000-0003-2981-9936"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yameng Sun","raw_affiliation_strings":["Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100440367","display_name":"Lei Li","orcid":"https://orcid.org/0000-0002-9180-8552","observed_orcids":["https://orcid.org/0000-0002-9180-8552"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2802957242","display_name":"Beijing Jishuitan Hospital","ror":"https://ror.org/035t17984","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802957242"]},{"id":"https://openalex.org/I4210147332","display_name":"Beijing YouAn Hospital","ror":"https://ror.org/04etaja30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147332"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Li","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China;","Department of Gastroenterology and Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2802957242"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435591","display_name":"Ping Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping Li","raw_affiliation_strings":["Department of Hepatology, Tianjin Second People's Hospital, Tianjin, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, Tianjin Second People's Hospital, Tianjin, China;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400063","display_name":"Minghui Li","orcid":"https://orcid.org/0000-0003-3233-5473","observed_orcids":["https://orcid.org/0000-0003-3233-5473"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210150338","display_name":"Beijing Ditan Hospital","ror":"https://ror.org/05kkkes98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150338"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghui Li","raw_affiliation_strings":["Liver Disease Center, Beijing Ditan Hospital, Capital Medical University, Beijing, China;"],"raw_orcid":"https://orcid.org/0000-0003-3233-5473","affiliations":[{"raw_affiliation_string":"Liver Disease Center, Beijing Ditan Hospital, Capital Medical University, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210150338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091729335","display_name":"Wei Jiang","orcid":"https://orcid.org/0000-0002-9354-6699","observed_orcids":["https://orcid.org/0000-0002-9354-6699"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Jiang","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China;","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015832055","display_name":"Mingyi Xu","orcid":"https://orcid.org/0000-0002-4834-3542","observed_orcids":["https://orcid.org/0000-0002-4834-3542"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingyi Xu","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Shanghai East Hospital, Shanghai, China;","Department of Gastroenterology and Hepatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Shanghai East Hospital, Shanghai, China;","institution_ids":["https://openalex.org/I4210128175"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650885","display_name":"Bo Feng","orcid":"https://orcid.org/0000-0001-5084-6715","observed_orcids":["https://orcid.org/0000-0001-5084-6715"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Feng","raw_affiliation_strings":["Hepatology Institute, Peking University People's Hospital, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatology Institute, Peking University People's Hospital, Beijing, China;","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034168127","display_name":"Xiaoyuan Xu","orcid":"https://orcid.org/0000-0002-1759-4330","observed_orcids":["https://orcid.org/0000-0002-1759-4330"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyuan Xu","raw_affiliation_strings":["Department of Infectious Disease, Peking University First Hospital, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Peking University First Hospital, Beijing, China;","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011275179","display_name":"Jilin Cheng","orcid":"https://orcid.org/0000-0001-8019-544X","observed_orcids":["https://orcid.org/0000-0001-8019-544X"]},"institutions":[{"id":"https://openalex.org/I4210106542","display_name":"Shanghai Public Health Clinical Center","ror":"https://ror.org/01nnwyz44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106542"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jilin Cheng","raw_affiliation_strings":["Department of Gastroenterology, Shanghai Public Health Clinical Center, Shanghai, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shanghai Public Health Clinical Center, Shanghai, China;","institution_ids":["https://openalex.org/I4210106542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052998000","display_name":"Wen Xie","orcid":"https://orcid.org/0000-0002-7314-8175","observed_orcids":["https://orcid.org/0000-0002-7314-8175"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210150338","display_name":"Beijing Ditan Hospital","ror":"https://ror.org/05kkkes98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150338"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Xie","raw_affiliation_strings":["Liver Disease Center, Beijing Ditan