{"id":"https://openalex.org/W4388399499","doi":"https://doi.org/10.12771/emj.2023.e17","title":"Protective Effects of Statins against Alzheimer Disease","display_name":"Protective Effects of Statins against Alzheimer Disease","publication_year":2023,"publication_date":"2023-10-31","ids":{"openalex":"https://openalex.org/W4388399499","doi":"https://doi.org/10.12771/emj.2023.e17","pmid":"https://pubmed.ncbi.nlm.nih.gov/40703952","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12093576"},"language":"en","primary_location":{"id":"doi:10.12771/emj.2023.e17","doi":"https://doi.org/10.12771/emj.2023.e17","is_oa":true,"landing_page_url":"https://doi.org/10.12771/emj.2023.e17","pdf_url":"http://www.e-emj.org/download/download_pdf?pid=emj-46-4-17","source":{"id":"https://openalex.org/S2764859838","display_name":"Ewha Medical Journal","issn_l":"1598-7450","issn":["1598-7450","2234-2591","2234-3180"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4364118887","host_organization_name":"Ewha Womans University College of Medicine","host_organization_lineage":["https://openalex.org/P4364118887"],"host_organization_lineage_names":["Ewha Womans University College of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Ewha Medical Journal","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.e-emj.org/download/download_pdf?pid=emj-46-4-17","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062665023","display_name":"Leila Rezakhani","orcid":"https://orcid.org/0000-0003-1501-6489","observed_orcids":["https://orcid.org/0000-0003-1501-6489"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Leila Rezakhani","raw_affiliation_strings":["Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran","Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":"https://orcid.org/0000-0003-1501-6489","affiliations":[{"raw_affiliation_string":"Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]},{"raw_affiliation_string":"Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075424484","display_name":"Zahra Salimi","orcid":"https://orcid.org/0000-0001-7041-5613","observed_orcids":["https://orcid.org/0000-0001-7041-5613"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Zahra Salimi","raw_affiliation_strings":["Department of Physiology, Kermanshah University of Medical Sciences, Kermanshah, Iran","Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":"https://orcid.org/0000-0001-7041-5613","affiliations":[{"raw_affiliation_string":"Department of Physiology, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]},{"raw_affiliation_string":"Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103044864","display_name":"Fatemeh Zarei","orcid":"https://orcid.org/0000-0003-0382-4518","observed_orcids":["https://orcid.org/0000-0003-0382-4518"]},"institutions":[{"id":"https://openalex.org/I1187138","display_name":"Razi University","ror":"https://ror.org/02ynb0474","country_code":"IR","type":"education","lineage":["https://openalex.org/I1187138"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Zarei","raw_affiliation_strings":["Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran"],"raw_orcid":"https://orcid.org/0000-0003-0382-4518","affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran","institution_ids":["https://openalex.org/I1187138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011818062","display_name":"Farshad Moradpour","orcid":"https://orcid.org/0000-0003-2123-7165","observed_orcids":["https://orcid.org/0000-0003-2123-7165"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Farshad Moradpour","raw_affiliation_strings":["Department of Physiology, Kermanshah University of Medical Sciences, Kermanshah, Iran","Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":"https://orcid.org/0000-0003-2123-7165","affiliations":[{"raw_affiliation_string":"Department of Physiology, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]},{"raw_affiliation_string":"Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082464122","display_name":"Mohammad Rasool Khazaei","orcid":"https://orcid.org/0000-0001-9818-0625","observed_orcids":["https://orcid.org/0000-0001-9818-0625"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Rasool Khazaei","raw_affiliation_strings":["Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran","Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":"https://orcid.org/0000-0001-9818-0625","affiliations":[{"raw_affiliation_string":"Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]},{"raw_affiliation_string":"Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057391825","display_name":"Mozafar Khazaei","orcid":"https://orcid.org/0000-0003-0536-3217","observed_orcids":["https://orcid.org/0000-0003-0536-3217","https://orcid.org/0000-0003-2288-4938"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mozafar Khazaei","raw_affiliation_strings":["Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran","Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":"https://orcid.org/0000-0003-0536-3217","affiliations":[{"raw_affiliation_string":"Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]},{"raw_affiliation_string":"Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5093201260","display_name":"Maryam Pourjalili","orcid":"https://orcid.org/0000-0003-1930-6205","observed_orcids":["https://orcid.org/0000-0003-1930-6205"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Maryam