{"id":"https://openalex.org/W4388340552","doi":"https://doi.org/10.14202/vetworld.2023.2186-2191","title":"Evaluation of the therapeutic efficacy of Vitex agnus-castus extract on cisplatin-induced hematotoxicity in female Wistar rats","display_name":"Evaluation of the therapeutic efficacy of Vitex agnus-castus extract on cisplatin-induced hematotoxicity in female Wistar rats","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4388340552","doi":"https://doi.org/10.14202/vetworld.2023.2186-2191","pmid":"https://pubmed.ncbi.nlm.nih.gov/38152275","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10750742"},"language":"en","primary_location":{"id":"doi:10.14202/vetworld.2023.2186-2191","doi":"https://doi.org/10.14202/vetworld.2023.2186-2191","is_oa":true,"landing_page_url":"https://doi.org/10.14202/vetworld.2023.2186-2191","pdf_url":"https://www.veterinaryworld.org/Vol.16/November-2023/1.pdf","source":{"id":"https://openalex.org/S2738474774","display_name":"Veterinary World","issn_l":"0972-8988","issn":["0972-8988","2231-0916"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318729","host_organization_name":"Veterinary World","host_organization_lineage":["https://openalex.org/P4310318729"],"host_organization_lineage_names":["Veterinary World"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary World","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4388340552"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.veterinaryworld.org/Vol.16/November-2023/1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021676096","display_name":"Aparna Tripathy","orcid":"https://orcid.org/0000-0001-7719-4999","observed_orcids":["https://orcid.org/0000-0001-7719-4999"]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aparna Tripathy","raw_affiliation_strings":["Division of Physiology, Department of Basic Medical Sciences, MAHE, Manipal, Karnataka, India"],"raw_orcid":"https://orcid.org/0000-0001-7719-4999","affiliations":[{"raw_affiliation_string":"Division of Physiology, Department of Basic Medical Sciences, MAHE, Manipal, Karnataka, India","institution_ids":["https://openalex.org/I164861460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059498682","display_name":"Archana Parampalli Raghavendra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Archana Parampalli Raghavendra","raw_affiliation_strings":["Division of Physiology, Department of Basic Medical Sciences, MAHE, Manipal, Karnataka, India"],"raw_orcid":"https://orcid.org/0000-0002-0945-7619","affiliations":[{"raw_affiliation_string":"Division of Physiology, Department of Basic Medical Sciences, MAHE, Manipal, Karnataka, India","institution_ids":["https://openalex.org/I164861460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011080045","display_name":"Babi Dutta","orcid":"https://orcid.org/0000-0003-4498-8914","observed_orcids":["https://orcid.org/0000-0003-4498-8914"]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Babi Dutta","raw_affiliation_strings":["Division of Biochemistry, Department of Basic Medical Sciences, MAHE, Manipal, Karnataka, India"],"raw_orcid":"https://orcid.org/0000-0003-4498-8914","affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Basic Medical Sciences, MAHE, Manipal, Karnataka, India","institution_ids":["https://openalex.org/I164861460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088678465","display_name":"Sudarshan Surendran","orcid":"https://orcid.org/0000-0003-0973-8856","observed_orcids":["https://orcid.org/0000-0003-0973-8856"]},"institutions":[{"id":"https://openalex.org/I896053408","display_name":"American University of Antigua","ror":"https://ror.org/001shqf12","country_code":"AG","type":"education","lineage":["https://openalex.org/I896053408"]}],"countries":["AG"],"is_corresponding":true,"raw_author_name":"Sudarshan Surendran","raw_affiliation_strings":["Department of Clinical Anatomy and Medical Imaging, American University of Antigua College of Medicine, Antigua"],"raw_orcid":"https://orcid.org/0000-0003-0973-8856","affiliations":[{"raw_affiliation_string":"Department of Clinical Anatomy and Medical Imaging, American University of Antigua College of