Hospital, Capital Medical University, Beijing, China;"],"raw_orcid":"https://orcid.org/0000-0002-7314-8175","affiliations":[{"raw_affiliation_string":"Liver Disease Center, Beijing Ditan Hospital, Capital Medical University, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210150338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077610464","display_name":"Tao Han","orcid":"https://orcid.org/0000-0003-4216-6968","observed_orcids":["https://orcid.org/0000-0003-4216-6968"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4210088587","display_name":"Tianjin Third Central Hospital","ror":"https://ror.org/00911j719","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088587"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Han","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Tianjin Union Medical Center Affiliated to Nankai University, Tianjin, China;","Department of Hepatology, Tianjin Third Central Hospital, Tianjin Medical University, Tianjin, China;"],"raw_orcid":"https://orcid.org/0000-0003-4216-6968","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tianjin Union Medical Center Affiliated to Nankai University, Tianjin, China;","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Department of Hepatology, Tianjin Third Central Hospital, Tianjin Medical University, Tianjin, China;","institution_ids":["https://openalex.org/I4210088587","https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108391501","display_name":"Xiaozhong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130768","display_name":"Xinjiang Uygur Autonomous Region Uygur Medicine Hospital","ror":"https://ror.org/03t47sr41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130768"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaozhong Wang","raw_affiliation_strings":["Department of Hepatology, Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital, Urumqi, Xinjiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital, Urumqi, Xinjiang, China;","institution_ids":["https://openalex.org/I4210130768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100429404","display_name":"Hai Li","orcid":"https://orcid.org/0000-0003-4174-9758","observed_orcids":["https://orcid.org/0000-0003-4174-9758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai Li","raw_affiliation_strings":["Department of Gastroenterology, Tianjin Xiqing Hospital, Tianjin, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tianjin Xiqing Hospital, Tianjin, China;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101235550","display_name":"Hongxin Piao","orcid":"https://orcid.org/0000-0002-4396-6070","observed_orcids":["https://orcid.org/0000-0002-4396-6070"]},"institutions":[{"id":"https://openalex.org/I1793135","display_name":"Yanbian University","ror":"https://ror.org/039xnh269","country_code":"CN","type":"education","lineage":["https://openalex.org/I1793135"]},{"id":"https://openalex.org/I4210131149","display_name":"Yanbian University Hospital","ror":"https://ror.org/037ve0v69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131149"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongxin Piao","raw_affiliation_strings":["Department of Infectious Diseases, Affiliated Hospital of Yanbian University, Yanji, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Affiliated Hospital of Yanbian University, Yanji, China;","institution_ids":["https://openalex.org/I1793135","https://openalex.org/I4210131149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020264368","display_name":"Xinyu Zhao","orcid":"https://orcid.org/0000-0003-4123-3030","observed_orcids":["https://orcid.org/0000-0003-4123-3030"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Zhao","raw_affiliation_strings":["Department of Clinical Epidemiology and EBM Unit, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing, China;"],"raw_orcid":"https://orcid.org/0000-0003-4123-3030","affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology and EBM Unit, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100684923","display_name":"Shuyan Chen","orcid":"https://orcid.org/0000-0003-2400-8413","observed_orcids":["https://orcid.org/0000-0003-2400-8413"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuyan Chen","raw_affiliation_strings":["Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;"],"raw_orcid":"https://orcid.org/0000-0003-2400-8413","affiliations":[{"raw_affiliation_string":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010037620","display_name":"Tongtong Meng","orcid":"https://orcid.org/0009-0002-4746-3662","observed_orcids":["https://orcid.org/0009-0002-4746-3662"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tongtong Meng","raw_affiliation_strings":["Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041809928","display_name":"Qiushuang Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiushuang Guan","raw_affiliation_strings":["Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088949314","display_name":"Fandong Meng","orcid":"https://orcid.org/0000-0002-2873-575X","observed_orcids":["https://orcid.org/0000-0002-2873-575X"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fandong