Pourjalili","raw_affiliation_strings":["School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran","Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":"https://orcid.org/0000-0003-1930-6205","affiliations":[{"raw_affiliation_string":"School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]},{"raw_affiliation_string":"Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057391825","https://openalex.org/A5075424484"],"corresponding_institution_ids":["https://openalex.org/I39642139"],"apc_list":null,"apc_paid":null,"fwci":0.1638,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.10403638,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"46","issue":"4","first_page":"e17","last_page":"e17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9269999861717224},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.8740000128746033},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":1.0},{"id":"https://openalex.org/keywords/cholesterol-lowering","display_name":"cholesterol lowering","score":0.7239999771118164},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8709999918937683},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9409999847412109},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9559999704360962},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":1.0},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.8360000252723694},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8340893387794495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6147488951683044},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6019882559776306},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.566160261631012},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.514300525188446},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5082711577415466},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4926770329475403},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.48366579413414},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.43462932109832764},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.43295779824256897},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.4210163652896881},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3264678716659546},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27260303497314453},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.18423327803611755},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16647878289222717},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.05455562472343445}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.12771/emj.2023.e17","doi":"https://doi.org/10.12771/emj.2023.e17","is_oa":true,"landing_page_url":"https://doi.org/10.12771/emj.2023.e17","pdf_url":"http://www.e-emj.org/download/download_pdf?pid=emj-46-4-17","source":{"id":"https://openalex.org/S2764859838","display_name":"Ewha Medical Journal","issn_l":"1598-7450","issn":["1598-7450","2234-2591","2234-3180"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4364118887","host_organization_name":"Ewha Womans University College of Medicine","host_organization_lineage":["https://openalex.org/P4364118887"],"host_organization_lineage_names":["Ewha Womans University College of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Ewha Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11094809","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12093576","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12093576/pdf/emj-46-4-17.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40703952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40703952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ewha medical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12093576","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12093576/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ewha Med J","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7d153157de9f4194a7f1857578fbf10e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7d153157de9f4194a7f1857578fbf10e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Ewha Medical Journal, Vol 46, Iss 4 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.12771/emj.2023.e17","doi":"https://doi.org/10.12771/emj.2023.e17","is_oa":true,"landing_page_url":"https://doi.org/10.12771/emj.2023.e17","pdf_url":"http://www.e-emj.org/download/download_pdf?pid=emj-46-4-17","source":{"id":"https://openalex.org/S2764859838","display_name":"Ewha Medical Journal","issn_l":"1598-7450","issn":["1598-7450","2234-2591","2234-3180"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4364118887","host_organization_name":"Ewha Womans University College of Medicine","host_organization_lineage":["https://openalex.org/P4364118887"],"host_organization_lineage_names":["Ewha Womans University College of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Ewha Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323227","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388399499.pdf","grobid_xml":"https://content.openalex.org/works/W4388399499.