Medicine, Antigua","institution_ids":["https://openalex.org/I896053408"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088678465"],"corresponding_institution_ids":["https://openalex.org/I896053408"],"apc_list":{"value":600,"currency":"USD","value_usd":600},"apc_paid":{"value":600,"currency":"USD","value_usd":600},"fwci":0.3406,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.46936148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"16","issue":"11","first_page":"2186","last_page":"2191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitex-agnus-castus","display_name":"Vitex agnus-castus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.824999988079071},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.5910000205039978},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7110000252723694},{"id":"https://openalex.org/keywords/hematological-parameters","display_name":"hematological parameters","score":0.5559999942779541},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.699999988079071},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.628000020980835},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.7609999775886536},{"id":"https://openalex.org/keywords/dose-dependent-protection","display_name":"dose-dependent protection","score":0.5879999995231628},{"id":"https://openalex.org/keywords/female-rats","display_name":"female rats","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6506961584091187},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.5058403015136719},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.5018243789672852},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.49705770611763},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4397689700126648},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3840028643608093},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36741501092910767},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.26521629095077515}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.14202/vetworld.2023.2186-2191","doi":"https://doi.org/10.14202/vetworld.2023.2186-2191","is_oa":true,"landing_page_url":"https://doi.org/10.14202/vetworld.2023.2186-2191","pdf_url":"https://www.veterinaryworld.org/Vol.16/November-2023/1.pdf","source":{"id":"https://openalex.org/S2738474774","display_name":"Veterinary World","issn_l":"0972-8988","issn":["0972-8988","2231-0916"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318729","host_organization_name":"Veterinary World","host_organization_lineage":["https://openalex.org/P4310318729"],"host_organization_lineage_names":["Veterinary World"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary World","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10750742","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10750742","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10750742/pdf/Vetworld-16-2186.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vet World","raw_type":"Text"},{"id":"pmid:38152275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38152275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary world","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c55f08a887fc47b7860889968f7ce06f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c55f08a887fc47b7860889968f7ce06f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Veterinary World, Vol 16, Iss 11, Pp 2186-2191 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.14202/vetworld.2023.2186-2191","doi":"https://doi.org/10.14202/vetworld.2023.2186-2191","is_oa":true,"landing_page_url":"https://doi.org/10.14202/vetworld.2023.2186-2191","pdf_url":"https://www.veterinaryworld.org/Vol.16/November-2023/1.pdf","source":{"id":"https://openalex.org/S2738474774","display_name":"Veterinary World","issn_l":"0972-8988","issn":["0972-8988","2231-0916"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318729","host_organization_name":"Veterinary World","host_organization_lineage":["https://openalex.org/P4310318729"],"host_organization_lineage_names":["Veterinary World"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary World","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318872","display_name":"Manipal Academy of Higher Education","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388340552.pdf","grobid_xml":"https://content.openalex.org/works/W4388340552.