Meng","raw_affiliation_strings":["Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-2873-575X","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012108815","display_name":"Yuanyuan Kong","orcid":"https://orcid.org/0000-0002-2586-1443","observed_orcids":["https://orcid.org/0000-0002-2586-1443"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Kong","raw_affiliation_strings":["Department of Clinical Epidemiology and EBM Unit, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing, China;"],"raw_orcid":"https://orcid.org/0000-0002-2586-1443","affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology and EBM Unit, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112731247","display_name":"Xiaojuan Ou","orcid":"https://orcid.org/0009-0002-4662-4970","observed_orcids":["https://orcid.org/0009-0002-4662-4970"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojuan Ou","raw_affiliation_strings":["Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008566878","display_name":"Jidong Jia","orcid":"https://orcid.org/0000-0002-4673-8890","observed_orcids":["https://orcid.org/0000-0002-4673-8890"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jidong Jia","raw_affiliation_strings":["Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;"],"raw_orcid":"https://orcid.org/0000-0002-4673-8890","affiliations":[{"raw_affiliation_string":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066330334","display_name":"Hong You","orcid":"https://orcid.org/0000-0001-9409-1158","observed_orcids":["https://orcid.org/0000-0001-9409-1158"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hong You","raw_affiliation_strings":["Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":20,"corresponding_author_ids":["https://openalex.org/A5008566878","https://openalex.org/A5066330334"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210089514","https://openalex.org/I4210147433"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.9672,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.72661106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"119","issue":"4","first_page":"700","last_page":"711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carvedilol","display_name":"carvedilol","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nucleos-t-ide-analogues","display_name":"nucleos(t)ide analogues","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hbv-related-liver-cirrhosis","display_name":"HBV-related liver cirrhosis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/compensated-cirrhosis","display_name":"compensated cirrhosis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/esophageal-varices","display_name":"esophageal varices","score":0.8960000276565552},{"id":"https://openalex.org/keywords/portal-hypertension","display_name":"portal hypertension","score":0.6919999718666077},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.8709999918937683},{"id":"https://openalex.org/keywords/viral-suppression","display_name":"viral suppression","score":0.7860000133514404},{"id":"https://openalex.org/keywords/variceal-regression","display_name":"variceal regression","score":0.7269999980926514},{"id":"https://openalex.org/keywords/hepatic-decompensation","display_name":"hepatic decompensation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.6579999923706055},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9367607831954956},{"id":"https://openalex.org/C2780591200","wikidata":"https://www.wikidata.org/wiki/Q412534","display_name":"Carvedilol","level":3,"score":0.8027921915054321},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.8023620247840881},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.77712082862854},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7397045493125916},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6928088665008545},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6378125548362732},{"id":"https://openalex.org/C2778721985","wikidata":"https://www.wikidata.org/wiki/Q1183680","display_name":"Decompensation","level":2,"score":0.5857529640197754},{"id":"https://openalex.org/C2777595160","wikidata":"https://www.wikidata.org/wiki/Q298278","display_name":"Esophageal varices","level":4,"score":0.5809434652328491},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5403727293014526},{"id":"https://openalex.org/C2778808290","wikidata":"https://www.wikidata.org/wiki/Q124604","display_name":"Portal hypertension","level":3,"score":0.3684625029563904},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.152614563703537}],"mesh":[{"descriptor_ui":"D000077261","descriptor_name":"Carvedilol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.14309/ajg.0000000000002569","doi":"https://doi.org/10.14309/ajg.0000000000002569","is_oa":false,"landing_page_url":"https://doi.org/10.14309/ajg.0000000000002569","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:37929952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37929952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Randomized