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W15429299","https://openalex.org/W952197207","https://openalex.org/W1685069336","https://openalex.org/W1915192275","https://openalex.org/W1963913523","https://openalex.org/W1965050626","https://openalex.org/W1966848219","https://openalex.org/W1967612716","https://openalex.org/W1970636819","https://openalex.org/W1975806945","https://openalex.org/W1979910503","https://openalex.org/W1989556851","https://openalex.org/W1993820843","https://openalex.org/W1998104918","https://openalex.org/W1999664376","https://openalex.org/W2002708977","https://openalex.org/W2007787335","https://openalex.org/W2014526361","https://openalex.org/W2022245293","https://openalex.org/W2022532556","https://openalex.org/W2024080895","https://openalex.org/W2024459482","https://openalex.org/W2025170364","https://openalex.org/W2030811909","https://openalex.org/W2031227126","https://openalex.org/W2031379379","https://openalex.org/W2034038074","https://openalex.org/W2035657272","https://openalex.org/W2039783607","https://openalex.org/W2044456875","https://openalex.org/W2046299498","https://openalex.org/W2046599479","https://openalex.org/W2047613132","https://openalex.org/W2048526645","https://openalex.org/W2050066016","https://openalex.org/W2052325227","https://openalex.org/W2055309257","https://openalex.org/W2055680859","https://openalex.org/W2056262005","https://openalex.org/W2061570982","https://openalex.org/W2062605111","https://openalex.org/W2070031257","https://openalex.org/W2071124826","https://openalex.org/W2071695496","https://openalex.org/W2072519644","https://openalex.org/W2072693941","https://openalex.org/W2077792958","https://openalex.org/W2079472896","https://openalex.org/W2080274663","https://openalex.org/W2085128107","https://openalex.org/W2086189875","https://openalex.org/W2089660664","https://openalex.org/W2096410114","https://openalex.org/W2099556509","https://openalex.org/W2107841008","https://openalex.org/W2113771464","https://openalex.org/W2115955912","https://openalex.org/W2124403224","https://openalex.org/W2127269142","https://openalex.org/W2127303373","https://openalex.org/W2129085204","https://openalex.org/W2138441572","https://openalex.org/W2142467924","https://openalex.org/W2148573574","https://openalex.org/W2151352883","https://openalex.org/W2166835313","https://openalex.org/W2185523358","https://openalex.org/W2243723775","https://openalex.org/W2316355486","https://openalex.org/W2326764800","https://openalex.org/W2340338776","https://openalex.org/W2346664883","https://openalex.org/W2590135512","https://openalex.org/W2592633538","https://openalex.org/W2594854995","https://openalex.org/W2740213823","https://openalex.org/W2772553845","https://openalex.org/W2774657197","https://openalex.org/W2775023944","https://openalex.org/W2800620204","https://openalex.org/W2801937771","https://openalex.org/W2807946721","https://openalex.org/W2885577641","https://openalex.org/W2889787710","https://openalex.org/W3021474991","https://openalex.org/W3080844991","https://openalex.org/W3183823961","https://openalex.org/W4214891130","https://openalex.org/W4247759744","https://openalex.org/W7101084658","https://openalex.org/W7214220836"],"related_works":["https://openalex.org/W4416590643","https://openalex.org/W1520122966","https://openalex.org/W2157524121","https://openalex.org/W1985623563","https://openalex.org/W2076948181","https://openalex.org/W2146689009","https://openalex.org/W2149742281","https://openalex.org/W2096590285","https://openalex.org/W2405748918","https://openalex.org/W1983666846"],"abstract_inverted_index":{"Alzheimer":[0],"disease":[1,18],"(AD)":[2],"is":[3],"a":[4,44,64,101],"common":[5],"neurodegenerative":[6,183],"disorder,":[7],"characterized":[8],"by":[9],"memory":[10],"impairment,":[11],"dementia,":[12],"and":[13,30,51,116,131,167],"diminished":[14],"cognitive":[15],"function.":[16],"This":[17],"affects":[19],"more":[20],"than":[21],"20":[22],"million":[23],"people":[24],"worldwide.":[25],"Amyloid":[26],"beta":[27],"(A\u03b2)":[28],"plaques":[29,115],"neurofibrillary":[31,117],"tangles":[32],"(NFTs)":[33],"are":[34,78,97,174],"important":[35],"pathological":[36],"markers":[37],"of":[38,54,75,89,121,126,146,172,194,198],"AD.":[39,201],"Multiple":[40],"studies":[41],"have":[42,157],"indicated":[43],"potential":[45,175],"association":[46],"between":[47],"elevated":[48],"cholesterol":[49,60,76,91],"levels":[50,88],"increased":[52],"risk":[53],"AD,":[55],"suggesting":[56],"that":[57],"lowering":[58,153],"the":[59,86,119,195],"level":[61],"could":[62,142],"be":[63,143],"viable":[65],"strategy":[66],"for":[67],"AD":[68,122,147],"treatment":[69,148],"or":[70],"prevention.":[71],"Statins,":[72],"potent":[73],"inhibitors":[74],"synthesis,":[77],"widely":[79],"used":[80],"in":[81,92,104,161,181],"clinical":[82],"practice":[83],"to":[84,99,113,152,190],"decrease":[85],"plasma":[87],"LDL":[90,154],"patients":[93,123],"with":[94,136],"hyperlipidemia.":[95],"Statins":[96],"known":[98],"play":[100],"neuroprotective":[102,140,168],"role":[103],"limiting":[105],"A\u03b2":[106,114],"pathology":[107],"through":[108],"cholesterol-lowering":[109],"therapies.":[110],"In":[111,150],"addition":[112,151],"tangles,":[118],"brains":[120],"exhibit":[124],"signs":[125],"oxidative":[127],"stress,":[128],"neuroinflammatory":[129],"responses,":[130],"synaptic":[132],"disruption.":[133],"Consequently,":[134],"compounds":[135],"antioxidant,":[137,165],"anti-inflammatory,":[138,166],"and/or":[139],"properties":[141,171],"beneficial":[144,179],"components":[145],"strategies.":[149],"cholesterol,":[155],"statins":[156,173,199],"demonstrated":[158],"therapeutic":[159],"efficacy":[160],"various":[162],"forms,":[163],"including":[164],"effects.":[169],"These":[170],"mechanisms":[176],"underlying":[177],"their":[178],"effects":[180,197],"treating":[182],"diseases.":[184],"Therefore,":[185],"this":[186],"review":[187],"was":[188],"conducted":[189],"provide":[191],"an":[192],"overview":[193],"protective":[196],"against":[200]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-11-06T00:00:00"}