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W190437744","https://openalex.org/W1969502948","https://openalex.org/W1982995414","https://openalex.org/W2007403640","https://openalex.org/W2016416965","https://openalex.org/W2066659636","https://openalex.org/W2069403965","https://openalex.org/W2077566839","https://openalex.org/W2084721834","https://openalex.org/W2182757391","https://openalex.org/W2310494312","https://openalex.org/W2511436715","https://openalex.org/W2521874173","https://openalex.org/W2560978526","https://openalex.org/W2574524248","https://openalex.org/W2595242701","https://openalex.org/W2604619953","https://openalex.org/W2605123937","https://openalex.org/W2616046754","https://openalex.org/W2797956345","https://openalex.org/W2838381105","https://openalex.org/W2900950868","https://openalex.org/W2938216505","https://openalex.org/W2943738258","https://openalex.org/W2949078293","https://openalex.org/W2965008467","https://openalex.org/W2997201089","https://openalex.org/W3015539956","https://openalex.org/W3091516068","https://openalex.org/W3095232388","https://openalex.org/W3133882691","https://openalex.org/W3150252631","https://openalex.org/W3153388280","https://openalex.org/W3164074915","https://openalex.org/W3184249973","https://openalex.org/W4200528529","https://openalex.org/W4220723989","https://openalex.org/W4221075400","https://openalex.org/W4238624129","https://openalex.org/W4309003561","https://openalex.org/W4360942200"],"related_works":["https://openalex.org/W3025884626","https://openalex.org/W4406114170","https://openalex.org/W3014863755","https://openalex.org/W4417179799","https://openalex.org/W2605123937","https://openalex.org/W4253998975","https://openalex.org/W2838381105","https://openalex.org/W2110961862","https://openalex.org/W4414143818","https://openalex.org/W2077566839"],"abstract_inverted_index":{"Background":[0],"and":[1,27,51,87,118,126,154,182],"Aim:":[2],"Cisplatin":[3],"(CP)":[4],"is":[5],"a":[6,106,135],"preferred":[7],"drug":[8,89],"for":[9,100,130],"cancer":[10],"treatment":[11,200],"but":[12,197],"it":[13],"has":[14,23],"dose-dependent":[15],"side":[16],"effects.":[17],"Vitex":[18,231],"agnus-castus":[19],"(VAC)":[20],"berry":[21],"extract":[22,38],"antioxidant,":[24],"free-radical":[25],"scavenging,":[26],"anti-inflammatory":[28],"activities.":[29],"This":[30],"study":[31],"explored":[32],"the":[33,88,143,159,162,173,177,186,194,198,207],"mitigating":[34],"effects":[35],"of":[36,109,121,138,185,193],"VAC":[37],"(VACE)":[39],"on":[40,176,206],"acute":[41],"hematotoxicity":[42],"induced":[43],"by":[44,116],"CP":[45,77,81,110,139,195],"in":[46,164,172],"female":[47],"Wistar":[48,54],"rats.":[49],"Materials":[50],"Methods:":[52],"Female":[53],"rats":[55],"(n":[56,65],"=":[57,66],"30)":[58],"were":[59,189],"randomly":[60],"divided":[61],"into":[62],"five":[63],"groups":[64,104,188],"6/group).":[67],"The":[68,76,180],"normal":[69],"control":[70,78,90],"(NC)":[71],"group":[72,79,91,175,201],"received":[73,80,93,105],"no":[74],"treatment.":[75],"(7":[82,111,140],"mg/kg.b.w.":[83,120],"ip,":[84],"single":[85,107,136],"dose)":[86],"(VACE-650)":[92],"VACE":[94,122,187,215],"(650":[95],"mg/kg":[96,112,141],"b.w.":[97,113],"oral,":[98],"daily)":[99],"7":[101,131],"days.":[102,132],"Both":[103],"dose":[108,137],"ip),":[114],"followed":[115],"350":[117],"650":[119],"daily":[123],"orally":[124],"(CPVACE-350":[125],"CPVACE-650":[127],"groups,":[128],"respectively)":[129],"Results:":[133],"After":[134],"b.w.),":[142],"red":[144],"blood":[145,151,222],"cells":[146,152,223],"(RBC),":[147],"hematocrit":[148],"(HCT),":[149],"white":[150],"(WBC),":[153],"platelets":[155],"significantly":[156],"decreased.":[157],"In":[158],"VAC-350":[160],"group,":[161],"reduction":[163],"total":[165],"WBC":[166],"count":[167],"was":[168],"less":[169],"than":[170,191],"that":[171,192,214],"VAC-650":[174],"3rd":[178,208],"day.":[179,209],"RBC":[181],"HCT":[183],"values":[184],"better":[190],"control,":[196],"VACE-350":[199],"showed":[202,213],"significant":[203],"improvement":[204],"only":[205],"Conclusion:":[210],"Our":[211],"findings":[212],"can":[216],"mitigate":[217],"CP-induced":[218],"damage":[219],"to":[220],"peripheral":[221],"at":[224],"lower":[225],"doses.":[226],"Keywords:":[227],"cisplatin,":[228],"hematotoxicity,":[229],"rats,":[230],"agnus-castus.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-05T00:00:00"}