Controlled Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G3396377202","display_name":null,"funder_award_id":"2017ZX10203202","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"},{"id":"https://openalex.org/G3577911001","display_name":null,"funder_award_id":"2018ZX10302-204","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"},{"id":"https://openalex.org/G6092214723","display_name":null,"funder_award_id":"82000568","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1803783718","https://openalex.org/W1950223850","https://openalex.org/W1964051982","https://openalex.org/W1981084674","https://openalex.org/W1987530799","https://openalex.org/W2007083511","https://openalex.org/W2016340416","https://openalex.org/W2033260776","https://openalex.org/W2041144771","https://openalex.org/W2047793423","https://openalex.org/W2077766583","https://openalex.org/W2101099470","https://openalex.org/W2148353653","https://openalex.org/W2159845343","https://openalex.org/W2166467296","https://openalex.org/W2422098140","https://openalex.org/W2512291917","https://openalex.org/W2515460802","https://openalex.org/W2525115149","https://openalex.org/W2546046192","https://openalex.org/W2588120710","https://openalex.org/W2922822790","https://openalex.org/W2997743779","https://openalex.org/W3002822153","https://openalex.org/W3034594034","https://openalex.org/W3112258955","https://openalex.org/W3132268042","https://openalex.org/W4214765868","https://openalex.org/W4281625022","https://openalex.org/W4283206840","https://openalex.org/W4311772160","https://openalex.org/W4361276104"],"related_works":["https://openalex.org/W4361276104","https://openalex.org/W2316744545","https://openalex.org/W2422098140","https://openalex.org/W4323806100","https://openalex.org/W1950223850","https://openalex.org/W4376132604","https://openalex.org/W4313398873","https://openalex.org/W4409148056","https://openalex.org/W4317870056","https://openalex.org/W7162316414"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Portal":[1],"hypertension":[2],"progression":[3,44,94,135,247],"can":[4],"be":[5],"relieved":[6],"after":[7],"controlling":[8],"the":[9,19,36,93,141,148,169,217,237,256],"etiology":[10],"of":[11,38,96,101,106,202],"liver":[12],"cirrhosis.":[13,53,254],"Whether":[14],"beta-blockers":[15],"could":[16],"additionally":[17],"enhance":[18],"effects":[20],"during":[21,45],"treatment,":[22],"particularly":[23],"for":[24,264],"small":[25,194],"esophageal":[26],"varices":[27],"(EV),":[28],"was":[29,92,137,214],"unclear.":[30],"This":[31,55],"study":[32],"aims":[33],"to":[34,41,74],"assess":[35],"efficacy":[37],"add-on":[39],"carvedilol":[40,80,119,239],"delay":[42],"EV":[43,97,134,167,180,246,268],"anti-hepatitis":[46],"B":[47],"virus":[48],"(HBV)":[49],"treatment":[50],"in":[51,140,147,178,193,244,248],"HBV-related":[52],"METHODS:":[54],"randomized":[56,113],"controlled":[57],"trial":[58],"enrolled":[59],"patients":[60,108,129,249,265],"with":[61,250,266],"virologically":[62,251],"suppressed":[63,252],"HBV-compensated":[64,253],"cirrhosis":[65],"and":[66,117,144,241],"small/medium":[67],"EV.":[68],"The":[69,88,200,227],"participants":[70],"were":[71,112],"randomly":[72],"assigned":[73],"receive":[75],"nucleos(t)ide":[76],"analog":[77],"(NUC)":[78],"or":[79,208],"12.5":[81],"mg":[82],"plus":[83,120],"NUC":[84,116,121,142,189,242],"(1:1":[85],"allocation":[86],"ratio).":[87],"primary":[89],"end":[90],"point":[91],"rate":[95,136],"at":[98],"2":[99,212,218],"years":[100,213],"follow-up.":[102],"RESULTS:":[103],"A":[104],"total":[105],"238":[107],"(small":[109],"EV,":[110],"77.3%)":[111],"into":[114],"119":[115,118],"(carvedilol":[122],"[CARV]":[123],"combination":[124,150,171],"group).":[125],"Among":[126],"them,":[127],"205":[128],"(86.1%)":[130],"completed":[131],"paired":[132],"endoscopies.":[133],"15.5%":[138],"(16/103)":[139],"group":[143,151,172],"12.7%":[145],"(13/102)":[146],"CARV":[149,170],"(relative":[152],"risk":[153],"=":[154,161,186,198,224],"0.79,":[155],"95%":[156],"confidence":[157],"interval":[158],"0.36-1.75,":[159],"P":[160,185,197,223],"0.567).":[162],"Subgroup":[163],"analysis":[164],"on":[165],"medium":[166,267],"showed":[168],"had":[173],"a":[174],"more":[175],"favorable":[176],"effect":[177],"promoting":[179],"regression":[181],"(43.5%":[182],"vs":[183,221],"13.1%,":[184],"0.022)":[187],"than":[188],"alone,":[190],"but":[191],"not":[192,231],"cases":[195],"(":[196],"0.534).":[199],"incidence":[201],"liver-related":[203],"events":[204],"(decompensation,":[205],"hepatocellular":[206],"carcinoma,":[207],"death/liver":[209],"transplantation)":[210],"within":[211],"similar":[215],"between":[216,236],"groups":[219],"(11.2%":[220],"10.4%,":[222],"0.881).":[225],"DISCUSSION:":[226],"overall":[228],"results":[229],"did":[230],"show":[232],"statistically":[233],"significant":[234],"differences":[235],"added":[238],"strategy":[240],"monotherapy":[243],"preventing":[245],"However,":[255],"carvedilol-added":[257],"approach":[258],"might":[259],"offer":[260],"improved":[261],"outcomes":[262],"specifically":[263],"(NCT03736265).":[269]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-11-07T00:00:00"}