{"id":"https://openalex.org/W4388364419","doi":"https://doi.org/10.1016/j.ibneur.2023.08.338","title":"GOLEXANOLONE IMPROVES PERIPHERAL INFLAMMATION, FATIGUE, LOCOMOTOR GAIT, MOTOR INCOORDINATION AND SHORT-TERM MEMORY IN RATS WITH CHOLESTASIS AND HEPATIC ENCEPHALOPATHY DUE TO BILE DUCT LIGATION","display_name":"GOLEXANOLONE IMPROVES PERIPHERAL INFLAMMATION, FATIGUE, LOCOMOTOR GAIT, MOTOR INCOORDINATION AND SHORT-TERM MEMORY IN RATS WITH CHOLESTASIS AND HEPATIC ENCEPHALOPATHY DUE TO BILE DUCT LIGATION","publication_year":2023,"publication_date":"2023-10-01","ids":{"openalex":"https://openalex.org/W4388364419","doi":"https://doi.org/10.1016/j.ibneur.2023.08.338"},"language":"en","primary_location":{"id":"doi:10.1016/j.ibneur.2023.08.338","doi":"https://doi.org/10.1016/j.ibneur.2023.08.338","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ibneur.2023.08.338","pdf_url":"https://www.ibroneuroreports.org/article/S2667-2421(23)00400-1/pdf","source":{"id":"https://openalex.org/S4210237554","display_name":"IBRO Neuroscience Reports","issn_l":"2667-2421","issn":["2667-2421"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IBRO Neuroscience Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ibroneuroreports.org/article/S2667-2421(23)00400-1/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052034904","display_name":"Yaiza Ma Arenas Ortiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Yaiza M\u00aa Arenas Ortiz","raw_affiliation_strings":["Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061730837","display_name":"Paula Izquierdo\u2010Altarejos","orcid":"https://orcid.org/0000-0001-6557-0483","observed_orcids":["https://orcid.org/0000-0001-6557-0483"]},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Paula Izquierdo Altarejos","raw_affiliation_strings":["Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057615508","display_name":"Mar Martinez\u2010Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar Martinez Garc\u00eda","raw_affiliation_strings":["Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071101122","display_name":"Carla Gim\u00e9nez Garz\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carla Gim\u00e9nez Garz\u00f3","raw_affiliation_strings":["Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039900490","display_name":"Gergana Mincheva","orcid":"https://orcid.org/0000-0002-2981-7060","observed_orcids":["https://orcid.org/0000-0002-2981-7060"]},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gergana Mincheva","raw_affiliation_strings":["Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018777090","display_name":"Magnus Doverskog","orcid":"https://orcid.org/0000-0001-8589-0724","observed_orcids":["https://orcid.org/0000-0001-8589-0724"]},"institutions":[{"id":"https://openalex.org/I4405267835","display_name":"Umecrine Cognition AB (Sweden)","ror":"https://ror.org/04mmvee29","country_code":"SE","type":"company","lineage":["https://openalex.org/I4405267835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Magnus Doverskog","raw_affiliation_strings":["Umecrine Cognition, Umecrine Cognition, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Umecrine Cognition, Umecrine Cognition, Solna, Sweden","institution_ids":["https://openalex.org/I4405267835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062390725","display_name":"Marta Llansola","orcid":"https://orcid.org/0000-0002-5565-5907","observed_orcids":["https://orcid.org/0000-0002-5565-5907"]},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Llansola","raw_affiliation_strings":["Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070740276","display_name":"Vicente Felipo","orcid":"https://orcid.org/0000-0003-3145-9538","observed_orcids":["https://orcid.org/0000-0003-3145-9538"]},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Vicente Felipo","raw_affiliation_strings":["Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research center of Pr\u00edncipe Felipe, Neurobiology, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":null,"first_page":"S212","last_page":"S212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.336899995803833,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.336899995803833,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.08879999816417694,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.052299998700618744,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholestasis","display_name":"cholestasis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bile-duct-ligation","display_name":"bile duct ligation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.7459999918937683},{"id":"https://openalex.org/keywords/motor-incoordination","display_name":"motor incoordination","score":0.968999981880188},{"id":"https://openalex.org/keywords/short-term-memory","display_name":"short-term memory","score":0.9950000047683716},{"id":"https://openalex.org/keywords/peripheral-inflammation","display_name":"peripheral inflammation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/cholestatic-liver-disease","display_name":"cholestatic liver disease","score":0.8389999866485596},{"id":"https://openalex.org/keywords/primary-sclerosing-cholangitis","display_name":"primary sclerosing cholangitis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.871999979019165},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.6924679279327393},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6047413349151611},{"id":"https://openalex.org/C2780325230","wikidata":"https://www.wikidata.org/wiki/Q642548","display_name":"Hepatic encephalopathy","level":3,"score":0.5700426697731018},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5107681751251221},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.4582935571670532},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.4556044936180115},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.400769978761673},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3456883430480957},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ibneur.2023.08.338","doi":"https://doi.org/10.1016/j.ibneur.2023.08.338","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ibneur.2023.08.338","pdf_url":"https://www.ibroneuroreports.org/article/S2667-2421(23)00400-1/pdf","source":{"id":"https://openalex.org/S4210237554","display_name":"IBRO Neuroscience Reports","issn_l":"2667-2421","issn":["2667-2421"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IBRO Neuroscience Reports","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ac983bcd5be14a10878207fb1ed330ee","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ac983bcd5be14a10878207fb1ed330ee","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IBRO Neuroscience Reports, Vol 15, Iss , Pp S212- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ibneur.2023.08.338","doi":"https://doi.org/10.1016/j.ibneur.2023.08.338","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ibneur.2023.08.338","pdf_url":"https://www.ibroneuroreports.org/article/S2667-2421(23)00400-1/pdf","source":{"id":"https://openalex.org/S4210237554","display_name":"IBRO Neuroscience Reports","issn_l":"2667-2421","issn":["2667-2421"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IBRO Neuroscience Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388364419.pdf","grobid_xml":"https://content.openalex.org/works/W4388364419.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389070536","https://openalex.org/W2100194419","https://openalex.org/W2043850342","https://openalex.org/W2059781199","https://openalex.org/W2054272841","https://openalex.org/W1964257182","https://openalex.org/W6990704816","https://openalex.org/W184377372","https://openalex.org/W2182053469","https://openalex.org/W1990634525"],"abstract_inverted_index":{"Cholestasis":[0],"may":[1,19,36],"appear":[2],"in":[3,76],"patients":[4],"with":[5,17,33,41,47],"primary":[6,9],"sclerosing":[7],"cholangitis,":[8,11],"biliary":[10],"or":[12,73],"drug-induced":[13],"liver":[14,34,57,77],"injury.":[15],"Patients":[16,32],"cholestasis":[18],"show":[20,38],"fatigue":[21,72],"and":[22,43,59],"other":[23],"alterations":[24,69],"that":[25],"severely":[26],"reduce":[27],"their":[28],"quality":[29],"of":[30,55,60],"life.":[31],"disease":[35,58],"also":[37],"hepatic":[39,61],"encephalopathy,":[40],"cognitive":[42],"motor":[44],"impairment.":[45],"Rats":[46],"bile-duct":[48],"ligation":[49],"(BDL)":[50],"are":[51,64],"a":[52],"model":[53],"both":[54],"cholestatic":[56],"encephalopathy.":[62],"There":[63],"no":[65],"effective":[66],"treatments":[67],"for":[68],"such":[70],"as":[71],"neurological":[74],"impairment":[75],"diseases.":[78]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2023-11-05T00:00:00"}